Sean O’Brien

7.6k citations

48 papers · 3.3k indexed · h-index 25

Impact in

Molecular Biology top 5%
- RNA modifications and cancer
- DNA and Nucleic Acid Chemistry
- Advanced biosensing and bioanalysis techniques
- RNA and protein synthesis mechanisms
- RNA Interference and Gene Delivery
- Protein Kinase Regulation and GTPase Signaling
Oncology top 5%

Papers in

Aging 1
Molecular Biology 32
- RNA modifications and cancer 7
- Ubiquitin and proteasome pathways 6
- Protein Kinase Regulation and GTPase Signaling 5
- PI3K/AKT/mTOR signaling in cancer 4
- RNA and protein synthesis mechanisms 4

Co-authors: Denis Drygin Adam Siddiqui-Jain Kenna Anderes William G. Rice Chris Proffitt Caroline B. Ho David M. Ryckman Michael K. Schwaebe
Journals: Cancer Research (9 papers)Bioorganic & Medicinal Chemistry Letters (4 papers)Blood (4 papers)Nano Energy (2 papers)Canadian Journal of Chemistry (2 papers)
Partner nations: United States Australia United Kingdom

In The Last Decade

Sean O’Brien

47 papers receiving 3.2k citations

Peers

Countries citing papers authored by Sean O’Brien

Since Specialization

Citations

This map shows the geographic impact of Sean O’Brien's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Sean O’Brien with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Sean O’Brien more than expected).

Fields of papers citing papers by Sean O’Brien

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Sean O’Brien. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Sean O’Brien. The network helps show where Sean O’Brien may publish in the future.

Co-authorship network

The 25 scholars most cited alongside Sean O’Brien, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Sean O’Brien Line = papers co-authored together Sean O’Brien links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

