Sylvain Cottens

4.4k citations

26 papers · 3.5k indexed · 2 hit papers · h-index 16

Impact in

Transplantation top 1%
- Renal Transplantation Outcomes and Treatments
Immunology and Allergy top 2%
- Cell Adhesion Molecules Research

Papers in

Pharmaceutical Science 4
- Fluorine in Organic Chemistry 4
Toxicology 2
- Bioactive Compounds and Antitumor Agents 2

Co-authors: Volker Brinkmann Christian Bruns Joerg Kallen Gabriele Weitz‐Schmidt Karl Welzenbach Ulrich Hommel Rainer Albert Richard Sedrani
Journals: Bioorganic & Medicinal Chemistry Letters (3 papers)Tetrahedron (2 papers)Helvetica Chimica Acta (2 papers)Journal of Medicinal Chemistry (2 papers)Transplantation (2 papers)
Partner nations: Switzerland United States France

In The Last Decade

Sylvain Cottens

26 papers receiving 3.4k citations

Hit Papers

align trajectories log scale

The Immune Modulator FTY720 Targets Sphingosine 1-Phosphate Receptors 2002 · 1.2k citations

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if any of the following hold:

it has ≥500 total citations;
it reaches ≥1.5× the top-1% citation threshold for papers in the same subfield and year (the threshold is the minimum needed to enter the top 1%, not the average within it);
it reaches the top citation threshold in at least one of its specific research topics.

2002 Journal of Biological Chemistry
2001 Nature Medicine

Peers

Countries citing papers authored by Sylvain Cottens

Since Specialization

Citations

This map shows the geographic impact of Sylvain Cottens's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Sylvain Cottens with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Sylvain Cottens more than expected).

Fields of papers citing papers by Sylvain Cottens

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Sylvain Cottens. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Sylvain Cottens. The network helps show where Sylvain Cottens may publish in the future.

Co-authorship network

The 25 scholars most cited alongside Sylvain Cottens, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Sylvain Cottens Line = papers co-authored together Sylvain Cottens links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

