Lee D. Arnold

2.7k citations

37 papers · 1.9k indexed · h-index 18

Impact in

Oncology top 5%
- HER2/EGFR in Cancer Research
- Colorectal Cancer Treatments and Studies
Organic Chemistry top 5%

Papers in

Organic Chemistry 12
- Free Radicals and Antioxidants 3
- Synthesis and Catalytic Reactions 2
- Asymmetric Synthesis and Catalysis 2
Molecular Medicine 2

Co-authors: John C. Vederas Thomas H. Kalantar Neil W. Gibson Matthew O’Connor Andrew Cooke Mark J. Mulvihill Maryland Rosenfeld-Franklin Qunsheng Ji
Journals: Journal of the American Chemical Society (4 papers)Bioorganic & Medicinal Chemistry Letters (4 papers)Molecular Cancer Therapeutics (3 papers)Journal of Medicinal Chemistry (3 papers)Journal of Biological Chemistry (2 papers)
Partner nations: United States Canada United Kingdom

In The Last Decade

Lee D. Arnold

37 papers receiving 1.8k citations

Peers

Countries citing papers authored by Lee D. Arnold

Since Specialization

Citations

This map shows the geographic impact of Lee D. Arnold's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Lee D. Arnold with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Lee D. Arnold more than expected).

Fields of papers citing papers by Lee D. Arnold

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Lee D. Arnold. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Lee D. Arnold. The network helps show where Lee D. Arnold may publish in the future.

Co-authorship network

The 25 scholars most cited alongside Lee D. Arnold, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Lee D. Arnold Line = papers co-authored together Lee D. Arnold links everyone, so they are left out of the graph.

All Works

Sort: Min cites: Since: Top N: Style:

