Alexander C. Huang

19.2k citations

42 papers · 4.0k indexed · 4 hit papers · h-index 19

Oncology top 1%
Immunology top 0.5%
Molecular Biology top 10%
Pulmonary and Respiratory Medicine top 10%
Cancer Research top 10%

Co-authors: Roberta Zappasodi E. John Wherry Sasikanth Manne Omar Khan Ravi K. Amaravadi Lynn M. Schuchter Kristen E. Pauken Makoto Kurachi
Topics: Cancer Immunotherapy and Biomarkers (21 papers)Immunotherapy and Immune Responses (18 papers)CAR-T cell therapy research (12 papers)
Cited by: Immunology Oncology Cancer Research
Journals: Science Cell Journal of Clinical Investigation
Partner nations: United States Netherlands Australia

In The Last Decade

Alexander C. Huang

38 papers receiving 3.9k citations

Hit Papers

align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Epigenetic stability of exhausted T cells limits durability of reinvigoration by PD-1 blockade

2016 900 citations Kristen E. Pauken, Morgan A. Sammons et al. Science profile →
Tumor Interferon Signaling Regulates a Multigenic Resistance Program to Immune Checkpoint Blockade

2016 804 citations Joseph L. Benci, Bihui Xu et al. Cell profile →
Developmental Relationships of Four Exhausted CD8+ T Cell Subsets Reveals Underlying Transcriptional and Epigenetic Landscape Control Mechanisms

2020 598 citations Sasikanth Manne, Mohamed S. Abdel-Hakeem et al. Immunity profile →
A decade of checkpoint blockade immunotherapy in melanoma: understanding the molecular basis for immune sensitivity and resistance

2022 364 citations Alexander C. Huang, Roberta Zappasodi Nature Immunology profile →

Peers

Countries citing papers authored by Alexander C. Huang

Since Specialization

Citations

This map shows the geographic impact of Alexander C. Huang's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Alexander C. Huang with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Alexander C. Huang more than expected).

Fields of papers citing papers by Alexander C. Huang

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Alexander C. Huang. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Alexander C. Huang. The network helps show where Alexander C. Huang may publish in the future.

Co-authorship network of co-authors of Alexander C. Huang

This figure shows the co-authorship network connecting the top 25 collaborators of Alexander C. Huang. A scholar is included among the top collaborators of Alexander C. Huang based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Alexander C. Huang. Alexander C. Huang is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

