Standout Papers

Immunity, Inflammation, and Cancer 1997 2026 2006 2016 8.1k
  1. Immunity, Inflammation, and Cancer (2010)
    Sergei I. Grivennikov, Florian R. Greten et al. Cell
  2. Mammalian MAP kinase signalling cascades (2001)
    Lufen Chang, Michael Karin Nature
  3. Nuclear Factor-κB — A Pivotal Transcription Factor in Chronic Inflammatory Diseases (1997)
    Peter J. Barnes, Michael Karin New England Journal of Medicine
  4. Phosphorylation Meets Ubiquitination: The Control of NF-κB Activity (2000)
    Michael Karin, Yinon Ben‐Neriah Annual Review of Immunology
  5. Missing Pieces in the NF-κB Puzzle (2002)
    Sankar Ghosh, Michael Karin Cell
  6. The role of Jun, Fos and the AP-1 complex in cell-proliferation and transformation (1991)
    Peter Angel, Michael Karin Biochimica et Biophysica Acta (BBA) - Reviews on Cancer
  7. JNK1: A protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain (1994)
    Benoit Dérijard, Masahiko Hibi et al. Cell
  8. Nuclear factor-κB in cancer development and progression (2006)
    Michael Karin Nature
  9. Phorbol ester-inducible genes contain a common cis element recognized by a TPA-modulated trans-acting factor (1987)
    Peter Angel, Masayoshi Imagawa et al. Cell
  10. A central role for JNK in obesity and insulin resistance (2002)
    Jiro Hirosumi, Gürol Tuncman et al. Nature
  11. NF-κB: linking inflammation and immunity to cancer development and progression (2005)
    Michael Karin, Florian R. Greten Nature reviews. Immunology
  12. AP-1 function and regulation (1997)
    Michael Karin, Zheng-gang Liu et al. Current Opinion in Cell Biology
  13. NF-κB at the crossroads of life and death (2002)
    Michael Karin, Anning Lin Nature Immunology
  14. AP-1 as a regulator of cell life and death (2002)
    Eitan Shaulian, Michael Karin Nature Cell Biology
  15. The Regulation of AP-1 Activity by Mitogen-activated Protein Kinases (1995)
    Michael Karin Journal of Biological Chemistry
  16. Regulation and Function of NF-κB Transcription Factors in the Immune System (2009)
    Sivakumar Vallabhapurapu, Michael Karin Annual Review of Immunology
  17. NF-κB in cancer: from innocent bystander to major culprit (2002)
    Michael Karin, Yixue Cao et al. Nature reviews. Cancer
  18. The two NF-κB activation pathways and their role in innate and adaptive immunity (2004)
    Giuseppina Bonizzi, Michael Karin Trends in Immunology
  19. IKKβ Links Inflammation and Tumorigenesis in a Mouse Model of Colitis-Associated Cancer (2004)
    Florian R. Greten, Lars Eckmann et al. Cell
  20. Immunosuppression by Glucocorticoids: Inhibition of NF-κB Activity Through Induction of IκB Synthesis (1995)
    Nathalie Auphan‐Anezin, Joseph A. DiDonato et al. Science
  21. NF-κB, inflammation, immunity and cancer: coming of age (2018)
    Koji Taniguchi, Michael Karin Nature reviews. Immunology
  22. A cytokine-responsive IκB kinase that activates the transcription factor NF-κB (1997)
    Joseph A. DiDonato, Makio Hayakawa et al. Nature
  23. Dissection of TNF Receptor 1 Effector Functions: JNK Activation Is Not Linked to Apoptosis While NF-κB Activation Prevents Cell Death (1996)
    Zheng-gang Liu, Hailing Hsu et al. Cell
  24. IL-6 and Stat3 Are Required for Survival of Intestinal Epithelial Cells and Development of Colitis-Associated Cancer (2009)
    Sergei I. Grivennikov, Eliad Karin et al. Cancer Cell
  25. Identification of an oncoprotein- and UV-responsive protein kinase that binds and potentiates the c-Jun activation domain. (1993)
    Masahiko Hibi, Anning Lin et al. Genes & Development
  26. The IκB Kinase Complex (IKK) Contains Two Kinase Subunits, IKKα and IKKβ, Necessary for IκB Phosphorylation and NF-κB Activation (1997)
    Ebrahim Zandi, David M. Rothwarf et al. Cell
  27. Inflammation and Colon Cancer (2010)
    Janoš Terzić, Sergei I. Grivennikov et al. Gastroenterology
  28. A cytokine-mediated link between innate immunity, inflammation, and cancer (2007)
    Wan‐Wan Lin, Michael Karin Journal of Clinical Investigation
  29. Reactive Oxygen Species Promote TNFα-Induced Death and Sustained JNK Activation by Inhibiting MAP Kinase Phosphatases (2005)
    Hideaki Kamata, Shinichi Honda et al. Cell
  30. Reversal of Obesity- and Diet-Induced Insulin Resistance with Salicylates or Targeted Disruption of Ikkβ (2001)
    Minsheng Yuan, Nicky Konstantopoulos et al. Science
  31. Gender Disparity in Liver Cancer Due to Sex Differences in MyD88-Dependent IL-6 Production (2007)
    Willscott E. Naugler, Toshiharu Sakurai et al. Science
  32. IKK-β links inflammation to obesity-induced insulin resistance (2005)
    Melek C. Arkan, Andrea L. Hevener et al. Nature Medicine
  33. AP-1 in cell proliferation and survival (2001)
    Eitan Shaulian, Michael Karin Oncogene
  34. A Method for Isolation of Intact, Translationally Active Ribonucleic Acid (1983)
    Guy Cathala, Bernardita Méndez et al. DNA
  35. Signal transduction by tumor necrosis factor and its relatives (2001)
