William C. Knowler

65.4k citations

522 papers · 43.9k indexed · 19 hit papers · h-index 105

Impact in

Endocrinology, Diabetes and Metabolism top 0.01%
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Diabetes Management and Research
- Diabetes Treatment and Management
Obstetrics and Gynecology top 0.05%

Papers in

Endocrinology, Diabetes and Metabolism 196
- Diabetes, Cardiovascular Risks, and Lipoproteins 123
- Diabetes Treatment and Management 51
Nephrology 48
- Chronic Kidney Disease and Diabetes 46

Co-authors: Peter H. Bennett Robert L. Hanson David J. Pettitt Robert G. Nelson Clifton Bogardus Éric Ravussin Stephen Lillioja Helen C. Looker
Journals: Diabetes (94 papers)Diabetes Care (76 papers)Diabetologia (47 papers)Obesity (21 papers)The Journal of Clinical Endocrinology & Metabolism (17 papers)
Partner nations: United States Sweden United Kingdom

In The Last Decade

William C. Knowler

510 papers receiving 42.0k citations

Hit Papers

15 papers align trajectories log scale

Long-term Metformin Use and Vitamin B12 Deficiency in the Diabetes Prevention Program Outcomes Study 2016 · 309 citations

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if any of the following hold:

it has ≥500 total citations;
it reaches ≥1.5× the top-1% citation threshold for papers in the same subfield and year (the threshold is the minimum needed to enter the top 1%, not the average within it);
it reaches the top citation threshold in at least one of its specific research topics.

2016 The Journal of Clinical Endocrinology & Metabolism
2015 The Journal of Clinical Endocrinology & Metabolism
2011 Diabetes Care
2010 New England Journal of Medicine
2006 New England Journal of Medicine
2003 Controlled Clinical Trials
2002 The Lancet
1996 Journal of Periodontology
1994 BMJ
1993 New England Journal of Medicine
1990 Diabetes Care
1990 American Journal of Physiology-Endocrinology and Metabolism
1988 New England Journal of Medicine
1988 PubMed Central
1988 New England Journal of Medicine
1987 Diabetes
1983 New England Journal of Medicine
1981 American Journal of Epidemiology
1978 American Journal of Epidemiology

Peers

Countries citing papers authored by William C. Knowler

Since Specialization

Citations

This map shows the geographic impact of William C. Knowler's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by William C. Knowler with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites William C. Knowler more than expected).

Fields of papers citing papers by William C. Knowler

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by William C. Knowler. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by William C. Knowler. The network helps show where William C. Knowler may publish in the future.

Co-authorship network

The 25 scholars most cited alongside William C. Knowler, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with William C. Knowler Line = papers co-authored together William C. Knowler links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

