Paul Polakis

28.5k total citations · 13 hit papers
118 papers, 21.9k citations indexed

About

Paul Polakis is a scholar working on Molecular Biology, Oncology and Cell Biology. According to data from OpenAlex, Paul Polakis has authored 118 papers receiving a total of 21.9k indexed citations (citations by other indexed papers that have themselves been cited), including 95 papers in Molecular Biology, 36 papers in Oncology and 20 papers in Cell Biology. Recurrent topics in Paul Polakis's work include Wnt/β-catenin signaling in development and cancer (45 papers), Cancer-related gene regulation (37 papers) and Protein Kinase Regulation and GTPase Signaling (20 papers). Paul Polakis is often cited by papers focused on Wnt/β-catenin signaling in development and cancer (45 papers), Cancer-related gene regulation (37 papers) and Protein Kinase Regulation and GTPase Signaling (20 papers). Paul Polakis collaborates with scholars based in United States, France and Canada. Paul Polakis's co-authors include Bonnee Rubinfeld, Iris Albert, S Munemitsu, Mark Peifer, Emilio Porfiri, Matthew J. Hart, Frank McCormick, Brian Souza, Brígida Souza and Oliver Müller and has published in prestigious journals such as Science, Cell and Proceedings of the National Academy of Sciences.

In The Last Decade

Paul Polakis

117 papers receiving 21.3k citations

Hit Papers

Wnt signaling and cancer 1993 2026 2004 2015 2000 1996 2000 1997 1993 500 1000 1.5k 2.0k 2.5k
What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

  1. Wnt signaling and cancer
    2000 2.7k citations Paul Polakis profile →
  2. Binding of GSK3β to the APC-β-Catenin Complex and Regulation of Complex Assembly
    1996 1.2k citations Bonnee Rubinfeld, Iris Albert et al. Science profile →
  3. Wnt Signaling in Oncogenesis and Embryogenesis--a Look Outside the Nucleus
    2000 1.1k citations Paul Polakis et al. Science profile →
  4. Stabilization of β-Catenin by Genetic Defects in Melanoma Cell Lines
    1997 1.1k citations Bonnee Rubinfeld, Iris Albert et al. Science profile →
  5. Association of the APC Gene Product with β-Catenin
    1993 1.0k citations Bonnee Rubinfeld, Iris Albert et al. Science profile →
  6. Regulation of intracellular beta-catenin levels by the adenomatous polyposis coli (APC) tumor-suppressor protein.
    1995 893 citations S Munemitsu, Iris Albert et al. profile →
  7. Downregulation of β-catenin by human Axin and its association with the APC tumor suppressor, β-catenin and GSK3β
    1998 729 citations Matthew J. Hart, Iris Albert et al. profile →
  8. The many ways of Wnt in cancer
    2007 721 citations Paul Polakis profile →
  9. Wnt Signaling in Cancer
    2012 697 citations Paul Polakis profile →
  10. The metalloproteinase matrilysin is a target of β-catenin transactivation in intestinal tumors
    1999 581 citations Bonnee Rubinfeld, Paul Polakis et al. profile →
  11. The F-box protein β-TrCP associates with phosphorylated β-catenin and regulates its activity in the cell
    1999 579 citations Matthew J. Hart, Iris Albert et al. profile →
  12. The oncogenic activation of β-catenin
    1999 555 citations Paul Polakis profile →
  13. Site-specific antibody drug conjugates for cancer therapy
    2013 517 citations Sunil Bhakta, Helga Raab et al. mAbs profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name h Career Trend Papers Cites
Paul Polakis United States 64 17.8k 4.9k 3.1k 2.6k 1.8k 118 21.9k
Jürgen Behrens Germany 58 15.5k 0.9× 3.8k 0.8× 3.4k 1.1× 1.5k 0.6× 1.4k 0.8× 113 19.3k
Jeffrey Settleman United States 72 14.0k 0.8× 10.4k 2.1× 3.7k 1.2× 1.7k 0.7× 794 0.4× 158 23.5k
David D.L. Bowtell Australia 71 11.6k 0.7× 5.4k 1.1× 1.9k 0.6× 1.3k 0.5× 2.1k 1.2× 221 18.4k
Glenn Merlino United States 73 10.9k 0.6× 6.1k 1.2× 2.2k 0.7× 908 0.4× 2.6k 1.4× 215 17.9k
Christopher J. Marshall United Kingdom 61 15.0k 0.8× 5.5k 1.1× 4.8k 1.6× 1.3k 0.5× 961 0.5× 94 20.2k
Gregory J. Riggins United States 55 11.7k 0.7× 4.1k 0.8× 1.6k 0.5× 1.6k 0.6× 1.3k 0.7× 117 18.4k
Martine F. Roussel United States 83 19.4k 1.1× 12.4k 2.5× 2.9k 1.0× 1.4k 0.5× 2.6k 1.4× 242 27.9k
Hartmut Land United States 43 10.9k 0.6× 5.3k 1.1× 1.4k 0.5× 843 0.3× 2.7k 1.5× 75 16.0k
Gerhard Christofori Switzerland 71 12.4k 0.7× 7.1k 1.4× 2.9k 1.0× 933 0.4× 1.3k 0.7× 163 19.6k
Michael Ittmann United States 71 13.4k 0.8× 4.6k 0.9× 1.7k 0.5× 1.3k 0.5× 2.2k 1.2× 279 20.8k

