Philipp Holliger

10.0k citations

92 papers · 7.6k indexed · 3 hit papers · h-index 41

Impact in

Radiology, Nuclear Medicine and Imaging top 0.5%
- Monoclonal and Polyclonal Antibodies Research
Molecular Biology top 0.5%
- Advanced biosensing and bioanalysis techniques
- RNA and protein synthesis mechanisms
- DNA and Nucleic Acid Chemistry
- Glycosylation and Glycoproteins Research
- Protein purification and stability

Papers in

Molecular Biology 83
- RNA and protein synthesis mechanisms 39
- Advanced biosensing and bioanalysis techniques 31
- DNA and Nucleic Acid Chemistry 29
- Glycosylation and Glycoproteins Research 13
- CRISPR and Genetic Engineering 13
Radiology, Nuclear Medicine and Imaging 26
- Monoclonal and Polyclonal Antibodies Research 26

Co-authors: Peter J. Hudson Greg Winter Vitor B. Pinheiro Teresa Di Prospero James Attwater Aniela Wochner Alexander I. Taylor Lutz Riechmann
Journals: Nature Chemistry (8 papers)Nature Biotechnology (6 papers)Nucleic Acids Research (6 papers)Proceedings of the National Academy of Sciences (6 papers)Journal of Molecular Biology (4 papers)
Partner nations: United Kingdom United States Belgium

In The Last Decade

Philipp Holliger

91 papers receiving 7.3k citations

Hit Papers

align trajectories log scale

Synthetic Genetic Polymers Capable of Heredity and Evolution 2012 · 546 citations

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if any of the following hold:

it has ≥500 total citations;
it reaches ≥1.5× the top-1% citation threshold for papers in the same subfield and year (the threshold is the minimum needed to enter the top 1%, not the average within it);
it reaches the top citation threshold in at least one of its specific research topics.

2012 Science
2005 Nature Biotechnology
1993 Proceedings of the National Academy of Sciences

Peers

Countries citing papers authored by Philipp Holliger

Since Specialization

Citations

This map shows the geographic impact of Philipp Holliger's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Philipp Holliger with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Philipp Holliger more than expected).

Fields of papers citing papers by Philipp Holliger

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Philipp Holliger. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Philipp Holliger. The network helps show where Philipp Holliger may publish in the future.

Co-authors

The 25 scholars most cited alongside Philipp Holliger, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Philipp Holliger Line = papers co-authored together Philipp Holliger links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

