James Shorter

26.9k total citations · 9 hit papers
161 papers, 15.9k citations indexed

About

James Shorter is a scholar working on Molecular Biology, Cell Biology and Neurology. According to data from OpenAlex, James Shorter has authored 161 papers receiving a total of 15.9k indexed citations (citations by other indexed papers that have themselves been cited), including 142 papers in Molecular Biology, 46 papers in Cell Biology and 44 papers in Neurology. Recurrent topics in James Shorter's work include RNA Research and Splicing (48 papers), Prion Diseases and Protein Misfolding (46 papers) and Amyotrophic Lateral Sclerosis Research (41 papers). James Shorter is often cited by papers focused on RNA Research and Splicing (48 papers), Prion Diseases and Protein Misfolding (46 papers) and Amyotrophic Lateral Sclerosis Research (41 papers). James Shorter collaborates with scholars based in United States, United Kingdom and Germany. James Shorter's co-authors include Susan Lindquist, Aaron D. Gitler, Oliver D. King, Graham Warren, Edward Gomes, Meredith E. Jackrel, Lin Guo, Leslie A. Lange, Brian S. Johnson and J. Michael McCaffery and has published in prestigious journals such as Nature, Science and Cell.

In The Last Decade

James Shorter

158 papers receiving 15.7k citations

Hit Papers

5 papers align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Protein Phase Separation: A New Phase in Cell Biology

2018 1.4k citations Nicolas L. Fawzi, James Shorter et al. profile →
Stress granules as crucibles of ALS pathogenesis

2013 678 citations James Shorter et al. profile →
TDP-43 Is Intrinsically Aggregation-prone, and Amyotrophic Lateral Sclerosis-linked Mutations Accelerate Aggregation and Increase Toxicity

2009 605 citations James Shorter et al. Journal of Biological Chemistry profile →
The molecular language of membraneless organelles

2018 533 citations Edward Gomes, James Shorter Journal of Biological Chemistry profile →
The tip of the iceberg: RNA-binding proteins with prion-like domains in neurodegenerative disease

2012 513 citations James Shorter et al. profile →
RNA Binding Antagonizes Neurotoxic Phase Transitions of TDP-43

2019 365 citations Edward Gomes, Katie E. Copley et al. profile →
Cytoplasmic TDP-43 De-mixing Independent of Stress Granules Drives Inhibition of Nuclear Import, Loss of Nuclear TDP-43, and Cell Death

2019 327 citations Lin Guo, James Shorter et al. profile →
Poly(ADP-Ribose) Prevents Pathological Phase Separation of TDP-43 by Promoting Liquid Demixing and Stress Granule Localization

2018 308 citations Edward Gomes, Lin Guo et al. profile →
FUS and TDP-43 Phases in Health and Disease

2021 189 citations Bede Portz, Bo Lim Lee et al. profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name	h						Papers	Cites
James Shorter United States	63	12.8k	4.0k	3.6k	1.7k	1.7k	161	15.9k
Simon Alberti Germany	58	17.2k 1.3×	1.5k 0.4×	2.8k 0.8×	1.1k 0.6×	606 0.4×	106	19.7k
Junmin Peng United States	78	16.9k 1.3×	1.5k 0.4×	3.4k 0.9×	2.3k 1.4×	705 0.4×	257	23.0k
Ron R. Kopito United States	67	14.6k 1.1×	2.5k 0.6×	7.3k 2.0×	3.6k 2.2×	619 0.4×	136	22.6k
Ludo Van Den Bosch Belgium	64	8.6k 0.7×	6.2k 1.5×	1.1k 0.3×	1.9k 1.2×	3.3k 2.0×	283	15.3k
Erika L.F. Holzbaur United States	79	10.5k 0.8×	3.0k 0.8×	9.5k 2.6×	2.5k 1.5×	1.0k 0.6×	205	19.0k
Henning Urlaub Germany	83	20.3k 1.6×	527 0.1×	2.2k 0.6×	1.1k 0.6×	478 0.3×	445	24.9k
Masayuki Miura Japan	64	8.6k 0.7×	640 0.2×	2.3k 0.7×	825 0.5×	267 0.2×	253	13.2k
Giampietro Schiavo United Kingdom	76	9.6k 0.7×	8.0k 2.0×	6.2k 1.7×	2.3k 1.4×	658 0.4×	260	19.7k
Magdalini Polymenidou Switzerland	32	6.7k 0.5×	4.0k 1.0×	494 0.1×	1.2k 0.7×	2.2k 1.3×	56	9.6k
Joost Schymkowitz Belgium	58	10.6k 0.8×	885 0.2×	1.2k 0.3×	3.4k 2.0×	354 0.2×	188	14.3k

Countries citing papers authored by James Shorter

Since Specialization

Citations

This map shows the geographic impact of James Shorter's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by James Shorter with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites James Shorter more than expected).

Fields of papers citing papers by James Shorter

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by James Shorter. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by James Shorter. The network helps show where James Shorter may publish in the future.

