Paul K. Brindle

12.0k total citations · 7 hit papers
54 papers, 8.3k citations indexed

About

Paul K. Brindle is a scholar working on Molecular Biology, Genetics and Cell Biology. According to data from OpenAlex, Paul K. Brindle has authored 54 papers receiving a total of 8.3k indexed citations (citations by other indexed papers that have themselves been cited), including 45 papers in Molecular Biology, 11 papers in Genetics and 6 papers in Cell Biology. Recurrent topics in Paul K. Brindle's work include Epigenetics and DNA Methylation (10 papers), Ubiquitin and proteasome pathways (9 papers) and Cancer-related gene regulation (9 papers). Paul K. Brindle is often cited by papers focused on Epigenetics and DNA Methylation (10 papers), Ubiquitin and proteasome pathways (9 papers) and Cancer-related gene regulation (9 papers). Paul K. Brindle collaborates with scholars based in United States, Japan and United Kingdom. Paul K. Brindle's co-authors include Marc Montminy, Lawryn H. Kasper, Fayçal Boussouar, James R. Feramisco, Michael Karin, Arthur S. Alberts, Wu Xu, David C. Bedford, Ted Abel and Masatoshi Hagiwara and has published in prestigious journals such as Nature, Cell and Proceedings of the National Academy of Sciences.

In The Last Decade

Paul K. Brindle

54 papers receiving 8.2k citations

Hit Papers

The CREB coactivator TORC2 is a key regulator of fastin... 1993 2026 2004 2015 2005 2007 1994 2011 2010 250 500 750
What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

  1. The CREB coactivator TORC2 is a key regulator of fasting glucose metabolism
    2005 815 citations Seung‐Hoi Koo, Lawrence Flechner et al. Nature profile →
  2. Histone Deacetylase Inhibitors Enhance Memory and Synaptic Plasticity via CREB: CBP-Dependent Transcriptional Activation
    2007 658 citations Christopher G. Vecsey, Joshua D. Hawk et al. Journal of Neuroscience profile →
  3. Activation of cAMP and mitogen responsive genes relies on a common nuclear factor
    1994 651 citations Jonathan Arias, Paul K. Brindle et al. Nature profile →
  4. Inactivating mutations of acetyltransferase genes in B-cell lymphoma
    2011 644 citations Laura Pasqualucci, Lawryn H. Kasper et al. Nature profile →
  5. Distinct roles of GCN5/PCAF‐mediated H3K9ac and CBP/p300‐mediated H3K18/27ac in nuclear receptor transactivation
    2010 619 citations Qihuang Jin, Li‐Rong Yu et al. The EMBO Journal profile →
  6. CREBBP mutations in relapsed acute lymphoblastic leukaemia
    2011 433 citations Lawryn H. Kasper, Stephanie Lerach et al. Nature profile →
  7. Coupling of Hormonal Stimulation and Transcription via the Cyclic AMP-Responsive Factor CREB Is Rate Limited by Nuclear Entry of Protein Kinase A
    1993 354 citations Paul K. Brindle, Robert Armstrong et al. Molecular and Cellular Biology profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name h Career Trend Papers Cites
Paul K. Brindle United States 36 6.0k 1.2k 1.0k 955 934 54 8.3k
Henryk Dudek United States 19 7.4k 1.2× 828 0.7× 1.6k 1.6× 2.0k 2.1× 952 1.0× 41 10.3k
Scott R. McKercher United States 41 4.5k 0.8× 629 0.5× 1.1k 1.1× 754 0.8× 2.5k 2.7× 74 8.8k
Bradley W. Doble Canada 35 8.2k 1.4× 1.2k 1.0× 767 0.8× 844 0.9× 478 0.5× 60 10.0k
Drazen B. Zimonjic United States 40 4.2k 0.7× 855 0.7× 1.6k 1.6× 492 0.5× 547 0.6× 91 6.5k
Xinmin Zhang United States 39 4.1k 0.7× 630 0.5× 701 0.7× 1.2k 1.3× 472 0.5× 140 7.2k
Debabrata Chakravarti United States 39 5.8k 1.0× 2.2k 1.8× 1.2k 1.2× 594 0.6× 982 1.1× 77 8.5k
Nigel Whittle Austria 34 4.2k 0.7× 854 0.7× 2.3k 2.3× 1.1k 1.1× 898 1.0× 51 8.3k
Matthew G. Guenther United States 23 10.9k 1.8× 1.7k 1.4× 1.1k 1.1× 579 0.6× 526 0.6× 32 12.3k
Vincent Goffin France 49 3.0k 0.5× 1.9k 1.5× 1.7k 1.7× 323 0.3× 771 0.8× 167 8.5k
Andrew J. H. Smith United Kingdom 33 3.4k 0.6× 706 0.6× 465 0.5× 701 0.7× 726 0.8× 57 5.7k

