David Loakes

2.8k citations

73 papers · 2.2k indexed · 1 hit paper · h-index 23

Molecular Biology top 5%
- DNA and Nucleic Acid Chemistry 29
- RNA and protein synthesis mechanisms 14
- DNA Repair Mechanisms 12
- Advanced biosensing and bioanalysis techniques 11
- CRISPR and Genetic Engineering 10
Genetics top 10%
Infectious Diseases top 10%
- HIV/AIDS drug development and treatment 16
Organic Chemistry top 10%
- Synthesis and Characterization of Heterocyclic Compounds 13
- Synthesis and Catalytic Reactions 7
Ecology top 10%

Co-authors: D. M. Brown Philipp Holliger V. Ramakrishnan Ann C. Kelley Albert Weixlbaumer R.M. Voorhees F. Hill Kazuo Negishi
Cited by: Molecular Biology Genetics Infectious Diseases
Journals: Nucleic Acids Research (8 papers)Nucleosides Nucleotides & Nucleic Acids (6 papers)Journal of the Chemical Society Perkin Transactions 1 (6 papers)
Partner nations: United Kingdom Japan United States

In The Last Decade

David Loakes

71 papers receiving 2.1k citations

Hit Papers

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Peers

Countries citing papers authored by David Loakes

Since Specialization

Citations

This map shows the geographic impact of David Loakes's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by David Loakes with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites David Loakes more than expected).

Fields of papers citing papers by David Loakes

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by David Loakes. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by David Loakes. The network helps show where David Loakes may publish in the future.

Co-authorship network

The 25 scholars most cited alongside David Loakes, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with David Loakes Line = papers co-authored together David Loakes links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

