Shyun Li

4.2k citations

19 papers · 3.3k indexed · 3 hit papers · h-index 14

Immunology top 1%
Cancer Research top 1%
Molecular Biology top 10%
Oncology top 10%
Epidemiology top 10%

Co-authors: Holger Wesche Zhaodan Cao William J. Henzel Wendy Shillinglaw Astrid Strelow Xiong Gao Jianing Huang Nigel P.C. Walker
Topics: Immune Response and Inflammation (8 papers)NF-κB Signaling Pathways (7 papers)Monoclonal and Polyclonal Antibodies Research (3 papers)
Cited by: Immunology Cancer Research Microbiology
Journals: Nature Proceedings of the National Academy of Sciences Journal of Biological Chemistry
Partner nations: United States Germany Switzerland

In The Last Decade

Shyun Li

19 papers receiving 3.2k citations

Hit Papers

align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

MyD88: An Adapter That Recruits IRAK to the IL-1 Receptor Complex

1997 944 citations Holger Wesche, William J. Henzel et al. Immunity profile →
Severe impairment of interleukin-1 and Toll-like receptor signalling in mice lacking IRAK-4

2002 650 citations Nobutaka Suzuki, Shinobu Suzuki et al. Nature profile →
IRAK-4: A novel member of the IRAK family with the properties of an IRAK-kinase

2002 546 citations Shyun Li, Astrid Strelow et al. Proceedings of the National Academy of Sciences profile →

Peers

Countries citing papers authored by Shyun Li

Since Specialization

Citations

This map shows the geographic impact of Shyun Li's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Shyun Li with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Shyun Li more than expected).

Fields of papers citing papers by Shyun Li

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Shyun Li. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Shyun Li. The network helps show where Shyun Li may publish in the future.

Co-authorship network of co-authors of Shyun Li

This figure shows the co-authorship network connecting the top 25 collaborators of Shyun Li. A scholar is included among the top collaborators of Shyun Li based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Shyun Li. Shyun Li is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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19 of 19 papers shown

