L Nelles

4.1k citations

68 papers · 3.2k indexed · h-index 29

Impact in

Cancer Research top 2%
- Protease and Inhibitor Mechanisms
Hematology top 2%
- Blood Coagulation and Thrombosis Mechanisms

Papers in ⓘ

Cancer Research 42
- Protease and Inhibitor Mechanisms 40
Molecular Biology 30
- TGF-β signaling in diseases 5
- Signaling Pathways in Disease 4
- Retinoids in leukemia and cellular processes 4

Co-authors: D Collen (27 shared papers)Danny Huylebroeck (13 shared papers)H.R. Lijnen (12 shared papers)Désiré Collen (11 shared papers)William E. Holmes (6 shared papers)Tom Van de Putte (8 shared papers)Kristin Verschueren (7 shared papers)Gunther Wuytens (4 shared papers)
Journals: Journal of Biological Chemistry (14 papers)European Journal of Biochemistry (8 papers)Thrombosis and Haemostasis (6 papers)Journal of Medicinal Chemistry (2 papers)DNA and Cell Biology (2 papers)
Partner nations: Belgium United States United Kingdom

In The Last Decade

L Nelles

68 papers receiving 3.1k citations

Peers

Countries citing papers authored by L Nelles

Since Specialization

Citations

This map shows the geographic impact of L Nelles's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by L Nelles with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites L Nelles more than expected).

Fields of papers citing papers by L Nelles

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by L Nelles. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by L Nelles. The network helps show where L Nelles may publish in the future.

Co-authors

The 25 scholars most cited alongside L Nelles, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with L Nelles Line = papers co-authored together L Nelles links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

Showing the 20 most-cited of 68 papers — load more, or switch the sort, to bring in the rest.

