Marcel J. de Groot

2.8k total citations
39 papers, 2.2k citations indexed

About

Marcel J. de Groot is a scholar working on Computational Theory and Mathematics, Pharmacology and Molecular Biology. According to data from OpenAlex, Marcel J. de Groot has authored 39 papers receiving a total of 2.2k indexed citations (citations by other indexed papers that have themselves been cited), including 19 papers in Computational Theory and Mathematics, 19 papers in Pharmacology and 12 papers in Molecular Biology. Recurrent topics in Marcel J. de Groot's work include Pharmacogenetics and Drug Metabolism (19 papers), Computational Drug Discovery Methods (18 papers) and Analytical Chemistry and Chromatography (8 papers). Marcel J. de Groot is often cited by papers focused on Pharmacogenetics and Drug Metabolism (19 papers), Computational Drug Discovery Methods (18 papers) and Analytical Chemistry and Chromatography (8 papers). Marcel J. de Groot collaborates with scholars based in United Kingdom, Netherlands and United States. Marcel J. de Groot's co-authors include Sean Ekins, Barry Jones, Nico Vermeulen, Jeffrey P. Jones, W. J. F. van der Vijgh, Dirk‐Jan van den Berg, Aalt Bast, S.A.B.E. van Acker, Mark J. Ackland and Sean O’Brien and has published in prestigious journals such as Journal of the American Chemical Society, Advanced Drug Delivery Reviews and Journal of Medicinal Chemistry.

In The Last Decade

Marcel J. de Groot

39 papers receiving 2.1k citations

Peers

Countries citing papers authored by Marcel J. de Groot

Since Specialization

Citations

This map shows the geographic impact of Marcel J. de Groot's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Marcel J. de Groot with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Marcel J. de Groot more than expected).

Fields of papers citing papers by Marcel J. de Groot

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Marcel J. de Groot. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Marcel J. de Groot. The network helps show where Marcel J. de Groot may publish in the future.

Co-authorship network of co-authors of Marcel J. de Groot

This figure shows the co-authorship network connecting the top 25 collaborators of Marcel J. de Groot. A scholar is included among the top collaborators of Marcel J. de Groot based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Marcel J. de Groot. Marcel J. de Groot is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

