Timothy Hla

43.2k total citations · 11 hit papers
245 papers, 35.3k citations indexed

About

Timothy Hla is a scholar working on Molecular Biology, Cell Biology and Pharmacology. According to data from OpenAlex, Timothy Hla has authored 245 papers receiving a total of 35.3k indexed citations (citations by other indexed papers that have themselves been cited), including 193 papers in Molecular Biology, 66 papers in Cell Biology and 57 papers in Pharmacology. Recurrent topics in Timothy Hla's work include Sphingolipid Metabolism and Signaling (137 papers), Inflammatory mediators and NSAID effects (57 papers) and Estrogen and related hormone effects (35 papers). Timothy Hla is often cited by papers focused on Sphingolipid Metabolism and Signaling (137 papers), Inflammatory mediators and NSAID effects (57 papers) and Estrogen and related hormone effects (35 papers). Timothy Hla collaborates with scholars based in United States, Japan and United Kingdom. Timothy Hla's co-authors include Karen M. Neilson, Catherine H. Liu, Shobha Thangada, T Maciag, Richard L. Proia, Regina M. Botting, Daniel L. Simmons, Ari Ristimäki, Nicolas Ancellin and Teresa Sánchez and has published in prestigious journals such as Nature, Science and Cell.

In The Last Decade

Timothy Hla

243 papers receiving 34.7k citations

Hit Papers

5 papers align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Cyclooxygenase Isozymes: The Biology of Prostaglandin Synthesis and Inhibition

2004 1.4k citations Timothy Hla et al. profile →
Human cyclooxygenase-2 cDNA.

1992 1.3k citations Timothy Hla et al. Proceedings of the National Academy of Sciences profile →
Expression of cyclooxygenase-1 and -2 in human colorectal cancer.

1995 1000 citations Timothy Hla et al. profile →
Edg-1, the G protein–coupled receptor for sphingosine-1-phosphate, is essential for vascular maturation

2000 965 citations Catherine H. Liu, Timothy Hla et al. Journal of Clinical Investigation profile →
Sphingosine-1-Phosphate as a Ligand for the G Protein-Coupled Receptor EDG-1

1998 882 citations Shobha Thangada, Catherine H. Liu et al. profile →
Vascular Endothelial Cell Adherens Junction Assembly and Morphogenesis Induced by Sphingosine-1-Phosphate

1999 864 citations Shobha Thangada, Catherine H. Liu et al. profile →
Overexpression of Cyclooxygenase-2 Is Sufficient to Induce Tumorigenesis in Transgenic Mice

2001 661 citations Catherine H. Liu, Sung-Hee Chang et al. Journal of Biological Chemistry profile →
Cyclooxygenase-1 and -2 expression in rheumatoid synovial tissues. Effects of interleukin-1 beta, phorbol ester, and corticosteroids.

1994 572 citations Timothy Hla et al. Journal of Clinical Investigation profile →
Endothelium-protective sphingosine-1-phosphate provided by HDL-associated apolipoprotein M

2011 491 citations Hideru Obinata, Sylvain Galvani et al. Proceedings of the National Academy of Sciences profile →
Emerging biology of sphingosine-1-phosphate: its role in pathogenesis and therapy

2015 420 citations Richard L. Proia, Timothy Hla Journal of Clinical Investigation profile →
Sphingosine 1-phosphate: Lipid signaling in pathology and therapy

2019 413 citations Andréane Cartier, Timothy Hla profile →

Peers

Countries citing papers authored by Timothy Hla

Since Specialization

Citations

This map shows the geographic impact of Timothy Hla's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Timothy Hla with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Timothy Hla more than expected).

Fields of papers citing papers by Timothy Hla

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Timothy Hla. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Timothy Hla. The network helps show where Timothy Hla may publish in the future.

Co-authorship network of co-authors of Timothy Hla

This figure shows the co-authorship network connecting the top 25 collaborators of Timothy Hla. A scholar is included among the top collaborators of Timothy Hla based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Timothy Hla. Timothy Hla is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

Sort: Min cites: Since: Top N: Style:

