M S Brown

18.8k total citations · 15 hit papers
57 papers, 16.0k citations indexed

About

M S Brown is a scholar working on Molecular Biology, Surgery and Cancer Research. According to data from OpenAlex, M S Brown has authored 57 papers receiving a total of 16.0k indexed citations (citations by other indexed papers that have themselves been cited), including 39 papers in Molecular Biology, 27 papers in Surgery and 11 papers in Cancer Research. Recurrent topics in M S Brown's work include Cholesterol and Lipid Metabolism (20 papers), Glycosylation and Glycoproteins Research (11 papers) and Cancer, Lipids, and Metabolism (9 papers). M S Brown is often cited by papers focused on Cholesterol and Lipid Metabolism (20 papers), Glycosylation and Glycoproteins Research (11 papers) and Cancer, Lipids, and Metabolism (9 papers). M S Brown collaborates with scholars based in United States and Poland. M S Brown's co-authors include J L Goldstein, J L Goldstein, Joseph L. Goldstein, Robert B. Rawson, Iichiro Shimomura, Y K Ho, Robert E. Hammer, Hitoshi Shimano, Jay D. Horton and Jin Y and has published in prestigious journals such as Cell, Proceedings of the National Academy of Sciences and Journal of Biological Chemistry.

In The Last Decade

M S Brown

57 papers receiving 15.3k citations

Hit Papers

ER Stress Induces Cleavag... 1977 2026 1993 2009 2000 2000 1980 1996 2000 400 800 1.2k
What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

  1. ER Stress Induces Cleavage of Membrane-Bound ATF6 by the Same Proteases that Process SREBPs
    2000 1.5k citations Jin Ye, Robert B. Rawson et al. Molecular Cell profile →
  2. Regulated Intramembrane Proteolysis
    2000 1.1k citations M S Brown, Jin Y et al. Cell profile →
  3. Multivalent feedback regulation of HMG CoA reductase, a control mechanism coordinating isoprenoid synthesis and cell growth.
    1980 1.0k citations M S Brown, J L Goldstein profile →
  4. Overproduction of cholesterol and fatty acids causes massive liver enlargement in transgenic mice expressing truncated SREBP-1a.
    1996 705 citations Hitoshi Shimano, Jay D. Horton et al. Journal of Clinical Investigation profile →
  5. Decreased IRS-2 and Increased SREBP-1c Lead to Mixed Insulin Resistance and Sensitivity in Livers of Lipodystrophic and ob/ob Mice
    2000 659 citations Iichiro Shimomura, Morihiro Matsuda et al. Molecular Cell profile →
  6. Differential expression of exons 1a and 1c in mRNAs for sterol regulatory element binding protein-1 in human and mouse organs and cultured cells.
    1997 649 citations Iichiro Shimomura, Hitoshi Shimano et al. Journal of Clinical Investigation profile →
  7. Receptor-mediated endocytosis: insights from the lipoprotein receptor system.
    1979 560 citations M S Brown, J L Goldstein Proceedings of the National Academy of Sciences profile →
  8. SREBP-2, a second basic-helix-loop-helix-leucine zipper protein that stimulates transcription by binding to a sterol regulatory element.
    1993 532 citations M S Brown, Joseph L. Goldstein et al. Proceedings of the National Academy of Sciences profile →
  9. 39-kDa protein modulates binding of ligands to low density lipoprotein receptor-related protein/alpha 2-macroglobulin receptor.
    1991 530 citations Joachim Herz, J L Goldstein et al. Journal of Biological Chemistry profile →
  10. Low density lipoprotein receptor-related protein mediates uptake of cholesteryl esters derived from apoprotein E-enriched lipoproteins.
    1989 516 citations Joachim Herz, Joseph L. Goldstein et al. Proceedings of the National Academy of Sciences profile →
  11. Increased binding of low density lipoprotein to liver membranes from rats treated with 17 alpha-ethinyl estradiol.
    1979 506 citations Petri T. Kovanen, M S Brown et al. Journal of Biological Chemistry profile →
  12. Lipoprotein receptors in the liver. Control signals for plasma cholesterol traffic.
    1983 450 citations M S Brown, J L Goldstein Journal of Clinical Investigation profile →
  13. Biosynthesis of N- and O-linked oligosaccharides of the low density lipoprotein receptor.
    1983 328 citations M S Brown, Joseph L. Goldstein et al. Journal of Biological Chemistry profile →
  14. Appearance of crystalloid endoplasmic reticulum in compactin-resistant Chinese hamster cells with a 500-fold increase in 3-hydroxy-3-methylglutaryl-coenzyme A reductase.
    1982 208 citations Daniel J. Chin, K L Luskey et al. Proceedings of the National Academy of Sciences profile →
  15. Lipoprotein-mediated regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity and cholesteryl ester metabolism in the adrenal gland of the rat.
    1977 186 citations Joseph L. Goldstein, J R Faust et al. Journal of Biological Chemistry profile →

