Hitoshi Shimano

32.9k total citations · 9 hit papers
380 papers, 24.0k citations indexed

About

Hitoshi Shimano is a scholar working on Molecular Biology, Surgery and Endocrinology, Diabetes and Metabolism. According to data from OpenAlex, Hitoshi Shimano has authored 380 papers receiving a total of 24.0k indexed citations (citations by other indexed papers that have themselves been cited), including 165 papers in Molecular Biology, 155 papers in Surgery and 99 papers in Endocrinology, Diabetes and Metabolism. Recurrent topics in Hitoshi Shimano's work include Cholesterol and Lipid Metabolism (92 papers), Peroxisome Proliferator-Activated Receptors (79 papers) and Diabetes, Cardiovascular Risks, and Lipoproteins (58 papers). Hitoshi Shimano is often cited by papers focused on Cholesterol and Lipid Metabolism (92 papers), Peroxisome Proliferator-Activated Receptors (79 papers) and Diabetes, Cardiovascular Risks, and Lipoproteins (58 papers). Hitoshi Shimano collaborates with scholars based in Japan, United States and India. Hitoshi Shimano's co-authors include Nobuhiro Yamada, Jay D. Horton, Iichiro Shimomura, Takashi Matsuzaka, Naoya Yahagi, Hirohito Sone, Takanari Gotoda, Ryuichiro Sato, Shun Ishibashi and J L Goldstein and has published in prestigious journals such as Proceedings of the National Academy of Sciences, The Lancet and Journal of Biological Chemistry.

In The Last Decade

Hitoshi Shimano

369 papers receiving 23.5k citations

Hit Papers

5 papers align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

SREBP-regulated lipid metabolism: convergent physiology — divergent pathophysiology

2017 820 citations Hitoshi Shimano et al. profile →
Isoform 1c of sterol regulatory element binding protein is less active than isoform 1a in livers of transgenic mice and in cultured cells.

1997 714 citations Hitoshi Shimano et al. Journal of Clinical Investigation profile →
Overproduction of cholesterol and fatty acids causes massive liver enlargement in transgenic mice expressing truncated SREBP-1a.

1996 705 citations Hitoshi Shimano et al. Journal of Clinical Investigation profile →
Differential expression of exons 1a and 1c in mRNAs for sterol regulatory element binding protein-1 in human and mouse organs and cultured cells.

1997 649 citations Hitoshi Shimano et al. Journal of Clinical Investigation profile →
Sterol regulatory element-binding proteins (SREBPs): transcriptional regulators of lipid synthetic genes

2001 626 citations Hitoshi Shimano profile →
Activation of cholesterol synthesis in preference to fatty acid synthesis in liver and adipose tissue of transgenic mice overproducing sterol regulatory element-binding protein-2.

1998 596 citations Hitoshi Shimano et al. Journal of Clinical Investigation profile →
Sterol Regulatory Element-binding Protein-1 as a Key Transcription Factor for Nutritional Induction of Lipogenic Enzyme Genes

1999 590 citations Hitoshi Shimano, Naoya Yahagi et al. profile →
Regulation of sterol regulatory element binding proteins in livers of fasted and refed mice

1998 558 citations Hitoshi Shimano et al. Proceedings of the National Academy of Sciences profile →
TGF-β activates Akt kinase through a microRNA-dependent amplifying circuit targeting PTEN

2009 501 citations Yoshimi Nakagawa, Hitoshi Shimano et al. profile →

Peers

Countries citing papers authored by Hitoshi Shimano

Since Specialization

Citations

This map shows the geographic impact of Hitoshi Shimano's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Hitoshi Shimano with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Hitoshi Shimano more than expected).

Fields of papers citing papers by Hitoshi Shimano

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Hitoshi Shimano. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Hitoshi Shimano. The network helps show where Hitoshi Shimano may publish in the future.

Co-authorship network of co-authors of Hitoshi Shimano

This figure shows the co-authorship network connecting the top 25 collaborators of Hitoshi Shimano. A scholar is included among the top collaborators of Hitoshi Shimano based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Hitoshi Shimano. Hitoshi Shimano is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