#	Work	Indexed citations
1	Tumor-Infiltrating Lymphocytes in Necrotic Tumors after Melanoma Neoadjuvant Anti–PD-1 Therapy Correlate with Pathologic Response and Recurrence-Free Survival 2024 ·Clinical Cancer Research ·(unknown),Tara C. Mitchell,(unknown),(unknown),(unknown),David E. Elder,(unknown),Phyllis A. Gimotty,Alexander C. Huang,Ravi K. Amaravadi,Lynn M. Schuchter,(unknown),John T. Miura,Giorgos C. Karakousis,Xiaowei Xu	1
2	FDG PET/CT Imaging 1 Week after a Single Dose of Pembrolizumab Predicts Treatment Response in Patients with Advanced Melanoma 2024 ·Clinical Cancer Research ·(unknown),(unknown),Alexander C. Huang,Xiaowei Xu,(unknown),(unknown),Rosemarie Mick,(unknown),Suzanne McGettigan,Kristin Kreider,Wei Xu,E. John Wherry,Lynn M. Schuchter,Ravi K. Amaravadi,Tara C. Mitchell,Michael D. Farwell	10
3	LAG-3 sustains TOX expression and regulates the CD94/NKG2-Qa-1b axis to govern exhausted CD8 T cell NK receptor expression and cytotoxicity 2024 ·Cell ·Shin Foong Ngiow,Sasikanth Manne,Yinghui Huang,(unknown),Zeyu Chen,Divij Mathew,Qingzhou Chen,Omar Khan,Jennifer E. Wu,Víctor Alcalde,(unknown),(unknown),Amy E. Baxter,Makoto Kurachi,Junwei Shi,Alexander C. Huang,Josephine R. Giles,Arlene H. Sharpe,Dario A.A. Vignali,E. John Wherry	47
4	Lack of compensation of energy intake explains the success of alternate day feeding to produce weight loss 2023 ·Physiology & Behavior ·Alexander C. Huang,(unknown),(unknown),(unknown),(unknown),(unknown),(unknown),(unknown),(unknown),David A. Levitsky	0
5	High-throughput interrogation of immune responses using the Human Immune Profiling Pipeline 2023 ·STAR Protocols ·(unknown),(unknown),Justin Kim,(unknown),Yuval Elhanati,Divij Mathew,E. John Wherry,Ramin S. Herati,Allison R. Greenplate,Benjamin D. Greenbaum,Santosha A. Vardhana,Alexander C. Huang	1
6	Impaired humoral immunity is associated with prolonged COVID-19 despite robust CD8 T cell responses 2022 ·Cancer Cell ·(unknown),Justin Kim,David Qualls,Madeline A. Hwee,(unknown),Sawsan R. Boutemine,Yuval Elhanati,Alexander Solovyov,(unknown),(unknown),N. Esther Babady,Lakshmi V. Ramanathan,Pallavi Vedantam,Chaitanya Bandlamudi,Sigrid Gouma,(unknown),Scott E. Hensley,Benjamin D. Greenbaum,Alexander C. Huang,Santosha A. Vardhana	32
7	Shared and distinct biological circuits in effector, memory and exhausted CD8+ T cells revealed by temporal single-cell transcriptomics and epigenetics 2022 ·Nature Immunology ·Josephine R. Giles,Shin Foong Ngiow,Sasikanth Manne,Amy E. Baxter,Omar Khan,Ping Wang,Ryan P. Staupe,Mohamed S. Abdel-Hakeem,Hua Huang,Divij Mathew,Mark M. Painter,Jennifer E. Wu,Yinghui Huang,Rishi R. Goel,Patrick Yan,Giorgos C. Karakousis,Xiaowei Xu,Tara C. Mitchell,Alexander C. Huang,E. John Wherry	119
8	A decade of checkpoint blockade immunotherapy in melanoma: understanding the molecular basis for immune sensitivity and resistancebreakdown → 2022 ·Nature Immunology ·Alexander C. Huang,Roberta Zappasodi	364
9	Role of nuclear localization in the regulation and function of T-bet and Eomes in exhausted CD8 T cells 2021 ·Cell Reports ·Laura M. McLane,Shin Foong Ngiow,Zeyu Chen,John Attanasio,Sasikanth Manne,Gordon Ruthel,Jennifer E. Wu,Ryan P. Staupe,Wei Xu,Ravi K. Amaravadi,Xiaowei Xu,Giorgos C. Karakousis,Tara C. Mitchell,Lynn M. Schuchter,Alexander C. Huang,Bruce D. Freedman,Michael R. Betts,E. John Wherry	77
10	Rates of COVID-19–Related Outcomes in Cancer Compared With Noncancer Patients 2020 ·JNCI Cancer Spectrum ·Lova Sun,(unknown),Anh N. Le,(unknown),Abigail Doucette,Peter Gabriel,Marylyn D. Ritchie,Daniel J. Rader,Ivan Maillard,Erin M. Bange,Alexander C. Huang,Robert H. Vonderheide,Angela DeMichele,Anurag Verma,Ronac Mamtani,Kara N. Maxwell	27
11	Association of Antibiotic Exposure With Survival and Toxicity in Patients With Melanoma Receiving Immunotherapy 2020 ·JNCI Journal of the National Cancer Institute ·Jahan J. Mohiuddin,Brian Chu,Andrea Facciabene,(unknown),Xingmei Wang,Abigail Doucette,Cathy Zheng,Wei Xu,Emily J. Anstadt,Ravi K. Amaravadi,Giorgos C. Karakousis,Tara C. Mitchell,Alexander C. Huang,Jacob E. Shabason,Alexander Lin,Samuel Swisher‐McClure,Amit Maity,Lynn M. Schuchter,John N. Lukens	96
12	Alpha-Fetoprotein-Producing Lung Hepatoid Adenocarcinoma with Brain Metastasis Treated with S-1 2020 ·Case Reports in Oncology ·Yuki Muroyama,(unknown),Goh Tanaka,(unknown),Alexander C. Huang,Derek A. Oldridge,Keisuke Matsusaka,Yutaka Takazawa,Taisuke Jo,Tetsuo Ushiku,Takahide Nagase	10