Countries citing papers authored by Paul K. Brindle

Since Specialization
Citations

This map shows the geographic impact of Paul K. Brindle's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Paul K. Brindle with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Paul K. Brindle more than expected).

Fields of papers citing papers by Paul K. Brindle

Since Specialization
Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Paul K. Brindle. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Paul K. Brindle. The network helps show where Paul K. Brindle may publish in the future.

Co-authorship network of co-authors of Paul K. Brindle

This figure shows the co-authorship network connecting the top 25 collaborators of Paul K. Brindle. A scholar is included among the top collaborators of Paul K. Brindle based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Paul K. Brindle. Paul K. Brindle is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

20 of 20 papers shown
1.
Zhang, Jiyuan, Sofija Vlasevska, Victoria A. Wells, et al.. (2017). The CREBBP Acetyltransferase Is a Haploinsufficient Tumor Suppressor in B-cell Lymphoma. Cancer Discovery. 7(3). 322–337. 151 indexed citations
2.
Paz, José C., Sang‐Ho Park, Shigenobu Matsumura, et al.. (2014). Combinatorial regulation of a signal-dependent activator by phosphorylation and acetylation. Proceedings of the National Academy of Sciences. 111(48). 17116–17121. 24 indexed citations
3.
Liu, Yujie, Liqing Wang, Jarrod D. Predina, et al.. (2013). Inhibition of p300 impairs Foxp3+ T regulatory cell function and promotes antitumor immunity. Nature Medicine. 19(9). 1173–1177. 161 indexed citations
4.
Bedford, David C. & Paul K. Brindle. (2012). Is histone acetylation the most important physiological function for CBP and p300?. Aging. 4(4). 247–255. 98 indexed citations
5.
Bedford, David C., Lawryn H. Kasper, Ruoning Wang, et al.. (2011). Disrupting the CH1 Domain Structure in the Acetyltransferases CBP and p300 Results in Lean Mice with Increased Metabolic Control. Cell Metabolism. 14(2). 219–230. 33 indexed citations
6.
Kasper, Lawryn H., Mary C. Thomas, Gerard P. Zambetti, & Paul K. Brindle. (2011). Double null cells reveal that CBP and p300 are dispensable for p53 targetsp21andMdm2but variably required for target genes of other signaling pathways. Cell Cycle. 10(2). 212–221. 26 indexed citations
7.
Oliveira, Ana M.M., et al.. (2011). Subregion-specific p300 conditional knock-out mice exhibit long-term memory impairments. Learning & Memory. 18(3). 161–169. 84 indexed citations
8.
Bedford, David C., Lawryn H. Kasper, Tomofusa Fukuyama, & Paul K. Brindle. (2010). Target gene context influences the transcriptional requirement for the KAT3 family of CBP and p300 histone acetyltransferases. Epigenetics. 5(1). 9–15. 231 indexed citations
9.
Jin, Qihuang, Li‐Rong Yu, Lifeng Wang, et al.. (2010). Distinct roles of GCN5/PCAF‐mediated H3K9ac and CBP/p300‐mediated H3K18/27ac in nuclear receptor transactivation. The EMBO Journal. 30(2). 249–262. 619 indexed citations breakdown →
10.
Vecsey, Christopher G., Joshua D. Hawk, K. Matthew Lattal, et al.. (2007). Histone Deacetylase Inhibitors Enhance Memory and Synaptic Plasticity via CREB: CBP-Dependent Transcriptional Activation. Journal of Neuroscience. 27(23). 6128–6140. 658 indexed citations breakdown →