Co-authorship network of co-authors of James Shorter

This figure shows the co-authorship network connecting the top 25 collaborators of James Shorter. A scholar is included among the top collaborators of James Shorter based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with James Shorter. James Shorter is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

Sort: Min cites: Since: Top N: Style:

20 of 20 papers shown

Reane, Denis Vecellio, Ryan R. Cupo, James Shorter, et al.. (2025). Dependence of mitochondrial calcium signalling and dynamics on the disaggregase, CLPB. Nature Communications. 16(1). 2810–2810. 2 indexed citations

Girdhar, Amandeep, M.E. Cicardi, Miyuki Hayashi, et al.. (2025). NLS-binding deficient Kapβ2 reduces neurotoxicity via selective interaction with C9orf72-ALS/FTD dipeptide repeats. Communications Biology. 8(1). 2–2. 2 indexed citations

Robinson, Emma C., et al.. (2024). Reversing aberrant phase transitions of ALS-linked disease protein FUS with RNA. Biophysical Journal. 123(3). 216a–216a. 1 indexed citations

Khalil, Bilal, et al.. (2024). Nuclear-import receptors as gatekeepers of pathological phase transitions in ALS/FTD. Molecular Neurodegeneration. 19(1). 8–8. 14 indexed citations

Dorweiler, Jane E., et al.. (2024). The middle domain of Hsp104 can ensure substrates are functional after processing. PLoS Genetics. 20(10). e1011424–e1011424. 3 indexed citations

Balendra, Rubika, Igor Ruiz de los Mozos, Hana M. Odeh, et al.. (2023). Transcriptome-wide RNA binding analysis of C9orf72 poly(PR) dipeptides. Life Science Alliance. 6(9). e202201824–e202201824. 5 indexed citations

Wiese, Sebastian, Amandeep Girdhar, Nadine Schwierz, et al.. (2023). Cryo-EM Structure of the Full-length hnRNPA1 Amyloid Fibril. Journal of Molecular Biology. 435(18). 168211–168211. 6 indexed citations

Peinado, Juan R., et al.. (2022). Sequestration of TDP-43 ^216-414 Aggregates by Cytoplasmic Expression of the proSAAS Chaperone. ACS Chemical Neuroscience. 13(11). 1651–1665. 9 indexed citations

Warren, Julia T., Ryan R. Cupo, David H. Spencer, et al.. (2021). Heterozygous variants of CLPB are a cause of severe congenital neutropenia. Blood. 139(5). 779–791. 24 indexed citations

10.

Hallegger, Martina, Anob M. Chakrabarti, Flora Lee, et al.. (2021). TDP-43 condensation properties specify its RNA-binding and regulatory repertoire. Cell. 184(18). 4680–4696.e22. 137 indexed citations

11.

Fare, Charlotte M., et al.. (2021). Higher-order organization of biomolecular condensates. Open Biology. 11(6). 210137–210137. 111 indexed citations

12.

March, Zachary M., Hanna Kim, Xiaohui Yan, et al.. (2020). Therapeutic genetic variation revealed in diverse Hsp104 homologs. eLife. 9. 23 indexed citations

13.

Fredrickson, Eric K., JiaBei Lin, Edward Chuang, et al.. (2019). The extent of Ssa1/Ssa2 Hsp70 chaperone involvement in nuclear protein quality control degradation varies with the substrate. Molecular Biology of the Cell. 31(3). 221–233. 14 indexed citations

14.

Gates, Stephanie N., Adam L. Yokom, JiaBei Lin, et al.. (2017). Ratchet-like polypeptide translocation mechanism of the AAA+ disaggregase Hsp104. Science. 357(6348). 273–279. 193 indexed citations

15.

Jackrel, Meredith E. & James Shorter. (2017). Protein-Remodeling Factors As Potential Therapeutics for Neurodegenerative Disease. Frontiers in Neuroscience. 11. 99–99. 29 indexed citations

16.

Shorter, James. (2016). Engineering therapeutic protein disaggregases. Molecular Biology of the Cell. 27(10). 1556–1560. 46 indexed citations

17.

DeSantis, Morgan E. & James Shorter. (2012). Hsp104 Drives “Protein-Only” Positive Selection of Sup35 Prion Strains Encoding Strong [PSI]. Chemistry & Biology. 19(11). 1400–1410. 39 indexed citations

18.

Shorter, James. (2010). Emergence and natural selection of drug-resistant prions. Molecular BioSystems. 6(7). 1115–1130. 43 indexed citations

19.

Watt, Brenda, Guillaume van Niel, Douglas M. Fowler, et al.. (2009). N-terminal Domains Elicit Formation of Functional Pmel17 Amyloid Fibrils. Journal of Biological Chemistry. 284(51). 35543–35555. 90 indexed citations

20.

Shorter, James & Susan Lindquist. (2004). Hsp104 Catalyzes Formation and Elimination of Self-Replicating Sup35 Prion Conformers. Science. 304(5678). 1793–1797. 389 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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