Timothy R. Billiar

78.1k citations

781 papers · 57.3k indexed · 15 hit papers · h-index 122

Molecular Biology top 0.05%
Immunology top 0.05%
Physiology top 0.02%
Surgery top 0.1%
Epidemiology top 0.1%

Co-authors: Richard L. Simmons David A. Geller Yoram Vodovotz Allan Tsung Andreas K. Nüssler Young‐Myeong Kim Andrew B. Peitzman Ronald Curran
Topics: Immune Response and Inflammation (173 papers)Nitric Oxide and Endothelin Effects (157 papers)Eicosanoids and Hypertension Pharmacology (94 papers)
Cited by: Biochemistry Critical Care and Intensive Care Medicine Clinical Biochemistry
Journals: Science Proceedings of the National Academy of Sciences Journal of the American Chemical Society
Partner nations: United States China South Korea

In The Last Decade

Timothy R. Billiar

768 papers receiving 56.2k citations

Hit Papers

5 papers align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

The nuclear factor HMGB1 mediates hepatic injury after murine liver ischemia-reperfusion

2005 944 citations Allan Tsung, Atsunori Nakao et al. The Journal of Experimental Medicine profile →
HMGB1 in health and disease

2014 787 citations Rui Kang, Ruochan Chen et al. profile →
Nitric Oxide Inhibits Apoptosis by Preventing Increases in Caspase-3-like Activity via Two Distinct Mechanisms

1997 763 citations Timothy R. Billiar et al. profile →
Inflammation, immunoregulation, and inducible nitric oxide synthase

1993 756 citations Timothy R. Billiar et al. profile →
The Tumor Suppressor p53 Limits Ferroptosis by Blocking DPP4 Activity

2017 737 citations Timothy R. Billiar, Rui Kang et al. profile →
Molecular cloning and expression of inducible nitric oxide synthase from human hepatocytes.

1993 721 citations David A. Geller, Richard A. Shapiro et al. Proceedings of the National Academy of Sciences profile →
Apoptosis induced in normal human hepatocytes by tumor necrosis factor-related apoptosis-inducing ligand

2000 705 citations Timothy R. Billiar et al. profile →
HMGB1: Endogenous Danger Signaling

2008 654 citations John R. Klune, Timothy R. Billiar et al. Molecular Medicine profile →
Cytokines, endotoxin, and glucocorticoids regulate the expression of inducible nitric oxide synthase in hepatocytes.

1993 583 citations David A. Geller, Richard A. Shapiro et al. Proceedings of the National Academy of Sciences profile →
HMGB1 release induced by liver ischemia involves Toll-like receptor 4–dependent reactive oxygen species production and calcium-mediated signaling

2007 521 citations Allan Tsung, John R. Klune et al. The Journal of Experimental Medicine profile →
Lipid Peroxidation Drives Gasdermin D-Mediated Pyroptosis in Lethal Polymicrobial Sepsis

2018 482 citations Rui Kang, Ling Zeng et al. profile →
Nitrogen Oxide Levels in Patients After Trauma and During Sepsis

1991 477 citations Timothy R. Billiar, Andrew B. Peitzman et al. profile →
PKM2-dependent glycolysis promotes NLRP3 and AIM2 inflammasome activation

2016 432 citations Rui Kang, Shan Zhu et al. profile →
Damage‐associated molecular pattern–activated neutrophil extracellular trap exacerbates sterile inflammatory liver injury

2015 424 citations Hai Huang, Patricia Loughran et al. profile →
Articular chondrocytes synthesize nitric oxide in response to cytokines and lipopolysaccharide

1991 390 citations Timothy R. Billiar et al. profile →

Peers

Countries citing papers authored by Timothy R. Billiar

Since Specialization

Citations

This map shows the geographic impact of Timothy R. Billiar's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Timothy R. Billiar with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Timothy R. Billiar more than expected).

Fields of papers citing papers by Timothy R. Billiar

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Timothy R. Billiar. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Timothy R. Billiar. The network helps show where Timothy R. Billiar may publish in the future.

