A. John Iafrate

73.6k citations

238 papers · 27.1k indexed · 15 hit papers · h-index 78

Impact in

Cancer Research top 0.05%
- Cancer Genomics and Diagnostics
Oncology top 0.05%
- Lung Cancer Research Studies

Papers in

Cancer Research 74
- Cancer Genomics and Diagnostics 67
Oncology 105
- Colorectal Cancer Treatments and Studies 31
- Lung Cancer Research Studies 29
- Pancreatic and Hepatic Oncology Research 15

Co-authors: Mari Mino–Kenudson Charles Lee Alice T. Shaw Jeffrey A. Engelman Long P. Le Dora Dias‐Santagata Miguel N. Rivera Stephen W. Scherer
Journals: Journal of Clinical Oncology (42 papers)Clinical Cancer Research (18 papers)Journal of Thoracic Oncology (12 papers)Annals of Oncology (10 papers)Journal of Molecular Diagnostics (10 papers)
Partner nations: United States South Korea Germany

In The Last Decade

A. John Iafrate

230 papers receiving 26.6k citations

Hit Papers

15 papers align trajectories log scale

mRNA-based COVID-19 vaccine boosters induce neutralizing immunity against SARS-CoV-2 Omicron variant 2022 · 651 citations

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if any of the following hold:

it has ≥500 total citations;
it reaches ≥1.5× the top-1% citation threshold for papers in the same subfield and year (the threshold is the minimum needed to enter the top 1%, not the average within it);
it reaches the top citation threshold in at least one of its specific research topics.

2022 Cell
2022 Cell
2021 Cell
2019 Annals of Oncology
2014 Nature Medicine
2014 Nature Biotechnology
2013 Clinical Cancer Research
2012 Science Translational Medicine
2011 Cancer Cell
2011 The Oncologist
2009 Journal of Clinical Oncology
2009 Clinical Cancer Research
2008 Journal of Clinical Oncology
2008 New England Journal of Medicine
2004 Nature Genetics

Peers

Countries citing papers authored by A. John Iafrate

Since Specialization

Citations

This map shows the geographic impact of A. John Iafrate's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by A. John Iafrate with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites A. John Iafrate more than expected).

Fields of papers citing papers by A. John Iafrate

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by A. John Iafrate. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by A. John Iafrate. The network helps show where A. John Iafrate may publish in the future.

Co-authors

The 25 scholars most cited alongside A. John Iafrate, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with A. John Iafrate Line = papers co-authored together A. John Iafrate links everyone, so they are left out of the graph.

All Works

Sort: Min cites: Since: Top N: Style:

