Standout Papers

Specificity and mechanism of action of some commonly used protein kinase inhib... 1995 2026 2005 2015 3.7k
  1. Specificity and mechanism of action of some commonly used protein kinase inhibitors (2000)
    Stephen Davies, Helen Reddy et al. Biochemical Journal
  2. PD 098059 Is a Specific Inhibitor of the Activation of Mitogen-activated Protein Kinase Kinase in Vitro and in Vivo (1995)
    Dario R. Alessi, Ana Cuenda et al. Journal of Biological Chemistry
  3. Specificity and mechanism of action of some commonly used protein kinase inhibitors (2000)
    Stephen Davies, Helen Reddy et al. Biochemical Journal
  4. The ground state of embryonic stem cell self-renewal (2008)
    Qi‐Long Ying, Jason Wray et al. Nature
  5. Mechanism of activation of protein kinase B by insulin and IGF-1. (1996)
    Dario R. Alessi, Mirjana Andjelković et al. The EMBO Journal
  6. THE STRUCTURE AND REGULATION OF PROTEIN PHOSPHATASES (1989)
    Philip Cohen Annual Review of Biochemistry
  7. The selectivity of protein kinase inhibitors: a further update (2007)
    Jenny Bain, Matt Elliott et al. Biochemical Journal
  8. Protein kinases — the major drug targets of the twenty-first century? (2002)
    Philip Cohen Nature Reviews Drug Discovery
  9. A novel kinase cascade triggered by stress and heat shock that stimulates MAPKAP kinase-2 and phosphorylation of the small heat shock proteins (1994)
    John Rouse, Philip Cohen et al. Cell
  10. Cyanobacterial microcystin‐LR is a potent and specific inhibitor of protein phosphatases 1 and 2A from both mammals and higher plants (1990)
    Carol MacKintosh, Kenneth A. Beattie et al. FEBS Letters
  11. The renaissance of GSK3 (2001)
    Philip Cohen, Sheelagh Frame Nature Reviews Molecular Cell Biology
  12. The specificities of protein kinase inhibitors: an update (2003)
    Jenny Bain, Hilary McLauchlan et al. Biochemical Journal
  13. GSK3 takes centre stage more than 20 years after its discovery (2001)
    Sheelagh Frame, Philip Cohen Biochemical Journal
  14. Protein Kinase C Isotypes Controlled by Phosphoinositide 3-Kinase Through the Protein Kinase PDK1 (1998)
    J. Ann Le Good, Wolfgang Ziegler et al. Science
  15. The role of protein phosphorylation in neural and hormonal control of cellular activity (1982)
    Philip Cohen Nature
  16. Role of Translocation in the Activation and Function of Protein Kinase B (1997)
    Mirjana Andjelković, Dario R. Alessi et al. Journal of Biological Chemistry
  17. The regulation of protein function by multisite phosphorylation – a 25 year update (2000)
    Philip Cohen Trends in Biochemical Sciences
  18. GSK3 takes centre stage more than 20 years after its discovery (2001)
    Sheelagh Frame, Philip Cohen Biochemical Journal
  19. The origins of protein phosphorylation (2002)
    Philip Cohen Nature Cell Biology
  20. Sustained activation of the mitogen-activated protein (MAP) kinase cascade may be required for differentiation of PC12 cells. Comparison of the effects of nerve growth factor and epidermal growth factor (1992)
    Sarah Traverse, Néstor Gómez et al. Biochemical Journal
  21. Inactivation of glycogen synthase kinase-3β by phosphorylation: new kinase connections in insulin and growth-factor signalling (1993)
    Calum Sutherland, Ian Leighton et al. Biochemical Journal
  22. Glycogen synthase kinase-3 from rabbit skeletal muscle. Separation from cyclic-AMP-dependent protein kinase and phosphorylase kinase. (1980)
    Noor Embi, Dennis B. Rylatt et al. PubMed
  23. Effects of the tumour promoter okadaic acid on intracellular protein phosphorylation and metabolism (1989)
    Timothy Haystead, David Carling et al. Nature
  24. On target with a new mechanism for the regulation of protein phosphorylation (1993)
    Michael J. Hubbard, Philip Cohen Trends in Biochemical Sciences
  25. Activation of the MAP kinase pathway by the protein kinase raf (1992)
    Louise R. Howe, Sally J. Leevers et al. Cell
  26. Glycogen Synthase Kinase‐3 from Rabbit Skeletal Muscle (1980)
    Philip Cohen et al. European Journal of Biochemistry
  27. Mechanism of activation and function of protein kinase B (1998)
    Dario R. Alessi, Philip Cohen Current Opinion in Genetics & Development
  28. The Subunit Structure of Rabbit‐Skeletal‐Muscle Phosphorylase Kinase, and the Molecular Basis of Its Activation Reactions (1973)
    Philip Cohen European Journal of Biochemistry
  29. GSK3 inhibitors: development and therapeutic potential (2004)
    Philip Cohen, Michel Goedert Nature Reviews Drug Discovery
  30. Kinase drug discovery 20 years after imatinib: progress and future directions (2021)
    Philip Cohen, Darren A.E. Cross et al. Nature Reviews Drug Discovery
  31. Phosphorylation of the Transcription Factor Forkhead Family Member FKHR by Protein Kinase B (1999)
    Graham Rena, Shaodong Guo et al. Journal of Biological Chemistry
  32. A Common Phosphate Binding Site Explains the Unique Substrate Specificity of GSK3 and Its Inactivation by Phosphorylation (2001)
    Sheelagh Frame, Philip Cohen et al. Molecular Cell
  33. The p38/RK mitogen-activated protein kinase pathway regulates interleukin-6 synthesis response to tumor necrosis factor. (1996)
    Rudi Beyaert, Ana Cuenda et al. The EMBO Journal
  34. FGF and stress regulate CREB and ATF-1 via a pathway involving p38 MAP kinase and MAPKAP kinase-2. (1996)
    Yejun Tan, John Rouse et al. The EMBO Journal
  35. Molecular basis for the substrate specificity of protein kinase B; comparison with MAPKAP kinase‐1 and p70 S6 kinase (1996)
    Dario R. Alessi, F. Barry Caudwell et al. FEBS Letters
  36. Protein Phosphatases: Properties and Role in Cellular Regulation (1983)
    Thomas S. Ingebritsen, Philip Cohen Science
  37. Protein phosphatases come of age (1989)
    Patricia T.W. Cohen, Philip Cohen Journal of Biological Chemistry
  38. Activation of serum- and glucocorticoid-regulated protein kinase by agonists that activate phosphatidylinositide 3-kinase is mediated by 3-phosphoinositide-dependent protein kinase-1 (PDK1) and PDK2 (1999)
    Takayasu Kobayashi, Philip Cohen Biochemical Journal
  39. Identification of the Ca2+‐dependent modulator protein as the fourth subunit of rabbit skeletal muscle phosphorylase kinase (1978)
    Philip Cohen, Ann N. Burchell et al. FEBS Letters
  40. Discovery of A Ca2+‐and calmodulin‐dependent protein phosphatase (1982)
    Alexander A. Stewart, Thomas S. Ingebritsen et al. FEBS Letters

