Xiaoling Cockcroft

2.0k citations

15 papers · 1.3k · h-index 11

Impact in

Oncology top 5%
- PARP inhibition in cancer therapy
- Cancer-related Molecular Pathways
Molecular Biology top 10%
- DNA Repair Mechanisms
- Cancer therapeutics and mechanisms
- CRISPR and Genetic Engineering
- Cell death mechanisms and regulation

Papers in

Molecular Biology 12
- Cancer therapeutics and mechanisms 6
- DNA Repair Mechanisms 5
- Chemical Synthesis and Analysis 3
Oncology 7
- PARP inhibition in cancer therapy 4

Co-authors: Keith Menear (10 shared papers)Graeme C.M. Smith (7 shared papers)Mark J. O’Connor (2 shared papers)Niall M.B. Martin (6 shared papers)Frank Kerrigan (4 shared papers)Laurent Rigoreau (3 shared papers)Sylvie Gomez (3 shared papers)Ian T.W. Matthews (2 shared papers)
Journals: Journal of Medicinal Chemistry (6 papers)Bioorganic & Medicinal Chemistry Letters (6 papers)Molecular Cancer Therapeutics (1 paper)Chemistry - A European Journal (1 paper)ChemInform (1 paper)
Partner nations: United Kingdom Austria Switzerland

In The Last Decade

Xiaoling Cockcroft

15 papers receiving 1.3k citations

Peers

Countries citing papers authored by Xiaoling Cockcroft

Since Specialization

Citations

This map shows the geographic impact of Xiaoling Cockcroft's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Xiaoling Cockcroft with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Xiaoling Cockcroft more than expected).

Fields of papers citing papers by Xiaoling Cockcroft

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Xiaoling Cockcroft. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Xiaoling Cockcroft. The network helps show where Xiaoling Cockcroft may publish in the future.

Co-authors

The 25 scholars most cited alongside Xiaoling Cockcroft, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Xiaoling Cockcroft Line = papers co-authored together Xiaoling Cockcroft links everyone, so they are left out of the graph.

