Shyun Li

4.2k total citations · 3 hit papers
19 papers, 3.3k citations indexed

About

Shyun Li is a scholar working on Molecular Biology, Immunology and Cancer Research. According to data from OpenAlex, Shyun Li has authored 19 papers receiving a total of 3.3k indexed citations (citations by other indexed papers that have themselves been cited), including 10 papers in Molecular Biology, 10 papers in Immunology and 8 papers in Cancer Research. Recurrent topics in Shyun Li's work include Immune Response and Inflammation (8 papers), NF-κB Signaling Pathways (7 papers) and Monoclonal and Polyclonal Antibodies Research (3 papers). Shyun Li is often cited by papers focused on Immune Response and Inflammation (8 papers), NF-κB Signaling Pathways (7 papers) and Monoclonal and Polyclonal Antibodies Research (3 papers). Shyun Li collaborates with scholars based in United States, Germany and Switzerland. Shyun Li's co-authors include Holger Wesche, Zhaodan Cao, William J. Henzel, Wendy Shillinglaw, Astrid Strelow, Xiong Gao, Jianing Huang, Nigel P.C. Walker, Josef Penninger and Douglas G. Millar and has published in prestigious journals such as Nature, Proceedings of the National Academy of Sciences and Journal of Biological Chemistry.

In The Last Decade

Shyun Li

19 papers receiving 3.2k citations

Hit Papers

align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

MyD88: An Adapter That Recruits IRAK to the IL-1 Receptor Complex

1997 944 citations Holger Wesche, William J. Henzel et al. Immunity profile →
Severe impairment of interleukin-1 and Toll-like receptor signalling in mice lacking IRAK-4

2002 650 citations Nobutaka Suzuki, Shinobu Suzuki et al. Nature profile →
IRAK-4: A novel member of the IRAK family with the properties of an IRAK-kinase

2002 546 citations Shyun Li, Astrid Strelow et al. Proceedings of the National Academy of Sciences profile →

Peers

Shyun Li

IMMUN

ONCOL

EPIDE

Jugnu Jain United States

Jean‐Luc Poyet France

Vijay Baichwal United States

Stacie A. Dalrymple United States

Euphemia Leung New Zealand

Patricia M. Cameron United States

Scott J. Snipas United States

Siquan Sun United States

Lyudmila G. Burdelya United States

Liping Wang China

Jugnu Jain United States

Shyun Li

1.6k ×0.7

IMMUN

856 ×0.8

2.8k ×2.7

722 ×1.6

ONCOL

319 ×1.3

EPIDE

Citations per year, relative to Shyun Li Shyun Li (= 1×) peers Jugnu Jain

Countries citing papers authored by Shyun Li

Since Specialization

Citations

This map shows the geographic impact of Shyun Li's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Shyun Li with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Shyun Li more than expected).

Fields of papers citing papers by Shyun Li

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Shyun Li. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Shyun Li. The network helps show where Shyun Li may publish in the future.

Co-authorship network of co-authors of Shyun Li

This figure shows the co-authorship network connecting the top 25 collaborators of Shyun Li. A scholar is included among the top collaborators of Shyun Li based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Shyun Li. Shyun Li is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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19 of 19 papers shown

Deegen, Petra, Oliver S. Thomas, Olivier Nolan-Stevaux, et al.. (2021). The PSMA-targeting Half-life Extended BiTE Therapy AMG 160 has Potent Antitumor Activity in Preclinical Models of Metastatic Castration-resistant Prostate Cancer. Clinical Cancer Research. 27(10). 2928–2937. 58 indexed citations

Li, Shyun, et al.. (2020). Combination of AMG 160, a PSMA x CD3 half-life extended bispecific T-cell engager (HLE BiTE) immune therapy, with an anti-PD-1 antibody in prostate cancer (PCa).. Journal of Clinical Oncology. 38(6_suppl). 155–155. 5 indexed citations

Bailis, Julie M., Petra Lutterbuese, Oliver S. Thomas, et al.. (2020). Abstract 3364: Preclinical evaluation of BiTE®immune therapy targeting MUC17 or CLDN18.2 for gastric cancer. Cancer Research. 80(16_Supplement). 3364–3364. 8 indexed citations

Bailis, Julie M., Petra Deegen, Oliver S. Thomas, et al.. (2019). Preclinical evaluation of AMG 160, a next-generation bispecific T cell engager (BiTE) targeting the prostate-specific membrane antigen PSMA for metastatic castration-resistant prostate cancer (mCRPC).. Journal of Clinical Oncology. 37(7_suppl). 301–301. 17 indexed citations