#	Work
1	Derivation of Rapamycin: Adventures in Natural Product Chemistry CHIMIA International Journal for Chemistry ·Sylvain Cottens, Jörg Kallen, W. Schüler, Richard Sedrani	2019	6
2	trans-3,4-Disubstituted pyrrolidines as inhibitors of the human aspartyl protease renin. Part II: Prime site exploration using an oxygen linker Bioorganic & Medicinal Chemistry Letters ·Holger Sellner, Sylvain Cottens, Frédéric Cumin, Claus Ehrhardt, Takatoshi Kosaka, Edwige Lorthiois, Nils Ostermann, Randy L. Webb, Dean F. Rigel, Trixie Wagner, Jürgen Maibaum	2015	1
3	Structure–Activity Relationship and Pharmacokinetic Studies of Sotrastaurin (AEB071), a Promising Novel Medicine for Prevention of Graft Rejection and Treatment of Psoriasis Journal of Medicinal Chemistry ·Jürgen Wagner, Peter Matt, Bernard Faller, Nigel G. Cooke, Rainer Albert, Richard Sedrani, Marine Estevez Vazquez, Shalika Tisinger, Christian Beerli, Gisbert Weckbecker, Jean-Pierre Evenou, Gerhard Zenke, Sylvain Cottens	2011	33
4	The Potent Protein Kinase C-Selective Inhibitor AEB071 (Sotrastaurin) Represents a New Class of Immunosuppressive Agents Affecting Early T-Cell Activation Journal of Pharmacology and Experimental Therapeutics ·Jean-Pierre Evenou, Jürgen Wagner, Gerhard Zenke, Volker Brinkmann, Kathrin Wagner, Jiří Kovařík, Karl Welzenbach, Gabriele Weitz‐Schmidt, Christine Guntermann, Harry Towbin, Sylvain Cottens, Sandra Kaminski, Thomas Letschka, Christina Lutz‐Nicoladoni, Thomas Gruber, Natascha Hermann‐Kleiter, Niκolaus Thuille, Gottfried Baier	2009	116
5	Discovery of 3-(1H-Indol-3-yl)-4-[2-(4-methylpiperazin-1-yl)quinazolin-4-yl]pyrrole-2,5-dione (AEB071), a Potent and Selective Inhibitor of Protein Kinase C Isotypes Journal of Medicinal Chemistry ·Jürgen Wagner, Peter Matt, Richard Sedrani, Rainer Albert, Nigel G. Cooke, Claus Ehrhardt, Martin Geiser, Gabriele Rummel, Wilhelm Stark, André Strauss, Sandra W. Cowan‐Jacob, Christian Beerli, Gisbert Weckbecker, Jean-Pierre Evenou, Gerhard Zenke, Sylvain Cottens	2009	104
6	Synthesis, and Helix or Hairpin-Turn Secondary Structures of ‘Mixed’α/β-Peptides Consisting of Residues with Proteinogenic Side Chains and of 2-Amino-2-methylpropanoic Acid (Aib) Helvetica Chimica Acta ·Dieter Seebàch, Bernhard Jaun, Radovan Šebesta, Aprian Dwi Nur Sembada, Oliver Flögel, Michael Limbach, Holger Sellner, Sylvain Cottens	2006	55
7	Islet allograft survival in nonhuman primates immunosuppressed with basiliximab, RAD, and FTY7201 Transplantation ·Martin Wijkstrom, Norma S. Kenyon, Nicole Kirchhof, Norman M. Kenyon, Claudy Mullon, Thalia C Slocombe, Sylvain Cottens, Camillo Ricordi, Bernhard J. Hering	2004	60
8	The Immune Modulator FTY720 Targets Sphingosine 1-Phosphate Receptors Journal of Biological Chemistry ·Volker Brinkmann, Michael D. Davis, Christopher E. Heise, Rainer Albert, Sylvain Cottens, Robert Hof, Christian Bruns, Eva E. Prieschl, Thomas Baumruker, Peter Hiestand, Carolyn A. Foster, Markus Zollinger, Kevin R. Lynch Hit paper breakdown →	2002	1246
9	Statins selectively inhibit leukocyte function antigen-1 by binding to a novel regulatory integrin site Nature Medicine ·Gabriele Weitz‐Schmidt, Karl Welzenbach, Volker Brinkmann, Sedigheh Hatami-Gig, Joerg Kallen, Christian Bruns, Sylvain Cottens, Yoshikazu Takada, Ulrich Hommel Hit paper breakdown →	2001	844
10	FTY720: dissection of membrane receptor-operated, stereospecific effects on cell migration from receptor-independent antiproliferative and apoptotic effects Transplantation Proceedings ·Volker Brinkmann, C.L. van der Wilt, Colette Kristofic, Zariana Nikolova, Robert P. Hof, Martin Bonte, Rainer Albert, Sylvain Cottens	2001	39
11	Cleavage of the cyclohexyl-subunit of rapamycin results in loss of immunosuppressive activity Bioorganic & Medicinal Chemistry Letters ·Richard Sedrani, Lyn H. Jones, Maria Esperanza Miraba, W. Schüler, Sylvain Cottens	1999	7
12	Half-filter experiments for assignment, structure determination and hydration analysis of unlabelled ligands bound to 13C/15N labelled proteins Journal of Biomolecular NMR ·Claudio Dalvit, Sylvain Cottens, Paul Ramage, Ulrich Hommel	1999	18
13	Structural basis for LFA-1 inhibition upon lovastatin binding to the CD11a I-domain 1 1Edited by F. E. Cohen Journal of Molecular Biology ·Joerg Kallen, Karl Welzenbach, Paul Ramage, Dieter Geyl, Richard W. Kriwacki, Glen B. Legge, Sylvain Cottens, Gabriele Weitz‐Schmidt, Ulrich Hommel	1999	214
14	Chemical modification of rapamycin: the discovery of SDZ RAD Transplantation Proceedings ·Richard Sedrani, Sylvain Cottens, Joerg Kallen, W. Schüler	1998	120
15	Dihydroxylation of the Triene Subunit of Rapamycin The Journal of Organic Chemistry ·Richard Sedrani, Rodríguez Mariani, Siti Dewi Winengsih, Sylvain Cottens	1998	3
16	SDZ RAD, A NEW RAPAMYCIN DERIVATIVE Transplantation ·W. Schüler, Richard Sedrani, Sylvain Cottens, Chun‐rong Chen, Manfred Schulz, Henk‐Jan Schuurman, Gerhard Zenke, Hans‐Günter Zerwes, Max H. Schreier	1997	476
17	ChemInform Abstract: Diels‐Alder Approach to Musk Odor Type Arenes. ChemInform ·Guoqiang Shi, Sylvain Cottens, Laura Múñoz, Manfred Schlosser	1993	1
18	The diels-alder approach to musk odor type arenes Tetrahedron ·Guoqiang Shi, Sylvain Cottens, Laura Múñoz, G. Genneper	1992	22
19	Interactions Between a Symmetrical Minor Groove Binding Compound and DNA Oligonucleotides: ¹H and ¹⁹F NMR Studies Journal of Biomolecular Structure and Dynamics ·Andrew H.‐J. Wang, Sylvain Cottens, Peter B. Dervan, James P. Yesinowski, Gijs A. van der Marel, Jacques H. van Boom	1989	8
20	Attempted and accomplished syntheses of a few monofluorinated chrysanthemic acid derivatives Tetrahedron ·Sylvain Cottens, Manfred Schlosser	1988	12

About Sylvain Cottens

Sylvain Cottens is a scholar working on Pharmaceutical Science, Toxicology, Organic Chemistry, Physiology and Immunology and Allergy, having authored 26 papers that have together received 3.5k indexed citations. Recurring topics across this work include Synthetic Organic Chemistry Methods (4 papers), Signaling Pathways in Disease (4 papers), Fluorine in Organic Chemistry (4 papers), Sphingolipid Metabolism and Signaling (4 papers), Carbohydrate Chemistry and Synthesis (3 papers), Monoclonal and Polyclonal Antibodies Research (3 papers), Bioactive Compounds and Antitumor Agents (2 papers) and Biochemical and Molecular Research (2 papers). The work is most often cited by research in Transplantation (349 citations), Immunology and Allergy (257 citations), Immunology (813 citations), Molecular Biology (1.8k citations) and Physiology (112 citations). Sylvain Cottens has collaborated with scholars based in Switzerland, United States and France. Frequent co-authors include Volker Brinkmann, Christian Bruns, Joerg Kallen, Gabriele Weitz‐Schmidt, Karl Welzenbach, Ulrich Hommel, Rainer Albert, Richard Sedrani, Markus Zollinger and Robert Hof. Their work appears in journals such as Bioorganic & Medicinal Chemistry Letters, Tetrahedron, Helvetica Chimica Acta, Journal of Medicinal Chemistry and Transplantation.

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