Standout Papers

Hallmarks of Cancer: The Next Generation 1995 2026 2005 2015 47.2k
  1. Hallmarks of Cancer: The Next Generation (2011)
    Douglas Hanahan, Robert A. Weinberg Cell
  2. The Hallmarks of Cancer (2000)
    Douglas Hanahan, Robert A. Weinberg Cell
  3. The basics of epithelial-mesenchymal transition (2009)
    Raghu Kalluri, Robert A. Weinberg Journal of Clinical Investigation
  4. The Epithelial-Mesenchymal Transition Generates Cells with Properties of Stem Cells (2008)
    Sendurai A. Mani, Wenjun Guo et al. Cell
  5. The retinoblastoma protein and cell cycle control (1995)
    Robert A. Weinberg Cell
  6. Understanding the tumor immune microenvironment (TIME) for effective therapy (2018)
    Mikhail Binnewies, Edward W. Roberts et al. Nature Medicine
  7. A Perspective on Cancer Cell Metastasis (2011)
    Christine L. Chaffer, Robert A. Weinberg Science
  8. Twist, a Master Regulator of Morphogenesis, Plays an Essential Role in Tumor Metastasis (2004)
    Jing Yang, Sendurai A. Mani et al. Cell
  9. Tumor Metastasis: Molecular Insights and Evolving Paradigms (2011)
    Scott Valastyan, Robert A. Weinberg Cell
  10. Stromal Fibroblasts Present in Invasive Human Breast Carcinomas Promote Tumor Growth and Angiogenesis through Elevated SDF-1/CXCL12 Secretion (2005)
    Akira Orimo, Piyush B. Gupta et al. Cell
  11. Transitions between epithelial and mesenchymal states: acquisition of malignant and stem cell traits (2009)
    Kornélia Polyák, Robert A. Weinberg Nature reviews. Cancer
  12. New insights into the mechanisms of epithelial–mesenchymal transition and implications for cancer (2018)
    Anushka Dongre, Robert A. Weinberg Nature Reviews Molecular Cell Biology
  13. Mesenchymal stem cells within tumour stroma promote breast cancer metastasis (2007)
    Antoine E. Karnoub, Ajeeta B. Dash et al. Nature
  14. Epithelial-Mesenchymal Transition: At the Crossroads of Development and Tumor Metastasis (2008)
    Jing Yang, Robert A. Weinberg Developmental Cell
  15. Tumorigenic conversion of primary embryo fibroblasts requires at least two cooperating oncogenes (1983)
    Hartmut Land, Luis F. Parada et al. Nature
  16. hSIR2SIRT1 Functions as an NAD-Dependent p53 Deacetylase (2001)
    Homayoun Vaziri, Scott Dessain et al. Cell
  17. A human DNA segment with properties of the gene that predisposes to retinoblastoma and osteosarcoma (1986)
    Stephen Friend, René Bernards et al. Nature
  18. Emerging Biological Principles of Metastasis (2017)
    Arthur W. Lambert, Diwakar R. Pattabiraman et al. Cell
  19. Tumour invasion and metastasis initiated by microRNA-10b in breast cancer (2007)
    Li Ma, Julie Teruya‐Feldstein et al. Nature
  20. An embryonic stem cell–like gene expression signature in poorly differentiated aggressive human tumors (2008)
    Ittai Ben‐Porath, Matthew Thomson et al. Nature Genetics
  21. Identification of Selective Inhibitors of Cancer Stem Cells by High-Throughput Screening (2009)
    Piyush B. Gupta, Tamer T. Önder et al. Cell
  22. EMT, CSCs, and drug resistance: the mechanistic link and clinical implications (2017)
    Tsukasa Shibue, Robert A. Weinberg Nature Reviews Clinical Oncology
  23. Creation of human tumour cells with defined genetic elements (1999)
    William C. Hahn, Christopher M. Counter et al. Nature
  24. Tumor spectrum analysis in p53-mutant mice (1994)
    Tyler Jacks, Lee Ann Remington et al. Current Biology
  25. hEST2, the Putative Human Telomerase Catalytic Subunit Gene, Is Up-Regulated in Tumor Cells and during Immortalization (1997)
    Matthew Meyerson, Christopher M. Counter et al. Cell
  26. EMT in cancer (2018)
    Thomas Brabletz, Raghu Kalluri et al. Nature reviews. Cancer
  27. Effects of an Rb mutation in the mouse (1992)
    Tyler Jacks, Amin Fazeli et al. Nature
  28. Tumor Suppressor Genes (1991)
    Robert A. Weinberg Science
  29. Association between an oncogene and an anti-oncogene: the adenovirus E1A proteins bind to the retinoblastoma gene product (1988)
    Peter Whyte, Karen Buchkovich et al. Nature
  30. Loss of E-Cadherin Promotes Metastasis via Multiple Downstream Transcriptional Pathways (2008)