20 of 20 papers shown

#	Work
1	Concordance between Tumor Tissue and Plasma DNA Genotyping in the NCI-MATCH Trial (EAY131) Clinical Cancer Research ·Mohamed A. Gouda, Filip Jankú, Ying Yuan, Leylah Drusbosky, Alice P. Chen, Xiaofeng Zheng, Keyur P. Patel, Stanley R. Hamilton, Mark J. Routbort, James V. Tricoli, P. Mickey Williams, A. John Iafrate, Jeffrey Sklar, Brent Coffey, Richard F. Little, Carlos L. Arteaga, Peter J. O’Dwyer, Keith T. Flaherty, Lyndsay N. Harris, Funda Meric‐Bernstam	2025	1
2	Defining genome-wide CRISPR–Cas genome-editing nuclease activity with GUIDE-seq Nature Protocols ·Nikolay Malinin, GaHyun Lee, Cícera R. Lazzarotto, Yichao Li, Zongli Zheng, Nathalie T. Nguyen, Matthew Liebers, Ved V. Topkar, A. John Iafrate, Long P. Le, Martin J. Aryee, J. Keith Joung, Shengdar Q. Tsai	2021	46
3	Tumor Tissue- versus Plasma-based Genotyping for Selection of Matched Therapy and Impact on Clinical Outcomes in Patients with Metastatic Breast Cancer Clinical Cancer Research ·Neelima Vidula, Andrzej Niemierko, Giuliana Malvarosa, Megan Yuen, Jochen K. Lennerz, A. John Iafrate, Seth A. Wander, Laura M. Spring, Dejan Juric, Steven J. Isakoff, Jerry Younger, Beverly Moy, Leif W. Ellisen, Aditya Bardia	2021	12
4	FGFR1 Amplification Mediates Endocrine Resistance but Retains TORC Sensitivity in Metastatic Hormone Receptor–Positive (HR+) Breast Cancer Clinical Cancer Research ·Joshua Z. Drago, Luigi Formisano, Dejan Juric, Andrzej Niemierko, Alberto Servetto, Seth A. Wander, Laura M. Spring, Neelima Vidula, Jerry Younger, Jeffrey Peppercorn, Megan Yuen, Giuliana Malvarosa, Dennis C. Sgroi, Steven J. Isakoff, Beverly Moy, Leif W. Ellisen, A. John Iafrate, Carlos L. Arteaga, Aditya Bardia	2019	47
5	A Phase I, Open-Label, Multicenter, Dose-escalation Study of the Oral Selective FGFR Inhibitor Debio 1347 in Patients with Advanced Solid Tumors Harboring FGFR Gene Alterations Clinical Cancer Research ·Martin H. Voss, Cinta Hierro, Rebecca S. Heist, James M. Cleary, Funda Meric‐Bernstam, Josep Tabernero, Filip Jankú, Leena Gandhi, A. John Iafrate, Darrell R. Borger, Nobuya Ishii, Youyou Hu, Yulia Kirpicheva, Valerie Nicolas‐Métral, Anna Pokorska-Bocci, Anne Vaslin Chessex, Claudio Zanna, Keith T. Flaherty, José Baselga	2019	102
6	The Alkylating Chemotherapeutic Temozolomide Induces Metabolic Stress in IDH1 -Mutant Cancers and Potentiates NAD+ Depletion–Mediated Cytotoxicity Cancer Research ·Kensuke Tateishi, Fumi Higuchi, Julie J. Miller, Mara V.A. Koerner, Nina Lelic, Ganesh M. Shankar, Shota Tanaka, David E. Fisher, Tracy T. Batchelor, A. John Iafrate, Hiroaki Wakimoto, S. Andrew, Daniel P. Cahill	2017	73
7	Blockade of transforming growth factor‐β signaling enhances oncolytic herpes simplex virus efficacy in patient‐derived recurrent glioblastoma models International Journal of Cancer ·Shinichi Esaki, Fares Nigim, Esther Moon, Samantha Luk, Juri Kiyokawa, William T. Curry, Daniel P. Cahill, S. Andrew, A. John Iafrate, Robert L. Martuza, Samuel D. Rabkin, Hiroaki Wakimoto	2017	37
8	Molecular Heterogeneity and Receptor Coamplification Drive Resistance to Targeted Therapy in MET -Amplified Esophagogastric Cancer Cancer Discovery ·Eunice L. Kwak, Leanne G. Ahronian, Giulia Siravegna, Benedetta Mussolin, Darrell R. Borger, Jason T. Godfrey, Nicholas A. Jessop, Jeffrey W. Clark, Lawrence S. Blaszkowsky, David P. Ryan, Jochen K. Lennerz, A. John Iafrate, Alberto Bardelli, Theodore S. Hong, Ryan B. Corcoran	2015	138
9	Treatment Response Assessment in IDH-Mutant Glioma Patients by Noninvasive 3D Functional Spectroscopic Mapping of 2-Hydroxyglutarate Clinical Cancer Research ·Ovidiu C. Andronesi, Franziska Loebel, Wolfgang Bogner, Małgorzata Marjańska, Matthew G. Vander Heiden, A. John Iafrate, Jörg Dietrich, Tracy T. Batchelor, Elizabeth R. Gerstner, William G. Kaelin, S. Andrew, Bruce R. Rosen, Daniel P. Cahill	2015	116
10	Two Novel ALK Mutations Mediate Acquired Resistance to the Next-Generation ALK Inhibitor Alectinib Clinical Cancer Research ·Ryohei Katayama, Luc Friboulet, Sumie Koike, Elizabeth L. Lockerman, Tahsin Khan, Justin F. Gainor, A. John Iafrate, Kengo Takeuchi, Makoto Taiji, Yasushi Okuno, Naoya Fujita, Jeffrey A. Engelman, Alice T. Shaw	2014	222
11	Targetable Signaling Pathway Mutations Are Associated with Malignant Phenotype in IDH -Mutant Gliomas Clinical Cancer Research ·Hiroaki Wakimoto, Shota Tanaka, William T. Curry, Franziska Loebel, Dan Zhao, Kensuke Tateishi, Juxiang Chen, Lindsay K. Klofas, Nina Lelic, James C. Kim, Dora Dias‐Santagata, Leif W. Ellisen, Darrell R. Borger, Sarah‐Maria Fendt, Matthew G. Vander Heiden, Tracy T. Batchelor, A. John Iafrate, Daniel P. Cahill, S. Andrew	2014	130
12	Brain Tumor Cells in Circulation Are Enriched for Mesenchymal Gene Expression Cancer Discovery ·James P. Sullivan, Brian V. Nahed, Marissa W. Madden, Samantha M. Oliveira, Simeon Springer, Deepak Bhere, S. Andrew, Hiroaki Wakimoto, S. Michael Rothenberg, Lecia V. Sequist, Ravi Kapur, Khalid Shah, A. John Iafrate, William T. Curry, Jay S. Loeffler, Tracy T. Batchelor, David N. Louis, Mehmet Toner, Shyamala Maheswaran, Daniel A. Haber	2014	200
13	Pediatric-type nodal follicular lymphoma: an indolent clonal proliferation in children and adults with high proliferation index and no BCL2 rearrangement Blood ·Abner Louissaint, Adam Ackerman, Dora Dias‐Santagata, Judith A. Ferry, Ephraim P. Hochberg, Mary Huang, A. John Iafrate, Daniel O. Lara, Geraldine S. Pinkus, Itziar Salaverría, Zakir Siddiquee, Reiner Siebert, Howard J. Weinstein, Lawrence Zukerberg, Nancy L. Harris, Robert P. Hasserjian	2012	89
14	Activation of PI3K Signaling in Merkel Cell Carcinoma Clinical Cancer Research ·Valentina Nardi, Youngchul Song, Juan A. Santamaria‐Barria, Arjola K. Cosper, Quynh Lam, Anthony C. Faber, Genevieve M. Boland, Beow Y. Yeap, Kristin Bergethon, Vanessa Scialabba, Hensin Tsao, Jeffrey Settleman, David P. Ryan, Darrell R. Borger, Atul K. Bhan, Mai P. Hoang, A. John Iafrate, James C. Cusack, Jeffrey A. Engelman, Dora Dias‐Santagata	2012	87
15	A Novel, Highly Sensitive Antibody Allows for the Routine Detection of ALK -Rearranged Lung Adenocarcinomas by Standard Immunohistochemistry Clinical Cancer Research ·Mari Mino–Kenudson, Lucian R. Chirieac, Kenny Law, Jason L. Hornick, Neal I. Lindeman, Eugene J. Mark, David Cohen, Bruce E. Johnson, Pasi A. Jänne, A. John Iafrate, Scott J. Rodig	2010	327
16	Unique Clinicopathologic Features Characterize ALK -Rearranged Lung Adenocarcinoma in the Western Population Clinical Cancer Research ·Scott J. Rodig, Mari Mino–Kenudson, Sanja Đačić, Beow Y. Yeap, Alice T. Shaw, Justine A. Barletta, Hannah Stubbs, Kenny Law, Neal I. Lindeman, Eugene J. Mark, Pasi A. Jänne, Thomas J. Lynch, Bruce E. Johnson, A. John Iafrate, Lucian R. Chirieac Hit paper breakdown →	2009	526
17	Clinical Features and Outcome of Patients With Non–Small-Cell Lung Cancer Who Harbor EML4-ALK Journal of Clinical Oncology ·Alice T. Shaw, Beow Y. Yeap, Mari Mino–Kenudson, Subba R. Digumarthy, Daniel B. Costa, Rebecca S. Heist, Benjamin Solomon, Hannah Stubbs, Sonal Admane, Ultan McDermott, Jeffrey Settleman, Susumu Kobayashi, Eugene J. Mark, Scott J. Rodig, Lucian R. Chirieac, Eunice L. Kwak, Thomas J. Lynch, A. John Iafrate Hit paper breakdown →	2009	1463
18	MSH6 Mutations Arise in Glioblastomas during Temozolomide Therapy and Mediate Temozolomide Resistance Clinical Cancer Research ·Stephen Yip, Jiangyong Miao, Daniel P. Cahill, A. John Iafrate, Ken Aldape, Catherine L. Nutt, David N. Louis	2009	292
19	Loss of the Mismatch Repair Protein MSH6 in Human Glioblastomas Is Associated with Tumor Progression during Temozolomide Treatment Clinical Cancer Research ·Daniel P. Cahill, Kymberly K. Levine, Rebecca A. Betensky, Patrick J. Codd, Candice A. Romany, Linsey B. Reavie, Tracy T. Batchelor, P. Andrew Futreal, Michael R. Stratton, William T. Curry, A. John Iafrate, David N. Louis	2007	330
20	An X Chromosome Gene, WTX , Is Commonly Inactivated in Wilms Tumor Science ·Miguel N. Rivera, Woo‐Jae Kim, Julie Wells, David R. Driscoll, Brian W. Brannigan, Moonjoo Han, James C. Kim, Andrew P. Feinberg, William L. Gerald, Sara O. Vargas, Lynda Chin, A. John Iafrate, Daphne W. Bell, Daniel A. Haber	2007	225

