Martin Scheffner

22.7k total citations · 6 hit papers
139 papers, 17.9k citations indexed

About

Martin Scheffner is a scholar working on Molecular Biology, Oncology and Genetics. According to data from OpenAlex, Martin Scheffner has authored 139 papers receiving a total of 17.9k indexed citations (citations by other indexed papers that have themselves been cited), including 109 papers in Molecular Biology, 75 papers in Oncology and 32 papers in Genetics. Recurrent topics in Martin Scheffner's work include Ubiquitin and proteasome pathways (73 papers), Cancer-related Molecular Pathways (51 papers) and Peptidase Inhibition and Analysis (19 papers). Martin Scheffner is often cited by papers focused on Ubiquitin and proteasome pathways (73 papers), Cancer-related Molecular Pathways (51 papers) and Peptidase Inhibition and Analysis (19 papers). Martin Scheffner collaborates with scholars based in Germany, United States and Israel. Martin Scheffner's co-authors include Peter M. Howley, Jon M. Huibregtse, Arnold J. Levine, Bruce A. Werness, Richard D. Vierstra, Ulrike A. Nuber, Karl Münger, Arnd Hengstermann, Sylvia E. Schwarz and J C Byrne and has published in prestigious journals such as Nature, Cell and Proceedings of the National Academy of Sciences.

In The Last Decade

Martin Scheffner

138 papers receiving 17.6k citations

Hit Papers

5 papers align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53

1990 3.3k citations Martin Scheffner, Jon M. Huibregtse et al. profile →
The HPV-16 E6 and E6-AP complex functions as a ubiquitin-protein ligase in the ubiquitination of p53

1993 1.9k citations Martin Scheffner, Jon M. Huibregtse et al. profile →
Protein ubiquitination involving an E1–E2–E3 enzyme ubiquitin thioester cascade

1995 814 citations Martin Scheffner, Jon M. Huibregtse et al. profile →
The state of the p53 and retinoblastoma genes in human cervical carcinoma cell lines.

1991 736 citations Martin Scheffner, Karl Münger et al. profile →
A cellular protein mediates association of p53 with the E6 oncoprotein of human papillomavirus types 16 or 18.

1991 696 citations Jon M. Huibregtse, Martin Scheffner et al. profile →
Hakai, a c-Cbl-like protein, ubiquitinates and induces endocytosis of the E-cadherin complex

2002 693 citations Martin Scheffner et al. profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name	h						Papers	Cites
Martin Scheffner Germany	55	12.1k	7.7k	5.0k	3.4k	1.9k	139	17.9k
Jon M. Huibregtse United States	50	8.9k 0.7×	5.7k 0.7×	4.8k 1.0×	2.5k 0.8×	1.4k 0.7×	85	14.7k
Nicholas J. Dyson United States	73	15.1k 1.2×	11.9k 1.5×	3.5k 0.7×	3.4k 1.0×	2.8k 1.4×	142	22.5k
Lawrence Banks Italy	64	6.7k 0.6×	5.9k 0.8×	8.1k 1.6×	3.2k 0.9×	1.9k 1.0×	242	15.3k
Ed Harlow United States	65	15.5k 1.3×	12.6k 1.6×	2.7k 0.5×	5.8k 1.7×	2.0k 1.0×	144	24.0k
James A. DeCaprio United States	75	13.0k 1.1×	11.3k 1.5×	1.6k 0.3×	3.7k 1.1×	2.1k 1.1×	208	21.4k
G. Yancey Gillespie United States	63	7.6k 0.6×	5.1k 0.7×	2.7k 0.5×	4.9k 1.5×	2.3k 1.2×	282	15.0k
Karl Münger United States	75	9.6k 0.8×	9.4k 1.2×	11.5k 2.3×	4.5k 1.3×	3.2k 1.7×	190	23.0k
Titia de Lange United States	97	29.5k 2.4×	3.5k 0.5×	2.5k 0.5×	2.3k 0.7×	1.7k 0.9×	180	38.8k
Anton Berns Netherlands	80	13.5k 1.1×	9.6k 1.2×	2.3k 0.5×	3.1k 0.9×	2.0k 1.0×	211	23.7k
Margaret C. Frame United Kingdom	69	8.3k 0.7×	3.6k 0.5×	3.3k 0.7×	1.7k 0.5×	1.8k 0.9×	174	16.5k

Countries citing papers authored by Martin Scheffner

Since Specialization

Citations

This map shows the geographic impact of Martin Scheffner's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Martin Scheffner with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Martin Scheffner more than expected).

Fields of papers citing papers by Martin Scheffner

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Martin Scheffner. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Martin Scheffner. The network helps show where Martin Scheffner may publish in the future.

