Michael C. Sanguinetti

28.3k total citations · 9 hit papers
166 papers, 21.2k citations indexed

About

Michael C. Sanguinetti is a scholar working on Molecular Biology, Cardiology and Cardiovascular Medicine and Cellular and Molecular Neuroscience. According to data from OpenAlex, Michael C. Sanguinetti has authored 166 papers receiving a total of 21.2k indexed citations (citations by other indexed papers that have themselves been cited), including 152 papers in Molecular Biology, 151 papers in Cardiology and Cardiovascular Medicine and 78 papers in Cellular and Molecular Neuroscience. Recurrent topics in Michael C. Sanguinetti's work include Cardiac electrophysiology and arrhythmias (151 papers), Ion channel regulation and function (149 papers) and Neuroscience and Neuropharmacology Research (46 papers). Michael C. Sanguinetti is often cited by papers focused on Cardiac electrophysiology and arrhythmias (151 papers), Ion channel regulation and function (149 papers) and Neuroscience and Neuropharmacology Research (46 papers). Michael C. Sanguinetti collaborates with scholars based in United States, Germany and United Kingdom. Michael C. Sanguinetti's co-authors include Mark T. Keating, Nancy K. Jurkiewicz, Martin Tristani‐Firouzi, Mark Curran, John S. Mitcheson, Robert S. Kass, Igor Splawski, Anruo Zou, Jun Chen and Peter Spector and has published in prestigious journals such as Nature, Science and Cell.

In The Last Decade

Michael C. Sanguinetti

164 papers receiving 20.7k citations

Hit Papers

align trajectories sort by overperformance

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

A mechanistic link between an inherited and an acquird cardiac arrthytmia: HERG encodes the IKr potassium channel

1995 2.0k citations Michael C. Sanguinetti, Mark Curran et al. profile →
Coassembly of KVLQT1 and minK (IsK) proteins to form cardiac IKS potassium channel

1996 1.4k citations Michael C. Sanguinetti, Mark Curran et al. Nature profile →
hERG potassium channels and cardiac arrhythmia

2006 1.2k citations Michael C. Sanguinetti, Martin Tristani‐Firouzi Nature profile →
Two components of cardiac delayed rectifier K+ current. Differential sensitivity to block by class III antiarrhythmic agents.

1990 1.2k citations Michael C. Sanguinetti, Nancy K. Jurkiewicz The Journal of General Physiology profile →
CaV1.2 Calcium Channel Dysfunction Causes a Multisystem Disorder Including Arrhythmia and Autism

2004 1.1k citations Igor Splawski, Katherine W. Timothy et al. profile →
Molecular and Cellular Mechanisms of Cardiac Arrhythmias

2001 763 citations Mark T. Keating, Michael C. Sanguinetti profile →
A structural basis for drug-induced long QT syndrome

2000 758 citations John S. Mitcheson, Jun Chen et al. Proceedings of the National Academy of Sciences profile →
International Union of Pharmacology. LIII. Nomenclature and Molecular Relationships of Voltage-Gated Potassium Channels

2005 686 citations George A. Gutman, Stephan Grissmer et al. profile →
Mutations in the hminK gene cause long QT syndrome and suppress lKs function

1997 581 citations Igor Splawski, Martin Tristani‐Firouzi et al. Nature Genetics profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name	h						Papers	Cites
Michael C. Sanguinetti United States	67	18.5k	16.8k	7.0k	564	529	166	21.2k
Robert S. Kass United States	69	12.4k 0.7×	11.2k 0.7×	5.5k 0.8×	512 0.9×	93 0.2×	208	15.2k
Martin J. Lohse Germany	91	22.2k 1.2×	5.5k 0.3×	10.9k 1.5×	844 1.5×	669 1.3×	355	29.4k
Heping Cheng China	77	16.3k 0.9×	10.5k 0.6×	6.5k 0.9×	1.0k 1.8×	77 0.1×	236	21.1k
Jörg Striessnig Austria	69	12.5k 0.7×	4.2k 0.2×	8.2k 1.2×	478 0.8×	118 0.2×	224	16.9k
András Varró Hungary	52	5.8k 0.3×	7.3k 0.4×	1.7k 0.2×	491 0.9×	137 0.3×	294	9.2k
H. Réuter Switzerland	53	10.9k 0.6×	6.9k 0.4×	8.3k 1.2×	351 0.6×	45 0.1×	147	14.4k
Howard Schulman United States	78	15.0k 0.8×	2.5k 0.2×	9.7k 1.4×	437 0.8×	283 0.5×	158	20.7k
Gary Yellen United States	57	11.3k 0.6×	4.9k 0.3×	6.7k 1.0×	167 0.3×	39 0.1×	100	13.6k
Harry A. Fozzard United States	56	6.9k 0.4×	5.5k 0.3×	4.1k 0.6×	462 0.8×	38 0.1×	170	10.1k
Heike Wulff United States	62	9.0k 0.5×	3.0k 0.2×	3.2k 0.5×	504 0.9×	171 0.3×	232	13.3k

Countries citing papers authored by Michael C. Sanguinetti

Since Specialization

Citations

This map shows the geographic impact of Michael C. Sanguinetti's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Michael C. Sanguinetti with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Michael C. Sanguinetti more than expected).

Fields of papers citing papers by Michael C. Sanguinetti

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Michael C. Sanguinetti. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Michael C. Sanguinetti. The network helps show where Michael C. Sanguinetti may publish in the future.

