Alexander C. Huang

19.2k total citations · 4 hit papers
42 papers, 4.0k citations indexed

About

Alexander C. Huang is a scholar working on Oncology, Immunology and Molecular Biology. According to data from OpenAlex, Alexander C. Huang has authored 42 papers receiving a total of 4.0k indexed citations (citations by other indexed papers that have themselves been cited), including 27 papers in Oncology, 24 papers in Immunology and 6 papers in Molecular Biology. Recurrent topics in Alexander C. Huang's work include Cancer Immunotherapy and Biomarkers (21 papers), Immunotherapy and Immune Responses (18 papers) and CAR-T cell therapy research (12 papers). Alexander C. Huang is often cited by papers focused on Cancer Immunotherapy and Biomarkers (21 papers), Immunotherapy and Immune Responses (18 papers) and CAR-T cell therapy research (12 papers). Alexander C. Huang collaborates with scholars based in United States, Netherlands and Australia. Alexander C. Huang's co-authors include Roberta Zappasodi, E. John Wherry, Sasikanth Manne, Omar Khan, Ravi K. Amaravadi, Lynn M. Schuchter, Kristen E. Pauken, Makoto Kurachi, Tara C. Mitchell and Bertram Bengsch and has published in prestigious journals such as Science, Cell and Journal of Clinical Investigation.

In The Last Decade

Alexander C. Huang

38 papers receiving 3.9k citations

Hit Papers

align trajectories sort by overperformance

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Epigenetic stability of exhausted T cells limits durability of reinvigoration by PD-1 blockade

2016 900 citations Kristen E. Pauken, Morgan A. Sammons et al. Science profile →
Tumor Interferon Signaling Regulates a Multigenic Resistance Program to Immune Checkpoint Blockade

2016 804 citations Joseph L. Benci, Bihui Xu et al. Cell profile →
Developmental Relationships of Four Exhausted CD8+ T Cell Subsets Reveals Underlying Transcriptional and Epigenetic Landscape Control Mechanisms

2020 598 citations Jean‐Christophe Beltra, Sasikanth Manne et al. Immunity profile →
A decade of checkpoint blockade immunotherapy in melanoma: understanding the molecular basis for immune sensitivity and resistance

2022 364 citations Alexander C. Huang, Roberta Zappasodi Nature Immunology profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name	h						Papers	Cites
Alexander C. Huang United States	19	2.6k	2.5k	951	326	271	42	4.0k
Álvaro Teijeira Spain	33	2.2k 0.8×	2.4k 0.9×	937 1.0×	315 1.0×	294 1.1×	74	3.9k
Justin Kline United States	33	2.8k 1.1×	3.6k 1.4×	1.2k 1.2×	248 0.8×	247 0.9×	146	5.5k
Pia Kvistborg Netherlands	22	2.2k 0.8×	2.1k 0.8×	926 1.0×	249 0.8×	249 0.9×	50	3.1k
Marka R. Crittenden United States	37	2.8k 1.1×	2.4k 0.9×	719 0.8×	583 1.8×	254 0.9×	106	4.0k
Harry Dolstra Netherlands	42	2.4k 0.9×	3.3k 1.3×	1.1k 1.2×	155 0.5×	194 0.7×	123	5.2k
Andreas Wieland United States	25	2.1k 0.8×	2.4k 0.9×	671 0.7×	288 0.9×	253 0.9×	48	3.6k
Andrea Schietinger United States	25	3.1k 1.2×	3.5k 1.4×	1.2k 1.3×	305 0.9×	336 1.2×	41	5.1k
Jon M. Wigginton United States	32	2.1k 0.8×	2.0k 0.8×	823 0.9×	376 1.2×	290 1.1×	100	3.5k
Antonella Sistigu Italy	24	1.6k 0.6×	1.5k 0.6×	825 0.9×	316 1.0×	276 1.0×	38	2.9k
Mark P. Rubinstein United States	32	2.1k 0.8×	3.4k 1.4×	817 0.9×	177 0.5×	339 1.3×	76	4.6k

Countries citing papers authored by Alexander C. Huang

Since Specialization

Citations

This map shows the geographic impact of Alexander C. Huang's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Alexander C. Huang with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Alexander C. Huang more than expected).

Fields of papers citing papers by Alexander C. Huang

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Alexander C. Huang. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Alexander C. Huang. The network helps show where Alexander C. Huang may publish in the future.

Co-authorship network of co-authors of Alexander C. Huang

This figure shows the co-authorship network connecting the top 25 collaborators of Alexander C. Huang. A scholar is included among the top collaborators of Alexander C. Huang based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Alexander C. Huang. Alexander C. Huang is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

Miura, John T., Mohammad Saad Farooq, Phyllis A. Gimotty, et al.. (2025). Neoadjuvant-adjuvant pembrolizumab in clinical stage IIB/C melanoma.. Journal of Clinical Oncology. 43(16_suppl). 9502–9502. 1 indexed citations

Huang, Alexander C., Xiaowei Xu, Rosemarie Mick, et al.. (2024). FDG PET/CT Imaging 1 Week after a Single Dose of Pembrolizumab Predicts Treatment Response in Patients with Advanced Melanoma. Clinical Cancer Research. 30(9). 1758–1767. 10 indexed citations

