Leaf Huang

58.8k total citations · 15 hit papers
545 papers, 47.2k citations indexed

About

Leaf Huang is a scholar working on Molecular Biology, Immunology and Biomaterials. According to data from OpenAlex, Leaf Huang has authored 545 papers receiving a total of 47.2k indexed citations (citations by other indexed papers that have themselves been cited), including 388 papers in Molecular Biology, 117 papers in Immunology and 95 papers in Biomaterials. Recurrent topics in Leaf Huang's work include RNA Interference and Gene Delivery (286 papers), Advanced biosensing and bioanalysis techniques (120 papers) and Immunotherapy and Immune Responses (96 papers). Leaf Huang is often cited by papers focused on RNA Interference and Gene Delivery (286 papers), Advanced biosensing and bioanalysis techniques (120 papers) and Immunotherapy and Immune Responses (96 papers). Leaf Huang collaborates with scholars based in United States, China and United Kingdom. Leaf Huang's co-authors include Shyh‐Dar Li, Xiang Gao, S Li, Vladimir P. Torchilin, Kazuo Maruyama, Yuhua Wang, Alexander L. Klibanov, Lei Miao, Lei Miao and Yunching Chen and has published in prestigious journals such as Nature, Proceedings of the National Academy of Sciences and Journal of the American Chemical Society.

In The Last Decade

Leaf Huang

517 papers receiving 45.9k citations

Hit Papers

Amphipathic polyethyleneglycols effectively prolong the c... 1990 2026 2002 2014 1990 2008 2002 1991 1993 500 1000 1.5k
What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

  1. Amphipathic polyethyleneglycols effectively prolong the circulation time of liposomes
    1990 1.6k citations Kazuo Maruyama, Leaf Huang et al. profile →
  2. Pharmacokinetics and Biodistribution of Nanoparticles
    2008 1.2k citations Leaf Huang et al. profile →
  3. Gene Therapy Progress and Prospects: Nonviral vectors
    2002 743 citations Leaf Huang et al. profile →
  4. A novel cationic liposome reagent for efficient transfection of mammalian cells
    1991 711 citations Leaf Huang et al. profile →
  5. Direct gene transfer with DNA-liposome complexes in melanoma: expression, biologic activity, and lack of toxicity in humans.
    1993 692 citations Leaf Huang et al. profile →
  6. mRNA vaccine for cancer immunotherapy
    2021 666 citations Leaf Huang et al. profile →
  7. The role of dioleoyl phosphatidylethanolamine in cationic liposome mediated gene transfer
    1995 638 citations Leaf Huang et al. Biochimica et Biophysica Acta (BBA) - Biomembranes profile →
  8. In vivo delivery of miRNAs for cancer therapy: Challenges and strategies
    2014 550 citations Leaf Huang et al. Advanced Drug Delivery Reviews profile →
  9. Liposome-mediated CFTR gene transfer to the nasal epithelium of patients with cystic fibrosis
    1995 530 citations Leaf Huang et al. profile →
  10. Cationic liposome-mediated gene transfer.
    1995 512 citations Leaf Huang et al. PubMed profile →
  11. Constitutive activation of Stat3 signaling abrogates apoptosis in squamous cell carcinogenesisin vivo
    2000 509 citations Leaf Huang et al. profile →
  12. Recent Advances in Nonviral Vectors for Gene Delivery
    2011 493 citations Leaf Huang et al. profile →
  13. Effect of liposome size on the circulation time and intraorgan distribution of amphipathic poly(ethylene glycol)-containing liposomes
    1994 440 citations Leaf Huang et al. Biochimica et Biophysica Acta (BBA) - Biomembranes profile →
  14. Synergistic and low adverse effect cancer immunotherapy by immunogenic chemotherapy and locally expressed PD-L1 trap
    2018 345 citations Tyler J. Goodwin, Leaf Huang et al. profile →
  15. Icaritin Exacerbates Mitophagy and Synergizes with Doxorubicin to Induce Immunogenic Cell Death in Hepatocellular Carcinoma
    2020 338 citations Zhuo Yu, Jianfeng Guo et al. ACS Nano profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name h Career Trend Papers Cites
Leaf Huang United States 116 30.5k 11.4k 9.8k 9.0k 7.9k 545 47.2k
Pieter R. Cullis Canada 99 29.7k 1.0× 10.8k 0.9× 6.9k 0.7× 3.5k 0.4× 2.7k 0.3× 331 41.4k
Yuquan Wei China 90 17.3k 0.6× 4.2k 0.4× 4.0k 0.4× 6.9k 0.8× 2.1k 0.3× 860 36.9k
Gert Storm Netherlands 95 13.2k 0.4× 12.6k 1.1× 9.9k 1.0× 4.2k 0.5× 1.2k 0.1× 441 30.9k
Philip S. Low United States 96 15.7k 0.5× 6.1k 0.5× 7.5k 0.8× 2.4k 0.3× 1.5k 0.2× 521 36.9k
Kazunori Kataoka Japan 138 29.1k 1.0× 34.2k 3.0× 21.0k 2.1× 2.1k 0.2× 3.2k 0.4× 780 71.8k
Zhen Gu United States 108 13.8k 0.5× 10.3k 0.9× 17.7k 1.8× 5.8k 0.6× 1.2k 0.1× 386 39.4k
Harold F. Dvorak United States 101 24.4k 0.8× 4.0k 0.3× 4.6k 0.5× 7.0k 0.8× 1.8k 0.2× 279 47.8k
Wim E. Hennink Netherlands 113 16.8k 0.6× 21.7k 1.9× 17.3k 1.8× 2.5k 0.3× 3.0k 0.4× 627 52.4k
Qian Chen China 97 13.0k 0.4× 6.5k 0.6× 16.9k 1.7× 7.9k 0.9× 1.2k 0.1× 901 41.4k
Ernst Wagner Germany 86 25.1k 0.8× 4.1k 0.4× 3.6k 0.4× 2.4k 0.3× 10.2k 1.3× 505 31.7k

