Rainer Machauer

1.1k citations

20 papers · 660 indexed · h-index 15

Impact in

Computational Theory and Mathematics top 2%
- Computational Drug Discovery Methods
Pharmacology top 10%
- Cholinesterase and Neurodegenerative Diseases

Papers in

Computational Theory and Mathematics 9
- Computational Drug Discovery Methods 9
Physiology 10
- Alzheimer's disease research and treatments 8
- Nitric Oxide and Endothelin Effects 2

Co-authors: Ulf Neumann Stephen F. Martin Matthias Staufenbiel Jean‐Michel Rondeau Herbert Waldmann Heinrich Rueeger Laura H. Jacobson Marina Tintelnot‐Blomley
Journals: Bioorganic & Medicinal Chemistry Letters (5 papers)Journal of Medicinal Chemistry (3 papers)ACS Medicinal Chemistry Letters (2 papers)Alzheimer s & Dementia (1 paper)Scientific Reports (1 paper)
Partner nations: Switzerland Germany United States

In The Last Decade

Rainer Machauer

20 papers receiving 651 citations

Peers

Countries citing papers authored by Rainer Machauer

Since Specialization

Citations

This map shows the geographic impact of Rainer Machauer's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Rainer Machauer with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Rainer Machauer more than expected).

Fields of papers citing papers by Rainer Machauer

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Rainer Machauer. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Rainer Machauer. The network helps show where Rainer Machauer may publish in the future.

Co-authorship network

The 25 scholars most cited alongside Rainer Machauer, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Rainer Machauer Line = papers co-authored together Rainer Machauer links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

