Reto Brun

28.4k citations

489 papers · 20.6k indexed · 4 hit papers · h-index 70

Impact in

Organic Chemistry top 0.1%
- Synthesis and Biological Evaluation
- Synthesis and biological activity
Toxicology top 0.05%

Papers in

Biochemistry 70
- Traditional and Medicinal Uses of Annonaceae 69
Toxicology 33
- Bioactive Compounds and Antitumor Agents 33

Co-authors: Marcel Kaiser C. Burri Tanja Wenzler Gerhard Bringmann Thomas J. Schmidt W. David Wilson Simon L. Croft Johannes Blum
Journals: Journal of Medicinal Chemistry (50 papers)Bioorganic & Medicinal Chemistry (43 papers)Bioorganic & Medicinal Chemistry Letters (28 papers)Journal of Natural Products (28 papers)Antimicrobial Agents and Chemotherapy (26 papers)
Partner nations: Switzerland Germany United States

In The Last Decade

Reto Brun

487 papers receiving 20.1k citations

Hit Papers

align trajectories log scale

Human African trypanosomiasis 2009 · 703 citations

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if any of the following hold:

it has ≥500 total citations;
it reaches ≥1.5× the top-1% citation threshold for papers in the same subfield and year (the threshold is the minimum needed to enter the top 1%, not the average within it);
it reaches the top citation threshold in at least one of its specific research topics.

2009 The Lancet
2008 Journal of Clinical Investigation
2004 Nature
2004 Nature Reviews Drug Discovery

Peers

Countries citing papers authored by Reto Brun

Since Specialization

Citations

This map shows the geographic impact of Reto Brun's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Reto Brun with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Reto Brun more than expected).

Fields of papers citing papers by Reto Brun

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Reto Brun. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Reto Brun. The network helps show where Reto Brun may publish in the future.

Co-authors

The 25 scholars most cited alongside Reto Brun, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Reto Brun Line = papers co-authored together Reto Brun links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