Co-authorship network of co-authors of Timothy R. Billiar

This figure shows the co-authorship network connecting the top 25 collaborators of Timothy R. Billiar. A scholar is included among the top collaborators of Timothy R. Billiar based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Timothy R. Billiar. Timothy R. Billiar is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

#	Work	Indexed citations
1	Myeloperoxidase-anchored ENO1 mediates neutrophil extracellular trap DNA to enhance Treg differentiation via IFITM2 during sepsis 2025 ·Journal of Clinical Investigation ·Wen Jiang,(unknown),(unknown),Hao Sun,Xinyi Wu,(unknown),Zhaoyuan Chen,Han Wu,Xiao-Qiang Zhao,Tongtong Zhang,Ronen Ben‐Ami,Le Yuan,Timothy R. Billiar,(unknown),Yuehua Zhang,Jun Wang,Wankun Chen	1
2	A neuroimmune pathway drives bacterial infection 2025 ·Science Advances ·Nian Wang,Jiao Liu,Runliu Wu,Feng Chen,Ruoxi Zhang,Chunhua Yu,Herbert J. Zeh,Xianzhong Xiao,Haichao Wang,Timothy R. Billiar,Ling Zeng,Jianxin Jiang,Daolin Tang,Rui Kang	3
3	Aconitate decarboxylase 1 is a mediator of polymicrobial sepsis 2022 ·Science Translational Medicine ·Runliu Wu,Jiao Liu,Nian Wang,Ling Zeng,Chunhua Yu,Feng Chen,Haichao Wang,Timothy R. Billiar,Jianxin Jiang,Daolin Tang,Rui Kang	47
4	Platelet TLR4-ERK5 Axis Facilitates NET-Mediated Capturing of Circulating Tumor Cells and Distant Metastasis after Surgical Stress 2021 ·Cancer Research ·Jinghua Ren,Jiayi He,Hongji Zhang,Yujia Xia,Zhiwei Hu,Patricia Loughran,Timothy R. Billiar,Hai Huang,Allan Tsung	120
5	The HIV protease inhibitor Saquinavir attenuates sepsis-induced acute lung injury and promotes M2 macrophage polarization via targeting matrix metalloproteinase-9 2021 ·Cell Death and Disease ·Yao Tong,Zhuang Yu,Zhixia Chen,(unknown),Xibing Ding,Xiaohu Yang,Xiaoyin Niu,Mengzhu Li,Lingling Zhang,Timothy R. Billiar,Bruce R. Pitt,Quan Li	33
6	HMGB1 released from nociceptors mediates inflammation 2021 ·Proceedings of the National Academy of Sciences ·Huan Yang,(unknown),Harold Silverman,(unknown),(unknown),(unknown),Meghan E. Addorisio,Jianhua Li,Téa Tsaava,(unknown),Timothy R. Billiar,Haichao Wang,Michael Brines,Jan Andersson,Valentin A. Pavlov,Eric H. Chang,Sangeeta S. Chavan,Kevin J. Tracey	60
7	Hepatocyte high-mobility group box 1 protects against steatosis and cellular stress during high fat diet feeding 2020 ·Molecular Medicine ·Minjie Lin,(unknown),Wenbo Li,Chenxuan Yang,Patricia Loughran,Robert M. O’Doherty,Timothy R. Billiar,Meihong Deng,Melanie J. Scott	15
8	Notch signaling protects CD4 T cells from STING-mediated apoptosis during acute systemic inflammation 2020 ·Science Advances ·Junke Long,Chenxuan Yang,Yawen Zheng,Patricia Loughran,Guang Fu,Yiming Li,Hong Liao,Melanie J. Scott,Daolin Tang,Timothy R. Billiar,Meihong Deng	35
9	A road map from single-cell transcriptome to patient classification for the immune response to trauma 2020 ·JCI Insight ·(unknown),Matthew J. Delano,Kong Chen,Jason L. Sperry,Rami A. Namas,(unknown),Meihong Deng,(unknown),Lyle L. Moldawer,Philip A. Efron,Patricia Loughran,Christopher Seymour,Derek C. Angus,Yoram Vodovotz,Wei Chen,Timothy R. Billiar	32
10	TLR9 signaling in fibroblastic reticular cells regulates peritoneal immunity 2019 ·Journal of Clinical Investigation ·Li Xu,Yiming Li,Chenxuan Yang,Patricia Loughran,Hong Liao,Rosemary A. Hoffman,Timothy R. Billiar,Meihong Deng	16
11	TSLP protects against liver I/R injury via activation of the PI3K/Akt pathway 2019 ·JCI Insight ·Shilai Li,Zhongjie Yi,Meihong Deng,Melanie J. Scott,Chenxuan Yang,(unknown),Lei Zhao,(unknown),Patricia Loughran,Timothy R. Billiar	31