11.
Xu, Wu, Lawryn H. Kasper, Stephanie Lerach, Trushar Jeevan, & Paul K. Brindle. (2007). Individual CREB‐target genes dictate usage of distinct cAMP‐responsive coactivation mechanisms. The EMBO Journal. 26(12). 2890–2903. 110 indexed citations
12.
Wood, Marcelo A., Michelle A. Attner, Ana M.M. Oliveira, Paul K. Brindle, & Ted Abel. (2006). A transcription factor-binding domain of the coactivator CBP is essential for long-term memory and the expression of specific target genes. Learning & Memory. 13(5). 609–617. 158 indexed citations
13.
Kasper, Lawryn H., Fayçal Boussouar, Kelli L. Boyd, et al.. (2005). Two transactivation mechanisms cooperate for the bulk of HIF‐1‐responsive gene expression. The EMBO Journal. 24(22). 3846–3858. 125 indexed citations
14.
Koo, Seung‐Hoi, Lawrence Flechner, Ling Qi, et al.. (2005). The CREB coactivator TORC2 is a key regulator of fasting glucose metabolism. Nature. 437(7062). 1109–1114. 815 indexed citations breakdown →
15.
Kasper, Lawryn H., Fayçal Boussouar, Paul A. Ney, et al.. (2002). A transcription-factor-binding surface of coactivator p300 is required for haematopoiesis. Nature. 419(6908). 738–743. 154 indexed citations
16.
Kasper, Lawryn H., Paul K. Brindle, Catherine A. Schnabel, et al.. (1999). CREB Binding Protein Interacts with Nucleoporin-Specific FG Repeats That Activate Transcription and Mediate NUP98-HOXA9 Oncogenicity. Molecular and Cellular Biology. 19(1). 764–776. 271 indexed citations
17.
Montminy, Marc, Paul K. Brindle, Jonathan Arias, Kevin Ferreri, & Robert Armstrong. (1996). Regulation of somatostatin gene transcription by cyclic adenosine monophosphate. Metabolism. 45(8 Suppl 1). 4–7. 24 indexed citations
18.
Brindle, Paul K., et al.. (1993). Protein-kinase-A-dependent activator in transcription factor CREB reveals new role for CREM repressers. Nature. 364(6440). 821–824. 150 indexed citations
19.
Brindle, Paul K. & Marc Montminy. (1992). The CREB family of transcription activators. Current Opinion in Genetics & Development. 2(2). 199–204. 259 indexed citations
20.
Holland, Janice P., Paul K. Brindle, & Michael J. Holland. (1990). Sequences within an Upstream Activation Site in the Yeast Enolase Gene EN02 Modulate Repression of EN02 Expression in Strains Carrying a Null Mutation in the Positive Regulatory Gene GCR1. Molecular and Cellular Biology. 10(9). 4863–4871. 8 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

Explore authors with similar magnitude of impact

Breakdown of academic impact, for papers by Henryk Dudek Breakdown of academic impact, for papers by Scott R. McKercher Breakdown of academic impact, for papers by Bradley W. Doble Breakdown of academic impact, for papers by Drazen B. Zimonjic Breakdown of academic impact, for papers by Xinmin Zhang Breakdown of academic impact, for papers by Debabrata Chakravarti Breakdown of academic impact, for papers by Nigel Whittle Breakdown of academic impact, for papers by Matthew G. Guenther Breakdown of academic impact, for papers by Vincent Goffin Breakdown of academic impact, for papers by Andrew J. H. Smith
Rankless by CCL
2026