#	Work
1	Synthesis of the Potent, Selective, and Efficacious β-Secretase (BACE1) Inhibitor NB-360 Journal of Medicinal Chemistry ·Heinrich Rueeger, Ângela Maria Lourenço, Rainer Machauer, Siem J. Veenstra, Philipp Holzer, Konstanze Hurth, Jacqueline U. Anaeto, Mathias Frederiksen, Jean‐Michel Rondeau, Marina Tintelnot‐Blomley, Laura H. Jacobson, Matthias Staufenbiel, Grit Laue, Ulf Neumann	2021	11
2	Discovery of Umibecestat (CNP520): A Potent, Selective, and Efficacious β-Secretase (BACE1) Inhibitor for the Prevention of Alzheimer’s Disease Journal of Medicinal Chemistry ·Rainer Machauer, Ângela Maria Lourenço, Konstanze Hurth, Siem J. Veenstra, Heinrich Rueeger, Jacqueline U. Anaeto, Marina Tintelnot‐Blomley, Jean‐Michel Rondeau, Laura H. Jacobson, Grit Laue, Karen Beltz, Ulf Neumann	2021	25
3	The β‐secretase (BACE) inhibitor NB‐360 in preclinical models: From amyloid‐β reduction to downstream disease‐relevant effects British Journal of Pharmacology ·Ulf Neumann, Rainer Machauer, Derya R. Shimshek	2019	18
4	Discovery and Structural Characterization of ATP-Site Ligands for the Wild-Type and V617F Mutant JAK2 Pseudokinase Domain ACS Chemical Biology ·Randall McNally, Qing Li, Kunhua Li, Carien Dekker, Eric Vangrevelinghe, Matthew D. Jones, Patrick Chêne, Rainer Machauer, Thomas Radimerski, Michael J. Eck	2019	20
5	Discovery of amino-1,4-oxazines as potent BACE-1 inhibitors Bioorganic & Medicinal Chemistry Letters ·Siem J. Veenstra, Heinrich Rueeger, Jacqueline U. Anaeto, Ângela Maria Lourenço, Philipp Holzer, Konstanze Hurth, Marina Tintelnot‐Blomley, Mathias Frederiksen, Jean‐Michel Rondeau, Laura H. Jacobson, Matthias Staufenbiel, Ulf Neumann, Rainer Machauer	2018	10
6	Discovery of Potent, Selective, and Structurally Novel Dot1L Inhibitors by a Fragment Linking Approach ACS Medicinal Chemistry Letters ·Henrik Möbitz, Rainer Machauer, Philipp Holzer, Andrea Vaupel, Frédéric Stauffer, Nyenke Bassara Godefroy, Giorgio Caravatti, Clemens Scheufler, César Fernández Fernández, Ulrich Hommel, Ralph Tiedt, Kim S. Beyer, Chao Chen, Hugh Zhu, Christoph Gaul	2017	42
7	Discovery of Novel Dot1L Inhibitors through a Structure-Based Fragmentation Approach ACS Medicinal Chemistry Letters ·Chao Chen, Hugh Zhu, Frédéric Stauffer, Giorgio Caravatti, 菊地英司, Rainer Machauer, Philipp Holzer, Henrik Möbitz, Clemens Scheufler, Martin Klumpp, Ralph Tiedt, Kim S. Beyer, Iman AL-GHAFRI, Daniel Guthy, Michael Kiffe, Jeff Zhang, Christoph Gaul	2016	51
8	Pharmacological BACE1 and BACE2 inhibition induces hair depigmentation by inhibiting PMEL17 processing in mice Scientific Reports ·Derya R. Shimshek, Laura H. Jacobson, Carine Kolly, Natasa Zamurovic, Kamal K. Balavenkatraman, Odecha Michael, Robert Kreutzer, Juliane Schelle, Mathias Jucker, Yaya Maïga, Diethilde Theil, Annabelle Heier, Karine Bigot, Karen Beltz, Rainer Machauer, Irena Brzak, Ludovic Perrot, Ulf Neumann	2016	49
9	A novel BACE inhibitor NB-360 shows a superior pharmacological profile and robust reduction of amyloid-β and neuroinflammation in APP transgenic mice Molecular Neurodegeneration ·Ulf Neumann, Heinrich Rueeger, Rainer Machauer, Ariel Mota Alves, Ângela Maria Lourenço, Marina Tintelnot‐Blomley, Grit Laue, Karen Beltz, Barbara Vogg, Peter Schmid, Wilfried Frieauff, Derya R. Shimshek, Matthias Staufenbiel, Laura H. Jacobson	2015	92
10	P4‐363: THE BACE INHIBITOR NB‐360 HAS EXCELLENT BRAIN PENETRATION AND EFFICACY ON AMYLOID‐B LOAD IN ANIMAL MODELS Alzheimer s & Dementia ·Ulf Neumann, Heinrich Rueeger, Rainer Machauer, Siem J. Veenstra, Ângela Maria Lourenço, Marina Tintelnot‐Blomley, Grit Laue, Karen Beltz, Barbara Vogg, Derya R. Shimshek, Wilfried Frieauff, Peter Schmid, Matthias Staufenbiel, Laura H. Jacobson	2014	1
11	Discovery of cyclic sulfoxide hydroxyethylamines as potent and selective β-site APP-cleaving enzyme 1 (BACE1) inhibitors: Structure based design and in vivo reduction of amyloid β-peptides Bioorganic & Medicinal Chemistry Letters ·Heinrich Rueeger, Ângela Maria Lourenço, Rainer Machauer, Ariel Mota Alves, Laura H. Jacobson, Matthias Staufenbiel, Sandrine Desrayaud, Jean‐Michel Rondeau, Henrik Möbitz, Ulf Neumann	2013	22
12	Discovery of Cyclic Sulfone Hydroxyethylamines as Potent and Selective β-Site APP-Cleaving Enzyme 1 (BACE1) Inhibitors: Structure-Based Design and in Vivo Reduction of Amyloid β-Peptides Journal of Medicinal Chemistry ·Heinrich Rueeger, Ângela Maria Lourenço, Olivier Rogel, Jean‐Michel Rondeau, Henrik Möbitz, Rainer Machauer, Laura H. Jacobson, Matthias Staufenbiel, Sandrine Desrayaud, Ulf Neumann	2012	82
13	Structure-based design and synthesis of macrocyclic peptidomimetic β-secretase (BACE-1) inhibitors Bioorganic & Medicinal Chemistry Letters ·Rainer Machauer, Siem J. Veenstra, Jean‐Michel Rondeau, Marina Tintelnot‐Blomley, Claudia Betschart, Ulf Neumann, Paolo Paganetti	2009	24
14	Macrocyclic peptidomimetic β-secretase (BACE-1) inhibitors with activity in vivo Bioorganic & Medicinal Chemistry Letters ·Rainer Machauer, Kurt Laumen, Siem J. Veenstra, Jean‐Michel Rondeau, Marina Tintelnot‐Blomley, Claudia Betschart, Anne-Lise Jaton, Sandrine Desrayaud, Matthias Staufenbiel, J.A. Reyes-Retana, Paolo Paganetti, Ulf Neumann	2009	44
15	Macrocyclic BACE-1 inhibitors acutely reduce Aβ in brain after po application Bioorganic & Medicinal Chemistry Letters ·Andreas Lerchner, Rainer Machauer, Claudia Betschart, Siem J. Veenstra, Heinrich Rueeger, Clive McCarthy, Marina Tintelnot‐Blomley, Anne-Lise Jaton, J.A. Reyes-Retana, Sandrine Desrayaud, Albert Enz, Matthias Staufenbiel, Paolo Paganetti, Jean‐Michel Rondeau, Ulf Neumann	2009	41
16	Enantioselective synthesis of (+)-anatoxin-a via enyne metathesis Tetrahedron ·Jehrod Brenneman, Rainer Machauer, Stephen F. Martin	2004	55
17	Synthesis of cis-2,5-disubstituted pyrrolidines via diastereoselective reduction of N-acyl iminium ions Tetrahedron Letters ·黄才贵, Rainer Machauer, Stephen F. Martin	2004	26
18	Synthesis of Lipidated eNOS Peptides by Combining Enzymatic, Noble Metal- and Acid-Mediated Protecting Group Techniques with Solid Phase Peptide Synthesis and Fragment Condensation in Solution Chemistry - A European Journal ·Rainer Machauer, Herbert Waldmann	2001	29
19	Synthese des N-terminalenN-myristoylierten undS-palmitoylierten Undetrigintapeptids der endothelialen NO-Synthase Angewandte Chemie ·Rainer Machauer, Herbert Waldmann	2000	7
20	Synthesis of the N-Terminal N-Myristoylated and S-Palmitoylated Undetrigintapeptide of Endothelial NO-Synthase Angewandte Chemie International Edition ·Rainer Machauer, Herbert Waldmann	2000	11

