Lyann Sim

2.2k citations

40 papers · 1.7k indexed · h-index 21

Impact in

Biotechnology top 0.5%
- Enzyme Production and Characterization
Nutrition and Dietetics top 2%
- Microbial Metabolites in Food Biotechnology
- Food composition and properties

Papers in ⓘ

Biotechnology 28
- Enzyme Production and Characterization 27
Molecular Biology 22
- Glycosylation and Glycoproteins Research 16

Co-authors: David R. Rose (20 shared papers)Buford L. Nichols (7 shared papers)Bernardine M. Pinto (7 shared papers)Roberto Quezada‐Calvillo (5 shared papers)Erwin E. Sterchi (4 shared papers)Sankar Mohan (5 shared papers)O. P. Ward (1 shared paper)Z-Y Li (1 shared paper)
Journals: The Journal of Organic Chemistry (4 papers)Carbohydrate Research (4 papers)Glycobiology (3 papers)Bioorganic & Medicinal Chemistry (3 papers)FEBS Journal (2 papers)
Partner nations: Canada United States Switzerland

In The Last Decade

Lyann Sim

38 papers receiving 1.7k citations

Peers

Countries citing papers authored by Lyann Sim

Since Specialization

Citations

This map shows the geographic impact of Lyann Sim's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Lyann Sim with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Lyann Sim more than expected).

Fields of papers citing papers by Lyann Sim

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Lyann Sim. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Lyann Sim. The network helps show where Lyann Sim may publish in the future.

Co-authors

The 25 scholars most cited alongside Lyann Sim, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Lyann Sim Line = papers co-authored together Lyann Sim links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

Showing the 20 most-cited of 40 papers — load more, or switch the sort, to bring in the rest.

