Holger Wesche

9.6k citations

47 papers · 7.7k indexed · 6 hit papers · h-index 29

Impact in

Immunology top 0.2%
- Immune Response and Inflammation
- Immune Cell Function and Interaction
- interferon and immune responses
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
Cancer Research top 0.5%
- NF-κB Signaling Pathways

Papers in

Immunology 25
- Immune Response and Inflammation 22
- Immune Cell Function and Interaction 8
Cancer Research 17
- NF-κB Signaling Pathways 15

Co-authors: Carsten J. Kirschning Mike Rothe Shyun Li Ralf Schwandner Roman Dziarski Michael U. Martin Zhaodan Cao William J. Henzel
Journals: Journal of Biological Chemistry (6 papers)Cancer Research (6 papers)Bioorganic & Medicinal Chemistry Letters (4 papers)FEBS Letters (3 papers)The Journal of Immunology (3 papers)
Partner nations: United States Germany United Kingdom

In The Last Decade

Holger Wesche

47 papers receiving 7.5k citations

Hit Papers

6 papers align trajectories log scale

Severe impairment of interleukin-1 and Toll-like receptor signalling in mice lacking IRAK-4 2002 · 650 citations

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if any of the following hold:

it has ≥500 total citations;
it reaches ≥1.5× the top-1% citation threshold for papers in the same subfield and year (the threshold is the minimum needed to enter the top 1%, not the average within it);
it reaches the top citation threshold in at least one of its specific research topics.

2002 Nature
2002 Proceedings of the National Academy of Sciences
1999 The Journal of Immunology
1999 Journal of Biological Chemistry
1998 The Journal of Experimental Medicine
1997 Immunity

Peers

Countries citing papers authored by Holger Wesche

Since Specialization

Citations

This map shows the geographic impact of Holger Wesche's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Holger Wesche with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Holger Wesche more than expected).

Fields of papers citing papers by Holger Wesche

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Holger Wesche. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Holger Wesche. The network helps show where Holger Wesche may publish in the future.

Co-authorship network

The 25 scholars most cited alongside Holger Wesche, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Holger Wesche Line = papers co-authored together Holger Wesche links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

