Standout Papers

Single Lgr5 stem cells build crypt-villus structures in... 1997 2026 2006 2016 5.0k
  1. Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche (2009)
    Toshiro Sato, Robert G.J. Vries et al. Nature
  2. Wnt/β-Catenin Signaling in Development and Disease (2006)
    Hans Clevers Cell
  3. Wnt/β-Catenin Signaling and Disease (2012)
    Hans Clevers, Roel Nusse Cell
  4. Identification of stem cells in small intestine and colon by marker gene Lgr5 (2007)
    Nick Barker, Johan H. van Es et al. Nature
  5. Activation of β-Catenin-Tcf Signaling in Colon Cancer by Mutations in β-Catenin or APC (1997)
    Patrice J. Morin, Andrew B. Sparks et al. Science
  6. Wnt/β-Catenin Signaling, Disease, and Emerging Therapeutic Modalities (2017)
    Roel Nusse, Hans Clevers Cell
  7. Wnt signalling in stem cells and cancer (2005)
    Tannishtha Reya, Hans Clevers Nature
  8. Constitutive Transcriptional Activation by a β-Catenin-Tcf Complex in APC −/− Colon Carcinoma (1997)
    Vladimír Kořínek, Nick Barker et al. Science
  9. Long-term Expansion of Epithelial Organoids From Human Colon, Adenoma, Adenocarcinoma, and Barrett's Epithelium (2011)
    Toshiro Sato, Daniel E. Stange et al. Gastroenterology
  10. Modeling Development and Disease with Organoids (2016)
    Hans Clevers Cell
  11. Cancer stem cells revisited (2017)
    Eduard Batlle, Hans Clevers Nature Medicine
  12. Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts (2010)
    Toshiro Sato, Johan H. van Es et al. Nature
  13. The β-Catenin/TCF-4 Complex Imposes a Crypt Progenitor Phenotype on Colorectal Cancer Cells (2002)
    Marc van de Wetering, Elena Sancho et al. Cell
  14. Crypt stem cells as the cells-of-origin of intestinal cancer (2008)
    Nick Barker, Rachel A. Ridgway et al. Nature
  15. XTcf-3 Transcription Factor Mediates β-Catenin-Induced Axis Formation in Xenopus Embryos (1996)
    Miranda Molenaar, Marc van de Wetering et al. Cell
  16. The cancer stem cell: premises, promises and challenges (2011)
    Hans Clevers Nature Medicine
  17. Intestinal Crypt Homeostasis Results from Neutral Competition between Symmetrically Dividing Lgr5 Stem Cells (2010)
    Hugo J.G. Snippert, Laurens G. van der Flier et al. Cell
  18. Stem Cells, Self-Renewal, and Differentiation in the Intestinal Epithelium (2008)
    Laurens G. van der Flier, Hans Clevers Annual Review of Physiology
  19. Linking Colorectal Cancer to Wnt Signaling (2000)
    Mariann Bienz, Hans Clevers Cell
  20. Depletion of epithelial stem-cell compartments in the small intestine of mice lacking Tcf-4 (1998)
    Vladimír Kořínek, Nick Barker et al. Nature Genetics
  21. Caught up in a Wnt storm: Wnt signaling in cancer (2003)
    Rachel H. Giles, Johan H. van Es et al. Biochimica et Biophysica Acta (BBA) - Reviews on Cancer
  22. Notch/γ-secretase inhibition turns proliferative cells in intestinal crypts and adenomas into goblet cells (2005)
    Johan H. van Es, Mariëlle van Gijn et al. Nature
  23. Canonical Wnt Signaling in Differentiated Osteoblasts Controls Osteoclast Differentiation (2005)
    Donald A. Glass, Peter Bialek et al. Developmental Cell
  24. Lgr5+ve Stem Cells Drive Self-Renewal in the Stomach and Build Long-Lived Gastric Units In Vitro (2010)
    Nick Barker, Meritxell Huch et al. Cell stem cell
  25. Organoids in cancer research (2018)
    Jarno Drost, Hans Clevers Nature reviews. Cancer
  26. In vitro expansion of single Lgr5+ liver stem cells induced by Wnt-driven regeneration (2013)
    Meritxell Huch, Craig Dorrell et al. Nature
  27. Armadillo Coactivates Transcription Driven by the Product of the Drosophila Segment Polarity Gene dTCF (1997)
    Marc van de Wetering, Rossana Cavallo et al. Cell
  28. Designer matrices for intestinal stem cell and organoid culture (2016)
    Nikolce Gjorevski, Norman Sachs et al. Nature
  29. An integral program for tissue renewal and regeneration: Wnt signaling and stem cell control (2014)
    Hans Clevers, Kyle M. Loh et al. Science
  30. Functional Repair of CFTR by CRISPR/Cas9 in Intestinal Stem Cell Organoids of Cystic Fibrosis Patients (2013)
    Gerald Schwank, Bon‐Kyoung Koo et al. Cell stem cell
  31. Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling (2011)
    Wim de Lau, Nick Barker et al. Nature
  32. Coexistence of Quiescent and Active Adult Stem Cells in Mammals (2010)
    Linheng Li, Hans Clevers Science
  33. β-Catenin and TCF Mediate Cell Positioning in the Intestinal Epithelium by Controlling the Expression of EphB/EphrinB (2002)
    Eduard Batlle, Jeffrey T. Henderson et al. Cell
  34. Negative Feedback Loop of Wnt Signaling through Upregulation of Conductin/Axin2 in Colorectal and Liver Tumors (2002)
    Boris Jerchow, Martin M. Sachs et al. Molecular and Cellular Biology
  35. The Intestinal Crypt, A Prototype Stem Cell Compartment (2013)
    Hans Clevers Cell
  36. Growing Self-Organizing Mini-Guts from a Single Intestinal Stem Cell: Mechanism and Applications (2013)
    Toshiro Sato, Hans Clevers Science
  37. Single-cell messenger RNA sequencing reveals rare intestinal cell types (2015)
    Dominic Grün, Anna Lyubimova et al. Nature
  38. Lineage Tracing Reveals Lgr5 + Stem Cell Activity in Mouse Intestinal Adenomas (2012)
    Arnout Schepers, Hugo J.G. Snippert et al. Science
  39. Canonical Wnt signals are essential for homeostasis of the intestinal epithelium (2003)
    Daniel Pinto, Alex Gregorieff et al. Genes & Development
  40. Sequential cancer mutations in cultured human intestinal stem cells (2015)
    Jarno Drost, Richard H. van Jaarsveld et al. Nature
  41. Notch1 functions as a tumor suppressor in mouse skin (2003)
    Michaël Nicolas, Anita Wolfer et al. Nature Genetics
  42. Lgr5 marks cycling, yet long-lived, hair follicle stem cells (2008)
    Viljar Jaks, Nick Barker et al. Nature Genetics
  43. APC, Signal transduction and genetic instability in colorectal cancer (2001)
    Riccardo Fodde, Ron Smits et al. Nature reviews. Cancer