    Véronique Baud, Michael Karin Trends in Cell Biology
  36. Dietary and Genetic Obesity Promote Liver Inflammation and Tumorigenesis by Enhancing IL-6 and TNF Expression (2010)
    Eek Joong Park, Jun Hee Lee et al. Cell
  37. NF‐κB and the link between inflammation and cancer (2012)
    Joseph A. DiDonato, Frank Mercurio et al. Immunological Reviews
  38. NF-κB links innate immunity to the hypoxic response through transcriptional regulation of HIF-1α (2008)
    Jordi Rius, Mónica Gumá et al. Nature
  39. The c-fos protein interacts with c-JunAP-1 to stimulate transcription of AP-1 responsive genes (1988)
    Robert Chiu, William J. Boyle et al. Cell
  40. Inflammation meets cancer, with NF-κB as the matchmaker (2011)
    Yinon Ben‐Neriah, Michael Karin Nature Immunology
  41. The regulation of transcription by phosphorylation (1992)
    Tony Hunter, Michael Karin Cell
  42. The IKK NF-κB system: a treasure trove for drug development (2004)
    Michael Karin, Yumi Yamamoto et al. Nature Reviews Drug Discovery
  43. The jun proto-oncogene is positively autoregulated by its product, Jun/AP-1 (1988)
    Peter Angel, Kazue Hattori et al. Cell
  44. Activation by IKKα of a Second, Evolutionary Conserved, NF-κB Signaling Pathway (2001)
    Uwe Senftleben, Yixue Cao et al. Science
  45. Hypothalamic IKKβ/NF-κB and ER Stress Link Overnutrition to Energy Imbalance and Obesity (2008)
    Xiaoqing Zhang, Guo Zhang et al. Cell
  46. p53 Target Genes Sestrin1 and Sestrin2 Connect Genotoxic Stress and mTOR Signaling (2008)
    Andrei V. Budanov, Michael Karin Cell
  47. Differential Activation of ERK and JNK Mitogen-Activated Protein Kinases by Raf-1 and MEKK (1994)
    Audrey Minden, Anning Lin et al. Science
  48. Regulation and Function of IKK and IKK-Related Kinases (2006)
    Hans Häcker, Michael Karin Science s STKE
  49. The gut–liver axis and the intersection with the microbiome (2018)
    Anupriya Tripathi, Justine W. Debelius et al. Nature Reviews Gastroenterology & Hepatology
  50. How NF-κB is activated: the role of the IκB kinase (IKK) complex (1999)
    Michael Karin Oncogene
  51. Activation of protein kinase C decreases phosphorylation of c-Jun at sites that negatively regulate its DNA-binding activity (1991)
    William J. Boyle, Tod Smeal et al. Cell
  52. IKKβ Couples Hepatocyte Death to Cytokine-Driven Compensatory Proliferation that Promotes Chemical Hepatocarcinogenesis (2005)
    Shin Maeda, Hideaki Kamata et al. Cell
  53. NF-κB and STAT3 – key players in liver inflammation and cancer (2010)
    Guobin He, Michael Karin Cell Research
  54. NF-κB Restricts Inflammasome Activation via Elimination of Damaged Mitochondria (2016)
    Zhenyu Zhong, Atsushi Umemura et al. Cell
  55. Intracellular pattern recognition receptors in the host response (2006)
    Etienne Meylan, Jürg Tschopp et al. Nature
  56. Ultraviolet Light and Osmotic Stress: Activation of the JNK Cascade Through Multiple Growth Factor and Cytokine Receptors (1996)
    Caridad Rosette, Michael Karin Science
  57. Dangerous liaisons: STAT3 and NF-κB collaboration and crosstalk in cancer (2009)
    Sergei I. Grivennikov, Michael Karin Cytokine & Growth Factor Reviews
  58. Carcinoma-produced factors activate myeloid cells through TLR2 to stimulate metastasis (2008)
    Sun-Hwa Kim, Hiroyuki Takahashi et al. Nature
  59. Oncogene jun encodes a sequence-specific trans- activator similar to AP-1 (1988)
    Peter Angel, Elizabeth A. Allegretto et al. Nature
  60. Is NF-κB a good target for cancer therapy? Hopes and pitfalls (2008)
    Véronique Baud, Michael Karin Nature Reviews Drug Discovery
  61. JNK is involved in signal integration during costimulation of T lymphocytes (1994)
    Bing Su, Estela Jacinto et al. Cell
  62. New mitochondrial DNA synthesis enables NLRP3 inflammasome activation (2018)
    Zhenyu Zhong, Shuang Liang et al. Nature
  63. The IκB kinase (IKK) and NF-κB: key elements of proinflammatory signalling (2000)
    Michael Karin, Mireille Delhase Seminars in Immunology
  64. Characterization of DNA sequences through which cadmium and glucocorticoid hormones induce human metallothionein-IIA gene (1984)
    Michael Karin, Alois Haslinger et al. Nature
  65. IKK-γ is an essential regulatory subunit of the IκB kinase complex (1998)
    David M. Rothwarf, Ebrahim Zandi et al. Nature
  66. The IKKβ Subunit of IκB Kinase (IKK) is Essential for Nuclear Factor κB Activation and Prevention of Apoptosis (1999)
    Zhiwei Li, Wen‐Ming Chu et al. The Journal of Experimental Medicine
  67. Specificity in Toll-like receptor signalling through distinct effector functions of TRAF3 and TRAF6 (2005)
    Hans Häcker, Vanessa Redecke et al. Nature
  68. The Lymphotoxin-β Receptor Induces Different Patterns of Gene Expression via Two NF-κB Pathways (2002)
    Emmanuel Dejardin, Nathalie Droin et al. Immunity
  69. p53-Dependent apoptosis in the absence of transcriptional activation of p53-target genes (1994)