Co-authorship network of co-authors of Michael C. Sanguinetti

This figure shows the co-authorship network connecting the top 25 collaborators of Michael C. Sanguinetti. A scholar is included among the top collaborators of Michael C. Sanguinetti based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Michael C. Sanguinetti. Michael C. Sanguinetti is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

Attali, Bernard, K. George Chandy, M. Hunter Giese, et al.. (2023). Voltage-gated potassium channels (K<sub>v</sub>) in GtoPdb v.2023.1. IUPHAR/BPS Guide to Pharmacology CITE. 2023(1). 2 indexed citations

Zangerl‐Plessl, Eva‐Maria, Martin Berger, Martina Drescher, et al.. (2019). Toward a Structural View of hERG Activation by the Small-Molecule Activator ICA-105574. Journal of Chemical Information and Modeling. 60(1). 360–371. 11 indexed citations

Wu, Wei & Michael C. Sanguinetti. (2016). Molecular Basis of Cardiac Delayed Rectifier Potassium Channel Function and Pharmacology. Cardiac Electrophysiology Clinics. 8(2). 275–284. 24 indexed citations

Grandi, Eleonora, Michael C. Sanguinetti, Daniel C. Bartos, et al.. (2016). Potassium channels in the heart: structure, function and regulation. The Journal of Physiology. 595(7). 2209–2228. 83 indexed citations

Chiamvimonvat, Nipavan, Ye Chen‐Izu, Colleen E. Clancy, et al.. (2016). Potassium currents in the heart: functional roles in repolarization, arrhythmia and therapeutics. The Journal of Physiology. 595(7). 2229–2252. 71 indexed citations

Sachse, Frank B., et al.. (2010). Modification of hERG1 channel gating by Cd2+. The Journal of General Physiology. 136(2). 203–224. 22 indexed citations

Splawski, Igor, Katherine W. Timothy, Niels Decher, et al.. (2005). Severe arrhythmia disorder caused by cardiac L-type calcium channel mutations. Proceedings of the National Academy of Sciences. 102(23). 8089–8096. 456 indexed citations

Sanguinetti, Michael C., Jun Chen, David Fernández, et al.. (2005). Physicochemical Basis for Binding and Voltage‐Dependent Block of hERG Channels by Structurally Diverse Drugs. Novartis Foundation symposium. 266. 159–170. 31 indexed citations

Sanguinetti, Michael C. & John S. Mitcheson. (2005). Predicting drug–hERG channel interactions that cause acquired long QT syndrome. Trends in Pharmacological Sciences. 26(3). 119–124. 229 indexed citations

10.

Sanguinetti, Michael C.. (2000). Maximal function of minimal K+ channel subunits. Trends in Pharmacological Sciences. 21(6). 199–201. 15 indexed citations

11.

Sanguinetti, Michael C., et al.. (2000). IS003 Open-state Block and Closed-state Unblock of HERG Channels by Vesnarinone. Japanese Circulation Journal-english Edition. 64. 121.

12.

Zhang, Jie, Saı̈d Bendahhou, Michael C. Sanguinetti, & Louis J. Ptáček. (2000). Functional consequences of chloride channel gene ( CLCN1) mutations causing myotonia congenita. Neurology. 54(4). 937–942. 44 indexed citations

13.

Mitcheson, John S., Jun Chen, & Michael C. Sanguinetti. (2000). Oita International Electrocardiology Symposium 2000 “Electrophysiology and Management of Lethal Arrhythmias in the New Millennium: From Genes to Bedside”. Japanese Journal of Electrocardiology. 20(Suppl3). 67–70. 1 indexed citations

14.

Chen, Jun, et al.. (1999). Long QT Syndrome-associated Mutations in the Per-Arnt-Sim (PAS) Domain of HERG Potassium Channels Accelerate Channel Deactivation. Journal of Biological Chemistry. 274(15). 10113–10118. 185 indexed citations

15.

Franqueza, Laura, Monica Lin, Igor Splawski, Mark T. Keating, & Michael C. Sanguinetti. (1999). Long QT Syndrome-associated Mutations in the S4-S5 Linker of KvLQT1 Potassium Channels Modify Gating and Interaction with minK Subunits. Journal of Biological Chemistry. 274(30). 21063–21070. 91 indexed citations

16.

Splawski, Igor, Martin Tristani‐Firouzi, Michael H. Lehmann, Michael C. Sanguinetti, & Mark T. Keating. (1997). Mutations in the hminK gene cause long QT syndrome and suppress lKs function. Nature Genetics. 17(3). 338–340. 581 indexed citations breakdown →

17.

Sanguinetti, Michael C., Mark Curran, Anruo Zou, et al.. (1996). Coassembly of KVLQT1 and minK (IsK) proteins to form cardiac IKS potassium channel. Nature. 384(6604). 80–83. 1425 indexed citations breakdown →

18.

Folander, Kimberly, et al.. (1994). Species variants of the I sK protein: differences in kinetics, voltage dependence, and La3+ block of the currents expressed in Xenopus oocytes. Pflügers Archiv - European Journal of Physiology. 426(1-2). 139–145. 24 indexed citations

19.

Sanguinetti, Michael C. & Nancy K. Jurkiewicz. (1990). Two components of cardiac delayed rectifier K+ current. Differential sensitivity to block by class III antiarrhythmic agents.. The Journal of General Physiology. 96(1). 195–215. 1206 indexed citations breakdown →

20.

Kamp, Timothy J., Michael C. Sanguinetti, & R. J. Miller. (1988). Voltage-dependent binding of dihydropyridine calcium channel blockers to guinea pig ventricular myocytes.. Journal of Pharmacology and Experimental Therapeutics. 247(3). 1240–1247. 15 indexed citations

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