    Tamer T. Önder, Piyush B. Gupta et al. Cancer Research
  31. Ras oncogenes: split personalities (2008)
    Antoine E. Karnoub, Robert A. Weinberg Nature Reviews Molecular Cell Biology
  32. Lentivirus-delivered stable gene silencing by RNAi in primary cells (2003)
    Sheila A. Stewart, Derek M. Dykxhoorn et al. RNA
  33. Mechanism of activation of a human oncogene (1982)
    Clifford J. Tabin, Scott M. Bradley et al. Nature
  34. miR-9, a MYC/MYCN-activated microRNA, regulates E-cadherin and cancer metastasis (2010)
    Li Ma, Jennifer J. Young et al. Nature Cell Biology
  35. Association of Sos Ras exchange protein with Grb2 is implicated in tyrosine kinase signal transduction and transformation (1993)
    Sean E. Egan, Mary W. Brooks et al. Nature
  36. The neu oncogene encodes an epidermal growth factor receptor-related protein (1986)
    Cornelia I. Bargmann, Mien‐Chie Hung et al. Nature
  37. Cellular Oncogenes and Multistep Carcinogenesis (1983)
    Hartmut Land, Luis F. Parada et al. Science
  38. The Biology of Cancer (2006)
    Robert A. Weinberg et al. Medical Entomology and Zoology
  39. Expression cloning of the TGF-β type II receptor, a functional transmembrane serine/threonine kinase (1992)
    Herbert Y. Lin, Xiao‐Fan Wang et al. Cell
  40. The epigenetics of epithelial-mesenchymal plasticity in cancer (2013)
    Wai Leong Tam, Robert A. Weinberg Nature Medicine
  41. The neu oncogene: an erb-B-related gene encoding a 185,000-Mr tumour antigen (1984)
    Alan L. Schechter, David F. Stern et al. Nature
  42. Regulation of retinoblastoma protein functions by ectopic expression of human cyclins (1992)
    Philip W. Hinds, Sibylle Mittnacht et al. Cell
  43. Normal and neoplastic nonstem cells can spontaneously convert to a stem-like state (2011)
    Christine L. Chaffer, Christina Scheel et al. Proceedings of the National Academy of Sciences
  44. Functional Inactivation of the Retinoblastoma Protein Requires Sequential Modification by at Least Two Distinct Cyclin-cdk Complexes (1998)
    Ante S. Lundberg, Robert A. Weinberg Molecular and Cellular Biology
  45. Cyclin D1 provides a link between development and oncogenesis in the retina and breast (1995)
    Piotr Siciński, Joana Liu Donaher et al. Cell
  46. Multiple independent activations of the neu oncogene by a point mutation altering the transmembrane domain of p185 (1986)
    Cornelia I. Bargmann, Mien‐Chie Hung et al. Cell
  47. Human Keratinocytes That Express hTERT and Also Bypass a p16INK4a-Enforced Mechanism That Limits Life Span Become Immortal yet Retain Normal Growth and Differentiation Characteristics (2000)
    Mark A. Dickson, William C. Hahn et al. Molecular and Cellular Biology
  48. Inhibition of telomerase limits the growth of human cancer cells (1999)
    William C. Hahn, Sheila A. Stewart et al. Nature Medicine
  49. The signals and pathways activating cellular senescence (2004)
    Ittai Ben‐Porath, Robert A. Weinberg The International Journal of Biochemistry & Cell Biology
  50. Core epithelial-to-mesenchymal transition interactome gene-expression signature is associated with claudin-low and metaplastic breast cancer subtypes (2010)
    Joseph H. Taube, Jason I. Herschkowitz et al. Proceedings of the National Academy of Sciences
  51. Tackling the cancer stem cells — what challenges do they pose? (2014)
    Diwakar R. Pattabiraman, Robert A. Weinberg Nature Reviews Drug Discovery
  52. Epithelial–Mesenchymal Plasticity: A Central Regulator of Cancer Progression (2015)
    Xin Ye, Robert A. Weinberg Trends in Cell Biology
  53. Slug and Sox9 Cooperatively Determine the Mammary Stem Cell State (2012)
    Wenjun Guo, Zuzana Keckesova et al. Cell
  54. Cancer stem cells: mirage or reality? (2009)
    Piyush B. Gupta, Christine L. Chaffer et al. Nature Medicine
  55. Human EJ bladder carcinoma oncogene is homologue of Harvey sarcoma virus ras gene (1982)
    Luis F. Parada, Clifford J. Tabin et al. Nature
  56. The tumour-induced systemic environment as a critical regulator of cancer progression and metastasis (2014)