About Rainer Machauer

Rainer Machauer is a scholar working on Computational Theory and Mathematics, Physiology, Oncology, Molecular Biology and Urology, having authored 20 papers that have together received 660 indexed citations. Recurring topics across this work include Computational Drug Discovery Methods (9 papers), Alzheimer's disease research and treatments (8 papers), Drug Transport and Resistance Mechanisms (6 papers), Chemical Synthesis and Analysis (5 papers), Receptor Mechanisms and Signaling (3 papers), Click Chemistry and Applications (2 papers), Nitric Oxide and Endothelin Effects (2 papers) and Synthetic Organic Chemistry Methods (2 papers). The work is most often cited by research in Computational Theory and Mathematics (225 citations), Pharmacology (149 citations), Physiology (216 citations), Organic Chemistry (189 citations) and Molecular Biology (311 citations). Rainer Machauer has collaborated with scholars based in Switzerland, Germany and United States. Frequent co-authors include Ulf Neumann, Stephen F. Martin, Matthias Staufenbiel, Jean‐Michel Rondeau, Herbert Waldmann, Heinrich Rueeger, Laura H. Jacobson, Marina Tintelnot‐Blomley, Jehrod Brenneman and Sandrine Desrayaud. Their work appears in journals such as Bioorganic & Medicinal Chemistry Letters, Journal of Medicinal Chemistry, ACS Medicinal Chemistry Letters, Alzheimer s & Dementia and Scientific Reports.

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