20 of 20 papers shown

#	Work
1	The Discovery of Exarafenib (KIN-2787): Overcoming the Challenges of Pan-RAF Kinase Inhibition Journal of Medicinal Chemistry ·Young K. Chen, Toufike Kanouni, Lee D. Arnold, Jason M. Cox, Elisabeth Gardiner, Kathryn B. Grandinetti, Ping Jiang, Stephen W. Kaldor, Catherine Lee, Chun Li, Eric S. Martin, Nichol Miller, Eric A. Murphy, Anderson Mojica, John Tyhonas, N. Tsopelas, Zhenyu Fan, Richard Williams, Yuan Ding, Robert S. Kania	2024	5
2	Evaluation of in vitro antiviral activity of SARS-CoV-2 M ^pro inhibitor pomotrelvir and cross-resistance to nirmatrelvir resistance substitutions Antimicrobial Agents and Chemotherapy ·Xi Han, Yvonne Gouin, Lee D. Arnold, Laura J. Stevens, Andrea J. Pruijssers, Seunghyi Kook, Uri Lopatin, Mark R. Denison, Ann D. Kwong	2023	17
3	Target-Directed Self-Assembly of Homodimeric Drugs Against β-Tryptase ACS Medicinal Chemistry Letters ·Sarah F. Giardina, Bowen Lan, Maneesh Pingle, Kenneth W. Foreman, Donald E. Bergstrom, Lee D. Arnold, Francis Barany	2018	5
4	A Novel, Nonpeptidic, Orally Active Bivalent Inhibitor of Human β-Tryptase Pharmacology ·Sarah F. Giardina, Bowen Lan, Maneesh Pingle, Donald E. Bergstrom, Lee D. Arnold, Francis Barany	2018	9
5	Reversible Linkage of Two Distinct Small Molecule Inhibitors of Myc Generates a Dimeric Inhibitor with Improved Potency That Is Active in Myc Over-Expressing Cancer Cell Lines PLoS ONE ·Jutta Wanner, Darlene Romashko, Bowen Lan, Earl W. May, Yue Peng, C. Gonçalo, Kenneth W. Foreman, Suzanne Russo, Lee D. Arnold, Maneesh Pingle, Donald E. Bergstrom, Francis Barany, Stuart Thomson	2015	13
6	Preclinical Characterization of OSI-027, a Potent and Selective Inhibitor of mTORC1 and mTORC2: Distinct from Rapamycin Molecular Cancer Therapeutics ·Shripad V. Bhagwat, Prafulla C. Gokhale, Andrew P. Crew, Anon, Yan Yao, Christine Mantis, Jennifer Kahler, B Woronowicz, Mark Bittner, Lorina Dudkin, David Epstein, Neil W. Gibson, Robert Wild, Lee D. Arnold, Peter J. Houghton, Jonathan A. Pachter	2011	159
7	Structural and Functional Profiling of the Human Histone Methyltransferase SMYD3 PLoS ONE ·Kenneth W. Foreman, Mark A. Brown, Zoirkhuja Ulmaskhujayev, Spencer Emtage, June V. Harriss, Chhaya Das, Li Zhu, Barbara Becker-Cantarino, Lee D. Arnold, Salam Shaaban, Philip W. Tucker	2011	89
8	A novel, potent, and selective insulin-like growth factor-I receptor kinase inhibitor blocks insulin-like growth factor-I receptor signaling in vitro and inhibits insulin-like growth factor-I receptor–dependent tumor growth in vivo Molecular Cancer Therapeutics ·Qunsheng Ji, Mark J. Mulvihill, Maryland Rosenfeld-Franklin, Andrew Cooke, Lixin Feng, Paul R. Wistermayer, Matthew O’Connor, Yan Yao, Caroline Pirritt, Elizabeth Buck, Alexandra Eyzaguirre, Lee D. Arnold, Neil W. Gibson, Jonathan A. Pachter	2007	118
9	Hit-to-lead optimization of 1,4-dihydroindeno[1,2-c]pyrazoles as a novel class of KDR kinase inhibitors Bioorganic & Medicinal Chemistry Letters ·Jürgen Dinges, Irini Akritopoulou‐Zanze, Lee D. Arnold, Teresa Barlozzari, Peter F. Bousquet, George A. Cunha, Anna Ericsson, B.M. Ahmedov, Michael R. Michaelides, Nobuo Ogawa, Miloslava Knopová, Paul Rafferty, Thomas J. Sowin, Kent D. Stewart, 曾令富, admin pTools, 徳是助川	2006	19
10	A 13C NMR approach to categorizing potential limitations of α,β-unsaturated carbonyl systems in drug-like molecules Bioorganic & Medicinal Chemistry Letters ·Kevin P. Cusack, Lee D. Arnold, Claude Barberis, Haipeng Chen, Anna Ericsson, Georgeen Gaza‐Bulseco, Aparecida Leonir da Silva, Christine Grinnell, Andreas Harsch, Maria Pellegrini, Edit Tarcsa	2004	13
11	Molecular interactions in crystal structures of potent inhibitors bound to the kinase domain of Tie-2 Lee D. Arnold, R.A. Dixon, Robert V. Talanian, Pedro A. Geraldi, Nancy J. Bump, T. P. Seshadri, Cornelia Bellamacina, JinShuai Li, W. Höffken, Mohmmad Imran Khan, Ying Xu	2002	2
12	Pyrrolo[2,3-d]pyrimidines containing an extended 5-substituent as potent and selective inhibitors of lck I Bioorganic & Medicinal Chemistry Letters ·Lee D. Arnold, David J. Calderwood, R. W. Dixon, 李喜来, Joanne Kamens, Ruilei Guo, Paul Rafferty, S Ratnofsky	2000	68
13	The nitrogen of the acetamido group of colchicine modulates P-glycoprotein-mediated multidrug resistance Biochemistry ·David F. Tang‐Wai, Arnold Brossi, Lee D. Arnold, Piet Gros	1993	48
14	Polymer-supported alkyl azodicarboxylates for Mitsunobu reactions Journal of the American Chemical Society ·Lee D. Arnold, Juan José Villalaín Santamaría, John C. Vederas	1989	52
15	ChemInform Abstract: Synthesis of Optically Pure α‐Amino Acids via Salts of α‐Amino‐β‐propiolactone. ChemInform ·Lee D. Arnold, Ovidiu Cristinel Stoica, John C. Vederas	1988	5
16	Analogs of diaminopimelic acid as inhibitors of meso-diaminopimelate dehydrogenase and LL-diaminopimelate epimerase. Journal of Biological Chemistry ·Luke K. T. Lam, Lee D. Arnold, Thomas H. Kalantar, Rory Stanley, Lily Sensuk, Monica M. Palcic, Michael A. Pickard, John C. Vederas	1988	44
17	Synthesis of optically pure .alpha.-amino acids via salts of .alpha.-amino-.beta.-propiolactone Journal of the American Chemical Society ·Lee D. Arnold, Ovidiu Cristinel Stoica, John C. Vederas	1988	112
18	Structural analyses of various Cu2+, Zn2+-superoxide dismutases by differential scanning calorimetry and Raman spectroscopy Archives of Biochemistry and Biophysics ·James R. Lepock, Lee D. Arnold, B. H. Torrie, 田部俊充, J. Kruuv	1985	59
19	Thermal denaturation of native and cross-linked bacillus cereus 569/II β-lactamase I Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology ·Lee D. Arnold, L. Keusters	1983	6
20	The use of bis(mercaptoacetato-S,O)hydroxoiron(III) complex for the determination of hydroxamates Journal of Biochemical and Biophysical Methods ·Lee D. Arnold, Thammaiah Viswanatha	1983	18

About Lee D. Arnold

Lee D. Arnold is a scholar working on Organic Chemistry, Molecular Medicine, Molecular Biology, Toxicology and Oncology, having authored 37 papers that have together received 1.9k indexed citations. Recurring topics across this work include Chemical Synthesis and Analysis (7 papers), Free Radicals and Antioxidants (3 papers), HER2/EGFR in Cancer Research (3 papers), Enzyme Structure and Function (3 papers), Synthesis and Catalytic Reactions (2 papers), PI3K/AKT/mTOR signaling in cancer (2 papers), Cancer therapeutics and mechanisms (2 papers) and Asymmetric Synthesis and Catalysis (2 papers). The work is most often cited by research in Oncology (540 citations), Organic Chemistry (493 citations), Molecular Biology (1.1k citations), Cancer Research (168 citations) and Endocrinology, Diabetes and Metabolism (182 citations). Lee D. Arnold has collaborated with scholars based in United States, Canada and United Kingdom. Frequent co-authors include John C. Vederas, Thomas H. Kalantar, Neil W. Gibson, Matthew O’Connor, Andrew Cooke, Mark J. Mulvihill, Maryland Rosenfeld-Franklin, Qunsheng Ji, Caroline Pirritt and Elizabeth Buck. Their work appears in journals such as Journal of the American Chemical Society, Bioorganic & Medicinal Chemistry Letters, Molecular Cancer Therapeutics, Journal of Medicinal Chemistry and Journal of Biological Chemistry.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

Explore authors with similar magnitude of impact