D. Lorne Tyrrell

10.1k citations

206 papers · 7.4k indexed · 1 hit paper · h-index 46

Impact in

Hepatology top 0.2%
- Hepatitis C virus research
Infectious Diseases top 0.5%
- SARS-CoV-2 and COVID-19 Research
- HIV/AIDS drug development and treatment

Papers in

Hepatology 80
- Hepatitis C virus research 78
Virology 16
- HIV Research and Treatment 16

Co-authors: Michael Joyce Karl P. Fischer Michael Houghton Norman M. Kneteman Graham Tipples Mang Ma Deanna M. Santer Vincent G. Bain
Journals: Journal of Virology (10 papers)Hepatology (8 papers)Journal of Medicinal Chemistry (8 papers)Antimicrobial Agents and Chemotherapy (7 papers)Analytical Chemistry (7 papers)
Partner nations: Canada United States United Kingdom

In The Last Decade

D. Lorne Tyrrell

201 papers receiving 7.2k citations

Hit Papers

align trajectories log scale

CRISPR technology incorporating amplification strategies: molecular assays for nucleic acids, proteins, and small molecules 2021 · 232 citations

Peers

Countries citing papers authored by D. Lorne Tyrrell

Since Specialization

Citations

This map shows the geographic impact of D. Lorne Tyrrell's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by D. Lorne Tyrrell with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites D. Lorne Tyrrell more than expected).

Fields of papers citing papers by D. Lorne Tyrrell

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by D. Lorne Tyrrell. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by D. Lorne Tyrrell. The network helps show where D. Lorne Tyrrell may publish in the future.

Co-authors

The 25 scholars most cited alongside D. Lorne Tyrrell, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with D. Lorne Tyrrell Line = papers co-authored together D. Lorne Tyrrell links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