Countries citing papers authored by Paul Polakis

Since Specialization
Citations

This map shows the geographic impact of Paul Polakis's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Paul Polakis with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Paul Polakis more than expected).

Fields of papers citing papers by Paul Polakis

Since Specialization
Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Paul Polakis. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Paul Polakis. The network helps show where Paul Polakis may publish in the future.

Co-authorship network of co-authors of Paul Polakis

This figure shows the co-authorship network connecting the top 25 collaborators of Paul Polakis. A scholar is included among the top collaborators of Paul Polakis based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Paul Polakis. Paul Polakis is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

20 of 20 papers shown
1.
Asundi, Jyoti, Lisa Crocker, Jarrod R. Tremayne, et al.. (2015). An Antibody–Drug Conjugate Directed against Lymphocyte Antigen 6 Complex, Locus E (LY6E) Provides Robust Tumor Killing in a Wide Range of Solid Tumor Malignancies. Clinical Cancer Research. 21(14). 3252–3262. 28 indexed citations
2.
Yu, Shang‐Fan, Bing Zheng, MaryAnn Go, et al.. (2015). A Novel Anti-CD22 Anthracycline-Based Antibody–Drug Conjugate (ADC) That Overcomes Resistance to Auristatin-Based ADCs. Clinical Cancer Research. 21(14). 3298–3306. 125 indexed citations
3.
Asundi, Jyoti, Jennifer A. Lacap, Suzanna Clark, et al.. (2014). MAPK Pathway Inhibition Enhances the Efficacy of an Anti-Endothelin B Receptor Drug Conjugate by Inducing Target Expression in Melanoma. Molecular Cancer Therapeutics. 13(6). 1599–1610. 20 indexed citations
4.
Bhakta, Sunil, Rajesh Vij, Dara Kallop, et al.. (2013). An improved and robust DNA immunization method to develop antibodies against extra-cellular loops of multi-transmembrane proteins. mAbs. 6(1). 95–107. 23 indexed citations
5.
Lau, Ted, Emily Chan, Marinella Callow, et al.. (2013). A Novel Tankyrase Small-Molecule Inhibitor Suppresses APC Mutation–Driven Colorectal Tumor Growth. Cancer Research. 73(10). 3132–3144. 256 indexed citations
6.
McGann, James C., Bob Y. Liu, Rami N. Hannoush, et al.. (2013). Phosphorylation of Dishevelled by Protein Kinase RIPK4 Regulates Wnt Signaling. Science. 339(6126). 1441–1445. 88 indexed citations
7.
Polson, Andrew G., Bing Zheng, MaryAnn Go, et al.. (2013). Abstract 4634: Anthracycline based antibody-drug conjugates (ADCs) for the treatment of non-Hodgkin's lymphoma are effective in cell lines resistant to auristatin based ADCs.. Cancer Research. 73(8_Supplement). 4634–4634. 1 indexed citations
8.
Liu, Bob Y., Irina Soloviev, Peter Mu‐Hsin Chang, et al.. (2012). Mammary Tumor Regression Elicited by Wnt Signaling Inhibitor Requires IGFBP5. Cancer Research. 72(6). 1568–1578. 19 indexed citations
