Patrick G. Needham

1.5k citations

29 papers · 1.1k indexed · 1 hit paper · h-index 16

Impact in

Cell Biology top 5%
- Endoplasmic Reticulum Stress and Disease
- Cellular transport and secretion
Neurology top 5%
- Amyotrophic Lateral Sclerosis Research

Papers in ⓘ

Cell Biology 9
- Endoplasmic Reticulum Stress and Disease 8
- Cellular transport and secretion 3
Physical and Theoretical Chemistry 3
- thermodynamics and calorimetric analyses 3

Co-authors: Jeffrey L. Brodsky (18 shared papers)Christopher J. Guerriero (2 shared papers)Udai Bhan Pandey (1 shared paper)Christopher J. Donnelly (1 shared paper)Bede Portz (1 shared paper)Bryan Hurtle (1 shared paper)James Shorter (1 shared paper)Jacob R. Mann (1 shared paper)
Journals: Journal of Biological Chemistry (4 papers)Scientific Reports (2 papers)Virology (2 papers)Yeast (1 paper)Neurotherapeutics (1 paper)
Partner nations: United States United Kingdom Germany

In The Last Decade

Patrick G. Needham

28 papers receiving 1.1k citations

Hit Papers

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RNA Binding Antagonizes Neurotoxic Phase Transitions of TDP-43 2019 · 365 citations

Peers

Countries citing papers authored by Patrick G. Needham

Since Specialization

Citations

This map shows the geographic impact of Patrick G. Needham's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Patrick G. Needham with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Patrick G. Needham more than expected).

Fields of papers citing papers by Patrick G. Needham

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Patrick G. Needham. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Patrick G. Needham. The network helps show where Patrick G. Needham may publish in the future.

Co-authors

The 25 scholars most cited alongside Patrick G. Needham, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Patrick G. Needham Line = papers co-authored together Patrick G. Needham links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

Showing the 20 most-cited of 29 papers — load more, or switch the sort, to bring in the rest.