Author Peers

Peers are selected by citation overlap in the author's most active subfields. citations · hero ref

Author Last Decade Papers Cites
M S Brown 8.8k 6.0k 3.2k 2.7k 2.2k 57 16.0k
John A. Glomset 6.6k 0.7× 4.5k 0.7× 1.5k 0.5× 1.9k 0.7× 2.3k 1.0× 85 13.3k
J L Goldstein 6.3k 0.7× 5.4k 0.9× 1.3k 0.4× 2.3k 0.9× 1.9k 0.9× 57 11.9k
Monty Krieger 11.0k 1.3× 9.4k 1.6× 2.9k 0.9× 3.3k 1.2× 3.4k 1.5× 185 24.2k
J L Goldstein 5.1k 0.6× 4.8k 0.8× 1.3k 0.4× 2.2k 0.8× 1.8k 0.8× 60 10.7k
Emile Van Schaftingen 9.8k 1.1× 2.9k 0.5× 1.4k 0.4× 2.3k 0.9× 2.8k 1.3× 263 15.6k
Timothy F. Osborne 7.3k 0.8× 4.8k 0.8× 767 0.2× 2.4k 0.9× 1.2k 0.5× 137 12.6k
Yves L. Marcel 4.5k 0.5× 4.9k 0.8× 833 0.3× 2.1k 0.8× 3.5k 1.6× 155 10.8k
T L Innerarity 5.1k 0.6× 6.1k 1.0× 813 0.3× 3.5k 1.3× 4.5k 2.0× 84 12.3k
Y K Ho 3.8k 0.4× 4.5k 0.8× 1.0k 0.3× 1.9k 0.7× 1.2k 0.5× 41 9.1k
Vassilis I. Zannis 5.3k 0.6× 4.6k 0.8× 609 0.2× 2.0k 0.8× 3.4k 1.6× 192 10.5k

Countries citing papers authored by M S Brown

Since Specialization
Citations

This map shows the geographic impact of M S Brown's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by M S Brown with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites M S Brown more than expected).

Fields of papers citing papers by M S Brown

Since Specialization
Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by M S Brown. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by M S Brown. The network helps show where M S Brown may publish in the future.

Co-authorship network of co-authors of M S Brown

This figure shows the co-authorship network connecting the top 25 collaborators of M S Brown. A scholar is included among the top collaborators of M S Brown based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with M S Brown. M S Brown is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