9.
Asundi, Jyoti, Chae Reed, Krista McCutcheon, et al.. (2011). An Antibody–Drug Conjugate Targeting the Endothelin B Receptor for the Treatment of Melanoma. Clinical Cancer Research. 17(5). 965–975. 44 indexed citations
10.
Junutula, Jagath R., Kelly M. Flagella, Richard Graham, et al.. (2010). Engineered Thio-Trastuzumab-DM1 Conjugate with an Improved Therapeutic Index to Target Human Epidermal Growth Factor Receptor 2–Positive Breast Cancer. Clinical Cancer Research. 16(19). 4769–4778. 214 indexed citations
11.
Chen, Youjun, Suzanna Clark, Terence Z. Wong, et al.. (2007). Armed Antibodies Targeting the Mucin Repeats of the Ovarian Cancer Antigen, MUC16, Are Highly Efficacious in Animal Tumor Models. Cancer Research. 67(10). 4924–4932. 70 indexed citations
12.
DeAlmeida, Venita, Miao Li, James A. Ernst, et al.. (2007). The Soluble Wnt Receptor Frizzled8CRD-hFc Inhibits the Growth of Teratocarcinomas In vivo. Cancer Research. 67(11). 5371–5379. 117 indexed citations
13.
Batson, Jennifer, et al.. (2007). Armed antibodies targeted to STEAP1 inhibit growth of human prostate xenografts in vivo. Cancer Research. 67. 4468–4468. 1 indexed citations
14.
Leow, Ching Ching, Maria S. Romero, Sarajane Ross, Paul Polakis, & Wei‐Qiang Gao. (2004). Hath1, Down-Regulated in Colon Adenocarcinomas, Inhibits Proliferation and Tumorigenesis of Colon Cancer Cells. Cancer Research. 64(17). 6050–6057. 107 indexed citations
15.
Tice, David A., Irina Soloviev, & Paul Polakis. (2002). Activation of the Wnt Pathway Interferes with Serum Response Element-driven Transcription of Immediate Early Genes. Journal of Biological Chemistry. 277(8). 6118–6123. 50 indexed citations
16.
Polakis, Paul, et al.. (2000). Structural basis of the Axin–adenomatous polyposis coli interaction. The EMBO Journal. 19(10). 2270–2279. 160 indexed citations
17.
Hart, Matthew J., et al.. (1996). Identification of a Novel Guanine Nucleotide Exchange Factor for the Rho GTPase. Journal of Biological Chemistry. 271(41). 25452–25458. 142 indexed citations
18.
Rubinfeld, Bonnee, Walter J. Crosier, Iris Albert, et al.. (1992). Localization of the raplGAP Catalytic Domain and Sites of Phosphorylation by Mutational Analysis. Molecular and Cellular Biology. 12(10). 4634–4642. 11 indexed citations
19.
Zhang, Ke, Alex G. Papageorge, Patrick Martin, et al.. (1991). Heterogeneous Amino Acids in Ras and Rap1A Specifying Sensitivity to GAP Proteins. Science. 254(5038). 1630–1634. 32 indexed citations
20.
Munemitsu, S, Michael A. Innis, Robin Clark, et al.. (1990). Molecular Cloning and Expression of a G25K cDNA, the Human Homolog of the Yeast Cell Cycle Gene CDC42. Molecular and Cellular Biology. 10(11). 5977–5982. 34 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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