#	Work	Indexed citations
1	Relationship Between Improvements in Glycemic Control and Risk of Pregnancy Complications in Patients With Diabetes Mellitus: Metaregression Analysis of Randomized Controlled Trials of Intensive Glucose Management 2025 ·Journal of Diabetes Research ·Satoru Kodama, (unknown), (unknown), Yoko Yachi, Chika Horikawa, (unknown), (unknown), Takaho Yamada, Kiminori Kato, Yoshimi Nakagawa, Shiro Tanaka, Hitoshi Shimano, Hirohito Sone	1
2	Mipep deficiency in adipocytes impairs mitochondrial protein maturation and leads to systemic inflammation and metabolic dysfunctions 2025 ·Scientific Reports ·Yuka Nozaki, Masaki Kobayashi, (unknown), (unknown), (unknown), (unknown), (unknown), (unknown), (unknown), (unknown), Yuhei Mizunoe, Mami Matsumoto, Nobuhiko Ohno, Tomonori Kaifu, Shogo Okazaki, Ryo Goitsuka, Yoshimi Nakagawa, Hitoshi Shimano, Yoichiro Iwakura, Yoshikazu Higami	0
3	Prediction of fetal Graves’ disease among pregnant women with Graves’ disease who have undergone thyroidectomy or radioactive iodine therapy: A retrospective observational study 2025 ·Endocrine Journal ·(unknown), Naoko Arata, (unknown), Shiori Sato, Akiko Sankoda, (unknown), (unknown), Chie Nagata, Seiji Wada, (unknown), Masako Waguri, Nobuaki Mitsuda, Hitoshi Shimano	0
4	Mechanisms of age-related Treg dysfunction in an arthritic environment 2024 ·Clinical Immunology ·Taihei Nishiyama, (unknown), Haruka Miki, Hiromitsu Asashima, Yuya Kondo, Hiroto Tsuboi, Hiroshi Ohno, Hitoshi Shimano, Isao Matsumoto	3
5	Abnormal saturated fatty acids and sphingolipids metabolism in asthma 2024 ·Respiratory Investigation ·Kazufumi Yoshida, Yuko Morishima, Yukio Ishii, (unknown), Hitoshi Shimano, Nobuyuki Hizawa	5
6	Dietary potassium intake and its interaction with sodium intake on risk of developing cardiovascular disease in persons with type 2 diabetes: The Japan Diabetes Complication and its Prevention Prospective study ( JDCP study 12) 2024 ·Diabetes Obesity and Metabolism ·Chika Horikawa, Mitsuyoshi Takahara, Naoto Katakami, (unknown), (unknown), Kazuya Fujihara, Hiroaki Suzuki, Narihito Yoshioka, Hitoshi Shimano, Jo Satoh, Yasuaki Hayashino, (unknown), Rimei Nishimura, Yoshimitsu Yamasaki, Hirohito Sone	0
7	Bioactive TNIIIA2 Sequence in Tenascin-C Is Responsible for Macrophage Foam Cell Transformation; Potential of FNIII14 Peptide Derived from Fibronectin in Suppression of Atherosclerotic Plaque Formation 2024 ·International Journal of Molecular Sciences ·Takuya Iyoda, (unknown), Yunong Wang, (unknown), (unknown), Naoyuki Okita, Sachiye Inouye, Yoshimi Nakagawa, Hitoshi Shimano, Fumio Fukai	2
8	C-Terminal Binding Protein 2 Emerges as a Critical Player Linking Metabolic Imbalance to the Pathogenesis of Obesity 2023 ·Journal of Atherosclerosis and Thrombosis ·Motohiro Sekiya, (unknown), Kenji Saito, (unknown), (unknown), (unknown), (unknown), (unknown), (unknown), Hitoshi Shimano	2
9	ELOVL5‐mediated fatty acid elongation promotes cellular proliferation and invasion in renal cell carcinoma 2022 ·Cancer Science ·(unknown), Shuya Kandori, Ken Tanaka, (unknown), (unknown), Yoshiyuki Nagumo, Hiromitsu Negoro, Takahiro Kojima, Bryan J. Mathis, Toru Shimazui, Takafumi Miyamoto, Takashi Matsuzaka, Hitoshi Shimano, Hiroyuki Nishiyama	21
10	Estimated Stearoyl-CoA-desaturase (SCD)-1 and Elongase of Very Long Chain Fatty Acids (Elovl) 6 Activities From Serum Fatty Acids Are Reciprocally Associated with Visceral Fat Area in Type 2 Diabetic Patients 2018 ·Shigeru Yatoh, (unknown), Takashi Matsuzaka, (unknown), Hiroaki Suzuki, Hitoshi Shimano	1