#	Work	Indexed citations
1	Computational Hit Finding: An Industry Perspective 2025 ·Journal of Medicinal Chemistry ·Paraskevi Gkeka, Fredrik Svensson, Carlos Roca, Marcel J. de Groot, Steven V. Jerome	1
2	Discovery of an Oral, Rule of 5 Compliant, Interleukin 17A Protein–Protein Interaction Modulator for the Potential Treatment of Psoriasis and Other Inflammatory Diseases 2022 ·Journal of Medicinal Chemistry ·(unknown), Kevin N. Dack, Marcel J. de Groot, Maja Lambert, (unknown), Mogens Larsen, Martin Stahlhut	14
3	From virtual to clinical: The discovery of PGN-1531, a novel antagonist of the prostanoid EP4 receptor 2014 ·Bioorganic & Medicinal Chemistry Letters ·(unknown), David E. Clark, Christopher Higgs, Marcel J. de Groot, Neil V. Harris, Andrea C. Taylor, Peter Lockey, Karen Maubach, (unknown), Richard J. Davis, Robert A. Coleman, Kenneth L. Clark	8
4	Subtype‐selective targeting of voltage‐gated sodium channels 2009 ·British Journal of Pharmacology ·(unknown), Marcel J. de Groot	92
5	Understanding CYP2D6 interactions 2009 ·Drug Discovery Today ·Marcel J. de Groot, Florian Wakenhut, Gavin A. Whitlock, Ruth Hyland	26
6	Designing better drugs: predicting cytochrome P450 metabolism 2006 ·Drug Discovery Today ·Marcel J. de Groot	87
7	The Discovery of CCR5 Receptor Antagonists for the Treatment of HIV Infection: Hit‐to‐Lead Studies 2006 ·ChemMedChem ·Duncan Armour, Marcel J. de Groot, Martin P. Edwards, Manos Perros, David A. Price, Blanda Stammen, Anthony Wood	17
8	Drug Binding Interactions in the Inner Cavity of hERG Channels: Molecular Insights from Structure-Activity Relationships of Clofilium and Ibutilide Analogs 2005 ·Molecular Pharmacology ·Matthew Perry, Phillip J. Stansfeld, Joanne L. Leaney, (unknown), Marcel J. de Groot, Derek J. Leishman, Michael J. Sutcliffe, John S. Mitcheson	69
9	Structural Determinants of HERG Channel Block by Clofilium and Ibutilide 2004 ·Molecular Pharmacology ·Matthew Perry, Marcel J. de Groot, R. M. Helliwell, Derek J. Leishman, Martin Tristani‐Firouzi, Michael C. Sanguinetti, John S. Mitcheson	135
10	Genetic Basis for Differential Activities of Fluconazole and Voriconazole against Candida krusei 2003 ·Antimicrobial Agents and Chemotherapy ·Takashi Fukuoka, Douglas A. Johnston, (unknown), Marcel J. de Groot, Catherine Burt, Christopher A. Hitchcock, Scott G. Filler	80
11	Pharmacophore modeling of cytochromes P450 2002 ·Advanced Drug Delivery Reviews ·Marcel J. de Groot, Sean Ekins	81
12	Regioselective hydroxylation of debrisoquine by cytochrome P4502D6: implications for active site modelling 2000 ·Xenobiotica ·J. Timothy Lightfoot, S. W. Ellis, (unknown), Mark J. Ackland, Frank E. Blaney, (unknown), Marcel J. de Groot, Nico Vermeulen, G. Michael Blackburn, M. S. Lennard, Geoffrey T. Tucker	32
13	Hydrogen atom abstraction of 3,5-disubstituted analogues of paracetamol by horseradish peroxidase and cytochrome P450 1998 ·Xenobiotica ·Jos Bessems, Marcel J. de Groot, (unknown), J.M. te Koppele, Nico Vermeulen	21
14	Ab initio calculations on iron-porphyrin model systems for intermediates in the oxidative cycle of cytochrome P450s 1998 ·Journal of Computer-Aided Molecular Design ·Marcel J. de Groot, Remco W. A. Havenith, H. Maarten Vinkers, (unknown), Nico Vermeulen, Joop H. van Lenthe	23
15	Modeling the Active Sites of Cytochrome P450s and GlutathioneS-Transferases, two of the Most Important Biotransformation Enzymes 1997 ·Drug Metabolism Reviews ·Marcel J. de Groot, Nico Vermeulen	15
16	4-Substituted 1-Chloro-2-nitrobenzenes: Structure−Activity Relationships and Extension of the Substrate Model of Rat Glutathione S-Transferase 4-4 1997 ·Chemical Research in Toxicology ·Ellen M. van der Aar, Marcel J. de Groot, (unknown), (unknown), Jan N. M. Commandeur, Nico Vermeulen	8
17	Extension of a predictive substrate model for human cytochrome P4502D6 1997 ·Xenobiotica ·Marcel J. de Groot, (unknown), F.A.A. van Acker, Célia Fonseca Guerra, J. G. Snijders	18
18	A Three-Dimensional Protein Model for Human Cytochrome P450 2D6 Based on the Crystal Structures of P450 101, P450 102, and P450 108 1996 ·Chemical Research in Toxicology ·Marcel J. de Groot, Nico Vermeulen, (unknown), F.A.A. van Acker, Gabriëlle M. Donné-Op den Kelder	55
19	Metabolite Predictions for Para-Substituted Anisoles Based on ab Initio Complete Active Space Self-Consistent Field Calculations 1995 ·Chemical Research in Toxicology ·Marcel J. de Groot, Gabriëlle M. Donné-Op den Kelder, Jan N. M. Commandeur, Joop H. van Lenthe, Nico Vermeulen	10
20	A Predictive Substrate Model for Rat Glutathione S-Transferase 4-4 1995 ·Chemical Research in Toxicology ·Marcel J. de Groot, Ellen M. van der Aar, P. J. Nieuwenhuizen, (unknown), (unknown), Jan N. M. Commandeur, Nico Vermeulen	8

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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