#	Work
1	Human Intestinal Maltase–Glucoamylase: Crystal Structure of the N-Terminal Catalytic Subunit and Basis of Inhibition and Substrate Specificity Journal of Molecular Biology ·Lyann Sim, Roberto Quezada‐Calvillo, Erwin E. Sterchi, Buford L. Nichols, David R. Rose	2007	273
2	Structural Basis for Substrate Selectivity in Human Maltase-Glucoamylase and Sucrase-Isomaltase N-terminal Domains Journal of Biological Chemistry ·Lyann Sim, Carly Willemsma, Sankar Mohan, Hassan Y. Naim, Bernardine M. Pinto, David R. Rose	2010	190
3	Production and characterisation of a biosurfactant isolated from Pseudomonas aeruginosa UW-1 Journal of Industrial Microbiology & Biotechnology ·Lyann Sim, O. P. Ward, Z-Y Li	1997	156
4	New Glucosidase Inhibitors from an Ayurvedic Herbal Treatment for Type 2 Diabetes: Structures and Inhibition of Human Intestinal Maltase-Glucoamylase with Compounds from Salacia reticulata Biochemistry ·Lyann Sim, Kumarasamy Jayakanthan, Sankar Mohan, N. Ravindranath, Blair D. Johnston, Bernardine M. Pinto, David R. Rose	2009	144
5	Luminal Starch Substrate “Brake” on Maltase-Glucoamylase Activity Is Located within the Glucoamylase Subunit3 Journal of Nutrition ·Roberto Quezada‐Calvillo, Lyann Sim, Zihua Ao, Bruce R. Hamaker, Andrea Quaroni, Gary D. Brayer, Erwin E. Sterchi, Claudia C. Robayo‐Torres, David R. Rose, Buford L. Nichols	2008	82
6	Total Syntheses of Casuarine and Its 6‐O‐α‐Glucoside: Complementary Inhibition towards Glycoside Hydrolases of the GH31 and GH37 Families Chemistry - A European Journal ·Francesca Cardona, Camilla Parmeggiani, Enrico Faggi, Claudia Bonaccini, Paola Gratteri, Lyann Sim, T.M. Gloster, S.M. Roberts, G.J. Davies, David R. Rose, Andrea Goti	2009	80
7	Inhibition of recombinant human maltase glucoamylase by salacinol and derivatives FEBS Journal ·Elena J. Rossi, Lyann Sim, D.A. Kuntz, Dagmar Hahn, Blair D. Johnston, Ahmad Ghavami, Monica G. Szczepina, Nag S. Kumar, Erwin E. Sterchi, Buford L. Nichols, Bernardine M. Pinto, David R. Rose	2006	73
8	Mapping the intestinal alpha-glucogenic enzyme specificities of starch digesting maltase-glucoamylase and sucrase-isomaltase Bioorganic & Medicinal Chemistry ·Kyra Jones, Lyann Sim, Sankar Mohan, Kumarasamy Jayakanthan, Hui Liu, Stephen E. Avery, Hassan Y. Naim, Roberto Quezada‐Calvillo, Buford L. Nichols, Bernardine M. Pinto, David R. Rose	2011	72
9	Evidence of native starch degradation with human small intestinal maltase‐glucoamylase (recombinant) FEBS Letters ·Zihua Ao, Roberto Quezada‐Calvillo, Lyann Sim, Buford L. Nichols, David R. Rose, Erwin E. Sterchi, Bruce R. Hamaker	2007	59
10	An enzymatic pathway in the human gut microbiome that converts A to universal O type blood Nature Microbiology ·Peter Rahfeld, Lyann Sim, Haisle Moon, Iren Constantinescu, Connor Morgan‐Lang, Steven Hallam, Jayachandran N. Kizhakkedathu, Stephen G. Withers	2019	54
11	Unexpected High Digestion Rate of Cooked Starch by the Ct-Maltase-Glucoamylase Small Intestine Mucosal α-Glucosidase Subunit PLoS ONE ·Amy Hui‐Mei Lin, Buford L. Nichols, Roberto Quezada‐Calvillo, Stephen E. Avery, Lyann Sim, David R. Rose, Hassan Y. Naim, Bruce R. Hamaker	2012	46
12	Crystal Structure of the Chlamydomonas Starch Debranching Enzyme Isoamylase ISA1 Reveals Insights into the Mechanism of Branch Trimming and Complex Assembly Journal of Biological Chemistry ·Lyann Sim, Sophie R. Beeren, Justin Findinier, David Dauvillée, Steven Ball, A. Henriksen, Monica M. Palcic	2014	46
13	A Bacterial Expression Platform for Production of Therapeutic Proteins Containing Human-like O-Linked Glycans Cell chemical biology ·Ting Du, Nakita Buenbrazo, Laura Kell, Sadia Rahmani, Lyann Sim, Stephen G. Withers, Shawn DeFrees, Warren W. Wakarchuk	2018	40
14	Studies Directed toward the Stereochemical Structure Determination of the Naturally Occurring Glucosidase Inhibitor, Kotalanol: Synthesis and Inhibitory Activities against Human Maltase Glucoamylase of Seven-Carbon, Chain-Extended Homologues of Salacinol The Journal of Organic Chemistry ·N. Ravindranath, Brian O. Patrick, Lyann Sim, David R. Rose, B. Mario Pinto	2008	40
15	New Synthetic Routes to Chain-Extended Selenium, Sulfur, and Nitrogen Analogues of the Naturally Occurring Glucosidase Inhibitor Salacinol and their Inhibitory Activities against Recombinant Human Maltase Glucoamylase The Journal of Organic Chemistry ·Hui Liu, N. Ravindranath, Kumarasamy Jayakanthan, Lyann Sim, Heather Heipel, David R. Rose, Bernardine M. Pinto	2007	36
16	A New Class of Glucosidase Inhibitor: Analogues of the Naturally Occurring Glucosidase Inhibitor Salacinol with Different Ring Heteroatom Substituents and Acyclic Chain Extension The Journal of Organic Chemistry ·Hui Liu, Lyann Sim, David R. Rose, Bernardine M. Pinto	2006	35
17	Testing by Sysmex UF-100 flow cytometer and with bacterial culture in a diagnostic laboratory: a comparison Journal of Clinical Pathology ·R. Evans, M.M. Davidson, Lyann Sim, A. Hay	2006	31
18	New Chain-Extended Analogues of Salacinol and Blintol and Their Glycosidase Inhibitory Activities. Mapping the Active-Site Requirements of Human Maltase Glucoamylase The Journal of Organic Chemistry ·N. Ravindranath, Lyann Sim, David R. Rose, B. Mario Pinto	2006	31
19	Oligosaccharide and Substrate Binding in the Starch Debranching Enzyme Barley Limit Dextrinase Journal of Molecular Biology ·Marie Sofie Møller, Michael Skovbo Windahl, Lyann Sim, Marie Bøjstrup, Maher Abou Hachem, Ole Hindsgaul, Monica M. Palcic, Birte Svensson, A. Henriksen	2015	30
20	Synthesis of S-alkylated sulfonium-ions and their glucosidase inhibitory activities against recombinant human maltase glucoamylase Carbohydrate Research ·Sankar Mohan, Lyann Sim, David R. Rose, Bernardine M. Pinto	2007	28

About Lyann Sim

Lyann Sim is a scholar working on Biotechnology, Molecular Biology, Organic Chemistry, Nutrition and Dietetics and Radiology, Nuclear Medicine and Imaging, having authored 40 papers that have together received 1.7k indexed citations. Recurring topics across this work include Enzyme Production and Characterization (27 papers), Carbohydrate Chemistry and Synthesis (21 papers), Glycosylation and Glycoproteins Research (16 papers), Food composition and properties (4 papers), Digestive system and related health (4 papers), Monoclonal and Polyclonal Antibodies Research (4 papers), Microbial Metabolites in Food Biotechnology (3 papers) and Natural Antidiabetic Agents Studies (3 papers). The work is most often cited by research in Biotechnology (528 citations), Nutrition and Dietetics (418 citations), Endocrinology, Diabetes and Metabolism (438 citations), Organic Chemistry (499 citations) and Biochemistry (93 citations). Lyann Sim has collaborated with scholars based in Canada, United States and Switzerland. Frequent co-authors include David R. Rose, Buford L. Nichols, Bernardine M. Pinto, Roberto Quezada‐Calvillo, Erwin E. Sterchi, Sankar Mohan, O. P. Ward, Z-Y Li, N. Ravindranath and Hassan Y. Naim. Their work appears in journals such as The Journal of Organic Chemistry, Carbohydrate Research, Glycobiology, Bioorganic & Medicinal Chemistry and FEBS Journal.

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