Darrell J. Irvine

36.6k citations

280 papers · 25.7k indexed · 17 hit papers · h-index 86

Impact in

Immunology top 0.05%
- Immunotherapy and Immune Responses
- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
Biomaterials top 0.1%
- Nanoparticle-Based Drug Delivery

Papers in

Immunology 181
- Immunotherapy and Immune Responses 139
- Immune Cell Function and Interaction 63
- T-cell and B-cell Immunology 52
Virology 30
- HIV Research and Treatment 30

Co-authors: Eric L. Dane Mark M. Davis James J. Moon Paula T. Hammond Matthias T. Stephan Marco A. Purbhoo Yiran Zheng Jin‐Wook Yoo
Journals: ACS Nano (12 papers)The Journal of Immunology (11 papers)Proceedings of the National Academy of Sciences (11 papers)Biomaterials (9 papers)Biomacromolecules (9 papers)
Partner nations: United States United Kingdom Switzerland

In The Last Decade

Darrell J. Irvine

270 papers receiving 25.4k citations

Hit Papers

15 papers align trajectories log scale

LNP-RNA-engineered adipose stem cells for accelerated diabetic wound healing 2024 · 46 citations

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if any of the following hold:

it has ≥500 total citations;
it reaches ≥1.5× the top-1% citation threshold for papers in the same subfield and year (the threshold is the minimum needed to enter the top 1%, not the average within it);
it reaches the top citation threshold in at least one of its specific research topics.

2024 Nature Communications
2023 Cell
2023 Science
2022 Science
2022 Nature Materials
2020 Nature Nanotechnology
2020 Nature reviews. Immunology
2019 Science
2018 Nature Biotechnology
2017 Nature Communications
2015 Chemical Reviews
2014 Nature
2011 Nature Reviews Drug Discovery
2011 Nature
2010 Nature Medicine
2008 Nature Materials
2002 Nature

Peers

Countries citing papers authored by Darrell J. Irvine

Since Specialization

Citations

This map shows the geographic impact of Darrell J. Irvine's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Darrell J. Irvine with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Darrell J. Irvine more than expected).

Fields of papers citing papers by Darrell J. Irvine

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Darrell J. Irvine. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Darrell J. Irvine. The network helps show where Darrell J. Irvine may publish in the future.

Co-authors

The 25 scholars most cited alongside Darrell J. Irvine, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Darrell J. Irvine Line = papers co-authored together Darrell J. Irvine links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