20 of 20 papers shown
1.
Brown, M S, et al.. (2000). Regulated Intramembrane Proteolysis. Cell. 100(4). 391–398. 1109 indexed citations breakdown →
2.
Ye, Jin, Robert B. Rawson, Ryutaro Komuro, et al.. (2000). ER Stress Induces Cleavage of Membrane-Bound ATF6 by the Same Proteases that Process SREBPs. Molecular Cell. 6(6). 1355–1364. 1477 indexed citations breakdown →
3.
Shimomura, Iichiro, Morihiro Matsuda, Robert E. Hammer, et al.. (2000). Decreased IRS-2 and Increased SREBP-1c Lead to Mixed Insulin Resistance and Sensitivity in Livers of Lipodystrophic and ob/ob Mice. Molecular Cell. 6(1). 77–86. 659 indexed citations breakdown →
4.
Shimomura, Iichiro, Hitoshi Shimano, Jay D. Horton, Joseph L. Goldstein, & M S Brown. (1997). Differential expression of exons 1a and 1c in mRNAs for sterol regulatory element binding protein-1 in human and mouse organs and cultured cells.. Journal of Clinical Investigation. 99(5). 838–845. 649 indexed citations breakdown →
5.
Shimano, Hitoshi, Iichiro Shimomura, Robert E. Hammer, et al.. (1997). Elevated levels of SREBP-2 and cholesterol synthesis in livers of mice homozygous for a targeted disruption of the SREBP-1 gene.. Journal of Clinical Investigation. 100(8). 2115–2124. 380 indexed citations
6.
Shimano, Hitoshi, Jay D. Horton, Robert E. Hammer, et al.. (1996). Overproduction of cholesterol and fatty acids causes massive liver enlargement in transgenic mice expressing truncated SREBP-1a.. Journal of Clinical Investigation. 98(7). 1575–1584. 705 indexed citations breakdown →
7.
Brown, M S, et al.. (1996). Purification and cDNA cloning of a second apoptosis-related cysteine protease that cleaves and activates sterol regulatory element binding proteins.. Proceedings of the National Academy of Sciences. 93(11). 5437–5442. 62 indexed citations
8.
Shoffner, John M., M S Brown, & Kirsi Huoponen. (1994). A mitochondrial DNA (mtDNA) mutation associated with maternally inherited Parkinson`s disease (PD) and deafness. The American Journal of Human Genetics. 55. 2 indexed citations
9.
Andres, Douglas, Athena Milatovich, Tayfun Özçelık, et al.. (1993). cDNA Cloning of the Two Subunits of Human CAAX Farnesyltransferase and Chromosomal Mapping of FNTA and FNTB Loci and Related Sequences. Genomics. 18(1). 105–112. 19 indexed citations
10.
Herz, Joachim, J L Goldstein, Dudley K. Strickland, Y K Ho, & M S Brown. (1991). 39-kDa protein modulates binding of ligands to low density lipoprotein receptor-related protein/alpha 2-macroglobulin receptor.. Journal of Biological Chemistry. 266(31). 21232–21238. 530 indexed citations breakdown →
11.
Hofmann, Sandra L., Dan Eaton, M S Brown, et al.. (1990). Overexpression of human low density lipoprotein receptors leads to accelerated catabolism of Lp(a) lipoprotein in transgenic mice.. Journal of Clinical Investigation. 85(5). 1542–1547. 158 indexed citations
12.
T.T., Phạm, Tokuo Yamamoto, J L Goldstein, & M S Brown. (1986). Increased mRNA for low density lipoprotein receptor in livers of rabbits treated with 17 alpha-ethinyl estradiol.. Proceedings of the National Academy of Sciences. 83(3). 792–796. 173 indexed citations
13.
Russell, David W., Mark A. Lehrman, Thomas C. Südhof, et al.. (1986). The LDL Receptor in Familial Hypercholesterolemia: Use of Human Mutations to Dissect a Membrane Protein. Cold Spring Harbor Symposia on Quantitative Biology. 51(0). 811–819. 38 indexed citations
14.
Luskey, K L, J R Faust, Daniel J. Chin, M S Brown, & J L Goldstein. (1983). Amplification of the gene for 3-hydroxy-3-methylglutaryl coenzyme A reductase, but not for the 53-kDa protein, in UT-1 cells.. Journal of Biological Chemistry. 258(13). 8462–8469. 174 indexed citations
15.
Kovanen, Petri T., M S Brown, S K Basu, D W Bilheimer, & J L Goldstein. (1981). Saturation and suppression of hepatic lipoprotein receptors: a mechanism for the hypercholesterolemia of cholesterol-fed rabbits.. Proceedings of the National Academy of Sciences. 78(3). 1396–1400. 291 indexed citations
16.
Kovanen, Petri T., M S Brown, & J L Goldstein. (1979). Increased binding of low density lipoprotein to liver membranes from rats treated with 17 alpha-ethinyl estradiol.. Journal of Biological Chemistry. 254(22). 11367–11373. 506 indexed citations breakdown →
17.
Brown, M S & J L Goldstein. (1979). Receptor-mediated endocytosis: insights from the lipoprotein receptor system.. Proceedings of the National Academy of Sciences. 76(7). 3330–3337. 560 indexed citations breakdown →
18.
Faust, J R, J L Goldstein, & M S Brown. (1977). Receptor-mediated uptake of low density lipoprotein and utilization of its cholesterol for steroid synthesis in cultured mouse adrenal cells.. Journal of Biological Chemistry. 252(14). 4861–4871. 216 indexed citations
19.
Ho, Y K, M S Brown, Herbert J. Kayden, & J L Goldstein. (1976). Binding, internalization, and hydrolysis of low density lipoprotein in long-term lymphoid cell lines from a normal subject and a patient with homozygous familial hypercholesterolemia.. The Journal of Experimental Medicine. 144(2). 444–455. 93 indexed citations
20.
Bilheimer, David W., J L Goldstein, S M Grundy, & M S Brown. (1975). Reduction in cholesterol and low density lipoprotein synthesis after portacaval shunt surgery in a patient with homozygous familial hypercholesterolemia.. Journal of Clinical Investigation. 56(6). 1420–1430. 198 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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