#	Work
1	Abstract 5070: Anti-tumor activity of HPN328, a DLL3-targeting tri-specific, half-life extended T cell engager, is enhanced by combining with an anti-PD-L1 antibody in an immunocompetent mouse model Cancer Research ·Anita Dili, Murray Elkins, Wade H. Aaron, Lucas Matheus Barreto Santana, St Mirna Apriani, Sen Lin, Lorenzo J. López, Valeriya Sergeyevna Myuller, Holger Wesche, amogh amogh, Banmeet S. Anand	2023	2
2	Abstract 4131: Long-term anti-tumor immunity induced by of HPN328, a DLL3-targeting trispecific, half-life extended T cell engager, in a preclinical immunocompetent mouse model Cancer Research ·amogh amogh, Anita Dili, Murray Elkins, Holger Wesche, Banmeet S. Anand	2023	1
3	Preclinical Characterization of HPN536, a Trispecific, T-Cell–Activating Protein Construct for the Treatment of Mesothelin-Expressing Solid Tumors Clinical Cancer Research ·amogh amogh, Richard J. Austin, Bryan D. Lemon, Wade H. Aaron, Patrick L. Cox, Heldalia Heldalia, Susan Dana Jones, Karen Yamile Díaz Otero, Chelsea A Allen-Brough, Kenneth G. Sexton, Lori Nerbonne, Timothy Z. Yu, Patrick A. Baeuerle, Che‐Leung Law, Holger Wesche	2020	35
4	Synthesis and optimization of substituted furo[2,3-d]-pyrimidin-4-amines and 7H-pyrrolo[2,3-d]pyrimidin-4-amines as ACK1 inhibitors Bioorganic & Medicinal Chemistry Letters ·Xian‐Yun Jiao, David J. Kopecky, Jinsong Liu, Jinqian Liu, Juan C. Jaén, Mario Cardozo, Rajiv Sharma, Nigel P.C. Walker, Holger Wesche, Shyun Li, Ellyn Farrelly, Shou-Hua Xiao, Zhulun Wang, Frank Kayser	2012	58
5	IRAK1 and IRAK4 Promote Phosphorylation, Ubiquitination, and Degradation of MyD88 Adaptor-like (Mal) Journal of Biological Chemistry ·Aisling Dunne, Susan Carpenter, Constantinos Brikos, Pearl Gray, Astrid Strelow, Holger Wesche, Nick Morrice, Luke O'neill	2010	60
6	Molecular Signatures of the Primitive Prostate Stem Cell Niche Reveal Novel Mesenchymal-Epithelial Signaling Pathways PLoS ONE ·Roy Blum, Stefano Forneris, Patricia E. Burger, Christopher S. Ontiveros, Sarah N. Salm, Xiaozhong Xiong, Alexander Kamb, Holger Wesche, Lisa A. Marshall, Gene Cutler, Xiangyun Wang, Jiří Zavadil, David Moscatelli, E. Lynette Wilson	2010	19
7	Molecular Signatures of Prostate Stem Cells Reveal Novel Signaling Pathways and Provide Insights into Prostate Cancer PLoS ONE ·Roy Blum, Rashmi Gupta, Patricia E. Burger, Christopher S. Ontiveros, Sarah N. Salm, Xiaozhong Xiong, Alexander Kamb, Holger Wesche, Lisa A. Marshall, Gene Cutler, Xiangyun Wang, Jiří Zavadil, David Moscatelli, E. Lynette Wilson	2009	54
8	The Growth Factor Midkine Antagonizes VEGF Signaling In Vitro and In Vivo Neoplasia ·Edward H. van der Horst, Brendon Frank, Lawrence Chinn, Angela Coxon, Shyun Li, Fanny Polesso, Anthony Slavin, Astrid Ruefli-Brasse, Holger Wesche	2008	31
9	Identification and optimization of N3,N6-diaryl-1H-pyrazolo[3,4-d]pyrimidine-3,6-diamines as a novel class of ACK1 inhibitors Bioorganic & Medicinal Chemistry Letters ·David J. Kopecky, Xiaolin Hao, Yi Chen, Jiasheng Fu, Xian‐Yun Jiao, Juan C. Jaén, Mario Cardozo, Jinsong Liu, Zhulun Wang, Nigel P.C. Walker, Holger Wesche, Shyun Li, Ellyn Farrelly, Shou-Hua Xiao, Frank Kayser	2008	31
10	Discovery of potent LPA2 (EDG4) antagonists as potential anticancer agents Bioorganic & Medicinal Chemistry Letters ·Hilary P. Beck, Todd J. Kohn, Steven M. Rubenstein, K. S. Long, Ralf Schwandner, Athifah Rifqoh, Kang Dai, Cong Li, Lingming Liang, Holger Wesche, Brendon Frank, احمد اشرف, Dineli Wickramasinghe, Juan C. Jaén, Julio C. Medina, Randall W. Hungate, Shen Wang	2007	36
11	Discovery and initial SAR of inhibitors of interleukin-1 receptor-associated kinase-4 Bioorganic & Medicinal Chemistry Letters ·Jay P. Powers, Shyun Li, Juan C. Jaén, Jinqian Liu, Nigel P.C. Walker, Zhulun Wang, Holger Wesche	2006	99
12	Sequential Autophosphorylation Steps in the Interleukin-1 Receptor-associated Kinase-1 Regulate its Availability as an Adapter in Interleukin-1 Signaling Journal of Biological Chemistry ·Christian Kollewe, 雷朱, Detlef Neumann, Johannes Knop, Ping Cao, Shyun Li, Holger Wesche, Michael U. Martin	2004	205
13	Characterization of Pellino2, a substrate of IRAK1 and IRAK4 FEBS Letters ·Astrid Strelow, Christian Kollewe, Holger Wesche	2003	46
14	Summary and comparison of the signaling mechanisms of the Toll/interleukin-1 receptor family Biochimica et Biophysica Acta (BBA) - Molecular Cell Research ·Michael U. Martin, Holger Wesche	2002	335
15	Identification of Essential Regions in the Cytoplasmic Tail of Interleukin-1 Receptor Accessory Protein Critical for Interleukin-1 Signaling Journal of Biological Chemistry ·Jürgen Radons, S. Gabler, Holger Wesche, Christian Korherr, Robert Hofmeister, Werner Falk	2002	37
16	IRAK-M Is a Novel Member of the Pelle/Interleukin-1 Receptor-associated Kinase (IRAK) Family Journal of Biological Chemistry ·Holger Wesche, Xiong Gao, Xiaoxia Li, Carsten J. Kirschning, George R. Stark, Zhaodan Cao	1999	355
17	The Type II IL-1 Receptor Interacts with the IL-1 Receptor Accessory Protein: A Novel Mechanism of Regulation of IL-1 Responsiveness The Journal of Immunology ·Detlef Lang, Johannes Knop, Holger Wesche, Ute Raffetseder, R. Kurrle, Diana Boraschi, Michael U. Martin	1998	133
18	A critical role for interleukin‐1 receptor accessory protein in interleukin‐1 signaling European Journal of Immunology ·Christian Korherr, Robert Hofmeister, Holger Wesche, Werner Falk	1997	144
19	MyD88: An Adapter That Recruits IRAK to the IL-1 Receptor Complex Immunity ·Holger Wesche, William J. Henzel, Wendy Shillinglaw, Shyun Li, Zhaodan Cao Hit paper breakdown →	1997	944
20	Overexpression of the bcl-2 oncogene in the mouse pre-B cell line SPGM-1 protects from apoptosis, but does not affect blocked B-lineage differentiation and lineage switch towards macrophage like cells Cell Death and Differentiation ·Detlef Neumann, Andreas Strasser, Holger Wesche, Klaus Resch, Michael U. Martin	1997	3

About Holger Wesche

Holger Wesche is a scholar working on Immunology, Cancer Research, Oncology, Radiology, Nuclear Medicine and Imaging and Molecular Biology, having authored 47 papers that have together received 7.7k indexed citations. Recurring topics across this work include Immune Response and Inflammation (22 papers), NF-κB Signaling Pathways (15 papers), Monoclonal and Polyclonal Antibodies Research (8 papers), CAR-T cell therapy research (8 papers), Immune Cell Function and Interaction (8 papers), Cytokine Signaling Pathways and Interactions (6 papers), Inflammasome and immune disorders (5 papers) and Prostate Cancer Treatment and Research (4 papers). The work is most often cited by research in Immunology (5.6k citations), Cancer Research (2.1k citations), Microbiology (713 citations), Parasitology (266 citations) and Oncology (890 citations). Holger Wesche has collaborated with scholars based in United States, Germany and United Kingdom. Frequent co-authors include Carsten J. Kirschning, Mike Rothe, Shyun Li, Ralf Schwandner, Roman Dziarski, Michael U. Martin, Zhaodan Cao, William J. Henzel, Wendy Shillinglaw and Astrid Strelow. Their work appears in journals such as Journal of Biological Chemistry, Cancer Research, Bioorganic & Medicinal Chemistry Letters, FEBS Letters and The Journal of Immunology.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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