#	Work
1	SIP1, a Novel Zinc Finger/Homeodomain Repressor, Interacts with Smad Proteins and Binds to 5′-CACCT Sequences in Candidate Target Genes Journal of Biological Chemistry ·Kristin Verschueren, Jacques Remacle, Clara Collart, H Kraft, Betty S. Baker, Przemko Tylżanowski, L Nelles, Gunther Wuytens, Ming-Tsan Su, Rolf Bodmer, James C. Smith, Danny Huylebroeck	1999	413
2	Activation of NF-κB by Akt upregulates Snail expression and induces epithelium mesenchyme transition Oncogene ·Sylvia Julien, Isabel Puig, Elena Caretti, Jacky Bonaventure, L Nelles, Frans van Roy, Catherine Dargemont, Antonio Garcı́a de Herreros, Alfonso Bellacosa, Lionel Larue	2007	399
3	Mice Lacking Zfhx1b, the Gene That Codes for Smad-Interacting Protein-1, Reveal a Role for Multiple Neural Crest Cell Defects in the Etiology of Hirschsprung Disease–Mental Retardation Syndrome The American Journal of Human Genetics ·Tom Van de Putte, Mitsuji Maruhashi, Annick Francis, L Nelles, Hisato Kondoh, Danny Huylebroeck, Yujiro Higashi	2003	228
4	Preclinical Characterization of GLPG0634, a Selective Inhibitor of JAK1, for the Treatment of Inflammatory Diseases The Journal of Immunology ·Luc Van Rompaey, René Galien, Ellen M. van der Aar, Philippe Clément-Lacroix, L Nelles, Bart Smets, L. Lepescheux, Thierry Christophe, Katja Conrath, N. Vandeghinste, Béatrice Vayssière, Steve De Vos, Stephen R. Fletcher, Reginald Brys, Gerben van ‘t Klooster, Jean H.M. Feyen, Christel Menet	2013	181
5	Nucleotide sequence of a crustacean 18S ribosomal RNA gene and secondary structure of eukaryotic small subunit ribosoraal RNAs Nucleic Acids Research ·L Nelles, Bao-Ling Fang, Guido Volckaert, Antoon Vandenberghe, Rupert De Wachter	1984	122
6	Primary structure of human alpha 2-antiplasmin, a serine protease inhibitor (serpin). Journal of Biological Chemistry ·William E. Holmes, L Nelles, H.R. Lijnen, Désiré Collen	1987	113
7	Interaction of AP-1-, AP-2-, and Sp1-like proteins with two distinct sites in the upstream regulatory region of the plasminogen activator inhibitor-1 gene mediates the phorbol 12-myristate 13-acetate response. Journal of Biological Chemistry ·K.A. Descheemaeker, Sabine Wyns, L Nelles, Johan Auwerx, Tor Ny, Désiré Collen	1992	98
8	Characterization of recombinant human single chain urokinase-type plasminogen activator mutants produced by site-specific mutagenesis of lysine 158. Journal of Biological Chemistry ·L Nelles, H.R. Lijnen, D Collen, William E. Holmes	1987	98
9	Triazolopyridines as Selective JAK1 Inhibitors: From Hit Identification to GLPG0634 Journal of Medicinal Chemistry ·Christel Menet, Stephen R. Fletcher, Guy Van Lommen, Raphaël Geney, Javier Blanc, Koen Smits, Nolwenn Jouannigot, Pierre Deprez, Ellen M. van der Aar, Philippe Clément-Lacroix, L. Lepescheux, René Galien, Béatrice Vayssière, L Nelles, Thierry Christophe, Reginald Brys, Muriel Uhring, Fabrice Ciesielski, Luc Van Rompaey	2014	93
10	Generation of the floxed allele of the SIP1 (Smad‐interacting protein 1) gene for Cre‐mediated conditional knockout in the mouse genesis ·Yujiro Higashi, Mitsuji Maruhashi, L Nelles, Tom Van de Putte, Kristin Verschueren, Tomoya Miyoshi, Aki Yoshimoto, Hisato Kondoh, Danny Huylebroeck	2002	88
11	Interaction between Smad-interacting Protein-1 and the Corepressor C-terminal Binding Protein Is Dispensable for Transcriptional Repression of E-cadherin Journal of Biological Chemistry ·Leo A. van Grunsven, Christine Michiels, Tom Van de Putte, L Nelles, Gunther Wuytens, Kristin Verschueren, Danny Huylebroeck	2003	83
12	Plasminogen activation with single-chain urokinase-type plasminogen activator (scu-PA). Studies with active site mutagenized plasminogen (Ser740----Ala) and plasmin-resistant scu-PA (Lys158----Glu). Journal of Biological Chemistry ·H.R. Lijnen, B. Van Hoef, L Nelles, Désiré Collen	1990	78
13	Characterization of a fusion protein consisting of amino acids 1 to 263 of tissue-type plasminogen activator and amino acids 144 to 411 of urokinase-type plasminogen activator. Journal of Biological Chemistry ·L Nelles, H.R. Lijnen, D Collen, William E. Holmes	1987	76
14	Purification and characterization of natural and recombinant human plasminogen activator inhibitor‐1 (PAI‐1) European Journal of Biochemistry ·Marie‐Christine Alessi, Paul Declerck, Maria De Mol, L Nelles, Désiré Collen	1988	71
15	Neural crest-specific removal of Zfhx1b in mouse leads to a wide range of neurocristopathies reminiscent of Mowat–Wilson syndrome Human Molecular Genetics ·Tom Van de Putte, Annick Francis, L Nelles, Leo A. van Grunsven, Danny Huylebroeck	2007	65
16	The C-terminal domain of Mad-like signal transducers is sufficient for biological activity in the Xenopus embryo and transcriptional activation Mechanisms of Development ·Geert Meersseman, Kristin Verschueren, L Nelles, Claudia Blumenstock, H Kraft, Gunther Wuytens, Jacques Remacle, Christine A. Kozak, Przemko Tylżanowski, Christof Niehrs, Danny Huylebroeck	1997	64
17	Evidence for two isoforms of the endoplasmic-reticulum Ca2+ pump in pig smooth muscle Biochemical Journal ·Jan Eggermont, Frank Wuytack, Sabine De Jaegere, L Nelles, R. Casteels	1989	62
18	α ₂ -Antiplasmin Enschede: Alanine Insertion and Abolition of Plasmin Inhibitory Activity Science ·W E Holmes, H. Roger Lijnen, L Nelles, Cornelis Kluft, H K Nieuwenhuis, D C Rijken, D Collen	1987	61
19	Biochemical and thrombolytic properties of a low molecular weight form (comprising Leu144 through Leu411) of recombinant single-chain urokinase-type plasminogen activator. Journal of Biological Chemistry ·H.R. Lijnen, L Nelles, William E. Holmes, D Collen	1988	52
20	Retinoic Acid Induction of Human Tissue-type Plasminogen Activator Gene Expression via a Direct Repeat Element (DR5) Located at −7 Kilobases Journal of Biological Chemistry ·F. Bulens, Inés Ibáñez-Tallon, Petra Van Acker, Astrid De Vriese, L Nelles, Alexandra Belayew, D Collen	1995	49

About L Nelles

L Nelles is a scholar working on Cancer Research, Molecular Biology, Hematology, Biotechnology and Pulmonary and Respiratory Medicine, having authored 68 papers that have together received 3.2k indexed citations. Recurring topics across this work include Protease and Inhibitor Mechanisms (40 papers), Enzyme Production and Characterization (16 papers), Blood Coagulation and Thrombosis Mechanisms (16 papers), Blood properties and coagulation (10 papers), TGF-β signaling in diseases (5 papers), Signaling Pathways in Disease (4 papers), Cell Adhesion Molecules Research (4 papers) and Retinoids in leukemia and cellular processes (4 papers). The work is most often cited by research in Cancer Research (992 citations), Hematology (595 citations), Immunology and Allergy (181 citations), Molecular Biology (1.8k citations) and Oncology (600 citations). L Nelles has collaborated with scholars based in Belgium, United States and United Kingdom. Frequent co-authors include D Collen, Danny Huylebroeck, H.R. Lijnen, Désiré Collen, William E. Holmes, Tom Van de Putte, Kristin Verschueren, Gunther Wuytens, Annick Francis and Jacques Remacle. Their work appears in journals such as Journal of Biological Chemistry, European Journal of Biochemistry, Thrombosis and Haemostasis, Journal of Medicinal Chemistry and DNA and Cell Biology.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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