    Carmé Caelles, Arno Helmberg et al. Nature
  70. Positive and Negative Regulation of IκB Kinase Activity Through IKKβ Subunit Phosphorylation (1999)
    Mireille Delhase, Makio Hayakawa et al. Science
  71. Innate Immunity Gone Awry: Linking Microbial Infections to Chronic Inflammation and Cancer (2006)
    Michael Karin, Toby Lawrence et al. Cell
  72. AU Binding Proteins Recruit the Exosome to Degrade ARE-Containing mRNAs (2001)
    Ching‐Yi Chen, Roberto Gherzi et al. Cell
  73. Oncogenic and transcriptional cooperation with Ha-Ras requires phosphorylation of c-Jun on serines 63 and 73 (1991)
    Tod Smeal, Bernard Binétruy et al. Nature
  74. Identification of a Dual Specificity Kinase That Activates the Jun Kinases and p38-Mpk2 (1995)
    Anning Lin, Audrey Minden et al. Science
  75. Abnormal Morphogenesis But Intact IKK Activation in Mice Lacking the IKKα Subunit of IκB Kinase (1999)
    Yinling Hu, Véronique Baud et al. Science
  76. c-Jun N-terminal kinase is required for metalloproteinase expression and joint destruction in inflammatory arthritis (2001)
    Zuoning Han, David L. Boyle et al. Journal of Clinical Investigation
  77. Activation of transcription by two factors that bind promoter and enhancer sequences of the human metallothionein gene and SV40 (1987)
    Alois Haslinger, Michael Karin et al. Nature
  78. Mitogen-activated protein kinase cascades and regulation of gene expression (1996)
    Bing Su, Michael Karin Current Opinion in Immunology
  79. Is NF-kappaB the sensor of oxidative stress? (1999)
    Nanxin Li, Michael Karin PubMed
  80. The pituitary-specific transcription factor GHF-1 is a homeobox-containing protein (1988)
    Mordechai Bodner, Lars E. Theill et al. Cell
  81. Prolonged activation of jun and collagenase genes by tumour necrosis factor-α (1989)
    David A. Brenner, Maureen O’Hara et al. Nature
  82. Activation of cAMP and mitogen responsive genes relies on a common nuclear factor (1994)
    Jonathan Arias, Arthur S. Alberts et al. Nature
  83. Mapping of the Inducible IκB Phosphorylation Sites That Signal Its Ubiquitination and Degradation† (1996)
    Joseph A. DiDonato, Frank Mercurio et al. Molecular and Cellular Biology
  84. Transcriptional control by protein phosphorylation: signal transmission from the cell surface to the nucleus (1995)
    Michael Karin, Tony Hunter Current Biology
  85. Jun-B differs in its biological properties from, and is a negative regulator of, c-Jun (1989)
    Robert Chiu, Peter Angel et al. Cell
  86. Inhibition of JNK activation through NF-κB target genes (2001)
    Guilin Tang, Yuzuru Minemoto et al. Nature
  87. Rapid and preferential activation of the c-jun gene during the mammalian UV response. (1991)
    Yoram Devary, Roberta A. Gottlieb et al. Molecular and Cellular Biology
  88. Nod2 Mutation in Crohn's Disease Potentiates NF-κB Activity and IL-1ß Processing (2005)
    Shin Maeda, Li‐Chung Hsu et al. Science
  89. Autoinduction of transforming growth factor beta 1 is mediated by the AP-1 complex. (1990)
    S J Kim, Peter Angel et al. Molecular and Cellular Biology
  90. The E3 Ubiquitin Ligase Itch Couples JNK Activation to TNFα-induced Cell Death by Inducing c-FLIPL Turnover (2006)
    Lufen Chang, Hideaki Kamata et al. Cell
  91. The wolf in sheep's clothing: the role of interleukin-6 in immunity, inflammation and cancer (2008)
    Willscott E. Naugler, Michael Karin Trends in Molecular Medicine
  92. Ha-Ras augments c-Jun activity and stimulates phosphorylation of its activation domain (1991)
    Bernard Binétruy, Tod Smeal et al. Nature
  93. The Beginning of the End: IκB Kinase (IKK) and NF-κB Activation (1999)
    Michael Karin Journal of Biological Chemistry
  94. Prevention of fat-induced insulin resistance by salicylate (2001)
    Jason K. Kim, Yun Joong Kim et al. Journal of Clinical Investigation
  95. JNK2 contains a specificity-determining region responsible for efficient c-Jun binding and phosphorylation. (1994)
    Tuula Kallunki, Bing Su et al. Genes & Development
  96. NF-kappa B activation by ultraviolet light not dependent on a nuclear signal (1993)
    Yoram Devary, Caridad Rosette et al. Science
  97. B-cell-derived lymphotoxin promotes castration-resistant prostate cancer (2010)
    Massimo Ammirante, Jun‐Li Luo et al. Nature
  98. Receptor-mediated endocytosis of transferrin in developmentally totipotent mouse teratocarcinoma stem cells. (1981)
    Michael Karin, Beatrice Mintz Journal of Biological Chemistry
  99. Human metallothionein genes—primary structure of the metallothionein-II gene and a related processed gene (1982)
    Michael Karin, Robert I. Richards Nature
  100. Metallothioneins: Proteins in search of function (1985)
    Michael Karin Cell
  101. Hybrid Periportal Hepatocytes Regenerate the Injured Liver without Giving Rise to Cancer (2015)
    Joan Font-Burgada, Shabnam Shalapour et al. Cell