#	Work	Indexed citations
1	The PSMA-targeting Half-life Extended BiTE Therapy AMG 160 has Potent Antitumor Activity in Preclinical Models of Metastatic Castration-resistant Prostate Cancer 2021 ·Clinical Cancer Research ·Petra Deegen,Oliver S. Thomas,Olivier Nolan-Stevaux,Shyun Li,Joachim Wahl,(unknown),Famke Aeffner,Matthias Friedrich,Michael Z. Liao,Katja Matthes,Doris Rau,Benno Rattel,Tobias Raum,Peter Kufer,Angela Coxon,Julie M. Bailis	58
2	Combination of AMG 160, a PSMA x CD3 half-life extended bispecific T-cell engager (HLE BiTE) immune therapy, with an anti-PD-1 antibody in prostate cancer (PCa). 2020 ·Journal of Clinical Oncology ·(unknown),Shyun Li,Julie M. Bailis,Gloria Juan	5
3	Abstract 3364: Preclinical evaluation of BiTE®immune therapy targeting MUC17 or CLDN18.2 for gastric cancer 2020 ·Cancer Research ·Julie M. Bailis,Petra Lutterbuese,Oliver S. Thomas,Kathrin Locher,John M. Harrold,Michael Boyle,Joachim Wahl,Shyun Li,Alexander Sternjak,Anja Henn,(unknown),(unknown),Benno Rattel,Tobias Raum,Angela Coxon	8
4	Preclinical evaluation of AMG 160, a next-generation bispecific T cell engager (BiTE) targeting the prostate-specific membrane antigen PSMA for metastatic castration-resistant prostate cancer (mCRPC). 2019 ·Journal of Clinical Oncology ·Julie M. Bailis,Petra Deegen,Oliver S. Thomas,(unknown),Joachim Wahl,(unknown),Shyun Li,Katja Matthes,(unknown),Doris Rau,Benno Rattel,Tobias Raum,Peter Kufer,Angela Coxon	17
5	Pillars Article: MyD88: An Adapter That Recruits IRAK to the IL-1 Receptor Complex. Immunity. 1997. 7: 837–847 2013 ·The Journal of Immunology ·Holger Wesche,William J. Henzel,Wendy Shillinglaw,Shyun Li,Zhaodan Cao	4
6	Pillars article: MyD88: an adapter that recruits IRAK to the IL-1 receptor complex. Immunity. 1997. 7: 837-847. 2013 ·PubMed ·Holger Wesche,William J. Henzel,Wendy Shillinglaw,Shyun Li,Zhaodan Cao	12
7	Synthesis and optimization of substituted furo[2,3-d]-pyrimidin-4-amines and 7H-pyrrolo[2,3-d]pyrimidin-4-amines as ACK1 inhibitors 2012 ·Bioorganic & Medicinal Chemistry Letters ·Xian‐Yun Jiao,David J. Kopecky,Jinsong Liu,Jinqian Liu,Juan C. Jaén,Mario Cardozo,Rajiv Sharma,Nigel P.C. Walker,Holger Wesche,Shyun Li,Ellyn Farrelly,Shou-Hua Xiao,Zhulun Wang,Frank Kayser	58
8	Structure-Guided Design, Synthesis, and Evaluation of Guanine-Derived Inhibitors of the eIF4E mRNA–Cap Interaction 2012 ·Journal of Medicinal Chemistry ·Xiaoqi Chen,David J. Kopecky,Jeff Mihalic,Shawn Jeffries,Xiaoshan Min,Julie A. Heath,(unknown),Sujen Lai,Zice Fu,Cristiano R. W. Guimarães,(unknown),Shyun Li,Sheree Johnstone,(unknown),Haoda Xu,Mario Cardozo,Shen Wang,Nigel P.C. Walker,Frank Kayser,Zhulun Wang	190
9	The Growth Factor Midkine Antagonizes VEGF Signaling In Vitro and In Vivo 2008 ·Neoplasia ·Edward H. van der Horst,Brendon Frank,Lawrence Chinn,Angela Coxon,Shyun Li,Fanny Polesso,Anthony Slavin,Astrid Ruefli-Brasse,Holger Wesche	31
10	Identification and optimization of N3,N6-diaryl-1H-pyrazolo[3,4-d]pyrimidine-3,6-diamines as a novel class of ACK1 inhibitors 2008 ·Bioorganic & Medicinal Chemistry Letters ·David J. Kopecky,Xiaolin Hao,Yi Chen,Jiasheng Fu,Xian‐Yun Jiao,Juan C. Jaén,Mario Cardozo,Jinsong Liu,Zhulun Wang,Nigel P.C. Walker,Holger Wesche,Shyun Li,Ellyn Farrelly,Shou-Hua Xiao,Frank Kayser	31
11	An ultrasensitive high-throughput electrochemiluminescence immunoassay for the Cdc42-associated protein tyrosine kinase ACK1 2007 ·Analytical Biochemistry ·Shou-Hua Xiao,Ellyn Farrelly,John V. Anzola,(unknown),Xian‐Yun Jiao,Jinqian Liu,(unknown),Shyun Li,Linda Huang,Rajiv Sharma,Frank Kayser,Holger Wesche,Stephen W. Young	8
12	Discovery and initial SAR of inhibitors of interleukin-1 receptor-associated kinase-4 2006 ·Bioorganic & Medicinal Chemistry Letters ·Jay P. Powers,Shyun Li,Juan C. Jaén,Jinqian Liu,Nigel P.C. Walker,Zhulun Wang,Holger Wesche	99
13	Crystal Structures of IRAK-4 Kinase in Complex with Inhibitors: A Serine/Threonine Kinase with Tyrosine as a Gatekeeper 2006 ·Structure ·Zhulun Wang,Jinsong Liu,Athena Sudom,(unknown),Shyun Li,Holger Wesche,Jay P. Powers,Nigel P.C. Walker	116
14	Metastatic properties and genomic amplification of the tyrosine kinase gene ACK1 2005 ·Proceedings of the National Academy of Sciences ·Edward H. van der Horst,Yan Degenhardt,Astrid Strelow,Anthony Slavin,Lawrence Chinn,Jessica Orf,Minqing Rong,Shyun Li,(unknown),(unknown),Timothy Hoey,Holger Wesche,Scott Powers	116
15	Sequential Autophosphorylation Steps in the Interleukin-1 Receptor-associated Kinase-1 Regulate its Availability as an Adapter in Interleukin-1 Signaling 2004 ·Journal of Biological Chemistry ·Christian Kollewe,(unknown),Detlef Neumann,Johannes Knop,Ping Cao,Shyun Li,Holger Wesche,Michael U. Martin	205
16	Severe impairment of interleukin-1 and Toll-like receptor signalling in mice lacking IRAK-4breakdown → 2002 ·Nature ·Nobutaka Suzuki,Shinobu Suzuki,Gordon S. Duncan,Douglas G. Millar,Teiji Wada,Christine Mirtsos,Hidetoshi Takada,Andrew Wakeham,Annick Itié,Shyun Li,Josef Penninger,Holger Wesche,Pamela S. Ohashi,Tak W. Mak,Wen-Chen Yeh	650
17	IRAK-4: A novel member of the IRAK family with the properties of an IRAK-kinasebreakdown → 2002 ·Proceedings of the National Academy of Sciences ·Shyun Li,Astrid Strelow,(unknown),Holger Wesche	546
18	MyD88: An Adapter That Recruits IRAK to the IL-1 Receptor Complexbreakdown → 1997 ·Immunity ·Holger Wesche,William J. Henzel,Wendy Shillinglaw,Shyun Li,Zhaodan Cao	944
19	Recruitment of IRAK to the interleukin 1 receptor complex requires interleukin 1 receptor accessory protein 1997 ·Proceedings of the National Academy of Sciences ·Jianing Huang,Xiong Gao,Shyun Li,Zhaodan Cao	178

About Shyun Li

Shyun Li is a scholar working on Cancer Research, Immunology and Oncology, having authored 19 papers that have together received 3.3k indexed citations. Recurring topics across this work include Immune Response and Inflammation (8 papers), NF-κB Signaling Pathways (7 papers) and Monoclonal and Polyclonal Antibodies Research (3 papers). The work is most often cited by research in Immunology (2.3k citations), Cancer Research (1.1k citations) and Microbiology (123 citations). Shyun Li has collaborated with scholars based in United States, Germany and Switzerland. Frequent co-authors include Holger Wesche, Zhaodan Cao, William J. Henzel, Wendy Shillinglaw, Astrid Strelow, Xiong Gao, Jianing Huang, Nigel P.C. Walker, Josef Penninger and Douglas G. Millar. Their work appears in journals such as Nature, Proceedings of the National Academy of Sciences and Journal of Biological Chemistry.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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