J L Goldstein

13.8k citations

57 papers · 11.9k indexed · 9 hit papers · h-index 47

Molecular Biology top 0.5%
Surgery top 0.2%
Cancer Research top 0.5%
Endocrinology, Diabetes and Metabolism top 0.5%
Cell Biology top 0.5%

Co-authors: M S Brown Michael S. Brown Matthew S. Brown Jay D. Horton Robert E. Hammer Iichiro Shimomura Hitoshi Shimano Petri T. Kovanen
Topics: Cholesterol and Lipid Metabolism (18 papers)RNA and protein synthesis mechanisms (15 papers)Cancer, Lipids, and Metabolism (11 papers)
Cited by: Biochemistry Cancer Research Surgery
Journals: Proceedings of the National Academy of Sciences Journal of Biological Chemistry Journal of Clinical Investigation
Partner nations: United States Poland Switzerland

In The Last Decade

J L Goldstein

56 papers receiving 11.3k citations

Hit Papers

5 papers align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Isoform 1c of sterol regulatory element binding protein is less active than isoform 1a in livers of transgenic mice and in cultured cells.

1997 714 citations Hitoshi Shimano, Jay D. Horton et al. Journal of Clinical Investigation profile →
Overproduction of cholesterol and fatty acids causes massive liver enlargement in transgenic mice expressing truncated SREBP-1a.

1996 705 citations Hitoshi Shimano, Jay D. Horton et al. Journal of Clinical Investigation profile →
Activation of cholesterol synthesis in preference to fatty acid synthesis in liver and adipose tissue of transgenic mice overproducing sterol regulatory element-binding protein-2.

1998 596 citations Jay D. Horton, Iichiro Shimomura et al. Journal of Clinical Investigation profile →
Receptor-mediated endocytosis: insights from the lipoprotein receptor system.

1979 560 citations M S Brown, J L Goldstein Proceedings of the National Academy of Sciences profile →
Increased binding of low density lipoprotein to liver membranes from rats treated with 17 alpha-ethinyl estradiol.

1979 506 citations Petri T. Kovanen, M S Brown et al. Journal of Biological Chemistry profile →
Mevinolin and colestipol stimulate receptor-mediated clearance of low density lipoprotein from plasma in familial hypercholesterolemia heterozygotes.

1983 456 citations Matthew S. Brown, J L Goldstein et al. Proceedings of the National Academy of Sciences profile →
The estradiol-stimulated lipoprotein receptor of rat liver. A binding site that membrane mediates the uptake of rat lipoproteins containing apoproteins B and E.

1980 408 citations E. Windler, Petri T. Kovanen et al. Journal of Biological Chemistry profile →
Regulatory role for hepatic low density lipoprotein receptors in vivo in the dog.

1981 366 citations Petri T. Kovanen, D W Bilheimer et al. Proceedings of the National Academy of Sciences profile →
Active and inactive forms of 3-hydroxy-3-methylglutaryl coenzyme A reductase in the liver of the rat. Comparison with the rate of cholesterol synthesis in different physiological states.

1979 273 citations Michael S. Brown, J L Goldstein et al. Journal of Biological Chemistry profile →

Peers

Countries citing papers authored by J L Goldstein

Since Specialization

Citations

This map shows the geographic impact of J L Goldstein's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by J L Goldstein with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites J L Goldstein more than expected).

Fields of papers citing papers by J L Goldstein

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by J L Goldstein. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by J L Goldstein. The network helps show where J L Goldstein may publish in the future.

Co-authorship network of co-authors of J L Goldstein

This figure shows the co-authorship network connecting the top 25 collaborators of J L Goldstein. A scholar is included among the top collaborators of J L Goldstein based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with J L Goldstein. J L Goldstein is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

