Frans van Roy

27.4k total citations · 9 hit papers
251 papers, 21.7k citations indexed

About

Frans van Roy is a scholar working on Molecular Biology, Oncology and Genetics. According to data from OpenAlex, Frans van Roy has authored 251 papers receiving a total of 21.7k indexed citations (citations by other indexed papers that have themselves been cited), including 187 papers in Molecular Biology, 39 papers in Oncology and 30 papers in Genetics. Recurrent topics in Frans van Roy's work include Wnt/β-catenin signaling in development and cancer (114 papers), Cancer-related gene regulation (74 papers) and Kruppel-like factors research (23 papers). Frans van Roy is often cited by papers focused on Wnt/β-catenin signaling in development and cancer (114 papers), Cancer-related gene regulation (74 papers) and Kruppel-like factors research (23 papers). Frans van Roy collaborates with scholars based in Belgium, United States and France. Frans van Roy's co-authors include Geert Berx, Friedel Nollet, M. Mareel, Walter Fiers, L. Vakaet, Jolanda van Hengel, Kris Vleminckx, Jürgen Behrens, Walter Birchmeier and Marc Mareel and has published in prestigious journals such as Cell, Proceedings of the National Academy of Sciences and Nucleic Acids Research.

In The Last Decade

Frans van Roy

249 papers receiving 21.2k citations

Hit Papers

5 papers align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Genetic manipulation of E-cadherin expression by epithelial tumor cells reveals an invasion suppressor role

1991 1.4k citations Kris Vleminckx, L. Vakaet et al. profile →
The Two-Handed E Box Binding Zinc Finger Protein SIP1 Downregulates E-Cadherin and Induces Invasion

2001 1.1k citations Geert Berx, Erik Bruyneel et al. profile →
The cell-cell adhesion molecule E-cadherin

2008 975 citations Frans van Roy, Geert Berx profile →
Dissecting tumor cell invasion: epithelial cells acquire invasive properties after the loss of uvomorulin-mediated cell-cell adhesion.

1989 822 citations M. Mareel, Frans van Roy et al. profile →
Loss of epithelial differentiation and gain of invasiveness correlates with tyrosine phosphorylation of the E-cadherin/beta-catenin complex in cells transformed with a temperature-sensitive v-SRC gene.

1993 812 citations L. Vakaet, Frans van Roy et al. profile →
E-cadherin is a tumour/invasion suppressor gene mutated in human lobular breast cancers.

1995 628 citations Geert Berx, Frans van Roy et al. profile →
Phylogenetic analysis of the cadherin superfamily allows identification of six major subfamilies besides several solitary members 1 1Edited by M. Yaniv

2000 573 citations Frans van Roy et al. profile →
The protein kinase Akt induces epithelial mesenchymal transition and promotes enhanced motility and invasiveness of squamous cell carcinoma lines.

2003 537 citations Alfonso Bellacosa, John J. Upson et al. PubMed profile →
Involvement of Members of the Cadherin Superfamily in Cancer

2009 512 citations Geert Berx, Frans van Roy profile →

Peers

Countries citing papers authored by Frans van Roy

Since Specialization

Citations

This map shows the geographic impact of Frans van Roy's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Frans van Roy with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Frans van Roy more than expected).

Fields of papers citing papers by Frans van Roy

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Frans van Roy. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Frans van Roy. The network helps show where Frans van Roy may publish in the future.

Co-authorship network of co-authors of Frans van Roy

This figure shows the co-authorship network connecting the top 25 collaborators of Frans van Roy. A scholar is included among the top collaborators of Frans van Roy based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Frans van Roy. Frans van Roy is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

