Standout Papers

Diffusible, nonfibrillar ligands derived from Aβ <sub>1–42</sub> are potent central nervous sy... 1998 2026 2007 2016 2.9k
  1. Diffusible, nonfibrillar ligands derived from Aβ 1–42 are potent central nervous system neurotoxins (1998)
    Mary P. Lambert, Avlin Barlow et al. Proceedings of the National Academy of Sciences
  2. Aβ Oligomer-Induced Aberrations in Synapse Composition, Shape, and Density Provide a Molecular Basis for Loss of Connectivity in Alzheimer's Disease (2007)
    Pascale N. Lacor, Maria C. Buniel et al. Journal of Neuroscience
  3. Alzheimer's disease-affected brain: Presence of oligomeric Aβ ligands (ADDLs) suggests a molecular basis for reversible memory loss (2003)
    Yuesong Gong, Lei Chang et al. Proceedings of the National Academy of Sciences
  4. Targeting small Aβ oligomers: the solution to an Alzheimer's disease conundrum? (2001)
    William L. Klein Trends in Neurosciences
  5. Synaptic Targeting by Alzheimer's-Related Amyloid β Oligomers (2004)
    Pascale N. Lacor, Maria C. Buniel et al. Journal of Neuroscience
  6. Aβ Oligomers Induce Neuronal Oxidative Stress through an N-Methyl-D-aspartate Receptor-dependent Mechanism That Is Blocked by the Alzheimer Drug Memantine (2007)
    Fernanda G. De Felice, Pauline T. Velasco et al. Journal of Biological Chemistry
  7. An anti-diabetes agent protects the mouse brain from defective insulin signaling caused by Alzheimer’s disease–associated Aβ oligomers (2012)
    Theresa R. Bomfim, Letícia Forny‐Germano et al. Journal of Clinical Investigation
  8. Detection of a Biomarker for Alzheimer's Disease from Synthetic and Clinical Samples Using a Nanoscale Optical Biosensor (2005)
    Amanda J. Haes, Lei Chang et al. Journal of the American Chemical Society
  9. Nanoparticle-based detection in cerebral spinal fluid of a soluble pathogenic biomarker for Alzheimer's disease (2005)
    D.G. Georganopoulou, Lei Chang et al. Proceedings of the National Academy of Sciences
  10. The Amyloid-β Oligomer Hypothesis: Beginning of the Third Decade (2018)
    Erika N. Cline, Maíra A. Bicca et al. Journal of Alzheimer s Disease
  11. A Localized Surface Plasmon Resonance Biosensor:  First Steps toward an Assay for Alzheimer's Disease (2004)
    Amanda J. Haes, W. Paige Hall et al. Nano Letters
  12. Protection of synapses against Alzheimer's-linked toxins: Insulin signaling prevents the pathogenic binding of Aβ oligomers (2009)
    Fernanda G. De Felice, Marcelo N. N. Vieira et al. Proceedings of the National Academy of Sciences
  13. Amyloid β oligomers in Alzheimer’s disease pathogenesis, treatment, and diagnosis (2015)
    Kirsten L. Viola, William L. Klein Acta Neuropathologica
  14. Energization of Active Transport by Escherichia coli (1972)
    William L. Klein, Paul D. Boyer Journal of Biological Chemistry

Immediate Impact

7 by Nobel laureates 54 from Science/Nature 270 standout
Sub-graph 1 of 11

Citing Papers

Alzheimer's disease: From immunotherapy to immunoprevention
2023 Standout
Amyloid β oligomers constrict human capillaries in Alzheimer’s disease via signaling to pericytes
2019 StandoutScience
13 intermediate papers

Works of William L. Klein being referenced

Targeting small Aβ oligomers: the solution to an Alzheimer's disease conundrum?
2001 Standout
Vaccination with soluble Aβ oligomers generates toxicity‐neutralizing antibodies
2001
and 22 more

Author Peers

Author Last Decade Papers Cites
William L. Klein 17172 9980 6544 185 24.7k
Jürgen Götz 12100 9610 5133 241 21.2k
Dominic M. Walsh 26394 14779 8070 159 33.3k
Todd E. Golde 18492 14019 5617 312 31.5k
Karen Duff 17678 10748 9467 233 28.8k
Rakez Kayed 16614 10841 4753 200 23.2k
Charles Glabe 18856 13405 4107 189 27.7k
Matthias Staufenbiel 16560 9378 6391 211 24.7k
Brian J. Bacskai 10270 6210 5396 192 19.2k
Matthew P. Frosch 16468 9195 6249 294 31.5k
Robert Vassar 10729 6383 4493 133 18.4k

All Works

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2026