Richard Sedrani

3.0k total citations · 1 hit paper
23 papers, 1.6k citations indexed

About

Richard Sedrani is a scholar working on Molecular Biology, Organic Chemistry and Oncology. According to data from OpenAlex, Richard Sedrani has authored 23 papers receiving a total of 1.6k indexed citations (citations by other indexed papers that have themselves been cited), including 17 papers in Molecular Biology, 8 papers in Organic Chemistry and 6 papers in Oncology. Recurrent topics in Richard Sedrani's work include Signaling Pathways in Disease (6 papers), Synthetic Organic Chemistry Methods (5 papers) and Peptidase Inhibition and Analysis (5 papers). Richard Sedrani is often cited by papers focused on Signaling Pathways in Disease (6 papers), Synthetic Organic Chemistry Methods (5 papers) and Peptidase Inhibition and Analysis (5 papers). Richard Sedrani collaborates with scholars based in Switzerland, France and United States. Richard Sedrani's co-authors include Jörg Eder, Christian Wiesmann, Sylvain Cottens, W. Schüler, Gerhard Zenke, Henk‐Jan Schuurman, Hans‐Günter Zerwes, Max H. Schreier, Manfred Schulz and Joerg Kallen and has published in prestigious journals such as Journal of the American Chemical Society, Journal of Biological Chemistry and Nature Communications.

In The Last Decade

Richard Sedrani

23 papers receiving 1.6k citations

Hit Papers

The discovery of first-in-class drugs: origins and evolution 2014 2026 2018 2022 2014 100 200 300
What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

  1. The discovery of first-in-class drugs: origins and evolution
    2014 328 citations Jörg Eder, Richard Sedrani et al. Nature Reviews Drug Discovery profile →

Peers

Richard Sedrani
Michael D. Varney Australia
Christos Papageorgiou Greece
Gerald J. Fetterly United States
Song Feng China
Shinichi Kurakata Japan
Eric Scholar United States
Xiao-bo Zhong United States
Frank Bennett United States
Kieran L. O’Loughlin United States
Tina Colombo Italy
Michael D. Varney Australia
Richard Sedrani
Citations per year, relative to Richard Sedrani Richard Sedrani (= 1×) peers Michael D. Varney

Countries citing papers authored by Richard Sedrani

Since Specialization
Citations

This map shows the geographic impact of Richard Sedrani's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Richard Sedrani with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Richard Sedrani more than expected).

Fields of papers citing papers by Richard Sedrani

Since Specialization
Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Richard Sedrani. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Richard Sedrani. The network helps show where Richard Sedrani may publish in the future.

Co-authorship network of co-authors of Richard Sedrani

This figure shows the co-authorship network connecting the top 25 collaborators of Richard Sedrani. A scholar is included among the top collaborators of Richard Sedrani based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Richard Sedrani. Richard Sedrani is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