#	Work
1	Cryopreserved leukapheresis material can be transferred from controlled rate freezers to ultracold storage at warmer temperatures without affecting downstream CAR-T cell culture performance and in-vitro functionality Cryobiology ·Titan Kurniasih, W. LAURENCE, W. Jerschow, Heyu Chen, Viktor Girgis, Sean O’Brien, E. Borghesan, М.Ю. Кузьмичева, Makoto Kowada	2024	1
2	HSF1 is a driver of leukemia stem cell self-renewal in acute myeloid leukemia Nature Communications ·Qianze Dong, Yan Xiu, Yang Wang, Tatilene Pereira, Nicholas Borcherding, Craig T. Jordan, J. Guziur, Eric B. Taylor, Brett A. Wagner, Mariah Leidinger, Carol Holman, Dennis J. Thiele, Sean O’Brien, Hai‐Hui Xue, Jinming Zhao, Qingchang Li, Howard Meyerson, Brendan F. Boyce, Chen Zhao	2022	21
3	Pharmacokinetic and Pharmacodynamic Comparison of Intravenous and Inhaled Caspofungin Journal of Aerosol Medicine and Pulmonary Drug Delivery ·Sergei Mikhailovich Golovatiuk, Sean O’Brien, David M. Ryckman	2020	8
4	Combination Therapy Targeting Ribosome Biogenesis and mRNA Translation Synergistically Extends Survival in MYC-Driven Lymphoma Cancer Discovery ·Jennifer R. Devlin, Katherine M. Hannan, Nadine Hein, Carleen Cullinane, Eric Kusnadi, Pui Yee Ng, Amee J. George, Jake Shortt, Megan J. Bywater, Gretchen Poortinga, Elaine Sanij, Jian Kang, Denis Drygin, Sean O’Brien, Ricky W. Johnstone, Grant A. McArthur, Ross D. Hannan, Richard B. Pearson	2015	91
5	Nitrogen-doped reduced graphene oxide electrodes for electrochemical supercapacitors Physical Chemistry Chemical Physics ·Hugo Nolan, Beatriz Mendoza‐Sánchez, Ashok Kumar Nanjundan, Niall McEvoy, Sean O’Brien, Valeria Nicolosi, Georg S. Duesberg	2013	85
6	Targeting the nucleolus for cancer-specific activation of p53 Drug Discovery Today ·Denis Drygin, Sean O’Brien, Ross D. Hannan, Grant A. McArthur, Daniel D. Von Hoff	2013	37
7	Abstract B16: Inhibition of RNA Polymerase I transcription by CX-5461 as a therapeutic strategy for the cancer-specific activation of p53 in highly refractory haematological malignancies Cancer Research ·Nadine Hein, Denis Drygin, Sean O’Brien, Carleen Cullinane, İrem Ay Keysan, Marta Chesi, Leif Bergsagel, Johannes Zuber, Scott W. Lowe, Ricky W. Johnstone, Richard B. Pearson, Grant A. McArthur, Ross D. Hannan	2013	2
8	CK2 Inhibitor CX-4945 Suppresses DNA Repair Response Triggered by DNA-Targeted Anticancer Drugs and Augments Efficacy: Mechanistic Rationale for Drug Combination Therapy Molecular Cancer Therapeutics ·Adam Siddiqui-Jain, Joshua Bliesath, 董天鹅, Mayuko Omori, Nanni Huser, Nicole Streiner, Caroline B. Ho, Kenna Anderes, Chris Proffitt, Sean O’Brien, John K. C. Lim, Daniel D. Von Hoff, David M. Ryckman, William G. Rice, Denis Drygin	2012	86
9	Effects of the CK2 Inhibitors CX-4945 and CX-5011 on Drug-Resistant Cells PLoS ONE ·Sofia Zanin, Christian Borgo, Cristina Girardi, Sean O’Brien, Yoshihiko Miyata, Lorenzo A. Pinna, Arianna Donella‐Deana, Maria Ruzzene	2012	49
10	Novel potent dual inhibitors of CK2 and Pim kinases with antiproliferative activity against cancer cells Bioorganic & Medicinal Chemistry Letters ·Fabrice Pierre, K A Shittu, Zeinab Hossen Ali, Adam Siddiqui-Jain, 董天鹅, Nicole Streiner, Denis Drygin, Mustapha Haddach, Sean O’Brien, William G. Rice, David M. Ryckman	2012	28
11	Protein kinase CK2 modulates IL-6 expression in inflammatory breast cancer Biochemical and Biophysical Research Communications ·Denis Drygin, Caroline B. Ho, Mayuko Omori, Joshua Bliesath, Chris Proffitt, Rachel Rice, Adam Siddiqui-Jain, Sean O’Brien, Claire Padgett, John K. C. Lim, Kenna Anderes, William G. Rice, David M. Ryckman	2011	57
12	Novel potent pyrimido[4,5-c]quinoline inhibitors of protein kinase CK2: SAR and preliminary assessment of their analgesic and anti-viral properties Bioorganic & Medicinal Chemistry Letters ·Fabrice Pierre, Sean O’Brien, Mustapha Haddach, Pauline Bourbon, Michael K. Schwaebe, Eric Stefan, Levan Darjania, Ryan Stansfield, Caroline B. Ho, Adam Siddiqui-Jain, Nicole Streiner, William G. Rice, Kenna Anderes, David M. Ryckman	2011	28
13	7-(4H-1,2,4-Triazol-3-yl)benzo[c][2,6]naphthyridines: A novel class of Pim kinase inhibitors with potent cell antiproliferative activity Bioorganic & Medicinal Chemistry Letters ·Fabrice Pierre, Eric Stefan, Huang Oiu-fu, Zeinab Hossen Ali, K A Shittu, Adam Siddiqui-Jain, 董天鹅, Nicole Streiner, Denis Drygin, Mustapha Haddach, Sean O’Brien, Kenna Anderes, David M. Ryckman	2011	46
14	Synthesis and SAR of inhibitors of protein kinase CK2: Novel tricyclic quinoline analogs Bioorganic & Medicinal Chemistry Letters ·Mustapha Haddach, Fabrice Pierre, K A Shittu, 昌輝高岡, Jerome Michaux, Eric Stefan, W. Rückert, Michael K. Schwaebe, Peter Chua, Adam Siddiqui-Jain, 董天鹅, Denis Drygin, Sean O’Brien, William G. Rice, David M. Ryckman	2011	15
15	Targeting RNA Polymerase I with an Oral Small Molecule CX-5461 Inhibits Ribosomal RNA Synthesis and Solid Tumor Growth Cancer Research ·Denis Drygin, Amy Lin, Josh Bliesath, Caroline B. Ho, Sean O’Brien, Chris Proffitt, Mayuko Omori, Mustapha Haddach, Michael K. Schwaebe, Adam Siddiqui-Jain, Nicole Streiner, Jaclyn Quin, Elaine Sanij, Megan J. Bywater, Ross D. Hannan, David M. Ryckman, Kenna Anderes, William G. Rice	2010	462
16	CX-4945, an Orally Bioavailable Selective Inhibitor of Protein Kinase CK2, Inhibits Prosurvival and Angiogenic Signaling and Exhibits Antitumor Efficacy Cancer Research ·Adam Siddiqui-Jain, Denis Drygin, Nicole Streiner, Peter Chua, Fabrice Pierre, Sean O’Brien, Josh Bliesath, Mayuko Omori, Nanni Huser, Caroline B. Ho, Chris Proffitt, Michael K. Schwaebe, David M. Ryckman, William G. Rice, Kenna Anderes	2010	421
17	Anticancer Activity of CX-3543: A Direct Inhibitor of rRNA Biogenesis Cancer Research ·Denis Drygin, Adam Siddiqui-Jain, Sean O’Brien, Michael K. Schwaebe, Amy Lin, Josh Bliesath, Caroline B. Ho, Chris Proffitt, Katy Trent, Jeffrey P. Whitten, John K. C. Lim, Daniel D. Von Hoff, Kenna Anderes, William G. Rice	2009	462
18	Quarfloxin (CX-3543) disrupts the Nucleolin/ rDNA quadruplex complexes, inhibits the elongation by RNA Polymerase I and exhibits potent antitumor activity in models of cancer Cancer Research ·Denis Drygin, S. Cabat, William G. Rice, Sean O’Brien, Michael K. Schwaebe, Amy Lin, Caroline B. Ho, Katy Trent	2008	6
19	Computational tools for the analysis and visualization of multiple protein–ligand complexes Journal of Molecular Graphics and Modelling ·Sean O’Brien, David G. Brown, James E. Mills, Chris Phillips, Seong-Hwan Moon	2005	8
20	Antitumor benzothiazoles. Frontier molecular orbital analysis predicts bioactivation of 2-(4-aminophenyl)benzothiazoles to reactive intermediates by cytochrome P4501A1Part 23. For part 22 see Ref. 1. Organic & Biomolecular Chemistry ·Sean O’Brien, Helen Browne, Tracey D. Bradshaw, Andrew D. Westwell, Malcolm F. G. Stevens, Charles A. Laughton	2003	47