Wesche, Holger, William J. Henzel, Wendy Shillinglaw, Shyun Li, & Zhaodan Cao. (2013). Pillars Article: MyD88: An Adapter That Recruits IRAK to the IL-1 Receptor Complex. Immunity. 1997. 7: 837–847. The Journal of Immunology. 190(1). 5–15. 4 indexed citations

Wesche, Holger, William J. Henzel, Wendy Shillinglaw, Shyun Li, & Zhaodan Cao. (2013). Pillars article: MyD88: an adapter that recruits IRAK to the IL-1 receptor complex. Immunity. 1997. 7: 837-847.. PubMed. 190(1). 5–15. 12 indexed citations

Jiao, Xian‐Yun, David J. Kopecky, Jinsong Liu, et al.. (2012). Synthesis and optimization of substituted furo[2,3-d]-pyrimidin-4-amines and 7H-pyrrolo[2,3-d]pyrimidin-4-amines as ACK1 inhibitors. Bioorganic & Medicinal Chemistry Letters. 22(19). 6212–6217. 58 indexed citations

Chen, Xiaoqi, David J. Kopecky, Jeff Mihalic, et al.. (2012). Structure-Guided Design, Synthesis, and Evaluation of Guanine-Derived Inhibitors of the eIF4E mRNA–Cap Interaction. Journal of Medicinal Chemistry. 55(8). 3837–3851. 190 indexed citations

Horst, Edward H. van der, Brendon Frank, Lawrence Chinn, et al.. (2008). The Growth Factor Midkine Antagonizes VEGF Signaling In Vitro and In Vivo. Neoplasia. 10(4). 340–IN3. 31 indexed citations

10.

Kopecky, David J., Xiaolin Hao, Yi Chen, et al.. (2008). Identification and optimization of N3,N6-diaryl-1H-pyrazolo[3,4-d]pyrimidine-3,6-diamines as a novel class of ACK1 inhibitors. Bioorganic & Medicinal Chemistry Letters. 18(24). 6352–6356. 31 indexed citations

11.

Xiao, Shou-Hua, Ellyn Farrelly, John V. Anzola, et al.. (2007). An ultrasensitive high-throughput electrochemiluminescence immunoassay for the Cdc42-associated protein tyrosine kinase ACK1. Analytical Biochemistry. 367(2). 179–189. 8 indexed citations

12.

Powers, Jay P., Shyun Li, Juan C. Jaén, et al.. (2006). Discovery and initial SAR of inhibitors of interleukin-1 receptor-associated kinase-4. Bioorganic & Medicinal Chemistry Letters. 16(11). 2842–2845. 99 indexed citations

13.

Wang, Zhulun, Jinsong Liu, Athena Sudom, et al.. (2006). Crystal Structures of IRAK-4 Kinase in Complex with Inhibitors: A Serine/Threonine Kinase with Tyrosine as a Gatekeeper. Structure. 14(12). 1835–1844. 116 indexed citations

14.

Horst, Edward H. van der, Yan Degenhardt, Astrid Strelow, et al.. (2005). Metastatic properties and genomic amplification of the tyrosine kinase gene ACK1. Proceedings of the National Academy of Sciences. 102(44). 15901–15906. 116 indexed citations

15.

Kollewe, Christian, Detlef Neumann, Johannes Knop, et al.. (2004). Sequential Autophosphorylation Steps in the Interleukin-1 Receptor-associated Kinase-1 Regulate its Availability as an Adapter in Interleukin-1 Signaling. Journal of Biological Chemistry. 279(7). 5227–5236. 205 indexed citations

16.

Suzuki, Nobutaka, Shinobu Suzuki, Gordon S. Duncan, et al.. (2002). Severe impairment of interleukin-1 and Toll-like receptor signalling in mice lacking IRAK-4. Nature. 416(6882). 750–754. 650 indexed citations breakdown →

17.

Li, Shyun, et al.. (2002). IRAK-4: A novel member of the IRAK family with the properties of an IRAK-kinase. Proceedings of the National Academy of Sciences. 99(8). 5567–5572. 546 indexed citations breakdown →

18.

Wesche, Holger, William J. Henzel, Wendy Shillinglaw, Shyun Li, & Zhaodan Cao. (1997). MyD88: An Adapter That Recruits IRAK to the IL-1 Receptor Complex. Immunity. 7(6). 837–847. 944 indexed citations breakdown →

19.

Huang, Jianing, Xiong Gao, Shyun Li, & Zhaodan Cao. (1997). Recruitment of IRAK to the interleukin 1 receptor complex requires interleukin 1 receptor accessory protein. Proceedings of the National Academy of Sciences. 94(24). 12829–12832. 178 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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