Immediate Impact

21 by Nobel laureates 88 from Science/Nature 190 standout
Sub-graph 1 of 17

Citing Papers

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2015 StandoutNature
Phosphorylation of innate immune adaptor proteins MAVS, STING, and TRIF induces IRF3 activation
2015 StandoutScience

Works of Philip Cohen being referenced

Protein kinase IKKβ-catalyzed phosphorylation of IRF5 at Ser462 induces its dimerization and nuclear translocation in myeloid cells
2014
Use of the Pharmacological Inhibitor BX795 to Study the Regulation and Physiological Roles of TBK1 and IκB Kinase ϵ
2009
and 1 more

Author Peers

Author Last Decade Papers Cites
Philip Cohen 67060 13461 3462 9697 488 88.5k
Roger J. Davis 61987 11605 1220 15513 563 91.7k
Dario R. Alessi 50134 10045 593 7625 308 64.7k
David M. Sabatini 70566 13245 1112 9434 253 98.9k
Kun‐Liang Guan 57090 31416 1138 9818 418 87.4k
Joseph Schlessinger 67577 16283 1294 24781 524 95.5k
Steven P. Gygi 87120 17827 1060 12298 689 119.3k
John R. Yates 77427 17203 652 7151 987 107.2k
Tony Hunter 77156 17369 1109 23136 502 103.0k
Shuh Narumiya 28576 11905 1333 5969 550 59.8k
Nahum Sonenberg 75137 7594 775 6966 664 94.7k

All Works

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