#	Work	Indexed citations
1	SREBPs: Transcriptional Mediators of Lipid Homeostasis 2002 ·Cold Spring Harbor Symposia on Quantitative Biology ·Jay D. Horton,J L Goldstein,Michael S. Brown	177
2	Blunted feedback suppression of SREBP processing by dietary cholesterol in transgenic mice expressing sterol-resistant SCAP(D443N). 1998 ·Journal of Clinical Investigation ·(unknown),Iichiro Shimomura,Yuriy K. Bashmakov,Robert E. Hammer,Jay D. Horton,J L Goldstein,Matthew S. Brown	61
3	Activation of cholesterol synthesis in preference to fatty acid synthesis in liver and adipose tissue of transgenic mice overproducing sterol regulatory element-binding protein-2.breakdown → 1998 ·Journal of Clinical Investigation ·Jay D. Horton,Iichiro Shimomura,Matthew Brown,Robert E. Hammer,J L Goldstein,Hitoshi Shimano	596
4	Elevated levels of SREBP-2 and cholesterol synthesis in livers of mice homozygous for a targeted disruption of the SREBP-1 gene. 1997 ·Journal of Clinical Investigation ·Hitoshi Shimano,Iichiro Shimomura,Robert E. Hammer,Joachim Herz,J L Goldstein,M S Brown,Jay D. Horton	380
5	Isoform 1c of sterol regulatory element binding protein is less active than isoform 1a in livers of transgenic mice and in cultured cells.breakdown → 1997 ·Journal of Clinical Investigation ·Hitoshi Shimano,Jay D. Horton,Iichiro Shimomura,Robert E. Hammer,Matthew S. Brown,J L Goldstein	714
6	Overproduction of cholesterol and fatty acids causes massive liver enlargement in transgenic mice expressing truncated SREBP-1a.breakdown → 1996 ·Journal of Clinical Investigation ·Hitoshi Shimano,Jay D. Horton,Robert E. Hammer,Iichiro Shimomura,M S Brown,J L Goldstein	705
7	Apolipoprotein C-I modulates the interaction of apolipoprotein E with beta-migrating very low density lipoproteins (beta-VLDL) and inhibits binding of beta-VLDL to low density lipoprotein receptor-related protein. 1990 ·Journal of Biological Chemistry ·Karl H. Weisgraber,Robert W. Mahley,Robert Kowal,Joachim Herz,J L Goldstein,Michael S. Brown	199
8	Evidence for a dominant gene that suppresses hypercholesterolemia in a family with defective low density lipoprotein receptors. 1989 ·Journal of Clinical Investigation ·Helen H. Hobbs,Eran Leitersdorf,(unknown),(unknown),Michael S. Brown,J L Goldstein	119
9	Operator constitutive mutation of 3-hydroxy-3-methylglutaryl coenzyme A reductase promoter abolishes protein binding to sterol regulatory element. 1988 ·Journal of Biological Chemistry ·Timothy F. Osborne,Gregorio Gil,J L Goldstein,Michael S. Brown	178
10	Exon-Alu recombination deletes 5 kilobases from the low density lipoprotein receptor gene, producing a null phenotype in familial hypercholesterolemia. 1986 ·Proceedings of the National Academy of Sciences ·Mark A. Lehrman,David W. Russell,J L Goldstein,Matthew S. Brown	148
11	Cytoplasmic 3-hydroxy-3-methylglutaryl coenzyme A synthase from the hamster. I. Isolation and sequencing of a full-length cDNA. 1986 ·Journal of Biological Chemistry ·Gregorio Gil,J L Goldstein,Clive A. Slaughter,Michael S. Brown	103
12	Imaging of hepatic low density lipoprotein receptors by radionuclide scintiscanning in vivo. 1984 ·Proceedings of the National Academy of Sciences ·M Huettinger,Jo Corbett,Wolfgang J. Schneider,James T. Willerson,M S Brown,J L Goldstein	28
13	Amplification of the gene for 3-hydroxy-3-methylglutaryl coenzyme A reductase, but not for the 53-kDa protein, in UT-1 cells. 1983 ·Journal of Biological Chemistry ·K L Luskey,J R Faust,Daniel J. Chin,M S Brown,J L Goldstein	174
14	Saturation and suppression of hepatic lipoprotein receptors: a mechanism for the hypercholesterolemia of cholesterol-fed rabbits. 1981 ·Proceedings of the National Academy of Sciences ·Petri T. Kovanen,M S Brown,S K Basu,D W Bilheimer,J L Goldstein	291
15	Monoclonal antibodies to the low density lipoprotein receptor as probes for study of receptor-mediated endocytosis and the genetics of familial hypercholesterolemia. 1981 ·Journal of Biological Chemistry ·Ulrike Beisiegel,Wolfgang J. Schneider,J L Goldstein,R G Anderson,Matthew S. Brown	325
16	The estradiol-stimulated lipoprotein receptor of rat liver. A binding site that membrane mediates the uptake of rat lipoproteins containing apoproteins B and E.breakdown → 1980 ·Journal of Biological Chemistry ·E. Windler,Petri T. Kovanen,Y S Chao,Mark S. Brown,Richard J. Havel,J L Goldstein	408
17	Increased binding of low density lipoprotein to liver membranes from rats treated with 17 alpha-ethinyl estradiol.breakdown → 1979 ·Journal of Biological Chemistry ·Petri T. Kovanen,M S Brown,J L Goldstein	506
18	Receptor-mediated endocytosis: insights from the lipoprotein receptor system.breakdown → 1979 ·Proceedings of the National Academy of Sciences ·M S Brown,J L Goldstein	560
19	Regulation of cholesterol synthesis by low density lipoprotein in isolated human lymphocytes 1977 ·The Journal of Experimental Medicine ·Y K Ho,(unknown),(unknown),MS Brown,J L Goldstein	127
20	PEPTIDE CHAIN TERMINATION, III. STIMULATION OF in vitro TERMINATION 1969 ·Proceedings of the National Academy of Sciences ·Gregory Milman,J L Goldstein,Edward M. Scolnick,T. Caskey	74

About J L Goldstein

J L Goldstein is a scholar working on Biochemistry, Cancer Research and Surgery, having authored 57 papers that have together received 11.9k indexed citations. Recurring topics across this work include Cholesterol and Lipid Metabolism (18 papers), RNA and protein synthesis mechanisms (15 papers) and Cancer, Lipids, and Metabolism (11 papers). The work is most often cited by research in Biochemistry (1.2k citations), Cancer Research (2.3k citations) and Surgery (5.4k citations). J L Goldstein has collaborated with scholars based in United States, Poland and Switzerland. Frequent co-authors include M S Brown, Michael S. Brown, Matthew S. Brown, Jay D. Horton, Robert E. Hammer, Iichiro Shimomura, Hitoshi Shimano, Petri T. Kovanen, Joachim Herz and Robert Kowal. Their work appears in journals such as Proceedings of the National Academy of Sciences, Journal of Biological Chemistry and Journal of Clinical Investigation.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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