All Works

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15 of 15 papers shown

#	Work
1	4-[3-(4-Cyclopropanecarbonylpiperazine-1-carbonyl)-4-fluorobenzyl]-2H-phthalazin-1-one: A Novel Bioavailable Inhibitor of Poly(ADP-ribose) Polymerase-1 Journal of Medicinal Chemistry ·Keith Menear, Claire Adcock, Robert Boulter, Xiaoling Cockcroft, Louise Copsey, Aaron Cranston, Krystyna J. Dillon, Jan Drzewiecki, Sheila Garman, Sylvie Gomez, Hashim Javaid, Frank Kerrigan, Charlotte Knights, Alan Lau, Vincent M. Loh, Ian T.W. Matthews, Stephen Moore, Mark J. O’Connor, Graeme C.M. Smith, Niall M.B. Martin	2008	483
2	Improved ATM kinase inhibitor KU-60019 radiosensitizes glioma cells, compromises insulin, AKT and ERK prosurvival signaling, and inhibits migration and invasion Molecular Cancer Therapeutics ·Sarah E. Golding, Elizabeth Rosenberg, Nicholas C.K. Valerie, Isa M. Hussaini, Mark Frigerio, Xiaoling Cockcroft, Wei Yee Chong, Marc Hummersone, Laurent Rigoreau, Keith Menear, Mark J. O’Connor, Lawrence F. Povirk, Timothy Van Meter, Kristoffer Valerie	2009	285
3	Discovery of Potent Chromen-4-one Inhibitors of the DNA-Dependent Protein Kinase (DNA-PK) Using a Small-Molecule Library Approach Journal of Medicinal Chemistry ·Ian R. Hardcastle, Xiaoling Cockcroft, Nicola J. Curtin, Marine Desage El-Murr, Justin J. J. Leahy, Martin L. Stockley, Bernard T. Golding, Laurent Rigoreau, Caroline J. Richardson, Graeme C.M. Smith, Roger J. Griffin	2005	137
4	Phthalazinones. Part 1: The design and synthesis of a novel series of potent inhibitors of poly(ADP-ribose)polymerase Bioorganic & Medicinal Chemistry Letters ·Vincent M. Loh, Xiaoling Cockcroft, Krystyna J. Dillon, Lesley Dixon, Jan Drzewiecki, Penny J. Eversley, Sylvie Gomez, Janet Hoare, Frank Kerrigan, Ian T.W. Matthews, Keith Menear, Niall M.B. Martin, Roger F. Newton, Jane T. Paul, Graeme C.M. Smith, Julia Vile, Alan J. Whittle	2005	79
5	Phthalazinones 2: Optimisation and synthesis of novel potent inhibitors of poly(ADP-ribose)polymerase Bioorganic & Medicinal Chemistry Letters ·Xiaoling Cockcroft, Krystyna J. Dillon, Lesley Dixon, Jan Drzewiecki, Frank Kerrigan, Vincent M. Loh, Niall M.B. Martin, Keith Menear, Graeme C.M. Smith	2005	70
6	Studies on Pyrrolopyrimidines as Selective Inhibitors of Multidrug-Resistance- Associated Protein in Multidrug Resistance Journal of Medicinal Chemistry ·Shouming Wang, Adrian Folkes, Irina Chuckowree, Xiaoling Cockcroft, Sukhjit Sohal, Warren Miller, John Milton, Stephen P. Wren, Nigel Vicker, Paul Depledge, John Scott, Lyndsay Smith, Hazel Jones, Prakash Mistry, Richard Faint, Deanne Thompson, Simon Cocks	2004	69
7	Pyranone, Thiopyranone, and Pyridone Inhibitors of Phosphatidylinositol 3-Kinase Related Kinases. Structure−Activity Relationships for DNA-Dependent Protein Kinase Inhibition, and Identification of the First Potent and Selective Inhibitor of the Ataxia Telangiectasia Mutated Kinase Journal of Medicinal Chemistry ·Jonathan J. Hollick, Laurent Rigoreau, Céline Cano, Xiaoling Cockcroft, Nicola J. Curtin, Mark Frigerio, Bernard T. Golding, Sophie Guiard, Ian R. Hardcastle, Ian Hickson, Marc Hummersone, Keith Menear, Niall M.B. Martin, Ian Matthews, David R. Newell, Rachel Ord, Caroline J. Richardson, Graeme C.M. Smith, Roger J. Griffin	2007	61
8	Identification and optimisation of novel and selective small molecular weight kinase inhibitors of mTOR Bioorganic & Medicinal Chemistry Letters ·Keith Menear, Sylvie Gomez, Karine Malagu, C. L. Bailey, Kristel Blackburn, Xiaoling Cockcroft, Sally Ewen, Alexandra Fundo, Armelle Le Gall, Gesine Hermann, Luisa Sebastian, Mihiro Sunose, Thomas Presnot, Eleanor Torode, Ian Hickson, Niall M.B. Martin, Graeme C.M. Smith, Kurt G. Pike	2009	51
9	DNA-Dependent Protein Kinase (DNA-PK) Inhibitors. Synthesis and Biological Activity of Quinolin-4-one and Pyridopyrimidin-4-one Surrogates for the Chromen-4-one Chemotype Journal of Medicinal Chemistry ·Céline Cano, Olivier Barbeau, C. L. Bailey, Xiaoling Cockcroft, Nicola J. Curtin, Heather M. E. Duggan, Mark Frigerio, Bernard T. Golding, Ian R. Hardcastle, Marc Hummersone, Charlotte Knights, Keith Menear, David R. Newell, Caroline J. Richardson, Graeme C. M. Smith, Ben Spittle, Roger J. Griffin	2010	35
10	Direct NMR Probing of Hydration Shells of Protein Ligand Interfaces and Its Application to Drug Design Journal of Medicinal Chemistry ·Leonhard Geist, Moriz Mayer, Xiaoling Cockcroft, B. Wolkerstorfer, Dirk Kessler, Harald Engelhardt, Darryl B. McConnell, Robert Konrat	2017	23
11	KRAS Binders Hidden in Nature Chemistry - A European Journal ·Andreas Bergner, Xiaoling Cockcroft, Gerhard W. Fischer, Andreas Gollner, Wolfgang Hela, Roland Kousek, Andreas Mantoulidis, Laetitia J. Martin, Moriz Mayer, Barbara Müllauer, Gabriella Siszler, B. Wolkerstorfer, Dirk Kessler, Darryl B. McConnell	2019	16
12	the design and synthesis of thrombin inhibitors: the introduction of in vivo efficacy and oral bioavailability into benzthiazolylalanine inhibitors Bioorganic & Medicinal Chemistry Letters ·Judy Hayler, Peter D. Kane, Darren LeGrand, Florence Lugrin, Keith Menear, Ric N. Price, Mark C. Allen, Xiaoling Cockcroft, John Ambler, Keith Butler, Karren Dunnet, Andrew Mitchelson, Mark Talbot, Morris Tweed, Nicholas Wills	2000	9
13	The design and synthesis of thrombin inhibitors: analogues of MD805 containing non-polar surrogates for arginine at the P1 position Bioorganic & Medicinal Chemistry Letters ·Urs Baettig, Lyndon Brown, Derek E. Brundish, C. P. Dell, Alex Furzer, Sheila Garman, Diana Janus, Peter D. Kane, Garrick Smith, Clive V Walker, Xiaoling Cockcroft, John Ambler, Andrew Mitchelson, Mark Talbot, Morris Tweed, Nicholas Wills	2000	8
14	Optimisation of the P2 pharmacophore in a series of thrombin inhibitors: Ion-dipole interactions with lysine 60G Bioorganic & Medicinal Chemistry Letters ·John Ambler, Lyndon Brown, Xiaoling Cockcroft, Markus G. Grütter, Judy Hayler, Diana Janus, Darryl Jones, Peter D. Kane, Keith Menear, John P. Priestle, Garrick Smith, Mark Talbot, Clive V Walker, Bernard Wathey	1999	5
15	Phthalazinones 2: Optimization and Synthesis of Novel Potent Inhibitors of Poly(ADP‐Ribose)polymerase. ChemInform ·Xiaoling Cockcroft, Krystyna J. Dillon, Lesley Dixon, Jan Drzewiecki, Frank Kerrigan, Vincent M. Loh, Niall M.B. Martin, Keith Menear, Graeme C.M. Smith	2006	4