#	Work
1	Simultaneous induction of multiple classes of broadly neutralizing antibody precursors by combination germline-targeting immunization in nonhuman primates Science Immunology ·Henry J. Sutton, Balkar Singh, Jon M. Steichen, Torben Schiffner, Mishima Hiromu, Alessia Liguori, B.I. Artemov, Michael Kubitz, Erik Georgeson, Nicole Phelps, Ryan Tingle, Nushin Alavi, Elana Ben‐Akiva, Xiaoya Zhou, Hong Zhang, Claudia T. Flynn, Eva G. Rakasz, Darrell J. Irvine, William R. Schief, Shane Crotty	2025	0
2	High‐Throughput Microfluidic‐Mediated Assembly of Layer‐By‐Layer Nanoparticles Advanced Functional Materials ·Ivan S. Pires, Leny Kerkhoffs, Heikyung Suh, Darrell J. Irvine, Paula T. Hammond	2025	2
3	Full-length single-cell BCR sequencing paired with RNA sequencing reveals convergent responses to pneumococcal vaccination Communications Biology ·Duncan M. Morgan, Azrin Azmi, Jin Hwan Kim, 海慧, Suddham Singh, Jakob Loschko, Naveen Surendran, Ognjen Sekulović, Chak-Wing Mak, Shuting Shi, Darrell J. Irvine, Sarita U. Patil, Isis Kanevsky, Henry Gaullieur, J. Christopher Love	2024	3
4	Cholesterol‐Amino‐Phosphate (CAP) Derived Lipid Nanoparticles for Delivery of Self‐Amplifying RNA and Restoration of Spermatogenesis in Infertile Mice Advanced Science ·Shi Du, Wenqing Li, Yuebao Zhang, Yonger Xue, Xucheng Hou, Jinyue Yan, Jeffrey K. J. Cheng, Binbin Deng, David W. McComb, Jennifer S Lin, Hong Zeng, Xiaolin Cheng, Darrell J. Irvine, Ron Weiss, Yizhou Dong	2023	36
5	Optimization of an alum-anchored clinical HIV vaccine candidate npj Vaccines ·Kristen A. Rodrigues, Christopher A. Cottrell, Jon M. Steichen, Bettina Gröschel, Wuhbet Abraham, Heikyung Suh, Yash Agarwal, Kaiyuan Ni, Jason Y.H. Chang, Parisa Yousefpour, Mariane B. Melo, William R. Schief, Darrell J. Irvine	2023	4
6	Universal redirection of CAR T cells against solid tumours via membrane-inserted ligands for the CAR Nature Biomedical Engineering ·Angela Q. Zhang, Niels Kranemann, 龚镇雄, M. Hansen, Wuhbet Abraham, 信白木, A Wolff, Laura Maiorino, Coralie M. Backlund, Aereas Aung, Mariane B. Melo, Na Li, Shengwei Wu, Darrell J. Irvine	2023	47
7	Mannose-binding lectin and complement mediate follicular localization and enhanced immunogenicity of diverse protein nanoparticle immunogens Cell Reports ·Benjamin J. Read, Hao-Ming Jeng, John C. Kraft, Isaac Sappington, Aereas Aung, Shengwei Wu, Julia Bals, Chengbo Chen, Kelly K. Lee, Daniel Lingwood, Neil P. King, Darrell J. Irvine	2022	34
8	The future of engineered immune cell therapies Science ·Darrell J. Irvine, Marcela V. Maus, David Mooney, Wilson W. Wong Hit paper breakdown →	2022	124
9	Surface Plasmon‐Enhanced Short‐Wave Infrared Fluorescence for Detecting Sub‐Millimeter‐Sized Tumors Advanced Materials ·Sipeng Sun, Ching‐Wei Lin, Jifa Qi, Ibón Silvera Rada, Yanpu He, Yingzhong Li, Neelkanth M. Bardhan, Darrell J. Irvine, Paula T. Hammond, Angela M. Belcher	2021	28
10	Cancer Cell Coating Nanoparticles for Optimal Tumor-Specific Cytokine Delivery ACS Nano ·Rocío Magaly, Sean G. Smith, Santiago Correa, Cathy Nguyen, محمد رضا رضایی راد, Mariane B. Melo, Talar Tokatlian, Heikyung Suh, Darrell J. Irvine, Paula T. Hammond	2020	70
11	Donor cell engineering with GSK3 inhibitor–loaded nanoparticles enhances engraftment after in utero transplantation Blood ·Stavros Loukogeorgakis, G. Galway, Rainer Deschner, Haiying Li, Li Tang, Aimee G. Kim, Jesse D. Vrecenak, John D. Stratigis, Nicholas J. Ahn, Ilana Nissim, Juuli Juntunen, Antônio Fernandes Moron, José Luiz Martins, William H. Peranteau, Paolo De Coppi, Darrell J. Irvine, Alan W. Flake	2019	14
12	Enhancement of Peptide Vaccine Immunogenicity by Increasing Lymphatic Drainage and Boosting Serum Stability Cancer Immunology Research ·Kelly D. Moynihan, Rebecca L. Holden, Naveen K. Mehta, Chensu Wang, Mark R. Karver, Moritz Rothe, Simon Liang, Wuhbet Abraham, Mariane B. Melo, Angela Q. Zhang, Na Li, Sylvie Le Gall, Bradley L. Pentelute, Darrell J. Irvine	2018	64
13	Synthetic Charge-Invertible Polymer for Rapid and Complete Implantation of Layer-by-Layer Microneedle Drug Films for Enhanced Transdermal Vaccination ACS Nano ·Yanpu He, Celestine Hong, Jiahe Li, Meeks Mv, Yingzhong Li, Michelle E. Turvey, Divakara S. S. M. Uppu, John R. Martin, Ketian Zhang, Darrell J. Irvine, Paula T. Hammond	2018	79
14	Combined HDAC and BET Inhibition Enhances Melanoma Vaccine Immunogenicity and Efficacy The Journal of Immunology ·Alexander Badamchi-Zadeh, Kelly D. Moynihan, Rafael A. Larocca, Malika Aïd, Nicholas M. Provine, M. Justin Iampietro, Ekaterina Kinnear, Pablo Penaloza‐MacMaster, Peter Abbink, Eryn Blass, John S. Tregoning, Darrell J. Irvine, Dan H. Barouch	2018	14
15	Cell and fluid sampling microneedle patches for monitoring skin-resident immunity Science Translational Medicine ·T. Uzawa, Archana V. Boopathy, A. Todd Newberry, Kelly D. Moynihan, Mary Welch, Nitasha R. Bennett, Michelle E. Turvey, Nikki Thai, A. A. FITCH, J. Christopher Love, Paula T. Hammond, Darrell J. Irvine	2018	129
16	Synthetic Lift-off Polymer beneath Layer-by-Layer Films for Surface-Mediated Drug Delivery ACS Macro Letters ·Yanpu He, Jiahe Li, Michelle E. Turvey, Allison Tirres, Celestine Hong, Divakara S. S. M. Uppu, Hongkun He, Darrell J. Irvine, Paula T. Hammond	2017	10
17	Localized Immunotherapy via Liposome-Anchored Anti-CD137 + IL-2 Prevents Lethal Toxicity and Elicits Local and Systemic Antitumor Immunity Cancer Research ·Brandon Kwong, S. Annie Gai, Jamal Elkhader, K. Dane Wittrup, Darrell J. Irvine	2013	168
18	Generation of Effector Memory T CellâBased Mucosal and Systemic Immunity with Pulmonary Nanoparticle Vaccination Europe PMC (PubMed Central) ·Michael Wolters, James J. Moon, Wuhbet Abraham, Heikyung Suh, Jamal Elkhader, Michael A. Seidman, 雄太田, Eung‐Jun Im, Maria Hottelet Foley, Dan H. Barouch, Darrell J. Irvine	2013	154
19	Design of lipid nanoparticle delivery agents for multivalent display of recombinant Env trimers in HIV vaccination SHILAP Revista de lepidopterología ·Keiser Jutta, 山輝夫坂川, Dan H. Barouch, Pascal Hugo, Darrell J. Irvine	2012	2
20	Immunological synapse arrays: Patterned protein surfaces that modulate immunological synapse structure formation in T cells Proceedings of the National Academy of Sciences ·Junsang Doh, Darrell J. Irvine	2006	153