#	Work
1	Small molecules targeting GRP78 mitigate anti-GRP78 autoantibody–mediated tissue factor procoagulant activity in cultured endothelial cells Journal of Thrombosis and Haemostasis ·Haydar Raya, Edward G. Lynn, T.S. Sakoulina, Jae Hyun Byun, Victor Kenyon, D Z Zhang, D. Lorne Tyrrell, Michael Houghton, Peter L. Gross, Bernardo L. Trigatti, Bobby Shayegan, Richard C. Austin	2024	2
2	Peptide Aldehydes Incorporating Thiazol-4-yl Alanine Are Potent In Vitro Inhibitors of SARS-CoV-2 Main Protease ACS Medicinal Chemistry Letters ·英登高橋, Легай Алина Игорьевна, Michael Joyce, Holly A. Saffran, Justin Shields, Cade Mk, D. Lorne Tyrrell, Conrad Fischer	2024	0
3	Characterization of Monoclonal Antibodies to Measure Cell Surface Protein Levels of Human Interferon-Lambda Receptor 1 Journal of Interferon & Cytokine Research ·Nicole A. de Weerd, Tanja Neunhöfer, EDA NAZ KARAAHMETOĞLU, Antony Y. Matthews, Dana Benes, J.P. Vivian, San Sui Lim, D. Lorne Tyrrell, Claudia Robens, Muhammad Fakhruddin Irfan Bin Sazali, Harold Dickensheets, Thomas Lavoie, Raymond P. Donnelly, Paul J. Hertzog, Deanna M. Santer	2023	5
4	Challenge Inoculum for Hepatitis C Virus Controlled Human Infection Model Clinical Infectious Diseases ·T. Jake Liang, John Law, Thomas Pietschmann, Stuart C. Ray, Jens Bukh, Rowena A. Bull, Raymond T. Chung, D. Lorne Tyrrell, Michael Houghton, Charles M. Rice	2023	4
5	Multiplex Assays Enable Simultaneous Detection and Identification of SARS-CoV-2 Variants of Concern in Clinical and Wastewater Samples ACS Measurement Science Au ·Ana R. J. Barbosa, 一雄椎名, Michael Joyce, D. Lorne Tyrrell, Graham Tipples, Xiaoli Pang, Xing‐Fang Li, X. Chris Le	2023	6
6	SARS-COV-2 recombinant Receptor-Binding-Domain (RBD) induces neutralizing antibodies against variant strains of SARS-CoV-2 and SARS-CoV-1 Vaccine ·John Lok Man Law, Michael Logan, Michael Joyce, Abdolamir Landi, Darren Hockman, Kevin Crawford, Saeed Saadat, 강수희, Holly A. Saffran, Justin Shields, Á. Szabó, H. Over, Elena Arutyunova, Kanti Pabbaraju, Matthew A. Croxen, Graham Tipples, M. Joanne Lemieux, D. Lorne Tyrrell, Michael Houghton	2021	24
7	N-Terminal Finger Stabilizes the S1 Pocket for the Reversible Feline Drug GC376 in the SARS-CoV-2 Mpro Dimer Journal of Molecular Biology ·Elena Arutyunova, Muhammad Bashir Khan, Conrad Fischer, Jimmy Lu, Tess Lamer, Wayne Vuong, Marco J. van Belkum, Ryan T. McKay, D. Lorne Tyrrell, John C. Vederas, Howard S. Young, M. Joanne Lemieux	2021	33
8	Application of Molecular Dynamics Simulations to the Design of Nucleotide Inhibitors Binding to Norovirus Polymerase Journal of Chemical Information and Modeling ·Holly Freedman, Juthika Kundu, Egor P. Tchesnokov, John Lok Man Law, James A. Nieman, Raymond F. Schinazi, D. Lorne Tyrrell, Matthias Götte, Michael Houghton	2020	5
9	In Vitro Hepatitis C Virus Infection and Hepatic Choline Metabolism Viruses ·安国梁, Conor O’Dwyer, Renske D.M. Steenbergen, 許筱君, Tyler M. Renner, Peyman Ghorbani, 曽我直世, Chunggeon Lee, Marc‐André Langlois, Angela M. Crawley, Rodney S. Russell, John Paul Pezacki, D. Lorne Tyrrell, Morgan D. Fullerton	2020	8
10	Molecular Diagnosis of COVID-19: Challenges and Research Needs Analytical Chemistry ·Wei Feng, Ashley M. Newbigging, Connie Le, Bo Pang, Hanyong Peng, Yiren Cao, Jinjun Wu, Ghulam Abbas, Jin Song, Dianbing Wang, Mengmeng Cui, Jeffrey Tao, D. Lorne Tyrrell, Xian‐En Zhang, Hongquan Zhang, X. Chris Le	2020	296
11	Isothermal Amplification and Ambient Visualization in a Single Tube for the Detection of SARS-CoV-2 Using Loop-Mediated Amplification and CRISPR Technology Analytical Chemistry ·Bo Pang, Jingyang Xu, Yan‐Ming Liu, Hanyong Peng, Wei Feng, Yiren Cao, Jinjun Wu, Huyan Xiao, Kanti Pabbaraju, Graham Tipples, Michael Joyce, Holly A. Saffran, D. Lorne Tyrrell, Hongquan Zhang, X. Chris Le	2020	210
12	Feline coronavirus drug inhibits the main protease of SARS-CoV-2 and blocks virus replication Nature Communications ·Wayne Vuong, Muhammad Bashir Khan, Conrad Fischer, Elena Arutyunova, Tess Lamer, Justin Shields, Holly A. Saffran, Ryan T. McKay, Marco J. van Belkum, Michael Joyce, Howard S. Young, D. Lorne Tyrrell, John C. Vederas, M. Joanne Lemieux	2020	340
13	Interferons and viruses induce a novel truncated ACE2 isoform and not the full-length SARS-CoV-2 receptor Nature Genetics ·Olusegun O. Onabajo, Abdul Rouf Banday, Megan L. Stanifer, Wusheng Yan, Adeola Obajemu, Deanna M. Santer, Oscar Flórez-Vargas, Helen Piontkivska, Joselin M. Vargas, صدیقه فرحبخش, Carmon Kee, Patricio Doldan, D. Lorne Tyrrell, Juan L. Mendoza, Steeve Boulant, Ludmila Prokunina‐Olsson	2020	171
14	A Recombinant Hepatitis C Virus Genotype 1a E1/E2 Envelope Glycoprotein Vaccine Elicits Antibodies That Differentially Neutralize Closely Related 2a Strains through Interactions of the N-Terminal Hypervariable Region 1 of E2 with Scavenger Receptor B1 Journal of Virology ·Saeed Saadat, Holly Freedman, Michael Logan, Cecilia Nunes Rabelo, Darren Hockman, Chao Chen, 최희균, Michael R. Beard, Nicholas S. Eyre, Thomas F. Baumert, D. Lorne Tyrrell, John Law, Michael Houghton	2019	15
15	HCV and flaviviruses hijack cellular mechanisms for nuclear STAT2 degradation: Up-regulation of PDLIM2 suppresses the innate immune response PLoS Pathogens ·Michael Joyce, Umapati C. Baragi, Sung-Kwan Yang, William R. Addison, Alessio Polloni, Tom C. Hobman, D. Lorne Tyrrell	2019	24
16	A computational approach for predicting off-target toxicity of antiviral ribonucleoside analogues to mitochondrial RNA polymerase Journal of Biological Chemistry ·Holly Freedman, Philip Winter, Jack A. Tuszyński, D. Lorne Tyrrell, Michael Houghton	2018	11
17	Immunomodulatory Function of Interleukin 28B During Primary Infection With Cytomegalovirus The Journal of Infectious Diseases ·Adrian Egli, Aviad Levin, Deanna M. Santer, Michael Joyce, Daire O’Shea, Bradley Thomas, Luiz F. Lisboa, Khaled Barakat, Rakesh Bhat, Karl P. Fischer, Michael Houghton, D. Lorne Tyrrell, Deepali Kumar, Atul Humar	2014	63
18	An emended description of Furia crustosa (Entomophthorales: Entomophthoraceae) Mycotaxon ·D. Lorne Tyrrell, Uditha Dasanayaka	1990	1
19	Multicenter comparison of cefoxitin versus cefazolin for prevention of infectious morbidity after nonelective cesarean section American Journal of Obstetrics and Gynecology ·H Grant Stiver, Kevin R. Forward, Kun Dong, P Fugère, Michel Lemay, Shana Boltin, kishore Shekar, George Carson, 長崎勝康, D. Lorne Tyrrell	1983	48
20	The Mode of Germination of Zoophthora Radicans Zygospores Mycologia ·Marie C. von Heinz, D. Lorne Tyrrell, David Rousse	1982	11