Countries citing papers authored by Leaf Huang

Since Specialization
Citations

This map shows the geographic impact of Leaf Huang's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Leaf Huang with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Leaf Huang more than expected).

Fields of papers citing papers by Leaf Huang

Since Specialization
Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Leaf Huang. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Leaf Huang. The network helps show where Leaf Huang may publish in the future.

Co-authorship network of co-authors of Leaf Huang

This figure shows the co-authorship network connecting the top 25 collaborators of Leaf Huang. A scholar is included among the top collaborators of Leaf Huang based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Leaf Huang. Leaf Huang is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

20 of 20 papers shown
1.
Huang, Leaf, et al.. (2025). Hsa-miR-526b-5p Regulates the Sensitivity of Colorectal Cancer to 5-Fluorouracil by Targeting TP53 in Organoid Models. Biochemical Genetics. 64(1). 660–683. 1 indexed citations
2.
Huang, Leaf, et al.. (2025). An acylaminoacyl-peptide hydrolase-activated fluorescent probe for ultrasensitive detection of pesticide residue. Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy. 338. 126152–126152. 1 indexed citations
3.
4.
Huang, Leaf, et al.. (2024). Clinical efficacy of washed microbiota transplantation on metabolic syndrome and metabolic profile of donor outer membrane vesicles. Frontiers in Nutrition. 11. 1465499–1465499. 1 indexed citations
5.
Sendi, Hossein, Mostafa Yazdimamaghani, Mengying Hu, et al.. (2021). Nanoparticle Delivery of miR-122 Inhibits Colorectal Cancer Liver Metastasis. Cancer Research. 82(1). 105–113. 53 indexed citations
6.
Xi, Yue, Yanping Li, Pengfei Xu, et al.. (2021). The anti-fibrotic drug pirfenidone inhibits liver fibrosis by targeting the small oxidoreductase glutaredoxin-1. Science Advances. 7(36). eabg9241–eabg9241. 50 indexed citations
7.
Guo, Jianfeng, Zhuo Yu, Manisit Das, & Leaf Huang. (2020). Nano Codelivery of Oxaliplatin and Folinic Acid Achieves Synergistic Chemo-Immunotherapy with 5-Fluorouracil for Colorectal Cancer and Liver Metastasis. ACS Nano. 14(4). 5075–5089. 175 indexed citations
8.
Xu, Huan, Mengying Hu, Mengrui Liu, et al.. (2020). Nano-puerarin regulates tumor microenvironment and facilitates chemo- and immunotherapy in murine triple negative breast cancer model. Biomaterials. 235. 119769–119769. 141 indexed citations
9.
Liu, Qi, Manisit Das, Yun Liu, & Leaf Huang. (2017). Targeted drug delivery to melanoma. Advanced Drug Delivery Reviews. 127. 208–221. 117 indexed citations
10.
Miao, Lei, Qi Liu, C. Michael Lin, et al.. (2016). Targeting Tumor-Associated Fibroblasts for Therapeutic Delivery in Desmoplastic Tumors. Cancer Research. 77(3). 719–731. 189 indexed citations
11.
12.
Goodwin, Tyler J. & Leaf Huang. (2014). Nonviral Vectors. Advances in genetics. 88. 1–12. 30 indexed citations
13.
Huang, Leaf, et al.. (2010). Cancer Immunotherapy and Nanomedicine. Pharmaceutical Research. 28(2). 200–214. 62 indexed citations
14.
15.
Chen, Weihsu Claire & Leaf Huang. (2005). Non‐Viral Vector as Vaccine Carrier. Advances in genetics. 54. 315–337. 43 indexed citations
16.
Li, Song, et al.. (2003). Cationic Liposome–Protamine–DNA Complexes for Gene Delivery. Methods in enzymology on CD-ROM/Methods in enzymology. 373. 332–342. 13 indexed citations
17.
Chesnoy, Sophie & Leaf Huang. (2002). Enhanced Cutaneous Gene Delivery Following Intradermal Injection of Naked DNA in a High Ionic Strength Solution. Molecular Therapy. 5(1). 57–62. 36 indexed citations
18.
Huang, Leaf, Mien‐Chie Hung, & Ernst Wagner. (1999). Non-viral vectors for gene therapy. Academic Press eBooks. 116 indexed citations
19.
Xing, Xiaojing, Angabin Matin, Yu Dong, et al.. (1996). Mutant SV40 large T antigen as a therapeutic agent for HER-2/neu-overexpressing ovarian cancer.. PubMed. 3(3). 168–74. 13 indexed citations
20.
Maruyama, Kazuo, et al.. (1991). Proteins and peptides bound to long-circulating liposomes. Biochimica et Biophysica Acta (BBA) - Biomembranes. 1070(1). 246–252. 19 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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