  44. A functional CFTR assay using primary cystic fibrosis intestinal organoids (2013)
    Johanna F. Dekkers, Caroline L. Wiegerinck et al. Nature Medicine
  45. Wnt Signaling through Inhibition of β-Catenin Degradation in an Intact Axin1 Complex (2012)
    Vivian Li, Ser Sue Ng et al. Cell
  46. Tumour suppressor RNF43 is a stem-cell E3 ligase that induces endocytosis of Wnt receptors (2012)
    Bon‐Kyoung Koo, Maureen Spit et al. Nature
  47. The Intestinal Stem Cell Signature Identifies Colorectal Cancer Stem Cells and Predicts Disease Relapse (2011)
    Anna Merlos‐Suárez, Francisco M. Barriga et al. Cell stem cell
  48. FoxM1 is required for execution of the mitotic programme and chromosome stability (2005)
    Jamila Laoukili, Alexandra Le Bras et al. Nature Cell Biology
  49. The T Cell Receptor/CD3 Complex: A Dynamic Protein Ensemble (1988)
    Hans Clevers, Balbino Alarcón et al. Annual Review of Immunology
  50. Tales from the crypt: new insights into intestinal stem cells (2018)
    Helmuth Gehart, Hans Clevers Nature Reviews Gastroenterology & Hepatology
  51. Loss of Apc in vivo immediately perturbs Wnt signaling, differentiation, and migration (2004)
    Owen J. Sansom, Karen R. Reed et al. Genes & Development
  52. Functional engraftment of colon epithelium expanded in vitro from a single adult Lgr5+ stem cell (2012)
    Shiro Yui, Tetsuya Nakamura et al. Nature Medicine
  53. In Vitro Expansion of Human Gastric Epithelial Stem Cells and Their Responses to Bacterial Infection (2014)
    Sina Bartfeld, Marc van de Wetering et al. Gastroenterology
  54. Disease Modeling in Stem Cell-Derived 3D Organoid Systems (2017)
    Devanjali Dutta, Inha Heo et al. Trends in Molecular Medicine
  55. Drosophila Tcf and Groucho interact to repress Wingless signalling activity (1998)
    Rossana Cavallo, Rachel T. Cox et al. Nature
  56. Cancer modeling meets human organoid technology (2019)
    David A. Tuveson, Hans Clevers Science
  57. De Novo Crypt Formation and Juvenile Polyposis on BMP Inhibition in Mouse Intestine (2004)
    Anna-Pavlina G. Haramis, Harry Begthel et al. Science
  58. Lgr6 Marks Stem Cells in the Hair Follicle That Generate All Cell Lineages of the Skin (2010)
    Hugo J.G. Snippert, Andrea Haegebarth et al. Science
  59. Mining the Wnt pathway for cancer therapeutics (2006)
    Nick Barker, Hans Clevers Nature Reviews Drug Discovery
  60. Reparative inflammation takes charge of tissue regeneration (2016)
    Michael Karin, Hans Clevers Nature
  61. Dll1+ secretory progenitor cells revert to stem cells upon crypt damage (2012)
    Johan H. van Es, Toshiro Sato et al. Nature Cell Biology
  62. The Xenopus Wnt effector XTcf-3 interacts with Groucho-related transcriptional repressors (1998)
    Jeroen P. Roose, Miranda Molenaar et al. Nature
  63. Long-Term Expansion of Functional Mouse and Human Hepatocytes as 3D Organoids (2018)
    Huili Hu, Helmuth Gehart et al. Cell
  64. The Lgr5 intestinal stem cell signature: robust expression of proposed quiescent ‘+4’ cell markers (2012)
    Javier Muñoz, Daniel E. Stange et al. The EMBO Journal
  65. Self-Renewal and Cancer of the Gut: Two Sides of a Coin (2005)
    Freddy Radtke, Hans Clevers Science
  66. Isolation and in vitro expansion of human colonic stem cells (2011)
    Peter Jung, Toshiro Sato et al. Nature Medicine
  67. Mutations in the APC tumour suppressor gene cause chromosomal instability (2001)
    Riccardo Fodde, Jeroen Kuipers et al. Nature Cell Biology
  68. Transcription Factor Achaete Scute-Like 2 Controls Intestinal Stem Cell Fate (2009)
    Laurens G. van der Flier, Mariëlle van Gijn et al. Cell
  69. Culture and establishment of self-renewing human and mouse adult liver and pancreas 3D organoids and their genetic manipulation (2016)
    Laura Broutier, Amanda Andersson-Rolf et al. Nature Protocols
  70. Identification of Multipotent Luminal Progenitor Cells in Human Prostate Organoid Cultures (2014)
    Wouter R. Karthaus, Phillip J. Iaquinta et al. Cell
  71. Unlimited in vitro expansion of adult bi-potent pancreas progenitors through the Lgr5/R-spondin axis (2013)
    Meritxell Huch, Paola Bonfanti et al. The EMBO Journal
  72. Wnt signaling in the intestinal epithelium: from endoderm to cancer (2005)
    Alex Gregorieff, Hans Clevers Genes & Development
  73. Wnt signalling induces maturation of Paneth cells in intestinal crypts (2005)
    Johan H. van Es, Philippe Jay et al. Nature Cell Biology
  74. The drug resistance-related protein LRP is the human major vault protein (1995)
    George L. Scheffer, Peter Wijngaard et al. Nature Medicine
  75. The TAK1–NLK–MAPK-related pathway antagonizes signalling between β-catenin and transcription factor TCF (1999)
    Tohru Ishitani, Jun Ninomiya‐Tsuji et al. Nature
  76. Homeostatic mini-intestines through scaffold-guided organoid morphogenesis (2020)
    Mikhail Nikolaev, Olga Mitrofanova et al. Nature
  77. Redundant Sources of Wnt Regulate Intestinal Stem Cells and Promote Formation of Paneth Cells (2012)
    Henner F. Farin, Johan H. van Es et al. Gastroenterology
  78. The R-spondin/Lgr5/Rnf43 module: regulator of Wnt signal strength (2014)
    Wim de Lau, Weng Chuan Peng et al. Genes & Development
  79. Paneth Cells: Maestros of the Small Intestinal Crypts (2013)
    Hans Clevers, Charles Bevins Annual Review of Physiology
  80. Organoid culture systems for prostate epithelial and cancer tissue (2016)
    Jarno Drost, Wouter R. Karthaus et al. Nature Protocols
  81. Apc Restoration Promotes Cellular Differentiation and Reestablishes Crypt Homeostasis in Colorectal Cancer (2015)
    Lukas E. Dow, Kevin P. O’Rourke et al. Cell
  82. Differentiated Troy+ Chief Cells Act as Reserve Stem Cells to Generate All Lineages of the Stomach Epithelium (2013)
    Daniel E. Stange, Bon‐Kyoung Koo et al. Cell
  83. De Novo Prediction of Stem Cell Identity using Single-Cell Transcriptome Data (2016)
    Dominic Grün, Mauro J. Muraro et al. Cell stem cell

