Andrew G. Leach

7.0k citations

112 papers · 5.3k indexed · 1 hit paper · h-index 37

Organic Chemistry top 0.5%
Molecular Biology top 5%
Computational Theory and Mathematics top 0.5%
Materials Chemistry top 10%
Spectroscopy top 2%

Co-authors: K. N. Houk Xiyun Zhang Guy C. Lloyd‐Jones Andrew D. Campbell Paul Alan Cox Ed Griffen Steven V. Ley Richard Storer
Topics: Chemical Synthesis and Analysis (21 papers)Analytical Chemistry and Chromatography (16 papers)Computational Drug Discovery Methods (16 papers)
Cited by: Organic Chemistry Pharmaceutical Science Computational Theory and Mathematics
Journals: Journal of the American Chemical Society Angewandte Chemie International EditionSHILAP Revista de lepidopterología
Partner nations: United Kingdom United States Sweden

In The Last Decade

Andrew G. Leach

109 papers receiving 5.2k citations

Hit Papers

align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Multi-step organic synthesis using solid-supported reagents and scavengers: a new paradigm in chemical library generation

2000 592 citations Andrew G. Leach et al. profile →

Peers

Countries citing papers authored by Andrew G. Leach

Since Specialization

Citations

This map shows the geographic impact of Andrew G. Leach's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Andrew G. Leach with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Andrew G. Leach more than expected).

Fields of papers citing papers by Andrew G. Leach

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Andrew G. Leach. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Andrew G. Leach. The network helps show where Andrew G. Leach may publish in the future.

Co-authorship network of co-authors of Andrew G. Leach

This figure shows the co-authorship network connecting the top 25 collaborators of Andrew G. Leach. A scholar is included among the top collaborators of Andrew G. Leach based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Andrew G. Leach. Andrew G. Leach is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