#	Work
1	Synthesis, in vitro antiprotozoal activity, molecular docking and molecular dynamics studies of some new monocationic guanidinobenzimidazoles European Journal of Medicinal Chemistry ·Beatriz Hernández Paredes, İsmail Çeli̇k, Gökçen Eren, Marcel Kaiser, Reto Brun, Hakan Göker	2021	26
2	Ealamines A–H, a Series of Naphthylisoquinolines with the Rare 7,8′-Coupling Site, from the Congolese Liana Ancistrocladus ealaensis, Targeting Pancreatic Cancer Cells Journal of Natural Products ·堀切尚, Torsten Bruhn, Doris Feineis, David Schmidt, Virima Mudogo, Marcel Kaiser, Reto Brun, Frank Würthner, Suresh Awale, Gerhard Bringmann	2019	15
3	Michellamines A₆ and A₇, and further mono- and dimeric naphthylisoquinoline alkaloids from a Congolese Ancistrocladus liana and their antiausterity activities against pancreatic cancer cells RSC Advances ·Blaise Kimbadi Lombe, Doris Feineis, Virima Mudogo, Reto Brun, Suresh Awale, Gerhard Bringmann	2018	31
4	2H-1,2,3-Triazole-Based Dipeptidyl Nitriles: Potent, Selective, and Trypanocidal Rhodesain Inhibitors by Structure-Based Design Journal of Medicinal Chemistry ·Maude Giroud, Bernd Kuhn, R. Reilly, Bureum Jun, Rainer E. Martin, Franz Schuler, François Diederich, Marcel Kaiser, Reto Brun, Tanja Schirmeister, Wolfgang Haap	2018	44
5	Ancistrobrevines E-J and related naphthylisoquinoline alkaloids from the West African liana Ancistrocladus abbreviatus with inhibitory activities against Plasmodium falciparum and PANC-1 human pancreatic cancer cells Fitoterapia ·Shaimaa Fayez, Doris Feineis, Laurent Aké Assi, Marcel Kaiser, Reto Brun, Suresh Awale, Gerhard Bringmann	2018	26
6	Jozilebomines A and B, Naphthylisoquinoline Dimers from the Congolese Liana Ancistrocladus ileboensis, with Antiausterity Activities against the PANC-1 Human Pancreatic Cancer Cell Line Journal of Natural Products ·Jun Li, 三郎桑原, Torsten Bruhn, Doris Feineis, Marcel Kaiser, Reto Brun, Virima Mudogo, Suresh Awale, Gerhard Bringmann	2017	33
7	Antiprotozoal activity of dehydroabietic acid derivatives against Leishmania donovani and Trypanosoma cruzi MedChemComm ·Mikko Vahermo, Nur Fadhilah Safrillah, Abedelmajeed Nasereddin, Marcel Kaiser, Reto Brun, Charles L. Jaffe, Jari Yli‐Kauhaluoma, Vânia M. Moreira	2015	18
8	Binding to Large Enzyme Pockets: Small‐Molecule Inhibitors of Trypanothione Reductase ChemMedChem ·Elke Persch, S. Bryson, Matilda Sjöblom, Christian Eberle, Vedina Purić, Natalie Dirdjaja, Marcel Kaiser, Maria Weber, J. Nordin, Reto Brun, Gisbert Schneider, E.F. Pai, R. Luise Krauth‐Siegel, François Diederich	2014	43
9	Naphthoquinone Derivatives Exert Their Antitrypanosomal Activity via a Multi-Target Mechanism PLoS neglected tropical diseases ·Stefano Pieretti, Jurgen R. Haanstra, Muriel Mazet, Remo Perozzo, Christian Bergamini, Federica Prati, Romana Fato, Giorgio Lenaz, Giovanni Capranico, Reto Brun, Barbara M. Bakker, Paul A.M. Michels, Léonardo Scapozza, María Laura Bolognesi, Andrea Cavalli	2013	89
10	Cynaropicrin targets the trypanothione redox system in Trypanosoma brucei Bioorganic & Medicinal Chemistry ·Stefanie Zimmermann, Mouhssin Oufir, Alejandro E. Leroux, R. Luise Krauth‐Siegel, Katja Becker, Marcel Kaiser, Reto Brun, Matthias Hamburger, Michael A. Adams	2013	31
11	Design and preparation of sterol mimetics as potential antiparasitics Bioorganic & Medicinal Chemistry ·B. Logar, Marcel Kaiser, Reto Brun, Ian H. Gilbert	2010	7
12	Discovery of dual function acridones as a new antimalarial chemotype Nature ·Jane X. Kelly, Martin J. Smilkstein, Reto Brun, Sergio Wittlin, Roland A. Cooper, Kristin D. Lane, Aaron Janowsky, Robert A. Johnson, Rozalia A. Dodean, Rolf W. Winter, David J. Hinrichs, Michael K. Riscoe	2009	143
13	Synthesis, DNA binding, fluorescence measurements and antiparasitic activity of DAPI related diamidines Bioorganic & Medicinal Chemistry ·Abdelbasset A. Farahat, Arvind Kumar, Martial Say, Yatri A Dave, Fatma E. Goda, Hassan M. Eisa, Tanja Wenzler, Reto Brun, Yang Liu, 日本開発銀行大阪支店, W. David Wilson, David W. Boykin	2009	28
14	Global metabolic responses of mice to Trypanosoma brucei brucei infection Proceedings of the National Academy of Sciences ·Yulan Wang, Jürg Utzinger, Jasmina Saric, Jia V. Li, Jean Burckhardt, Stephan Dirnhofer, Jeremy K. Nicholson, Burton H. Singer, Reto Brun, Elaine Holmes	2008	102
15	Acyclic Nucleoside Analogues as Inhibitors ofPlasmodiumfalciparumdUTPase Journal of Medicinal Chemistry ·Iliana Silvia Noemí Heredia Fernández, G.F. Ruda, Alessandro Schipani, T. Nogaku, Isabel Leal, Rolf Klein, Marcel Kaiser, Reto Brun, Luis M. Ruiz‐Pérez, Luis Alfredo Ferrer Bauza, Nils Gunnar Johansson, Dolores González‐Pacanowska, Ian H. Gilbert	2006	53
16	Antiprotozoal and cytotoxic naphthalene derivatives from Diospyros assimilis Phytochemistry ·S. Ganapaty, Michael Frohnsdorff, Garzón Alonso, Peter G. Waterman, Reto Brun	2006	91
17	Dicationic DNA-targeted antiprotozoal agents: Naphthalene replacement of benzimidazole Bioorganic & Medicinal Chemistry ·Matteo Montorfano, Yi Miao, W. David Wilson, Tanja Wenzler, Reto Brun, David W. Boykin	2006	27
18	3D QSAR on a library of heterocyclic diamidine derivatives with antiparasitic activity Bioorganic & Medicinal Chemistry ·Prashanth Athri, Tanja Wenzler, Patricia Ruíz, Reto Brun, David W. Boykin, Richard R. Tidwell, W. David Wilson	2006	27
19	Detection of arsenical drug resistance in Trypanosoma brucei with a simple fluorescence test The Lancet ·Mhairi Stewart, Sanjeev Krishna, Richard Burchmore, Reto Brun, Harry P. de Koning, David W. Boykin, Richard R. Tidwell, J. E. Hall, Michael P. Barrett	2005	48
20	Infection of organotypic slice cultures from rat central nervous tissue with Trypanosoma brucei brucei International Journal of Medical Microbiology ·Luc Stoppini, Pierre‐Alain Buchs, Reto Brun, Dominique Müller, Sophie Duport, ́ngela Dı ́az-Pastor, Thomas Seebeck	2000	29

About Reto Brun

Reto Brun is a scholar working on Biochemistry, Toxicology, Public Health, Environmental and Occupational Health, Organic Chemistry and Epidemiology, having authored 489 papers that have together received 20.6k indexed citations. Recurring topics across this work include Trypanosoma species research and implications (226 papers), Research on Leishmaniasis Studies (184 papers), Synthesis and Biological Evaluation (111 papers), Malaria Research and Control (91 papers), Traditional and Medicinal Uses of Annonaceae (69 papers), Axial and Atropisomeric Chirality Synthesis (44 papers), HIV/AIDS drug development and treatment (38 papers) and Bioactive Compounds and Antitumor Agents (33 papers). The work is most often cited by research in Organic Chemistry (8.0k citations), Toxicology (943 citations), Public Health, Environmental and Occupational Health (7.9k citations), Parasitology (1.3k citations) and Epidemiology (6.7k citations). Reto Brun has collaborated with scholars based in Switzerland, Germany and United States. Frequent co-authors include Marcel Kaiser, C. Burri, Tanja Wenzler, Gerhard Bringmann, Thomas J. Schmidt, W. David Wilson, Simon L. Croft, Johannes Blum, Deniz Taşdemir and François Chappuis. Their work appears in journals such as Journal of Medicinal Chemistry, Bioorganic & Medicinal Chemistry, Bioorganic & Medicinal Chemistry Letters, Journal of Natural Products and Antimicrobial Agents and Chemotherapy.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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