    Sandra S. McAllister, Robert A. Weinberg Nature Cell Biology
  57. Paracrine and Autocrine Signals Induce and Maintain Mesenchymal and Stem Cell States in the Breast (2011)
    Christina Scheel, Elinor Ng Eaton et al. Cell
  58. Cancer stem cells and epithelial–mesenchymal transition: Concepts and molecular links (2012)
    Christina Scheel, Robert A. Weinberg Seminars in Cancer Biology
  59. Rules for Making Human Tumor Cells (2002)
    William C. Hahn, Robert A. Weinberg New England Journal of Medicine
  60. Human breast cancer cells generated by oncogenic transformation of primary mammary epithelial cells (2001)
    Brian Elenbaas, Lisa Spirio et al. Genes & Development
  61. Modelling the molecular circuitry of cancer (2002)
    William C. Hahn, Robert A. Weinberg Nature reviews. Cancer
  62. Physical interaction of the retinoblastoma protein with human D cyclins (1993)
    Steven F. Dowdy, Philip W. Hinds et al. Cell
  63. Poised Chromatin at the ZEB1 Promoter Enables Breast Cancer Cell Plasticity and Enhances Tumorigenicity (2013)
    Christine L. Chaffer, Nemanja D. Marjanovic et al. Cell
  64. Isolation of a transforming sequence from a human bladder carcinoma cell line (1982)
    Chiaho Shih, Robert A. Weinberg Cell
  65. Autocrine TGF-β and stromal cell-derived factor-1 (SDF-1) signaling drives the evolution of tumor-promoting mammary stromal myofibroblasts (2010)
    Yasushi Kojima, Ahmet Acar et al. Proceedings of the National Academy of Sciences
  66. Phenotype of mice lacking functional Deleted in colorectal cancer (Dec) gene (1997)
    Amin Fazeli, Stephanie Dickinson et al. Nature
  67. Metastasis genes: A progression puzzle (2002)
    René Bernards, Robert A. Weinberg Nature
  68. EMT, cell plasticity and metastasis (2016)
    Christine L. Chaffer, Beatriz P. San Juan et al. Cancer and Metastasis Reviews
  69. Cooperation between gene encoding p53 tumour antigen and ras in cellular transformation (1984)
    Luis F. Parada, Hartmut Land et al. Nature
  70. Stromal Fibroblasts in Cancer: A Novel Tumor-Promoting Cell Type (2006)
    Akira Orimo, Robert A. Weinberg Cell Cycle
  71. Transforming genes of carcinomas and neuroblastomas introduced into mouse fibroblasts (1981)
    Chiaho Shih, L. C. Padhy et al. Nature
  72. Reconstruction of functionally normal and malignant human breast tissues in mice (2004)
    Charlotte Kuperwasser, Tony E. Chavarria et al. Proceedings of the National Academy of Sciences
  73. Therapeutic silencing of miR-10b inhibits metastasis in a mouse mammary tumor model (2010)
    Li Ma, Ferenc Reinhardt et al. Nature Biotechnology
  74. Tumour predisposition in mice heterozygous for a targeted mutation in Nf1 (1994)
    Tyler Jacks, T. Shane Shih et al. Nature Genetics
  75. Cyclin D2 is an FSH-responsive gene involved in gonadal cell proliferation and oncogenesis (1996)
    Piotr Siciński, Joana Liu Donaher et al. Nature
  76. Suppression of intestinal neoplasia by DNA hypomethylation (1995)
    Peter W. Laird, Laurie Jackson‐Grusby et al. Cell
  77. The Action of Oncogenes in the Cytoplasm and Nucleus (1985)
    Robert A. Weinberg Science
  78. Distinct EMT programs control normal mammary stem cells and tumour-initiating cells (2015)
    Xin Ye, Wai Leong Tam et al. Nature
  79. Expression cloning and characterization of the TGF-β type III receptor (1991)
    Xiao‐Fan Wang, Herbert Y. Lin et al. Cell
  80. Dissociation among in vitro telomerase activity, telomere maintenance, and cellular immortalization (1998)
    Christopher M. Counter, William C. Hahn et al. Proceedings of the National Academy of Sciences
  81. Multiple protein-binding sites in the 5'-flanking region regulate c-fos expression. (1986)
    Michael Gilman, Robert A. Weinberg et al. Molecular and Cellular Biology
  82. Small molecular weight monodisperse nuclear RNA (1968)
    Robert A. Weinberg, Sheldon Penman Journal of Molecular Biology
  83. Passage of phenotypes of chemically transformed cells via transfection of DNA and chromatin. (1979)
    Chiaho Shih, Ben‐Zion Shilo et al. Proceedings of the National Academy of Sciences