About Darrell J. Irvine

Darrell J. Irvine is a scholar working on Immunology, Virology, Pharmaceutical Science, Oncology and Surfaces, Coatings and Films, having authored 280 papers that have together received 25.7k indexed citations. Recurring topics across this work include Immunotherapy and Immune Responses (139 papers), RNA Interference and Gene Delivery (63 papers), Immune Cell Function and Interaction (63 papers), T-cell and B-cell Immunology (52 papers), CAR-T cell therapy research (40 papers), Monoclonal and Polyclonal Antibodies Research (33 papers), HIV Research and Treatment (30 papers) and Cancer Immunotherapy and Biomarkers (19 papers). The work is most often cited by research in Immunology (10.9k citations), Biomaterials (3.9k citations), Pharmaceutical Science (1.6k citations), Virology (966 citations) and Oncology (4.8k citations). Darrell J. Irvine has collaborated with scholars based in United States, United Kingdom and Switzerland. Frequent co-authors include Eric L. Dane, Mark M. Davis, James J. Moon, Paula T. Hammond, Matthias T. Stephan, Marco A. Purbhoo, Yiran Zheng, Jin‐Wook Yoo, Samir Mitragotri and Dennis E. Discher. Their work appears in journals such as ACS Nano, The Journal of Immunology, Proceedings of the National Academy of Sciences, Biomaterials and Biomacromolecules.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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