Immediate Impact

36 by Nobel laureates 102 from Science/Nature 223 standout
Sub-graph 1 of 18

Citing Papers

Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries
2021 Standout
Long-Term Expansion of Functional Mouse and Human Hepatocytes as 3D Organoids
2018 StandoutNobel
1 intermediate paper

Works of Michael Karin being referenced

Hybrid Periportal Hepatocytes Regenerate the Injured Liver without Giving Rise to Cancer
2015 Standout
Dietary and Genetic Obesity Promote Liver Inflammation and Tumorigenesis by Enhancing IL-6 and TNF Expression
2010 Standout
and 1 more

Author Peers

Author Last Decade Papers Cites
Michael Karin 112099 56122 59606 646 209.7k
Guido Kroemer 125595 28279 50391 1.3k 229.0k
Craig B. Thompson 90608 43942 36314 513 148.6k
Robert A. Weinberg 133196 55373 25388 377 219.6k
Shizuo Akira 78422 28699 162208 1.2k 256.9k
Richard A. Flavell 74744 13645 85870 1.2k 176.5k
Lewis C. Cantley 103801 29279 16649 702 148.2k
David Baltimore 75494 32214 46402 701 140.0k
Douglas Hanahan 78402 35907 18924 224 134.4k
Douglas R. Green 79879 14932 34890 605 123.0k
Bert Vogelstein 133033 56218 14996 546 226.9k

All Works

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