20 of 20 papers shown
1.
Henry, Chrystèle, Callum J. Dickson, Florian Georgescauld, et al.. (2024). Dynamic conformational equilibria in the active states of KRAS and NRAS. RSC Chemical Biology. 6(1). 106–118. 7 indexed citations
2.
Cottens, Sylvain, Jörg Kallen, W. Schüler, & Richard Sedrani. (2019). Derivation of Rapamycin: Adventures in Natural Product Chemistry. CHIMIA International Journal for Chemistry. 73(7-8). 581–581. 6 indexed citations
3.
Schlierf, Anita, Eva Altmann, Jean Quancard, et al.. (2016). Targeted inhibition of the COP9 signalosome for treatment of cancer. Nature Communications. 7(1). 13166–13166. 125 indexed citations
4.
Namoto, Kenji, Finton Sirockin, Nils Ostermann, et al.. (2014). Discovery of C-(1-aryl-cyclohexyl)-methylamines as selective, orally available inhibitors of dipeptidyl peptidase IV. Bioorganic & Medicinal Chemistry Letters. 24(3). 731–736. 15 indexed citations
5.
Eder, Jörg, Richard Sedrani, & Christian Wiesmann. (2014). The discovery of first-in-class drugs: origins and evolution. Nature Reviews Drug Discovery. 13(8). 577–587. 328 indexed citations breakdown →
6.
Wagner, Jürgen, Peter Matt, Bernard Faller, et al.. (2011). Structure–Activity Relationship and Pharmacokinetic Studies of Sotrastaurin (AEB071), a Promising Novel Medicine for Prevention of Graft Rejection and Treatment of Psoriasis. Journal of Medicinal Chemistry. 54(17). 6028–6039. 33 indexed citations
7.
Webb, Randy L., Nikolaus Schiering, Richard Sedrani, & Jürgen Maibaum. (2010). Direct Renin Inhibitors as a New Therapy for Hypertension. Journal of Medicinal Chemistry. 53(21). 7490–7520. 51 indexed citations
8.
Wagner, Jürgen, Peter Matt, Richard Sedrani, et al.. (2009). Discovery of 3-(1H-Indol-3-yl)-4-[2-(4-methylpiperazin-1-yl)quinazolin-4-yl]pyrrole-2,5-dione (AEB071), a Potent and Selective Inhibitor of Protein Kinase C Isotypes. Journal of Medicinal Chemistry. 52(20). 6193–6196. 104 indexed citations
9.
Zollinger, Markus, et al.. (2008). The Macrolide Everolimus Forms an Unusual Metabolite in Animals and Humans: Identification of a Phosphocholine Ester. Drug Metabolism and Disposition. 36(8). 1457–1460. 6 indexed citations
10.
Kallen, Joerg, Richard Sedrani, Gerhard Zenke, & Juergen Wagner. (2005). Structure of Human Cyclophilin A in Complex with the Novel Immunosuppressant Sanglifehrin A at 1.6 Å Resolution. Journal of Biological Chemistry. 280(23). 21965–21971. 39 indexed citations
11.
Sedrani, Richard, Jörg Kallen, L. M. MARTIN CABREJAS, et al.. (2003). Sanglifehrin−Cyclophilin Interaction:  Degradation Work, Synthetic Macrocyclic Analogues, X-ray Crystal Structure, and Binding Data. Journal of the American Chemical Society. 125(13). 3849–3859. 87 indexed citations
12.
Sedrani, Richard, et al.. (1999). Cleavage of the cyclohexyl-subunit of rapamycin results in loss of immunosuppressive activity. Bioorganic & Medicinal Chemistry Letters. 9(3). 459–462. 7 indexed citations
13.
Sedrani, Richard, Sylvain Cottens, Joerg Kallen, & W. Schüler. (1998). Chemical modification of rapamycin: the discovery of SDZ RAD. Transplantation Proceedings. 30(5). 2192–2194. 120 indexed citations
14.
Sedrani, Richard, et al.. (1998). Dihydroxylation of the Triene Subunit of Rapamycin. The Journal of Organic Chemistry. 63(26). 10069–10073. 3 indexed citations
15.
Schüler, W., Richard Sedrani, Sylvain Cottens, et al.. (1997). SDZ RAD, A NEW RAPAMYCIN DERIVATIVE. Transplantation. 64(1). 36–42. 476 indexed citations
16.
Marshall, James A. & Richard Sedrani. (1991). A convergent, highly stereoselective synthesis of a C-11-C-21 subunit of the macbecins. The Journal of Organic Chemistry. 56(19). 5496–5498. 34 indexed citations
17.
Alexakis, A., Richard Sedrani, J. F. NORMANT, & Pierre Mangeney. (1990). Chiral aminal templates 3 diastereoselectivity of organometallic attack on aldehydes bearing a chiral imidazolidine group. Tetrahedron Asymmetry. 1(5). 283–286. 25 indexed citations
18.
Alexakis, A., Richard Sedrani, & Pierre Mangeney. (1990). Stereochemical effects of trimethylsilyl chloride (TMSCl) on the conjugate addition of organocopper reagents. Tetrahedron Letters. 31(3). 345–348. 22 indexed citations
19.
Alexakis, A., Richard Sedrani, Pierre Mangeney, & J. F. NORMANT. (1988). Diastereoselective conjugate addition with acetals, oxazolidines and imidazolidines as chiral auxiliaries. Tetrahedron Letters. 29(35). 4411–4414. 33 indexed citations
20.
Alexakis, Alexandre, et al.. (1988). Chiral acetals in enantio- and diastereoselective substitution or elimination reactions. Pure and Applied Chemistry. 60(1). 49–56. 37 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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