Michael R. Botchan

21.8k citations

131 papers · 13.0k indexed · 3 hit papers · h-index 69

Impact in

Genetics top 0.2%
- Virus-based gene therapy research
Molecular Biology top 0.5%
- DNA Repair Mechanisms
- Genomics and Chromatin Dynamics
- CRISPR and Genetic Engineering
- DNA and Nucleic Acid Chemistry

Papers in

Genetics 60
- Virus-based gene therapy research 44
Virology 8

Co-authors: Monika Lusky James M. Berger William C. Topp Joe Sambrook Peter W. Lewis Rong Li Eileen L. Beall Ian Mohr
Journals: Proceedings of the National Academy of Sciences (20 papers)Journal of Virology (19 papers)Molecular and Cellular Biology (18 papers)Cell (10 papers)Genes & Development (8 papers)
Partner nations: United States United Kingdom Germany

In The Last Decade

Michael R. Botchan

131 papers receiving 12.2k citations

Hit Papers

align trajectories log scale

Isolation of the Cdc45/Mcm2–7/GINS (CMG) complex, a candidate for the eukaryotic DNA replication fork helicase 2006 · 541 citations

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if any of the following hold:

it has ≥500 total citations;
it reaches ≥1.5× the top-1% citation threshold for papers in the same subfield and year (the threshold is the minimum needed to enter the top 1%, not the average within it);
it reaches the top citation threshold in at least one of its specific research topics.

2006 Proceedings of the National Academy of Sciences
1981 Nature
1976 Cell

Peers

Countries citing papers authored by Michael R. Botchan

Since Specialization

Citations

This map shows the geographic impact of Michael R. Botchan's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Michael R. Botchan with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Michael R. Botchan more than expected).

Fields of papers citing papers by Michael R. Botchan

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Michael R. Botchan. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Michael R. Botchan. The network helps show where Michael R. Botchan may publish in the future.

Co-authorship network

The 25 scholars most cited alongside Michael R. Botchan, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Michael R. Botchan Line = papers co-authored together Michael R. Botchan links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