#	Work
1	Long-term effects and effect heterogeneity of lifestyle and metformin interventions on type 2 diabetes incidence over 21 years in the US Diabetes Prevention Program randomised clinical trial The Lancet Diabetes & Endocrinology ·William C. Knowler, C Angermann, Sharon L. Edelstein, Peter H. Bennett, Dana Dabelea, Mary A. Hoskin, Steven E. Kahn, Rita R. Kalyani, Catherine Kim, F. Xavier Pi‐Sunyer, Sridharan Raghavan, Vallabh O. Shah, Marinella Temprosa, Elizabeth M. Venditti, David M. Nathan, (unknown), (unknown), (unknown), (unknown), (unknown), (unknown), (unknown), (unknown), (unknown), (unknown), (unknown), (unknown), (unknown), (unknown), (unknown), (unknown), (unknown), (unknown), (unknown), (unknown), (unknown), (unknown), (unknown), (unknown), (unknown), (unknown), (unknown), (unknown), (unknown), (unknown), (unknown), (unknown), (unknown), (unknown), (unknown), (unknown), (unknown), (unknown), (unknown), (unknown), (unknown), (unknown), (unknown), (unknown), (unknown), (unknown), (unknown), (unknown), (unknown), (unknown), (unknown), (unknown), (unknown), (unknown), (unknown), (unknown), (unknown), (unknown), (unknown), (unknown), (unknown), (unknown), (unknown), (unknown), (unknown), (unknown), (unknown), (unknown), (unknown), (unknown), (unknown), (unknown), (unknown), (unknown), (unknown), (unknown), (unknown), (unknown), (unknown), (unknown), (unknown), (unknown), (unknown), (unknown), (unknown), (unknown), (unknown), (unknown), (unknown), (unknown), 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(unknown), (unknown), (unknown), (unknown), (unknown), (unknown), (unknown), (unknown), (unknown), (unknown), (unknown), (unknown), (unknown), (unknown), (unknown), (unknown), (unknown), (unknown), (unknown), (unknown), (unknown), (unknown), (unknown), (unknown), (unknown)	2025	3
2	Randomized Study of Metformin and Intensive Lifestyle Intervention on Cancer Incidence over 21 Years of Follow-up in the Diabetes Prevention Program Cancer Prevention Research ·Brandy M. Heckman‐Stoddard, Jill P. Crandall, Sharon L. Edelstein, Philip C. Prorok, Dana Dabelea, Richard F. Hamman, Helen P. Hazuda, Edward S. Horton, Mary A. Hoskin, Marjorie Perloff, Senkatile Jackson Sebake, William C. Knowler, Leslie G. Ford, Marinella Temprosa	2025	3
3	Effects of metformin and intensive lifestyle interventions on the incidence of kidney disease in adults in the DPP/DPPOS Journal of Diabetes and its Complications ·Mark E. Molitch, Mark Tripputi, Andrew S. Levey, Jill P. Crandall, Dana Dabelea, William H. Herman, William C. Knowler, Trevor J. Orchard, Emily B. Schroeder, Preethi Srikanthan, Marinella Temprosa, Neil H. White, David M. Nathan	2023	3
4	Effects of Long-term Metformin and Lifestyle Interventions on Cardiovascular Events in the Diabetes Prevention Program and Its Outcome Study Circulation ·Ronald Goldberg, Trevor J. Orchard, Jill P. Crandall, Edward J. Boyko, Matthew J. Budoff, Dana Dabelea, Kishore M. Gadde, William C. Knowler, Christine G. Lee, David M. Nathan, Karol E. Watson, Marinella Temprosa	2022	96
5	The Moderating Effects of Genetic Variations on Changes in Physical Activity Level and Cardiorespiratory Fitness in Response to a Life-Style Intervention: A Randomized Controlled Trial Psychosomatic Medicine ·Harold Lee, John E. McGeary, Shira Dunsiger, Laura D. Baker, Ashok Balasubramanyam, William C. Knowler, David M. Williams	2021	2
6	Per- and polyfluoroalkyl substance plasma concentrations and metabolomic markers of type 2 diabetes in the Diabetes Prevention Program trial International Journal of Hygiene and Environmental Health ·Susanna D. Mitro, Jinxi Liu, Lindsay M. Jaacks, Abby F. Fleisch, Paige L. Williams, William C. Knowler, Blandine Laferrère, Wei Perng, George A. Bray, Amisha Wallia, Marie‐France Hivert, Emily Oken, Tamarra James‐Todd, Marinella Temprosa	2020	18
7	COVID-19 in People With Diabetes: Urgently Needed Lessons From Early Reports Diabetes Care ·Matthew C. Riddle, John B. Buse, Paul W. Franks, William C. Knowler, Robert E. Ratner, Elizabeth Selvin, Deborah J. Wexler, Steven E. Kahn	2020	72
8	Provider Preference for Growth Charts in Tracking Children with Obesity The Journal of Pediatrics ·Melissa Chambers, Jayoti Gupta, Muideen T. Olaiya, Leda Santana de Oliveira Noleto, Tatiana A. Kalyuzhnaya, Mary A. Hoskin, William C. Knowler, Madhumita Sinha	2020	0
9	Effect of severe obesity in childhood and adolescence on risk of type 2 diabetes in youth and early adulthood in an American Indian population Pediatric Diabetes ·Stephanie K. Tanamas, Jayoti Gupta, Melissa Chambers, Serap Topal, Leda Santana de Oliveira Noleto, Robert L. Hanson, Robert G. Nelson, William C. Knowler, Madhumita Sinha	2017	34
10	Impact of Lifestyle and Metformin Interventions on the Risk of Progression to Diabetes and Regression to Normal Glucose Regulation in Overweight or Obese People With Impaired Glucose Regulation Diabetes Care ·William H. Herman, Qing Pan, Sharon L. Edelstein, Kieren J. Mather, Leigh Perreault, Elizabeth Barrett‐Connor, Dana Dabelea, Edward S. Horton, Steven E. Kahn, William C. Knowler, Carlos Lorenzo, F. Xavier Pi‐Sunyer, Elizabeth M. Venditti, Wen Ye	2017	43
11	Depressive Symptoms, Antidepressant Medication Use, and Inflammatory Markers in the Diabetes Prevention Program Psychosomatic Medicine ·Mary de Groot, David G. Marrero, Lisa Mele, Todd Doyle, Frank Schwartz, Kieren J. Mather, Ronald Goldberg, David W. Price, Yong Ma, William C. Knowler	2017	9
12	Replication of the Association of BDNF and MC4R Variants With Dietary Intake in the Diabetes Prevention Program Psychosomatic Medicine ·Jeanne M. McCaffery, Kathleen A. Jablonski, Paul W. Franks, Linda M. Delahanty, Vanita R. Aroda, David G. Marrero, Richard F. Hamman, Edward S. Horton, Samuel Dagogo‐Jack, Judith Wylie‐Rosett, Elizabeth Barrett‐Connor, Abbas E. Kitabchi, William C. Knowler, Rena R. Wing, José C. Florez	2016	9
13	Depressive Symptoms, Antidepressant Medication Use, and New Onset of Diabetes in Participants of the Diabetes Prevention Program and the Diabetes Prevention Program Outcomes Study Psychosomatic Medicine ·David G. Marrero, Yong Ma, Mary de Groot, Edward S. Horton, Vignesh Raj Sivaperumal, Elizabeth Barrett‐Connor, Mercedes R. Carnethon, William C. Knowler	2015	6
14	A calpain-10 gene polymorphism is associated with reduced muscle mRNA levels and insulin resistance Journal of Clinical Investigation ·Leslie J. Baier, Paskasari A. Permana, Xiaolin Yang, Richard E. Pratley, Robert L. Hanson, Gong-Qing Shen, David M. Mott, William C. Knowler, Nancy J. Cox, Yukio Horikawa, Naohisa Oda, Graeme I. Bell, Clifton Bogardus	2000	233
15	An amino acid substitution in the human intestinal fatty acid binding protein is associated with increased fatty acid binding, increased fat oxidation, and insulin resistance. Journal of Clinical Investigation ·Leslie J. Baier, James C. Sacchettini, William C. Knowler, Janina C. Eads, Giuseppe Paolisso, P. Antonio Tataranni, H Mochizuki, Peter H. Bennett, Clifton Bogardus, Michal Procházka	1995	307
16	Glycated haemoglobin predicts progression to diabetes mellitus in Pima Indians with impaired glucose tolerance Diabetologia ·Randie R. Little, J D England, Hsiao-Mei Wiedmeyer, Richard Madsen, David J. Pettitt, William C. Knowler, David E. Goldstein	1994	35
17	Glucose, insulin concentrations and obesity in childhood and adolescence as predictors of NIDDM Diabetologia ·David R. McCance, David J. Pettitt, Robert L. Hanson, L. Jacobsson, Peter H. Bennett, William C. Knowler	1994	84
18	Glomerular function in Pima Indians with noninsulin-dependent diabetes mellitus of recent onset. Journal of Clinical Investigation ·Bryan D. Myers, Robert G. Nelson, George W. Williams, Paul Bennett, Sheila Hardy, Kyla Jane Mendez, Nicholas R. Loon, William C. Knowler, William E. Mitch	1991	101
19	Medial arterial calcification and its association with mortality and complications of diabetes Diabetologia ·James E. Everhart, David J. Pettitt, William C. Knowler, Frederick A. Rose, Peter H. Bennett	1988	227
20	Using the ADAP Learning Algorithm to Forecast the Onset of Diabetes Mellitus PubMed Central ·Jack W. Smith, James E. Everhart, Javier Saucedo Monarque, William C. Knowler, R.S. Johannes Hit paper breakdown →	1988	473