13	Landmark analysis of immunotherapy duration and disease free survival in advanced melanoma patients with a complete response. 2020 ·Journal of Clinical Oncology ·(unknown),Alexander C. Huang,Giorgos C. Karakousis,Wei Xu,Cathy Zheng,Mary Carberry,Lydia Giles,Kristin Kreider,Suzanne McGettigan,John N. Lukens,Lynn M. Schuchter,Ravi K. Amaravadi,Tara C. Mitchell	2
14	Pathological response and survival with neoadjuvant therapy in melanoma: A pooled analysis from the International Neoadjuvant Melanoma Consortium (INMC). 2019 ·Journal of Clinical Oncology ·Alexander M. Menzies,Elisa A. Rozeman,Rodabe Navroze Amaria,Alexander C. Huang,Richard A. Scolyer,Michael T. Tetzlaff,Bart A. van de Wiel,Serigne Lo,Ahmad A. Tarhini,Hussein Tawbi,Elizabeth M. Burton,Giorgos C. Karakousis,Paolo A. Ascierto,Andrew J. Spillane,Michael A. Davies,Alexander Christopher Jonathan Van Akkooi,Tara C. Mitchell,Georgina V. Long,Jennifer A. Wargo,Christian U. Blank	63
15	Non-conventional Inhibitory CD4+Foxp3−PD-1hi T Cells as a Biomarker of Immune Checkpoint Blockade Activity 2018 ·Cancer Cell ·Roberta Zappasodi,Sadna Budhu,Matthew D. Hellmann,Michael A. Postow,Yasin Şenbabaoğlu,Sasikanth Manne,Billel Gasmi,Cailian Liu,Hong Zhong,Yanyun Li,Alexander C. Huang,Daniel Hirschhorn-Cymerman,Katherine S. Panageas,E. John Wherry,Taha Merghoub,Jedd D. Wolchok	113
16	Epigenomic-Guided Mass Cytometry Profiling Reveals Disease-Specific Features of Exhausted CD8 T Cells 2018 ·Immunity ·Bertram Bengsch,Takuya Ohtani,Omar Khan,Manu Setty,Sasikanth Manne,Shaun O’Brien,Pier Federico Gherardini,Ramin S. Herati,Alexander C. Huang,Kyong‐Mi Chang,Evan W. Newell,Niels Bovenschen,Dana Pe’er,Steven Μ. Albelda,E. John Wherry	183
17	A phase I trial of pembrolizumab with hypofractionated radiotherapy in patients with metastatic solid tumours 2018 ·British Journal of Cancer ·Amit Maity,Rosemarie Mick,Alexander C. Huang,Sangeeth M. George,Michael D. Farwell,John N. Lukens,Abigail T. Berman,Tara C. Mitchell,(unknown),Lynn M. Schuchter,Mark H. O’Hara,Lilie L. Lin,Angela DeMichele,John P. Christodouleas,Naomi B. Haas,Dana Patsch,Stephen M. Hahn,Andy J. Minn,E. John Wherry,Robert H. Vonderheide	79
18	Epigenetic stability of exhausted T cells limits durability of reinvigoration by PD-1 blockadebreakdown → 2016 ·Science ·Kristen E. Pauken,Morgan A. Sammons,Pamela M. Odorizzi,Sasikanth Manne,Jernej Godec,Omar Khan,Adam Drake,Zeyu Chen,Debattama R. Sen,Makoto Kurachi,R. Anthony Barnitz,Caroline Bartman,Bertram Bengsch,Alexander C. Huang,Jason M. Schenkel,Golnaz Vahedi,W. Nicholas Haining,Shelley L. Berger,E. John Wherry	900
19	Tumor Interferon Signaling Regulates a Multigenic Resistance Program to Immune Checkpoint Blockadebreakdown → 2016 ·Cell ·Joseph L. Benci,Bihui Xu,Yu Qiu,Tony J. Wu,Hannah Dada,Christina Twyman-Saint Victor,Lisa Cucolo,David S.M. Lee,Kristen E. Pauken,Alexander C. Huang,Tara C. Gangadhar,Ravi K. Amaravadi,Lynn M. Schuchter,Michael D. Feldman,Hemant Ishwaran,Robert H. Vonderheide,Amit Maity,E. John Wherry,Andy J. Minn	804
20	IL-12p70–producing patient DC vaccine elicits Tc1-polarized immunity 2013 ·Journal of Clinical Investigation ·Beatriz M. Carreno,Michelle Becker‐Hapak,Alexander C. Huang,(unknown),(unknown),Wen‐Rong Lie,Rebecca Aft,Lynn A. Cornelius,Kathryn Trinkaus,Gerald P. Linette	135

About Alexander C. Huang

Alexander C. Huang is a scholar working on Immunology, Oncology and Biological Psychiatry, having authored 42 papers that have together received 4.0k indexed citations. Recurring topics across this work include Cancer Immunotherapy and Biomarkers (21 papers), Immunotherapy and Immune Responses (18 papers) and CAR-T cell therapy research (12 papers). The work is most often cited by research in Immunology (2.5k citations), Oncology (2.6k citations) and Cancer Research (271 citations). Alexander C. Huang has collaborated with scholars based in United States, Netherlands and Australia. Frequent co-authors include Roberta Zappasodi, E. John Wherry, Sasikanth Manne, Omar Khan, Ravi K. Amaravadi, Lynn M. Schuchter, Kristen E. Pauken, Makoto Kurachi, Tara C. Mitchell and Bertram Bengsch. Their work appears in journals such as Science, Cell and Journal of Clinical Investigation.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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