About Xiaoling Cockcroft

Xiaoling Cockcroft is a scholar working on Molecular Biology, Oncology, Organic Chemistry, Infectious Diseases and Toxicology, having authored 15 papers that have together received 1.3k indexed citations. Recurring topics across this work include Cancer therapeutics and mechanisms (6 papers), DNA Repair Mechanisms (5 papers), PARP inhibition in cancer therapy (4 papers), Chemical Synthesis and Analysis (3 papers), Click Chemistry and Applications (2 papers), Toxin Mechanisms and Immunotoxins (2 papers), HIV/AIDS drug development and treatment (2 papers) and Bioactive Compounds and Antitumor Agents (2 papers). The work is most often cited by research in Oncology (717 citations), Molecular Biology (857 citations), Organic Chemistry (326 citations), Toxicology (37 citations) and Physiology (31 citations). Xiaoling Cockcroft has collaborated with scholars based in United Kingdom, Austria and Switzerland. Frequent co-authors include Keith Menear, Graeme C.M. Smith, Mark J. O’Connor, Niall M.B. Martin, Frank Kerrigan, Laurent Rigoreau, Sylvie Gomez, Ian T.W. Matthews, Mark Frigerio and Charlotte Knights. Their work appears in journals such as Journal of Medicinal Chemistry, Bioorganic & Medicinal Chemistry Letters, Molecular Cancer Therapeutics, Chemistry - A European Journal and ChemInform.

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