#	Work
1	RNA Binding Antagonizes Neurotoxic Phase Transitions of TDP-43 Neuron ·Jacob R. Mann, Amanda M. Gleixner, Jocelyn C. Mauna, Edward Gomes, Michael R. DeChellis-Marks, Patrick G. Needham, Katie E. Copley, Bryan Hurtle, Bede Portz, Noah J. Pyles, Lin Guo, Christopher B. Calder, Zachary P. Wills, Udai Bhan Pandey, Julia Kofler, Jeffrey L. Brodsky, Amantha Thathiah, James Shorter, Christopher J. Donnelly Hit paper breakdown →	2019	365
2	A COPII subunit acts with an autophagy receptor to target endoplasmic reticulum for degradation Science ·Yixian Cui, Smriti Parashar, Muhammad Zahoor, Patrick G. Needham, Muriel Mari, Ming Zhu, Shuliang Chen, Hsuan-Chung Ho, Fulvio Reggiori, Hesso Farhan, Jeffrey L. Brodsky, Susan Ferro‐Novick	2019	120
3	Chaperoning Endoplasmic Reticulum–Associated Degradation (ERAD) and Protein Conformational Diseases Cold Spring Harbor Perspectives in Biology ·Patrick G. Needham, Christopher J. Guerriero, Jeffrey L. Brodsky	2019	97
4	Dietary protein energy supplementation of pregnant Asian mothers at Sorrento, Birmingham. II: Selective during third trimester only. BMJ ·O. A. C. Viegas, P. Scott, T J Cole, Phyllis M. Eaton, Patrick G. Needham, B A Wharton	1982	73
5	How early studies on secreted and membrane protein quality control gave rise to the ER associated degradation (ERAD) pathway: The early history of ERAD Biochimica et Biophysica Acta (BBA) - Molecular Cell Research ·Patrick G. Needham, Jeffrey L. Brodsky	2013	55
6	Adeno-associated virus interactions with B23/Nucleophosmin: Identification of sub-nucleolar virion regions Virology ·Joyce Bevington, Patrick G. Needham, Kristin C. Verrill, Roy F. Collaco, Venkatesh Basrur, James P. Trempe	2006	48
7	Hsp70 and Hsp90 Multichaperone Complexes Sequentially Regulate Thiazide-sensitive Cotransporter Endoplasmic Reticulum-associated Degradation and Biogenesis Journal of Biological Chemistry ·Bridget F. Donnelly, Patrick G. Needham, Avin C. Snyder, Ankita Roy, Shaheen Khadem, Jeffrey L. Brodsky, Arohan R. Subramanya	2013	47
8	Plasmodium falciparum encodes a single cytosolic type I Hsp40 that functionally interacts with Hsp70 and is upregulated by heat shock Cell Stress and Chaperones ·Melissa Botha, Annette Chiang, Patrick G. Needham, Linda L. Stephens, Heinrich C. Hoppe, Simone Külzer, Jude M. Przyborski, Klaus Lingelbach, Peter Wipf, Jeffrey L. Brodsky, Addmore Shonhai, Gregory L. Blatch	2010	43
9	The Thiazide-sensitive NaCl Cotransporter Is Targeted for Chaperone-dependent Endoplasmic Reticulum-associated Degradation Journal of Biological Chemistry ·Patrick G. Needham, Kasia Mikoluk, Pradeep Dhakarwal, Shaheen Khadem, Avin C. Snyder, Arohan R. Subramanya, Jeffrey L. Brodsky	2011	41
10	ESCRT regulates surface expression of the Kir2.1 potassium channel Molecular Biology of the Cell ·Alexander Kolb, Patrick G. Needham, Cari Rothenberg, Christopher J. Guerriero, Paul A. Welling, Jeffrey L. Brodsky	2013	29
11	Prion-impairing mutations in Hsp70 chaperone Ssa1: Effects on ATPase and chaperone activities Archives of Biochemistry and Biophysics ·Patrick G. Needham, Daniel C. Masison	2008	23
12	Dihydropyrimidinones and -thiones with improved activity against human polyomavirus family members Bioorganic & Medicinal Chemistry Letters ·Alexandra Manos‐Turvey, Hiba A. Al-Ashtal, Patrick G. Needham, Caroll B. Hartline, Mark N. Prichard, Peter Wipf, Jeffrey L. Brodsky	2016	22
13	Symmetry breaking during homodimeric assembly activates an E3 ubiquitin ligase Scientific Reports ·Zhaofeng Ye, Patrick G. Needham, Samuel K. Estabrooks, Susan K. Whitaker, Brandon L. Garcia, Saurav Misra, Jeffrey L. Brodsky, Carlos J. Camacho	2017	19
14	Synthesis and evaluation of esterified Hsp70 agonists in cellular models of protein aggregation and folding Bioorganic & Medicinal Chemistry ·Annette Chiang, Mary Liang, Antonio Dominguez‐Meijide, Caterina Masaracchia, Jennifer L. Goeckeler-Fried, Carly S. Mazzone, David Newhouse, Nathan M. Kendsersky, Megan E. Yates, Alexandra Manos‐Turvey, Patrick G. Needham, Tiago F. Outeiro, Peter Wipf, Jeffrey L. Brodsky	2018	17
15	Mutations in the Yeast Hsp70, Ssa1, at P417 Alter ATP Cycling, Interdomain Coupling, and Specific Chaperone Functions Journal of Molecular Biology ·Patrick G. Needham, Hardik J. Patel, Gabriela Chiosis, Patrick H. Thibodeau, Jeffrey L. Brodsky	2015	16
16	Select α-arrestins control cell-surface abundance of the mammalian Kir2.1 potassium channel in a yeast model Journal of Biological Chemistry ·Natalie Hager, Collin J. Krasowski, Timothy D. Mackie, Alexander Kolb, Patrick G. Needham, Andrew A. Augustine, Alison Dempsey, Christopher Szent-Györgyi, Marcel P. Bruchez, Daniel J. Bain, Adam V. Kwiatkowski, Allyson F. O’Donnell, Jeffrey L. Brodsky	2018	15
17	Loss of Ypk1, the Yeast Homolog to the Human Serum- and Glucocorticoid-induced Protein Kinase, Accelerates Phospholipase B1-mediated Phosphatidylcholine Deacylation Journal of Biological Chemistry ·Beth A. Surlow, Benjamin M. Cooley, Patrick G. Needham, Jeffrey L. Brodsky, Jana Patton‐Vogt	2014	13
18	In vitro thymus suppression of hemagglutinin production in Xenopus laevis: location, drug and temperature sensitivity. PubMed ·Ruben Ln, Clothier Rh, Abigail C. Buenafe, Patrick G. Needham, James Hs, Michael Balls	1984	13
19	Adeno-Associated Virus Rep Protein-Mediated Inhibition of Transcription of the Adenovirus Major Late Promoter In Vitro Journal of Virology ·Patrick G. Needham, John M. Casper, Vivian Kalman‐Maltese, Kristin C. Verrill, John David Dignam, James P. Trempe	2006	13
20	Expression of three topologically distinct membrane proteins elicits unique stress response pathways in the yeastSaccharomyces cerevisiae Physiological Genomics ·Teresa M. Buck, Rick Jordan, James Lyons‐Weiler, Joshua L. Adelman, Patrick G. Needham, Thomas R. Kleyman, Jeffrey L. Brodsky	2015	9

About Patrick G. Needham

Patrick G. Needham is a scholar working on Cell Biology, Physical and Theoretical Chemistry, Molecular Biology, Genetics and Microbiology, having authored 29 papers that have together received 1.1k indexed citations. Recurring topics across this work include Endoplasmic Reticulum Stress and Disease (8 papers), Heat shock proteins research (7 papers), Virus-based gene therapy research (3 papers), Fungal and yeast genetics research (3 papers), Bacterial Genetics and Biotechnology (3 papers), thermodynamics and calorimetric analyses (3 papers), Cellular transport and secretion (3 papers) and Autophagy in Disease and Therapy (3 papers). The work is most often cited by research in Cell Biology (312 citations), Neurology (199 citations), Molecular Biology (717 citations), Genetics (107 citations) and Aging (17 citations). Patrick G. Needham has collaborated with scholars based in United States, United Kingdom and Germany. Frequent co-authors include Jeffrey L. Brodsky, Christopher J. Guerriero, Udai Bhan Pandey, Christopher J. Donnelly, Bede Portz, Bryan Hurtle, James Shorter, Jacob R. Mann, Jocelyn C. Mauna and Zachary P. Wills. Their work appears in journals such as Journal of Biological Chemistry, Scientific Reports, Virology, Yeast and Neurotherapeutics.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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