About William C. Knowler

William C. Knowler is a scholar working on Endocrinology, Diabetes and Metabolism, Nephrology, Pharmacy, Genetics and Obstetrics and Gynecology, having authored 522 papers that have together received 43.9k indexed citations. Recurring topics across this work include Diabetes, Cardiovascular Risks, and Lipoproteins (123 papers), Genetic Associations and Epidemiology (68 papers), Diabetes and associated disorders (64 papers), Metabolism, Diabetes, and Cancer (62 papers), Diabetes Treatment and Management (51 papers), Birth, Development, and Health (46 papers), Obesity, Physical Activity, Diet (46 papers) and Chronic Kidney Disease and Diabetes (46 papers). The work is most often cited by research in Endocrinology, Diabetes and Metabolism (14.7k citations), Obstetrics and Gynecology (3.6k citations), Periodontics (1.9k citations), Nephrology (2.8k citations) and Physiology (10.2k citations). William C. Knowler has collaborated with scholars based in United States, Sweden and United Kingdom. Frequent co-authors include Peter H. Bennett, Robert L. Hanson, David J. Pettitt, Robert G. Nelson, Clifton Bogardus, Éric Ravussin, Stephen Lillioja, Helen C. Looker, Mohammed Saad and David J. Pettitt. Their work appears in journals such as Diabetes, Diabetes Care, Diabetologia, Obesity and The Journal of Clinical Endocrinology & Metabolism.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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