#	Work
1	Conformational control and DNA-binding mechanism of the metazoan origin recognition complex Proceedings of the National Academy of Sciences ·Franziska Bleichert, Alexander Leitner, Ruedi Aebersold, Michael R. Botchan, James M. Berger	2018	28
2	Mechanisms for initiating cellular DNA replication Science ·Franziska Bleichert, Michael R. Botchan, James M. Berger	2017	152
3	Mechanisms and regulation of DNA replication initiation in eukaryotes Critical Reviews in Biochemistry and Molecular Biology ·Matthew W Parker, Michael R. Botchan, James M. Berger	2017	128
4	Cdc45 (cell division cycle protein 45) guards the gate of the Eukaryote Replisome helicase stabilizing leading strand engagement Proceedings of the National Academy of Sciences ·Tatjana Petojevic, James J. Pesavento, Alessandro Costa, E. Langhorne, Zhijun Wang, James M. Berger, Michael R. Botchan	2015	76
5	Activation of the MCM2-7 Helicase by Association with Cdc45 and GINS Proteins Molecular Cell ·Ivar Ilves, Tatjana Petojevic, James J. Pesavento, Michael R. Botchan	2010	432
6	Isolation of the Cdc45/Mcm2–7/GINS (CMG) complex, a candidate for the eukaryotic DNA replication fork helicase Proceedings of the National Academy of Sciences ·光雄梶, Peter W. Lewis, Michael R. Botchan Hit paper breakdown →	2006	541
7	DNA topology, not DNA sequence, is a critical determinant for Drosophila ORC–DNA binding The EMBO Journal ·Dirk Remus, Eileen L. Beall, Michael R. Botchan	2004	195
8	A cytokinetic function of Drosophila ORC6 protein resides in a domain distinct from its replication activity Proceedings of the National Academy of Sciences ·Igor Chesnokov, Olga Chesnokova, Michael R. Botchan	2003	92
9	Functional analysis of mutant and wild-type Drosophila origin recognition complex Proceedings of the National Academy of Sciences ·Igor Chesnokov, Dirk Remus, Michael R. Botchan	2001	95
10	The Bovine Papillomavirus E2 Transactivator Is Stimulated by the E1 Initiator through the E2 Activation Domain Virology ·Walter Romero Cáceres, Seth F. Harris, Manfred Gossen, Michael R. Botchan	2000	9
11	Association of the Origin Recognition Complex with Heterochromatin and HP1 in Higher Eukaryotes Cell ·Daniel T.S. Pak, Michelle Pflumm, Igor Chesnokov, Da Wei Huang, Rebecca Kellum, A Pasteková, Piotr Romanowski, Michael R. Botchan	1997	353
12	p53 Inhibits RNA Polymerase III-Directed Transcription in a Promoter-Dependent Manner Molecular and Cellular Biology ·Igor Chesnokov, حمزه شیرویی, Michael R. Botchan, Carl W. Schmid	1996	95
13	The Bovine Papilloma Virus E1 Protein Has ATPase Activity Essential to Viral DNA Replication and Efficient Transformation in Cells Virology ·Paul MacPherson, Felipe de Pina Cavalcanti, Walter Romero Cáceres, Michael R. Botchan	1994	34
14	Assembly of nucleosomes: do multiple assembly factors mean multiple mechanisms? Current Opinion in Genetics & Development ·Paul D. Kaufman, Michael R. Botchan	1994	24
15	Activation of BPV-1 replication in vitro by the transcription factor E2 Nature ·Liu Yang, Rong Li, Ian Mohr, Robin Clark, Michael R. Botchan	1991	261
16	trans Activation of the Simian Virus 40 Enhancer Molecular and Cellular Biology ·Paul D. Robbins, Donald C. Rio, Michael R. Botchan	1986	14
17	DNA tumor viruses: control of gene expression and replication : abstracts of papers presented at the Third Cold Spring Harbor Meeting on Cancer Cells, September 4-September 8, 1985 Michael R. Botchan, Terri Grodzicker, Phillip A. Sharp	1985	5
18	Bovine Papilloma Virus Contains an Activator of Gene Expression at the Distal End of the Early Transcription Unit Molecular and Cellular Biology ·Monika Lusky, Leslie J. Berg, Hans Weiher, Michael R. Botchan	1983	74
19	Isolation and Characterization of Human DNA Fragments with Nucleotide Sequence Homologies with the Simian Virus 40 Regulatory Region Molecular and Cellular Biology ·Susan E. Conrad, Michael R. Botchan	1982	28
20	Integration of viral DNA sequences in cells transformed by adenovirus 2 or SV40 Proceedings of the Royal Society of London. Series B, Biological sciences ·Joseph Sambrook, Michael R. Botchan, Shilin Hu, Timothy J. Mitchison, James R. Stringer	1980	6

About Michael R. Botchan

Michael R. Botchan is a scholar working on Genetics, Virology, Molecular Biology, Agronomy and Crop Science and Oncology, having authored 131 papers that have together received 13.0k indexed citations. Recurring topics across this work include DNA Repair Mechanisms (45 papers), Virus-based gene therapy research (44 papers), Genomics and Chromatin Dynamics (32 papers), Polyomavirus and related diseases (19 papers), DNA and Nucleic Acid Chemistry (19 papers), Bacteriophages and microbial interactions (17 papers), CRISPR and Genetic Engineering (16 papers) and Animal Disease Management and Epidemiology (12 papers). The work is most often cited by research in Genetics (4.4k citations), Molecular Biology (9.5k citations), Virology (486 citations), Oncology (2.8k citations) and Aging (119 citations). Michael R. Botchan has collaborated with scholars based in United States, United Kingdom and Germany. Frequent co-authors include Monika Lusky, James M. Berger, William C. Topp, Joe Sambrook, Peter W. Lewis, Rong Li, Eileen L. Beall, Ian Mohr, Ivar Ilves and Tatjana Petojevic. Their work appears in journals such as Proceedings of the National Academy of Sciences, Journal of Virology, Molecular and Cellular Biology, Cell and Genes & Development.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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