#	Work	Indexed citations
1	Diagnosing progressive multifocal leukoencephalopathy: Positive predictive value of CSF JC virus quantitative PCR and importance of recognizing suggestive neuroimaging findings 2025 ·Journal of the Neurological Sciences ·Rong Zhou, (unknown), Ana Cabrera, (unknown), (unknown), Frans van Roy, Michael Silverman, Manas Sharma, Adrian Budhram	0
2	Altered socio-affective communication and amygdala development in mice with protocadherin10-deficient interneurons 2024 ·Open Biology ·(unknown), (unknown), (unknown), (unknown), (unknown), (unknown), Annick Francis, Elise Pepermans, Geert Baggerman, Frans van Roy, Markus Wöhr, Eve Seuntjens	2
3	Plakophilin3 loss leads to increased adenoma formation and rectal prolapse in APCmin mice 2021 ·Biochemical and Biophysical Research Communications ·(unknown), (unknown), (unknown), (unknown), (unknown), (unknown), Rahul Thorat, Jolanda van Hengel, (unknown), Frans van Roy, Sorab N. Dalal	9
4	N-cadherin stabilises neural identity by dampening anti-neural signals 2019 ·Development ·(unknown), (unknown), (unknown), Guillaume Blin, K G Macleod, Neil O. Carragher, Tim Pieters, Frans van Roy, (unknown), Sally Lowell	18
5	New Insights into the Evolution of Metazoan Cadherins and Catenins 2013 ·Progress in molecular biology and translational science ·Paco Hulpiau, (unknown), Frans van Roy	41
6	Aberrant Activation of Fatty Acid Synthesis Suppresses Primary Cilium Formation and Distorts Tissue Development 2010 ·Cancer Research ·(unknown), Evelien Rysman, Koen Brusselmans, Griet Van Imschoot, Frank Vanderhoydonc, Katrien Moerloose, Evelyne Lerut, Guido Verhoeven, Frans van Roy, Kris Vleminckx, Johannes V. Swinnen	32
7	ConTra: a promoter alignment analysis tool for identification of transcription factor binding sites across species 2008 ·Nucleic Acids Research ·Bart Hooghe, Paco Hulpiau, Frans van Roy, Pieter De Bleser	55
8	Plakophilin-3-Deficient Mice Develop Hair Coat Abnormalities and Are Prone to Cutaneous Inflammation 2007 ·Journal of Investigative Dermatology ·(unknown), Stefan Bonné, (unknown), Geertrui Denecker, Steven Goossens, Riet De Rycke, Gaëtan Borgonie, Michael R. Bösl, Frans van Roy, Jolanda van Hengel	62
9	E-Cadherin Regulates Human Nanos1, which Interacts with p120ctn and Induces Tumor Cell Migration and Invasion 2006 ·Cancer Research ·Kristin Strumane, Arnaud Bonnomet, Christophe P. Stove, Roosmarijn E. Vandenbroucke, Béatrice Nawrocki‐Raby, Erik Bruyneel, Marc Mareel, Philippe Birembaut, Geert Berx, Frans van Roy	27
10	The Transcription Factor Snail Induces Tumor Cell Invasion through Modulation of the Epithelial Cell Differentiation Program 2005 ·Cancer Research ·Bram De Craene, Barbara Gilbert, Christophe P. Stove, Erik Bruyneel, Frans van Roy, Geert Berx	204
11	p120 catenin is required for morphogenetic movements involved in the formation of the eyes and the craniofacial skeleton in Xenopus 2004 ·Journal of Cell Science ·Malgorzata Ciesiolka, Mieke Delvaeye, Griet Van Imschoot, (unknown), Pierre D. McCrea, Frans van Roy, Kris Vleminckx	42
12	The protein kinase Akt induces epithelial mesenchymal transition and promotes enhanced motility and invasiveness of squamous cell carcinoma lines. breakdown → 2003 ·PubMed ·(unknown), Alfonso Bellacosa, John J. Upson, Andres J. Klein–Szanto, Frans van Roy, Whaseon Lee‐Kwon, Mark Donowitz, Philip N. Tsichlis, Lionel Larue	537
13	E-cadherin gene alterations are rare events in thyroid tumors 1997 ·International Journal of Cancer ·Paula Soares, Geert Berx, Frans van Roy, Manuel Sobrinho‐Simões	73
14	Ecadherin gene alterations are rare events in thyroid tumors 1997 ·International Journal of Cancer ·Paula Soares, Geert Berx, Frans van Roy, Manuel Sobrinho‐Simões	4
15	Molecular mechanisms of cancer invasion 1997 ·Ghent University Academic Bibliography (Ghent University) ·Marcus Mareel, (unknown), Frans van Roy, Patrick De Baetselier	7
16	Downregulation in vivo of the invasion-suppressor molecule E-cadherin in experimental and clinical cancer 1994 ·Ghent University Academic Bibliography (Ghent University) ·Marcus Mareel, Kris Vleminckx, Stefan Vermeulen, (unknown), Marc Bracke, Frans van Roy	5
17	Expression of E-cadherin in embryogenetic ingression and cancer invasion 1993 ·The International Journal of Developmental Biology ·M. Mareel, (unknown), Frans van Roy, L. Vakaet	15
18	Normal and chimeric avian embryo ecosystems of invasion 1991 ·Ghent University Academic Bibliography (Ghent University) ·Marcus Mareel, Marianne Stowell Bracke, (unknown), Frans van Roy	1
19	Tumor Necrosis Factor: A Potential Antitumor Agent? 1987 ·Journal of Interferon Research ·Walter Fiers, Rudi Beyaert, Peter Brouckaert, Bert Everaert, P Suffys, Jan Tavernier, (unknown), Frans van Roy	6
20	Expression of cell surface glycoproteins in tumour invasion in vitro 1986 ·Ghent University Academic Bibliography (Ghent University) ·Marcus Mareel, (unknown), Robert Hooghe, Erik Bruyneel, Marc Bracke, Frans van Roy, (unknown), Georges De Bruyne, Walter Fiers	5

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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