Co-authorship network of co-authors of Martin Scheffner

This figure shows the co-authorship network connecting the top 25 collaborators of Martin Scheffner. A scholar is included among the top collaborators of Martin Scheffner based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Martin Scheffner. Martin Scheffner is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

Sort: Min cites: Since: Top N: Style:

20 of 20 papers shown

Velimirović, Milica, et al.. (2025). E6AP is essential for the proliferation of HPV-positive cancer cells by preventing senescence. PLoS Pathogens. 21(2). e1012914–e1012914. 1 indexed citations

Scheffner, Martin, et al.. (2025). Proteomic Profiling of Potential E6AP Substrates via Ubiquitin‐based Photo‐Crosslinking Assisted Affinity Enrichment. ChemBioChem. 26(4). e202400831–e202400831. 1 indexed citations

Catone, Nicola, et al.. (2023). FAT10 and NUB1L cooperate to activate the 26S proteasome. Life Science Alliance. 6(8). e202201463–e202201463. 5 indexed citations

Bogomolovas, Julius, Jennifer R. Fleming, Barbara Franke, et al.. (2021). Titin kinase ubiquitination aligns autophagy receptors with mechanical signals in the sarcomere. EMBO Reports. 22(10). e48018–e48018. 31 indexed citations

Rao, Ashit, Teresa Roncal‐Herrero, Markus Drechsler, et al.. (2019). On Biomineralization: Enzymes Switch on Mesocrystal Assembly. ACS Central Science. 5(2). 357–364. 22 indexed citations

Bulkescher, Julia, et al.. (2019). Effects of the antifungal agent ciclopirox in HPV‐positive cancer cells: Repression of viral E6/E7 oncogene expression and induction of senescence and apoptosis. International Journal of Cancer. 146(2). 461–474. 30 indexed citations

Berg, Andrej, et al.. (2018). Towards a molecular basis of ubiquitin signaling: A dual-scale simulation study of ubiquitin dimers. PLoS Computational Biology. 14(11). e1006589–e1006589. 22 indexed citations

Schneider, Daniel, et al.. (2013). Improving bioorthogonal protein ubiquitylation by click reaction. Bioorganic & Medicinal Chemistry. 21(12). 3430–3435. 17 indexed citations

Chan, Ai-Leen, Tamar Grossman, Valentina Zuckerman, et al.. (2013). c-Abl Phosphorylates E6AP and Regulates Its E3 Ubiquitin Ligase Activity. Biochemistry. 52(18). 3119–3129. 18 indexed citations

10.

Dohmen, R. Jürgen & Martin Scheffner. (2012). Ubiquitin Family Modifiers and the Proteasome. Methods in molecular biology. 17 indexed citations

11.

Xirodimas, Dimitris P. & Martin Scheffner. (2010). Ubiquitin Family Members in the Regulation of the Tumor Suppressor p53. Sub-cellular biochemistry. 54. 116–135. 4 indexed citations

12.

Johnsen, Steven A., Cenap Güngör, Sabine Riethdorf, et al.. (2008). Regulation of Estrogen-Dependent Transcription by the LIM Cofactors CLIM and RLIM in Breast Cancer. Cancer Research. 69(1). 128–136. 52 indexed citations

13.

Singh, Rajesh, et al.. (2007). Hetero-oligomerization with MdmX Rescues the Ubiquitin/Nedd8 Ligase Activity of RING Finger Mutants of Mdm2. Journal of Biological Chemistry. 282(15). 10901–10907. 54 indexed citations

14.

Pelzer, Christiane, Konstantin Matentzoglu, Rajesh Singh, et al.. (2007). UBE1L2, a Novel E1 Enzyme Specific for Ubiquitin*. Journal of Biological Chemistry. 282(32). 23010–23014. 135 indexed citations

15.

Salvat, Catherine, Claire Acquaviva, Martin Scheffner, et al.. (2000). Molecular characterization of the thermosensitive E1 ubiquitin‐activating enzyme cell mutant A31N‐ts20. European Journal of Biochemistry. 267(12). 3712–3722. 40 indexed citations

16.

Hengstermann, Arnd, et al.. (1998). Characterization of sequence elements involved in p53 stability regulation reveals cell type dependence for p53 degradation. Oncogene. 17(22). 2933–2941. 27 indexed citations

17.

Scheffner, Martin. (1998). Ubiquitin, E6-AP, and Their Role in p53 Inactivation. Pharmacology & Therapeutics. 78(3). 129–139. 82 indexed citations

18.

Scheffner, Martin, H Romanczuk, Karl Münger, et al.. (1994). Functions of Human Papillomavirus Proteins. Current topics in microbiology and immunology. 186. 83–99. 92 indexed citations

19.

Huibregtse, Jon M., Martin Scheffner, & Peter M. Howley. (1994). E6-AP Directs the HPV E6-dependent Inactivation of p53 and Is Representative of a Family of Structurally and Functionally Related Proteins. Cold Spring Harbor Symposia on Quantitative Biology. 59(0). 237–245. 43 indexed citations

20.

Huibregtse, Jon M., Martin Scheffner, & Peter M. Howley. (1993). Cloning and Expression of the cDNA for E6-AP, a Protein that Mediates the Interaction of the Human Papillomavirus E6 Oncoprotein with p53. Molecular and Cellular Biology. 13(2). 775–784. 179 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

Explore authors with similar magnitude of impact