#	Work	Indexed citations
1	Design and synthesis of a chemically diverse, lead-like DNA-encoded library from sequential amide coupling 2025 ·RSC Medicinal Chemistry ·(unknown),(unknown),Rodney C. Young,Fredrik Svensson,Andreas Brunschweiger,Sam Butterworth,Andrew G. Leach,Michael J. Waring	0
2	Accessing Rare α‐Heterocyclic Aziridines via Brønsted Acid‐catalyzed Michael Addition/Annulation: Scope, Limitations, and Mechanism 2024 ·Chemistry - A European Journal ·(unknown),Andrew G. Leach,(unknown),Allan J. B. Watson	2
3	Squaramides enhance NLRP3 inflammasome activation by lowering intracellular potassium 2023 ·Cell Death Discovery ·Paula I. Seoane,(unknown),Andrew G. Leach,(unknown),(unknown),Kevin N. Couper,Martin Lowe,Sally Freeman,David Brough	1
4	Trialkylammonium salt degradation: implications for methylation and cross-coupling 2021 ·Chemical Science ·(unknown),(unknown),Chunhui Yan,(unknown),(unknown),Andrew G. Leach,(unknown),Marc Reid	14
5	Enantiomer stability of atropisomeric 1,5-disubstituted 1,2,3-triazoles 2021 ·SHILAP Revista de lepidopterología ·(unknown),William D. G. Brittain,Louise Male,Cécile S. Le Duff,Benjamin R. Buckley,Andrew G. Leach,John Fossey	9
6	Mapping Ligand-Shape Space for Protein–Ligand Systems: Distinguishing Key-in-Lock and Hand-in-Glove Proteins 2021 ·Journal of Chemical Information and Modeling ·(unknown),(unknown),(unknown),(unknown),(unknown),Steven J. Enoch,Alexander G. Dossetter,Ed Griffen,Andrew G. Leach	2
7	Fragment-oriented synthesis: β-elaboration of cyclic amine fragments using enecarbamates as platform intermediates 2020 ·Chemical Communications ·Alexandre F. Trindade,(unknown),Andrew G. Leach,Adam Nelson,Stephen P. Marsden	26
8	Chemists: AI Is Here; Unite To Get the Benefits 2020 ·Journal of Medicinal Chemistry ·Ed Griffen,Alexander G. Dossetter,Andrew G. Leach	27
9	Development of Brain Targeting Peptide Based MMP-9 Inhibiting Nanoparticles for the Treatment of Brain Diseases with Elevated MMP-9 Activity 2020 ·Journal of Pharmaceutical Sciences ·(unknown),(unknown),Stefano Pluchino,M. Sivakumaran,Meritxell Teixidò,Andrew G. Leach,Amos A. Fatokun,James R. Downing,Christopher R. Coxon,Touraj Ehtezazi	16
10	Predicting protein–ligand binding affinity and correcting crystal structures with quantum mechanical calculations: lactate dehydrogenase A 2019 ·Chemical Science ·(unknown),(unknown),Richard A. Ward,Stephen A. St-Gallay,Judith C. Madden,Andrew G. Leach	11
11	Palladium and Platinum 2,4-cis-amino Azetidine and Related Complexes 2018 ·Frontiers in Chemistry ·(unknown),Antonio Feula,Andrew G. Leach,Louise Male,John Fossey	4
12	Can we accelerate medicinal chemistry by augmenting the chemist with Big Data and artificial intelligence? 2018 ·Drug Discovery Today ·(unknown),Alexander G. Dossetter,Andrew G. Leach,(unknown)	32
13	Rigid and concave, 2,4-cis-substituted azetidine derivatives: A platform for asymmetric catalysis 2018 ·Scientific Reports ·(unknown),Antonio Feula,Louise Male,Andrew G. Leach,John Fossey	12
14	MIDA boronates are hydrolysed fast and slow by two different mechanisms 2016 ·Nature Chemistry ·Jorge A. González,O. Maduka Ogba,Greg. F. Morehouse,(unknown),K. N. Houk,Andrew G. Leach,Paul Ha‐Yeon Cheong,Martin D. Burke,Guy C. Lloyd‐Jones	95
15	Designing Hydroxamates and Reversed Hydroxamates to Inhibit Zinc‐containing Proteases but not Cytochrome P450s: Insights from Quantum Mechanics and Protein‐ligand Crystal Structures 2015 ·Molecular Informatics ·(unknown),(unknown),Andrew G. Leach	1
16	Mechanistic Studies on a Sulfoxide Transfer Reaction Mediated by Diphenyl Sulfoxide/Triflic Anhydride 2012 ·Chemistry - A European Journal ·Martin A. Fascione,(unknown),Pintu Kumar Mandal,C.A. Kilner,Andrew G. Leach,W. Bruce Turnbull	28
17	Do Glycosyl Sulfonium Ions Engage in Neighbouring‐Group Participation? A Study of Oxathiane Glycosyl Donors and the Basis for their Stereoselectivity 2011 ·Chemistry - A European Journal ·Martin A. Fascione,C.A. Kilner,Andrew G. Leach,W. Bruce Turnbull	38
18	Inhibitors of the tyrosine kinase EphB4. Part 1: Structure-based design and optimization of a series of 2,4-bis-anilinopyrimidines 2008 ·Bioorganic & Medicinal Chemistry Letters ·Catherine Bardelle,Darren A.E. Cross,Sara Davenport,Jason G. Kettle,Eun Jung Ko,Andrew G. Leach,Andrew Mortlock,Jon Read,Nicola Roberts,Peter Robins,Emma Williams	49
19	An unexpected bispericyclic transition structure leading to 4 + 2 and 2 + 4 cycloadducts in the endo dimerization of cyclopentadiene 2002 ·Research Explorer (The University of Manchester) ·Andrew G. Leach,K. N. Houk	1
20	The first optically active BINOL-BINAP copolymer catalyst: Highly stereoselective tandem asymmetric reactions 2000 ·Research Explorer (The University of Manchester) ·K. N. Houk,Andrew G. Leach	0

About Andrew G. Leach

Andrew G. Leach is a scholar working on Organic Chemistry, Pharmaceutical Science and Spectroscopy, having authored 112 papers that have together received 5.3k indexed citations. Recurring topics across this work include Chemical Synthesis and Analysis (21 papers), Analytical Chemistry and Chromatography (16 papers) and Computational Drug Discovery Methods (16 papers). The work is most often cited by research in Organic Chemistry (3.3k citations), Pharmaceutical Science (346 citations) and Computational Theory and Mathematics (665 citations). Andrew G. Leach has collaborated with scholars based in United Kingdom, United States and Sweden. Frequent co-authors include K. N. Houk, Xiyun Zhang, Guy C. Lloyd‐Jones, Andrew D. Campbell, Paul Alan Cox, Ed Griffen, Steven V. Ley, Richard Storer, James S. Scott and Stephen Taylor. Their work appears in journals such as Journal of the American Chemical Society, Angewandte Chemie International Edition and SHILAP Revista de lepidopterología.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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