Immediate Impact

91 by Nobel laureates 145 from Science/Nature 196 standout
Sub-graph 1 of 14

Citing Papers

The biology , function , and biomedical applications of exosomes
2020 StandoutScience
Hypoxia induces the breast cancer stem cell phenotype by HIF-dependent and ALKBH5-mediated m 6 A-demethylation of NANOG mRNA
2016 StandoutNobel
32 intermediate papers

Works of Robert A. Weinberg being referenced

Paracrine and Autocrine Signals Induce and Maintain Mesenchymal and Stem Cell States in the Breast
2011 Standout
An embryonic stem cell–like gene expression signature in poorly differentiated aggressive human tumors
2008 Standout
and 19 more

Author Peers

Author Last Decade Papers Cites
Robert A. Weinberg 133196 93880 55373 377 219.6k
Bert Vogelstein 133033 90820 56218 546 226.9k
Guido Kroemer 125595 44900 28279 1.3k 229.0k
Douglas Hanahan 78402 43041 35907 224 134.4k
Hans Clevers 96581 52291 18194 721 156.0k
Michael Karin 112099 45340 56122 646 209.7k
Joan Massagué 94714 46583 22328 356 135.6k
Lewis C. Cantley 103801 27070 29279 702 148.2k
Isabelle Soerjomataram 65346 70956 42755 232 196.2k
Kenneth W. Kinzler 78978 48789 37023 377 130.0k
Craig B. Thompson 90608 24948 43942 513 148.6k

All Works

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2026