12	cAMP metabolism controls caspase-11 inflammasome activation and pyroptosis in sepsis 2019 ·Science Advances ·Ruochan Chen,Ling Zeng,Shan Zhu,Jiao Liu,Herbert J. Zeh,Guido Kroemer,Haichao Wang,Timothy R. Billiar,Jianxin Jiang,Daolin Tang,Rui Kang	116
13	cGAS-mediated autophagy protects the liver from ischemia-reperfusion injury independently of STING 2018 ·American Journal of Physiology-Gastrointestinal and Liver Physiology ·Lei Zhao,Meihong Deng,Zhongjie Yi,Qian Sun,Richard A. Shapiro,Hongbo Xu,(unknown),Patricia Loughran,(unknown),Hai Huang,Melanie J. Scott,Feizhou Huang,Timothy R. Billiar	90
14	Distance matters 2017 ·The Journal of Trauma: Injury, Infection, and Critical Care ·Joshua B. Brown,Matthew R. Rosengart,Timothy R. Billiar,Andrew B. Peitzman,Jason L. Sperry	45
15	Plumbagin Protects Mice from Lethal Sepsis by Modulating Immunometabolism Upstream of PKM2 2016 ·Molecular Medicine ·Zhaoxia Zhang,Wenjun Deng,Rui Kang,Min Xie,Timothy R. Billiar,Haichao Wang,Lizhi Cao,Daolin Tang	40
16	Helicopter transport improves survival following injury in the absence of a time-saving advantage 2015 ·Surgery ·Joshua B. Brown,Mark L. Gestring,Francis X. Guyette,Matthew R. Rosengart,Nicole A. Stassen,Raquel M. Forsythe,Timothy R. Billiar,Andrew B. Peitzman,Jason L. Sperry	72
17	Induction and stability of human Th17 cells require endogenous NOS2 and cGMP-dependent NO signaling 2013 ·The Journal of Experimental Medicine ·Nataša Obermajer,Jeffrey L. Wong,Robert P. Edwards,Kong Chen,Melanie J. Scott,Shabaana A. Khader,Jay K. Kolls,Kunle Odunsi,Timothy R. Billiar,Paweł Kaliński	93
18	Body Adipose Content is Independently Associated With a Higher Risk of Organ Failure and Nosocomial Infection in the Nonobese Patient Postinjury 2011 ·The Journal of Trauma: Injury, Infection, and Critical Care ·(unknown),Joseph Cuschieri,Joseph P. Minei,Matthew R. Rosengart,Ronald V. Maier,Brian G. Harbrecht,Timothy R. Billiar,Andrew B. Peitzman,Ernest E. Moore,Jason L. Sperry	15
19	Mechanisms of Toll-Like Receptor 4 (TLR4)-Mediated Inflammation After Cold Ischemia/Reperfusion in the Heart 2009 ·Transplantation ·David Kaczorowski,Atsunori Nakao,Raghuveer Vallabhaneni,Kevin P. Mollen,Ryujiro Sugimoto,Junichi Kohmoto,Brian S. Zuckerbraun,Kenneth R. McCurry,Timothy R. Billiar	92
20	A NOVEL INHIBITORY PEPTIDE OF TOLL-LIKE RECEPTOR SIGNALING LIMITS LIPOPOLYSACCHARIDE-INDUCED PRODUCTION OF INFLAMMATORY MEDIATORS AND ENHANCES SURVIVAL IN MICE 2007 ·Shock ·Allan Tsung,Sharon L. McCoy,John R. Klune,David A. Geller,Timothy R. Billiar,Steven H. Hefeneider	30

About Timothy R. Billiar

Timothy R. Billiar is a scholar working on Biochemistry, Critical Care and Intensive Care Medicine and Immunology, having authored 781 papers that have together received 57.3k indexed citations. Recurring topics across this work include Immune Response and Inflammation (173 papers), Nitric Oxide and Endothelin Effects (157 papers) and Eicosanoids and Hypertension Pharmacology (94 papers). The work is most often cited by research in Biochemistry (5.3k citations), Critical Care and Intensive Care Medicine (3.8k citations) and Clinical Biochemistry (4.6k citations). Timothy R. Billiar has collaborated with scholars based in United States, China and South Korea. Frequent co-authors include Richard L. Simmons, David A. Geller, Yoram Vodovotz, Allan Tsung, Andreas K. Nüssler, Young‐Myeong Kim, Andrew B. Peitzman, Ronald Curran, Michael T. Lotze and Brian G. Harbrecht. Their work appears in journals such as Science, Proceedings of the National Academy of Sciences and Journal of the American Chemical Society.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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