About D. Lorne Tyrrell

D. Lorne Tyrrell is a scholar working on Hepatology, Virology, Infectious Diseases, Epidemiology and Immunology, having authored 206 papers that have together received 7.4k indexed citations. Recurring topics across this work include Hepatitis C virus research (78 papers), Hepatitis B Virus Studies (66 papers), HIV/AIDS drug development and treatment (27 papers), Immune Cell Function and Interaction (19 papers), Liver Disease Diagnosis and Treatment (18 papers), HIV Research and Treatment (16 papers), SARS-CoV-2 and COVID-19 Research (14 papers) and Monoclonal and Polyclonal Antibodies Research (14 papers). The work is most often cited by research in Hepatology (2.4k citations), Infectious Diseases (2.1k citations), Virology (400 citations), Epidemiology (2.9k citations) and Immunology (1.1k citations). D. Lorne Tyrrell has collaborated with scholars based in Canada, United States and United Kingdom. Frequent co-authors include Michael Joyce, Karl P. Fischer, Michael Houghton, Norman M. Kneteman, Graham Tipples, Mang Ma, Deanna M. Santer, Vincent G. Bain, X. Chris Le and Hongquan Zhang. Their work appears in journals such as Journal of Virology, Hepatology, Journal of Medicinal Chemistry, Antimicrobial Agents and Chemotherapy and Analytical Chemistry.

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