11	Myocardial dysfunction identified by three-dimensional speckle tracking echocardiography in type 2 diabetes patients relates to complications of microangiopathy 2016 ·Journal of Cardiology ·(unknown), Tomoko Ishizu, Yoshihiro Seo, (unknown), Hiroaki Suzuki, Hitoshi Shimano, Yasushi Kawakami, Kazutaka Aonuma	43
12	Crucial Role of Elovl6 in Chondrocyte Growth and Differentiation during Growth Plate Development in Mice 2016 ·PLoS ONE ·(unknown), Masako Shimada, Takashi Matsuzaka, Kiyo‐aki Ishii, Yoshimi Nakagawa, (unknown), Nobuhiro Yamada, Hitoshi Shimano	9
13	Circulating Malondialdehyde-Modified LDL-Related Variables and Coronary Artery Stenosis in Asymptomatic Patients with Type 2 Diabetes 2015 ·Journal of Diabetes Research ·Kazuya Fujihara, Hiroaki Suzuki, Akira Sato, Satoru Kodama, Yoriko Heianza, Kazumi Saito, Hitoshi Iwasaki, Kazuto Kobayashi, Shigeru Yatoh, Akimitsu Takahashi, Naoya Yahagi, Hiroaki Yagyu, Hirohito Sone, Hitoshi Shimano	8
14	Eplerenone ameliorates the phenotypes of metabolic syndrome with NASH in liver-specific SREBP-1c Tg mice fed high-fat and high-fructose diet 2013 ·American Journal of Physiology-Endocrinology and Metabolism ·Tsutomu Wada, (unknown), (unknown), (unknown), Yuto Nakamura, Yoko Ishii, Masakiyo Sasahara, Keizo Kanasaki, Munehiro Kitada, Daisuke Koya, Hitoshi Shimano, Hiroshi Tsuneki, Toshiyasu Sasaoka	65
15	Transgenic mice expressing an intestine-specific secretory protein, IBCAP, demonstrates pancreatic beta cell augmenting activity 2010 ·Diabetologia ·Mariko Kawakami, Yoshimitsu Okazaki, Nami Yamada, Hideaki Toyoshima, (unknown), Hitoshi Shimano, Hirohumi Suzuki, (unknown), Kyoko Watanabe, Takashi Yokoo	1
16	Development of a bioassay to screen for chemicals mimicking the anti-aging effects of calorie restriction 2010 ·Biochemical and Biophysical Research Communications ·Takuya Chiba, Tomoshi Tsuchiya, Toshimitsu Komatsu, Ryoichi Mori, Hiroko Hayashi, Hitoshi Shimano, Stephen R. Spindler, Isao Shimokawa	11
17	SCAP is required for timely and proper myelin membrane synthesis 2009 ·Proceedings of the National Academy of Sciences ·Mark H. G. Verheijen, Nutabi Camargo, Valérie Verdier, Karim Nadra, (unknown), Jean‐Jacques Médard, Adrienne Luoma, (unknown), Hideyo Inouye, Hitoshi Shimano, Su Chen, Jos F. Brouwers, J. Bernd Helms, M. Laura Feltri, Lawrence Wrabetz, Daniel A. Kirschner, Roman Chrast, August B. Smit	88
18	Co-ordinate activation of lipogenic enzymes in hepatocellular carcinoma 2005 ·European Journal of Cancer ·Naoya Yahagi, Hitoshi Shimano, Kiyoshi Hasegawa, Kenichi Ohashi, Takashi Matsuzaka, Yuho Najima, Motohiro Sekiya, Sachiko Tomita, Hiroaki Okazaki, Yoshiaki Tamura, Yoko Iizuka, Ken Ohashi, Ryozo Nagai, Shun Ishibashi, Takashi Kadowaki, Masatoshi Makuuchi, S. Tsuyoshi Ohnishi, Jun-ichi Osuga, Nobuhiro Yamada	205
19	PKCλ in liver mediates insulin-induced SREBP-1c expression and determines both hepatic lipid content and overall insulin sensitivity 2003 ·Journal of Clinical Investigation ·Michihiro Matsumoto, Wataru Ogawa, Kazunori Akimoto, Hiroshi Inoue, Kazuaki Miyake, Kensuke Furukawa, Yoshitake Hayashi, Haruhisa Iguchi, Yasushi Matsuki, Ryuji Hiramatsu, Hitoshi Shimano, Nobuhiro Yamada, Shigeo Ohno, Masato Kasuga, Tetsuo Noda	151
20	PKCλ in liver mediates insulin-induced SREBP-1c expression and determines both hepatic lipid content and overall insulin sensitivity 2003 ·Journal of Clinical Investigation ·Michihiro Matsumoto, Wataru Ogawa, Kazunori Akimoto, Hiroshi Inoue, Kazuaki Miyake, Kensuke Furukawa, Yoshitake Hayashi, Haruhisa Iguchi, Yasushi Matsuki, Ryuji Hiramatsu, Hitoshi Shimano, Nobuhiro Yamada, Shigeo Ohno, Masato Kasuga, Tetsuo Noda	138

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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