#	Work
1	Roles of dimeric intermediates in RNA-catalyzed rolling circle synthesis Nucleic Acids Research ·Emil L. Kristoffersen, Ewan K.S. McRae, Yvonne Klenk, Philipp Holliger, Ebbe Sloth Andersen	2025	0
2	Trinucleotide substrates under pH–freeze–thaw cycles enable open-ended exponential RNA replication by a polymerase ribozyme Nature Chemistry ·James Attwater, R. Zang, Taifeng Wang, حسين علي فقير مبارك, Paula Letícia Nemes Schawb Gomes, Rowena Foo, Philipp Holliger	2025	1
3	Cryo-EM structure and functional landscape of an RNA polymerase ribozyme Proceedings of the National Academy of Sciences ·Ewan K.S. McRae, YANMi, Emil L. Kristoffersen, Maximiliano Soares Silva, Rowena Foo, Isaac Gállego, Taifeng Wang, James Attwater, Philipp Holliger, Ebbe Sloth Andersen	2024	14
4	Emergence of ATP‐ and GTP‐Binding Aptamers from Single RNA Sequences by Error‐Prone Replication and Selection** ChemSystemsChem ·Falk Wachowius, Benjamin T. Porebski, C. Mark Johnson, Philipp Holliger	2023	1
5	Discovery and evolution of RNA and XNA reverse transcriptase function and fidelity Nature Chemistry ·Gillian Houlihan, Sebastian Arangundy‐Franklin, Benjamin T. Porebski, Nithya Subramanian, Alexander I. Taylor, Philipp Holliger	2020	45
6	Isoguanine and 5‐Methyl‐Isocytosine Bases, In Vitro and In Vivo Chemistry - A European Journal ·Omprakash Bande, Justin Ng, Darren Braddick, Janna Mehrtens, Valérie Pezo, Guy Schepers, Vitor B. Pinheiro, Eveline Lescrinier, Philipp Holliger, Philippe Marlière, Piet Herdewijn	2015	32
7	Enzymatische Synthese von Nukleinsäuren mit definierten regioisomeren 2′‐5′‐Verknüpfungen Angewandte Chemie ·Christopher Cozens, Hannes Mutschler, Geoffrey M. Nelson, Gillian Houlihan, Alexander I. Taylor, Philipp Holliger	2015	1
8	Towards XNA nanotechnology: new materials from synthetic genetic polymers Trends in biotechnology ·Vitor B. Pinheiro, Philipp Holliger	2014	105
9	A synthetic approach to abiogenesis Nature Methods ·James Attwater, Philipp Holliger	2014	19
10	In-ice evolution of RNA polymerase ribozyme activity Nature Chemistry ·James Attwater, Aniela Wochner, Philipp Holliger	2013	194
11	A short adaptive path from DNA to RNA polymerases Proceedings of the National Academy of Sciences ·Christopher Cozens, Vitor B. Pinheiro, Alexandra Vaisman, Roger Woodgate, Philipp Holliger	2012	98
12	Synthetic Genetic Polymers Capable of Heredity and Evolution Science ·Vitor B. Pinheiro, Alexander I. Taylor, Christopher Cozens, Mikhail Abramov, Marleen Renders, Su Zhang, John C. Chaput, Jesper Wengel, Sew‐Yeu Peak‐Chew, Stephen H. McLaughlin, Piet Herdewijn, Philipp Holliger Hit paper breakdown →	2012	546
13	Darwinian chemistry: towards the synthesis of a simple cell Molecular BioSystems ·David Loakes, Philipp Holliger	2009	18
14	Polymerase engineering: towards the encoded synthesis of unnatural biopolymers Chemical Communications ·David Loakes, Philipp Holliger	2009	68
15	Compartmentalized Self-Replication: A Novel Method for the Directed Evolution of Polymerases and Other Enzymes Humana Press eBooks ·Farid J. Ghadessy, Philipp Holliger	2006	20
16	Expression of Antibody Fragments in Pichia pastoris Humana Press eBooks ·Philipp Holliger	2003	3
17	[28] Methods for generating multivalent and bispecific antibody fragments Methods in enzymology on CD-ROM/Methods in enzymology ·Ian M. Tomlinson, Philipp Holliger	2000	16
18	CD3� anti-nitrophenyl bispecific diabodies: Universal immunotherapeutic tools for retargeting T cells to tumors International Journal of Cancer ·Oliver Manzke, Kevin Fitzgerald, Philipp Holliger, Xuelei Jiao, Mervat H. Husseina, Bernd K. Fleischmann, Juergen Hescheler, Qinghua Liu, Kevin S. Johnson, Volker Diehl, Hennie R. Hoogenboom, Heribert Bohlen	1999	12
19	Artificial antibodies and enzymes: mimicking nature and beyond Trends in biotechnology ·Philipp Holliger, Hennie R. Hoogenboom	1995	17
20	Site‐directed mutagenesis of bovine pancreatic ribonuclease: Lysine‐41 and aspartate‐121 FEBS Letters ·Syamsul Alam, Philipp Holliger, Joseph Stackhouse, Steven A. Benner	1991	39

About Philipp Holliger

Philipp Holliger is a scholar working on Molecular Biology, Radiology, Nuclear Medicine and Imaging, Astronomy and Astrophysics, Ecology and Genetics, having authored 92 papers that have together received 7.6k indexed citations. Recurring topics across this work include RNA and protein synthesis mechanisms (39 papers), Advanced biosensing and bioanalysis techniques (31 papers), DNA and Nucleic Acid Chemistry (29 papers), Monoclonal and Polyclonal Antibodies Research (26 papers), Bacteriophages and microbial interactions (16 papers), Origins and Evolution of Life (15 papers), Glycosylation and Glycoproteins Research (13 papers) and CRISPR and Genetic Engineering (13 papers). The work is most often cited by research in Radiology, Nuclear Medicine and Imaging (2.6k citations), Molecular Biology (6.1k citations), Astronomy and Astrophysics (852 citations), Ecology (965 citations) and Immunology (738 citations). Philipp Holliger has collaborated with scholars based in United Kingdom, United States and Belgium. Frequent co-authors include Peter J. Hudson, Greg Winter, Vitor B. Pinheiro, Teresa Di Prospero, James Attwater, Aniela Wochner, Alexander I. Taylor, Lutz Riechmann, Farid J. Ghadessy and Christopher Cozens. Their work appears in journals such as Nature Chemistry, Nature Biotechnology, Nucleic Acids Research, Proceedings of the National Academy of Sciences and Journal of Molecular Biology.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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