20 of 20 papers shown

#	Work	Indexed citations
1	Sphingosine kinase 1 is integral for elastin deficiency-induced arterial hypermuscularization 2026 ·Nature Cardiovascular Research ·(unknown), Jui M. Dave, (unknown), Nandhini Sadagopan, Inamul Kabir, George Tellides, R. Kirk Riemer, (unknown), Sarah Spiegel, Timothy Hla, Daniel M. Greif	0
2	ApoM-bound S1P acts via endothelial S1PR1 to suppress choroidal neovascularization and vascular leakage 2025 ·Angiogenesis ·B. Jung, (unknown), Andrew Kuo, (unknown), Masanori Aikawa, (unknown), Sasha A. Singh, Andrew J. Dannenberg, (unknown), Colin Niaudet, Lois E. H. Smith, Timothy Hla	2
3	Inflamed endothelial cells express S1PR1 inhibitor CD69 to induce vascular leak 2025 ·Journal of Biological Chemistry ·(unknown), Andréane Cartier, Yueh‐Chien Lin, (unknown), Hanming Zhang, Balkrishna Chaube, Mantu Bhaumik, Jakob Körbelin, Yajaira Suárez, Carlos Fernández‐Hernando, Timothy Hla	0
4	Endothelial cell sphingosine 1-phosphate receptor 1 restrains VE-cadherin cleavage and attenuates experimental inflammatory arthritis 2024 ·JCI Insight ·Nathalie Burg, (unknown), Linda Alex, (unknown), (unknown), Andrew Kuo, (unknown), (unknown), (unknown), Tilla S. Worgall, (unknown), Susan M. Goodman, Bella Mehta, Michael Brenner, Dietmar Vestweber, Kevin Wei, Carl Blobel, Timothy Hla, Jane E. Salmon	3
5	Therapeutic activation of endothelial sphingosine‐1‐phosphate receptor 1 by chaperone‐bound S1P suppresses proliferative retinal neovascularization 2023 ·EMBO Molecular Medicine ·Colin Niaudet, B. Jung, Andrew Kuo, Steven Swendeman, (unknown), (unknown), (unknown), Zhongjie Fu, Lois E. H. Smith, Timothy Hla	13
6	CLIC1 and CLIC4 mediate endothelial S1P receptor signaling to facilitate Rac1 and RhoA activity and function 2021 ·Science Signaling ·(unknown), (unknown), (unknown), Bhairavi Swaminathan, Hideru Obinata, Yulia Komarova, Kayla J. Bayless, Timothy Hla, Jan Kitajewski	18
7	Endothelial sphingosine 1-phosphate receptors promote vascular normalization and antitumor therapy 2020 ·Proceedings of the National Academy of Sciences ·Andréane Cartier, (unknown), Catherine H. Liu, Timothy Hla	78
8	CD4 T cell sphingosine 1-phosphate receptor (S1PR)1 and S1PR4 and endothelial S1PR2 regulate afferent lymphatic migration 2019 ·Science Immunology ·Yanbao Xiong, Wenji Piao, C. Colin Brinkman, Lushen Li, Joseph M. Kulinski, Ana Olivera, Andréane Cartier, Timothy Hla, Keli L. Hippen, Bruce R. Blazar, Susan R. Schwab, Jonathan S. Bromberg	73
9	Post‐transcriptional regulation of Nrf2‐mRNA by the mRNA‐binding proteins HuR and AUF1 2019 ·The FASEB Journal ·Jesse R. Poganik, Marcus J. C. Long, (unknown), Xuyu Liu, (unknown), Timothy Hla, Yimon Aye	54
10	HDL-bound sphingosine 1-phosphate acts as a biased agonist for the endothelial cell receptor S1P ₁ to limit vascular inflammation 2015 ·Science Signaling ·Sylvain Galvani, Marie Sanson, Victoria A. Blaho, Steven Swendeman, Hideru Obinata, (unknown), Björn Dahlbäck, Mari Kono, Richard L. Proia, Jonathan D. Smith, Timothy Hla	252
11	Intestinal Epithelial HuR Modulates Distinct Pathways of Proliferation and Apoptosis and Attenuates Small Intestinal and Colonic Tumor Development 2014 ·Cancer Research ·Antonina Giammanco, Valérie Blanc, (unknown), (unknown), Yan Xie, Susan Kennedy, Jianyang Luo, Sung-Hee Chang, Timothy Hla, ILKe Nalbantoglu, Sekhar Dharmarajan, Nicholas Davidson	57
12	Inhibitory Role of Sphingosine 1-Phosphate Receptor 2 in Macrophage Recruitment during Inflammation 2009 ·The Journal of Immunology ·Jason Michaud, Dong‐Soon Im, Timothy Hla	111
13	Induction of Antiproliferative Connective Tissue Growth Factor Expression in Wilms' Tumor Cells by Sphingosine-1-Phosphate Receptor 2 2008 ·Molecular Cancer Research ·(unknown), Teresa Sánchez, Anna Maria Pappalardo, Kevin R. Lynch, Timothy Hla, Fernando Ferrer	56
14	Vascular Endothelium As a Contributor of Plasma Sphingosine 1-Phosphate 2008 ·Circulation Research ·Krishnan Venkataraman, Yong-Moon Lee, Jason Michaud, Shobha Thangada, Youxi Ai, Herbert L. Bonkovsky, Nehal S. Parikh, (unknown), Timothy Hla	391
15	Normal acute and chronic inflammatory responses in sphingosine kinase 1 knockout mice 2006 ·FEBS Letters ·Jason Michaud, Masataka Kohno, Richard L. Proia, Timothy Hla	71
16	The G Protein–Coupled Receptor S1P2 Regulates Rho/Rho Kinase Pathway to Inhibit Tumor Cell Migration 2005 ·Cancer Research ·Denise Lepley, Jihye Paik, Timothy Hla, Fernando Ferrer	147
17	HER2/neu-Induced Mammary Tumorigenesis and Angiogenesis Are Reduced in Cyclooxygenase-2 Knockout Mice 2005 ·Cancer Research ·Louise R. Howe, (unknown), (unknown), Rachelle L. Dillon, Lawrence J.T. Young, Robert D. Cardiff, Robert A. Newman, Peiying Yang, Howard T. Thaler, William J. Muller, Clifford A. Hudis, Anthony M.C. Brown, Timothy Hla, Kotha Subbaramaiah, Andrew J. Dannenberg	114
18	Requirement for sphingosine 1–phosphate receptor-1 in tumor angiogenesis demonstrated by in vivo RNA interference 2004 ·Journal of Clinical Investigation ·Sung‐Suk Chae, Jihye Paik, Henry Furneaux, Timothy Hla	171
19	Sphingosine 1-phosphate receptors. 2001 ·Prostaglandins ·Timothy Hla	47
20	The Nuclear Receptor PPARγ and Immunoregulation: PPARγ Mediates Inhibition of Helper T Cell Responses 2000 ·The Journal of Immunology ·Robert B. Clark, David Bishop‐Bailey, Tatiana Estrada-Hernandez, Timothy Hla, Lynn Puddington, Steven J. Padula	409

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

Explore authors with similar magnitude of impact