About A. John Iafrate

A. John Iafrate is a scholar working on Cancer Research, Oncology, Pulmonary and Respiratory Medicine, Genetics and Pathology and Forensic Medicine, having authored 238 papers that have together received 27.1k indexed citations. Recurring topics across this work include Lung Cancer Treatments and Mutations (86 papers), Cancer Genomics and Diagnostics (67 papers), Colorectal Cancer Treatments and Studies (31 papers), Lung Cancer Research Studies (29 papers), Glioma Diagnosis and Treatment (27 papers), Genetic factors in colorectal cancer (18 papers), Cholangiocarcinoma and Gallbladder Cancer Studies (17 papers) and Pancreatic and Hepatic Oncology Research (15 papers). The work is most often cited by research in Cancer Research (6.4k citations), Oncology (10.6k citations), Pulmonary and Respiratory Medicine (11.6k citations), Genetics (2.7k citations) and Molecular Biology (11.4k citations). A. John Iafrate has collaborated with scholars based in United States, South Korea and Germany. Frequent co-authors include Mari Mino–Kenudson, Charles Lee, Alice T. Shaw, Jeffrey A. Engelman, Long P. Le, Dora Dias‐Santagata, Miguel N. Rivera, Stephen W. Scherer, Ying Qi and Marc Listewnik. Their work appears in journals such as Journal of Clinical Oncology, Clinical Cancer Research, Journal of Thoracic Oncology, Annals of Oncology and Journal of Molecular Diagnostics.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

Explore authors with similar magnitude of impact