Immediate Impact

12 by Nobel laureates 76 from Science/Nature 176 standout
Sub-graph 1 of 19

Citing Papers

De novo design of modular protein hydrogels with programmable intra- and extracellular viscoelasticity
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Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries
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1 intermediate paper

Works of Hans Clevers being referenced

Designer matrices for intestinal stem cell and organoid culture
2016 StandoutNature
Apc Restoration Promotes Cellular Differentiation and Reestablishes Crypt Homeostasis in Colorectal Cancer
2015 Standout

Author Peers

Author Last Decade Papers Cites
Hans Clevers 96581 52291 23870 721 156.0k
Robert A. Weinberg 133196 93880 18045 377 219.6k
Douglas Hanahan 78402 43041 13213 224 134.4k
Joan Massagué 94714 46583 9178 356 135.6k
Guido Kroemer 125595 44900 8591 1.3k 229.0k
Kenneth W. Kinzler 78978 48789 14694 377 130.0k
Zena Werb 45042 34757 7757 411 108.4k
Bert Vogelstein 133033 90820 28497 546 226.9k
Lewis C. Cantley 103801 27070 7127 702 148.2k
Judah Folkman 62209 24238 5535 391 103.7k
Irving L. Weissman 58306 29534 8030 826 129.3k

All Works

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