Stephen H. Leppla

23.4k citations

301 papers · 18.3k indexed · 3 hit papers · h-index 77

Impact in

Biotechnology top 0.02%
- Microbial Inactivation Methods
Virology top 0.5%

Papers in

Biotechnology 93
- Microbial Inactivation Methods 74
- Transgenic Plants and Applications 20
Virology 27
- Poxvirus research and outbreaks 23

Co-authors: Mahtab Moayeri Shihui Liu Kurt R. Klimpel V M Gordon Naveen Arora Robert Liddington Gijs R. van den Brink Laurence Abrami
Journals: Infection and Immunity (37 papers)Journal of Biological Chemistry (23 papers)Proceedings of the National Academy of Sciences (17 papers)PLoS ONE (11 papers)PLoS Pathogens (9 papers)
Partner nations: United States India United Kingdom

In The Last Decade

Stephen H. Leppla

294 papers receiving 17.7k citations

Hit Papers

align trajectories log scale

Proteolytic Inactivation of MAP-Kinase-Kinase by Anthrax Lethal Factor 1998 · 824 citations

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if any of the following hold:

it has ≥500 total citations;
it reaches ≥1.5× the top-1% citation threshold for papers in the same subfield and year (the threshold is the minimum needed to enter the top 1%, not the average within it);
it reaches the top citation threshold in at least one of its specific research topics.

1998 Science
1997 Nature
1982 Proceedings of the National Academy of Sciences

Peers

Countries citing papers authored by Stephen H. Leppla

Since Specialization

Citations

This map shows the geographic impact of Stephen H. Leppla's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Stephen H. Leppla with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Stephen H. Leppla more than expected).

Fields of papers citing papers by Stephen H. Leppla

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Stephen H. Leppla. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Stephen H. Leppla. The network helps show where Stephen H. Leppla may publish in the future.

Co-authors

The 25 scholars most cited alongside Stephen H. Leppla, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Stephen H. Leppla Line = papers co-authored together Stephen H. Leppla links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