Mitchell, Tara C., David E. Elder, Phyllis A. Gimotty, et al.. (2024). Tumor-Infiltrating Lymphocytes in Necrotic Tumors after Melanoma Neoadjuvant Anti–PD-1 Therapy Correlate with Pathologic Response and Recurrence-Free Survival. Clinical Cancer Research. 30(21). 4987–4994. 1 indexed citations

Ngiow, Shin Foong, Sasikanth Manne, Yinghui Huang, et al.. (2024). LAG-3 sustains TOX expression and regulates the CD94/NKG2-Qa-1b axis to govern exhausted CD8 T cell NK receptor expression and cytotoxicity. Cell. 187(16). 4336–4354.e19. 47 indexed citations

Kim, Justin, David Qualls, Madeline A. Hwee, et al.. (2022). Impaired humoral immunity is associated with prolonged COVID-19 despite robust CD8 T cell responses. Cancer Cell. 40(7). 738–753.e5. 32 indexed citations

Tchou, Julia, Amy S. Clark, Neil K. Taunk, et al.. (2022). 644 Major pathologic response after a single radiotherapy fraction + a single pembrolizumab dose given preoperatively in patients with cT1N0 triple negative breast cancer (TNBC) – preliminary results of a phase 1b/2 study (NCT04454528). Regular and Young Investigator Award Abstracts. A675–A675. 2 indexed citations

Giles, Josephine R., Shin Foong Ngiow, Sasikanth Manne, et al.. (2022). Shared and distinct biological circuits in effector, memory and exhausted CD8+ T cells revealed by temporal single-cell transcriptomics and epigenetics. Nature Immunology. 23(11). 1600–1613. 119 indexed citations

Ou, Lingling, Huaishan Wang, Hui Huang, et al.. (2022). Preclinical platforms to study therapeutic efficacy of human γδ T cells. Clinical and Translational Medicine. 12(6). e814–e814. 28 indexed citations

McLane, Laura M., Shin Foong Ngiow, Zeyu Chen, et al.. (2021). Role of nuclear localization in the regulation and function of T-bet and Eomes in exhausted CD8 T cells. Cell Reports. 35(6). 109120–109120. 77 indexed citations

10.

Sun, Lova, Anh N. Le, Abigail Doucette, et al.. (2020). Rates of COVID-19–Related Outcomes in Cancer Compared With Noncancer Patients. JNCI Cancer Spectrum. 5(1). 27 indexed citations

11.

Mohiuddin, Jahan J., Brian Chu, Andrea Facciabene, et al.. (2020). Association of Antibiotic Exposure With Survival and Toxicity in Patients With Melanoma Receiving Immunotherapy. JNCI Journal of the National Cancer Institute. 113(2). 162–170. 96 indexed citations

12.

Muroyama, Yuki, Goh Tanaka, Alexander C. Huang, et al.. (2020). Alpha-Fetoprotein-Producing Lung Hepatoid Adenocarcinoma with Brain Metastasis Treated with S-1. Case Reports in Oncology. 13(3). 1552–1559. 10 indexed citations

13.

Huang, Alexander C., Giorgos C. Karakousis, Wei Xu, et al.. (2020). Landmark analysis of immunotherapy duration and disease free survival in advanced melanoma patients with a complete response.. Journal of Clinical Oncology. 38(15_suppl). 10054–10054. 2 indexed citations

14.

Beltra, Jean‐Christophe, Sasikanth Manne, Mohamed S. Abdel-Hakeem, et al.. (2020). Developmental relationships of four exhausted CD8 T cell subsets reveals underlying transcriptional and epigenetic control mechanisms. The Journal of Immunology. 204(1_Supplement). 77.16–77.16. 2 indexed citations

15.

Zappasodi, Roberta, Sadna Budhu, Matthew D. Hellmann, et al.. (2018). Non-conventional Inhibitory CD4+Foxp3−PD-1hi T Cells as a Biomarker of Immune Checkpoint Blockade Activity. Cancer Cell. 33(6). 1017–1032.e7. 113 indexed citations

16.

Bengsch, Bertram, Takuya Ohtani, Omar Khan, et al.. (2018). Epigenomic-Guided Mass Cytometry Profiling Reveals Disease-Specific Features of Exhausted CD8 T Cells. Immunity. 48(5). 1029–1045.e5. 183 indexed citations

17.

Serrano, Leona, Harpal S. Sandhu, Katherine E. Uyhazi, et al.. (2018). FREQUENT SUBCLINICAL MACULAR CHANGES IN COMBINED BRAF/MEK INHIBITION WITH HIGH-DOSE HYDROXYCHLOROQUINE AS TREATMENT FOR ADVANCED METASTATIC BRAF MUTANT MELANOMA. Retina. 39(3). 502–513. 22 indexed citations

18.

Pauken, Kristen E., Morgan A. Sammons, Pamela M. Odorizzi, et al.. (2016). Epigenetic stability of exhausted T cells limits durability of reinvigoration by PD-1 blockade. Science. 354(6316). 1160–1165. 900 indexed citations breakdown →

19.

Benci, Joseph L., Bihui Xu, Yu Qiu, et al.. (2016). Tumor Interferon Signaling Regulates a Multigenic Resistance Program to Immune Checkpoint Blockade. Cell. 167(6). 1540–1554.e12. 804 indexed citations breakdown →

20.

Carreno, Beatriz M., Michelle Becker‐Hapak, Alexander C. Huang, et al.. (2013). IL-12p70–producing patient DC vaccine elicits Tc1-polarized immunity. Journal of Clinical Investigation. 123(8). 3383–3394. 135 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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