#	Work
1	Darwinian chemistry: towards the synthesis of a simple cell Molecular BioSystems ·David Loakes,Philipp Holliger	2009	18
2	Polymerase engineering: towards the encoded synthesis of unnatural biopolymers Chemical Communications ·David Loakes,Philipp Holliger	2009	68
3	Insights into substrate stabilization from snapshots of the peptidyl transferase center of the intact 70S ribosomebreakdown → Nature Structural & Molecular Biology ·R.M. Voorhees,Albert Weixlbaumer,David Loakes,Ann C. Kelley,V. Ramakrishnan	2009	292
4	Binding of MutS protein to oligonucleotides containing a methylated or an ethylated guanine residue, and correlation with mutation frequency Mutation research. Fundamental and molecular mechanisms of mutagenesis ·إيمان محمد على فرماوي,Satya Omprabha,Augusto Coronel,Ma Carmen Barrado Belmar,Keinosuke Okamoto,Sakae Arimoto,David Loakes,Leroy Worth,Roel M. Schaaper,Kohji Seio,Mitsuo Sekine,Kazuo Negishi,Tomoe Negishi	2008	8
5	Translesion synthesis across the (6-4) photoproduct and its Dewar valence isomer by the Y-family and engineered DNA polymerases Nucleic Acids Symposium Series ·Junpei Yamamoto,David Loakes,Chikahide Masutani,Afonso Celso Medina,Felicitas de Benito Pascual,Fumio Hanaoka,Philipp Holliger,Shigenori Iwai	2008	6
6	Nucleotide incorporation against 7,8-dihydro-8-oxoguanine is influenced by neighboring base sequences in TLS DNA polymerase reaction Nucleic Acids Symposium Series ·Cathleen M. Yung,Tetsuya Suzuki,Yoshinaga Okugawa,Atsushi Kawakami,David Loakes,Kazuo Negishi,Tomoe Negishi	2007	6
7	Solution structure and dynamics of DNA duplexes containing the universal base analogues 5-nitroindole and 5-nitroindole 3-carboxamide Nucleic Acids Research ·José Gallego,David Loakes	2007	20
8	Anti-malarial activity of N6-modified purine analogues Bioorganic & Medicinal Chemistry ·Honggui Lin,D. M. Brown,Emily Bongard,Vanessa Yardley,Livia Vivas,David Loakes	2007	27
9	Mutagenic properties of ribonucleotide analogues in reverse transcription with HIV and AMV reverse transcriptases Nucleic Acids Symposium Series ·Tetsuya Suzuki,George V Joby,Jonathan Oldbuck,K. Moriyama,David Loakes,Kazuo Negishi	2005	1
10	Roles of the polymerase and BRCT domains of Rev1 protein in translesion DNA synthesis in yeast in vivo Mutation research. Fundamental and molecular mechanisms of mutagenesis ·Jonathan Oldbuck,G M Wijayanti,Shigenori Iwai,David Loakes,Kazuo Negishi	2005	44
11	Generic expansion of the substrate spectrum of a DNA polymerase by directed evolution Nature Biotechnology ·Farid J. Ghadessy,Nicola Ramsay,François Boudsocq,David Loakes,Anthony P. Brown,Shigenori Iwai,Alexandra Vaisman,Roger Woodgate,Philipp Holliger	2004	136
12	Use of yeast transformation by oligonucleotides to study DNA lesion bypass in vivo Mutation research. Fundamental and molecular mechanisms of mutagenesis ·Jonathan Oldbuck,Keita Kobayashi,Erik William Herrmann,G M Wijayanti,K. Moriyama,K Yang,Shigenori Iwai,David Loakes,Vladimir N. Noskov,Youri I. Pavlov,Kazuo Negishi	2002	20
13	Binding specificities of the mismatch binding protein, MutS, to oligonucleotides containing modified bases Nucleic Acids Symposium Series ·Kazuo Negishi,Ma Carmen Barrado Belmar,Bijan Shahriari,David Loakes,Leroy Worth,Roel M. Schaaper,Kohji Seio,M. SEKINE,Tomoe Negishi	2001	2
14	DNA Polymerase Incorporation of Universal Base Triphosphates Nucleosides and Nucleotides ·Cassandra L. Smith,Adrian C. Simmonds,Ryan Rothman,A. Hamilton,Sandeep Kumar,Selma Gl?ria de Jesus,David Loakes,F. Hill,D. M. Brown	1998	18
15	A thymine-like base analogue forms wobble pairs with adenine in a Z-DNA duplex Journal of Molecular Biology ·Kathleen B. LaSala,Luc Van Meervelt,David Loakes,D. M. Brown,Paul Kong Thoo Lin,M. H. Moore,Stephen A. Salisbury	1998	11
16	The use of tailed octamer primers for cycle sequencing Nucleic Acids Research ·Sarah Ball,K. Sudhakar,Nobuko KIBE,F. Hill,D. M. Brown,David Loakes	1998	17
17	Stability and structure of DNA oligonucleotides containing non-specific base analogues Journal of Molecular Biology ·David Loakes,F. Hill,D. M. Brown,Stephen A. Salisbury	1997	40
18	DNA conformation and its changes upon binding transcription factors Advances in Biophysics ·Miki Suzuki,David Loakes,Naoto Yagi	1996	6
19	3-Nitropyrrole and 5-nitroindole as universal bases in primers for DNA sequencing and PCR Nucleic Acids Research ·David Loakes,D. M. Brown,M. Izawa,F. Hill	1995	78
20	5-Nitroindole as an universal base analogue Nucleic Acids Research ·David Loakes,D. M. Brown	1994	128

About David Loakes

David Loakes is a scholar working on Infectious Diseases, Organic Chemistry, Molecular Biology, Virology and Physiology, having authored 73 papers that have together received 2.2k indexed citations. Recurring topics across this work include DNA and Nucleic Acid Chemistry (29 papers), HIV/AIDS drug development and treatment (16 papers), RNA and protein synthesis mechanisms (14 papers), Synthesis and Characterization of Heterocyclic Compounds (13 papers), DNA Repair Mechanisms (12 papers), Advanced biosensing and bioanalysis techniques (11 papers), CRISPR and Genetic Engineering (10 papers) and Synthesis and Catalytic Reactions (7 papers). The work is most often cited by research in Molecular Biology (1.8k citations), Genetics (303 citations), Infectious Diseases (190 citations), Organic Chemistry (288 citations) and Ecology (220 citations). David Loakes has collaborated with scholars based in United Kingdom, Japan and United States. Frequent co-authors include D. M. Brown, Philipp Holliger, V. Ramakrishnan, Ann C. Kelley, Albert Weixlbaumer, R.M. Voorhees, F. Hill, Kazuo Negishi, Alexandra Vaisman and Roger Woodgate. Their work appears in journals such as Nucleic Acids Research, Nucleosides Nucleotides & Nucleic Acids, Journal of the Chemical Society Perkin Transactions 1, Mutation research. Fundamental and molecular mechanisms of mutagenesis and Tetrahedron Letters.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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