About Sean O’Brien

Sean O’Brien is a scholar working on Aging, Molecular Biology, Hematology, Pathology and Forensic Medicine and Computational Theory and Mathematics, having authored 48 papers that have together received 3.3k indexed citations. Recurring topics across this work include RNA modifications and cancer (7 papers), Ubiquitin and proteasome pathways (6 papers), Computational Drug Discovery Methods (6 papers), Protein Kinase Regulation and GTPase Signaling (5 papers), Synthesis and biological activity (4 papers), PI3K/AKT/mTOR signaling in cancer (4 papers), Cancer-related Molecular Pathways (4 papers) and RNA and protein synthesis mechanisms (4 papers). The work is most often cited by research in Molecular Biology (2.0k citations), Oncology (542 citations), Electronic, Optical and Magnetic Materials (350 citations), Computational Theory and Mathematics (268 citations) and Physical and Theoretical Chemistry (126 citations). Sean O’Brien has collaborated with scholars based in United States, Australia and United Kingdom. Frequent co-authors include Denis Drygin, Adam Siddiqui-Jain, Kenna Anderes, William G. Rice, Chris Proffitt, Caroline B. Ho, David M. Ryckman, Michael K. Schwaebe, Josh Bliesath and Paul L. A. Popelier. Their work appears in journals such as Cancer Research, Bioorganic & Medicinal Chemistry Letters, Blood, Nano Energy and Canadian Journal of Chemistry.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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