#	Work
1	Structural basis of R-loop recognition by the S9.6 monoclonal antibody Nature Communications ·Charles Bou‐Nader, Ankur Bothra, David N. Garboczi, Stephen H. Leppla, Jinwei Zhang	2022	51
2	ERK and c-Myc signaling in host-derived tumor endothelial cells is essential for solid tumor growth Proceedings of the National Academy of Sciences ·Zehua Zuo, Jie Liu, Zhihao Sun, Yu‐Wei Cheng, Michael Ewing, Thomas Bugge, Toren Finkel, Stephen H. Leppla, Shihui Liu	2022	19
3	Selective targeting of metastatic ovarian cancer using an engineered anthrax prodrug activated by membrane-anchored serine proteases Proceedings of the National Academy of Sciences ·Nadire Duru, Nisha R. Pawar, Erik W. Martin, Marguerite S. Buzza, Gregory D. Conway, Rena G. Lapidus, Shihui Liu, Jocelyn Reader, Gautam G. Rao, Dana M. Roque, Stephen H. Leppla, Toni Antalis	2022	8
4	PrkC, a Transmembrane Serine/Threonine Protein Kinase, Regulates Bacterial Chain Length in Bacillus anthracis Journal of Bacteriology ·Neha Dhasmana, Nishant Kumar, Aakriti Gangwal, Chetkar Chandra Keshavam, Lalit Kumar Singh, Nitika Sangwan, Payal Nashier, Sagarika Biswas, Andrei P. Pomerantsev, Stephen H. Leppla, Yogendra Singh, Meetu Gupta	2021	6
5	The Crystal Structure of Bacillus cereus HblL1 Toxins ·Harley L. Worthy, Lainey J. Williamson, Husam Sabah Auhim, Stephen H. Leppla, Inka Sastalla, Rochelle D. Ahmed, P.J. Rizkallah, Colin Berry	2021	8
6	Characterization of the NLRP1 inflammasome response in bovine species Innate Immunity ·Catherine E. Vrentas, Paola M. Boggiatto, Steven C. Olsen, Stephen H. Leppla, Mahtab Moayeri	2019	5
7	Anthrax edema toxin disrupts distinct steps in Rab11-dependent junctional transport PLoS Pathogens ·Annabel Guichard, Prashant Jain, Mahtab Moayeri, Ruth Schwartz, Stephen Chin, Lin Zhu, Beatriz Cruz-Moreno, Janet Z. Liu, Bernice Aguilar, Andrew Hollands, Stephen H. Leppla, Victor Nizet, Ethan Bier	2017	11
8	Inhibition of Tumor Angiogenesis by the Matrix Metalloproteinase–Activated Anthrax Lethal Toxin in an Orthotopic Model of Anaplastic Thyroid Carcinoma Molecular Cancer Therapeutics ·Randall W. Alfano, Stephen H. Leppla, Shihui Liu, Thomas Bugge, Janelle Ortiz, Terry C. Lairmore, Nicholas S. Duesbery, Ian C. Mitchell, Fiemu E. Nwariaku, Arthur E. Frankel	2010	26
9	Selective abrogation of the uPA-uPAR interaction in vivo reveals a novel role in suppression of fibrin-associated inflammation Blood ·B. Connolly, Eun Young Choi, Henrik Gårdsvoll, Alexandra L. Bey, Brooke M. Currie, Triantafyllos Chavakis, Shihui Liu, Alfredo A. Molinolo, Michael Ploug, Stephen H. Leppla, Thomas Bugge	2010	72
10	Matrix Metalloproteinase–Activated Anthrax Lethal Toxin Inhibits Endothelial Invasion and Neovasculature Formation during In vitro Morphogenesis Molecular Cancer Research ·Randall W. Alfano, Stephen H. Leppla, Shihui Liu, Thomas Bugge, Cynthia J. Meininger, Terry C. Lairmore, Arlynn F. Mulne, Samuel Davis, Nicholas S. Duesbery, Arthur E. Frankel	2009	16
11	Capillary morphogenesis protein-2 is the major receptor mediating lethality of anthrax toxin in vivo Proceedings of the National Academy of Sciences ·Shihui Liu, Devorah Crown, Sharmina Miller-Randolph, Mahtab Moayeri, Hailun Wang, Haijing Hu, Thomas Morley, Stephen H. Leppla	2009	118
12	Cytotoxicity of the matrix metalloproteinase–activated anthrax lethal toxin is dependent on gelatinase expression and B-RAF status in human melanoma cells Molecular Cancer Therapeutics ·Randall W. Alfano, Stephen H. Leppla, Shihui Liu, Thomas Bugge, Meenhard Herlyn, Keiran S.M. Smalley, Jennifer L. Bromberg-White, Nicholas S. Duesbery, Arthur E. Frankel	2008	16
13	Systematic Urokinase-Activated Anthrax Toxin Therapy Produces Regressions of Subcutaneous Human Non–Small Cell Lung Tumor in Athymic Nude Mice Cancer Research ·Yunpeng Su, Janelle Ortiz, Shihui Liu, Thomas Bugge, Ravibhushan Singh, Stephen H. Leppla, Arthur E. Frankel	2007	24
14	Receptor palmitoylation and ubiquitination regulate anthrax toxin endocytosis The Journal of Cell Biology ·Laurence Abrami, Stephen H. Leppla, Gijs R. van den Brink	2006	163
15	Blocking anthrax lethal toxin at the protective antigen channel by using structure-inspired drug design Proceedings of the National Academy of Sciences ·Vladimir A. Karginov, Ekaterina M. Nestorovich, Mahtab Moayeri, Stephen H. Leppla, Sergey M. Bezrukov	2005	102
16	Anthrax toxin triggers endocytosis of its receptor via a lipid raft–mediated clathrin-dependent process The Journal of Cell Biology ·Laurence Abrami, Shihui Liu, Pierre Cosson, Stephen H. Leppla, Gijs R. van den Brink	2003	383
17	Bacillus anthracis lethal toxin induces TNF-α–independent hypoxia-mediated toxicity in mice Journal of Clinical Investigation ·Mahtab Moayeri, Diana C. Haines, Howard A. Young, Stephen H. Leppla	2003	246
18	Development of an improved vaccine for anthrax Journal of Clinical Investigation ·Stephen H. Leppla, John B. Robbins, Rachel Schneerson, Joseph Shiloach	2002	96
19	Development of an improved vaccine for anthrax Journal of Clinical Investigation ·Stephen H. Leppla, John B. Robbins, Rachel Schneerson, Joseph Shiloach	2002	94
20	[13] Purification and characterization of adenylyl cyclase from Bacillus anthracis Methods in enzymology on CD-ROM/Methods in enzymology ·Stephen H. Leppla	1991	29

About Stephen H. Leppla

Stephen H. Leppla is a scholar working on Biotechnology, Virology, Genetics, Molecular Biology and Immunology, having authored 301 papers that have together received 18.3k indexed citations. Recurring topics across this work include Bacillus and Francisella bacterial research (243 papers), Bacterial Genetics and Biotechnology (127 papers), Microbial Inactivation Methods (74 papers), Bacteriophages and microbial interactions (64 papers), Toxin Mechanisms and Immunotoxins (46 papers), Poxvirus research and outbreaks (23 papers), Viral Infections and Outbreaks Research (23 papers) and Transgenic Plants and Applications (20 papers). The work is most often cited by research in Biotechnology (4.1k citations), Virology (1.3k citations), Genetics (6.6k citations), Molecular Biology (14.9k citations) and Immunology (3.6k citations). Stephen H. Leppla has collaborated with scholars based in United States, India and United Kingdom. Frequent co-authors include Mahtab Moayeri, Shihui Liu, Kurt R. Klimpel, V M Gordon, Naveen Arora, Robert Liddington, Gijs R. van den Brink, Laurence Abrami, Devorah Crown and Thomas Bugge. Their work appears in journals such as Infection and Immunity, Journal of Biological Chemistry, Proceedings of the National Academy of Sciences, PLoS ONE and PLoS Pathogens.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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