Frans van Roy

27.4k total citations · 9 hit papers
251 papers, 21.7k citations indexed

About

Frans van Roy is a scholar working on Molecular Biology, Oncology and Genetics. According to data from OpenAlex, Frans van Roy has authored 251 papers receiving a total of 21.7k indexed citations (citations by other indexed papers that have themselves been cited), including 187 papers in Molecular Biology, 39 papers in Oncology and 30 papers in Genetics. Recurrent topics in Frans van Roy's work include Wnt/β-catenin signaling in development and cancer (114 papers), Cancer-related gene regulation (74 papers) and Kruppel-like factors research (23 papers). Frans van Roy is often cited by papers focused on Wnt/β-catenin signaling in development and cancer (114 papers), Cancer-related gene regulation (74 papers) and Kruppel-like factors research (23 papers). Frans van Roy collaborates with scholars based in Belgium, United States and France. Frans van Roy's co-authors include Geert Berx, Friedel Nollet, M. Mareel, Walter Fiers, L. Vakaet, Jolanda van Hengel, Kris Vleminckx, Jürgen Behrens, Walter Birchmeier and Paco Hulpiau and has published in prestigious journals such as Cell, Proceedings of the National Academy of Sciences and Nucleic Acids Research.

In The Last Decade

Frans van Roy

249 papers receiving 21.2k citations

Hit Papers

Genetic manipulation of E... 1989 2026 2001 2013 1991 2001 2008 1989 1993 400 800 1.2k
What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

  1. Genetic manipulation of E-cadherin expression by epithelial tumor cells reveals an invasion suppressor role
    1991 1.4k citations Kris Vleminckx, L. Vakaet et al. profile →
  2. The Two-Handed E Box Binding Zinc Finger Protein SIP1 Downregulates E-Cadherin and Induces Invasion
    2001 1.1k citations Geert Berx, Erik Bruyneel et al. profile →
  3. The cell-cell adhesion molecule E-cadherin
    2008 975 citations Frans van Roy, Geert Berx profile →
  4. Dissecting tumor cell invasion: epithelial cells acquire invasive properties after the loss of uvomorulin-mediated cell-cell adhesion.
    1989 822 citations M. Mareel, Frans van Roy et al. profile →
  5. Loss of epithelial differentiation and gain of invasiveness correlates with tyrosine phosphorylation of the E-cadherin/beta-catenin complex in cells transformed with a temperature-sensitive v-SRC gene.
    1993 812 citations L. Vakaet, Frans van Roy et al. profile →
  6. E-cadherin is a tumour/invasion suppressor gene mutated in human lobular breast cancers.
    1995 628 citations Geert Berx, Frans van Roy et al. profile →
  7. Phylogenetic analysis of the cadherin superfamily allows identification of six major subfamilies besides several solitary members 1 1Edited by M. Yaniv
    2000 573 citations Frans van Roy et al. profile →
  8. The protein kinase Akt induces epithelial mesenchymal transition and promotes enhanced motility and invasiveness of squamous cell carcinoma lines.
    2003 537 citations Alfonso Bellacosa, John J. Upson et al. Ghent University Academic Bibliography (Ghent University) profile →
  9. Involvement of Members of the Cadherin Superfamily in Cancer
    2009 512 citations Geert Berx, Frans van Roy profile →

Author Peers

Peers are selected by citation overlap in the author's most active subfields. citations · hero ref

Author Last Decade Papers Cites
Frans van Roy 15.2k 5.2k 3.8k 2.9k 1.8k 251 21.7k
Akira Kikuchi 20.4k 1.3× 3.3k 0.6× 6.2k 1.6× 1.7k 0.6× 982 0.5× 463 26.8k
Johji Inazawa 13.1k 0.9× 4.2k 0.8× 2.0k 0.5× 4.8k 1.6× 2.2k 1.2× 410 20.6k
Bengt Westermark 16.4k 1.1× 5.4k 1.0× 4.0k 1.1× 4.2k 1.4× 929 0.5× 340 29.1k
Hartmut Beug 16.1k 1.1× 7.4k 1.4× 2.8k 0.8× 3.4k 1.2× 1.2k 0.7× 254 25.3k
Geert Berx 10.5k 0.7× 5.6k 1.1× 1.7k 0.5× 3.8k 1.3× 1.6k 0.9× 137 15.9k
Tetsuo Noda 15.6k 1.0× 2.9k 0.6× 2.7k 0.7× 2.6k 0.9× 1.0k 0.6× 260 24.3k
Keiko Nakayama 15.7k 1.0× 6.9k 1.3× 2.7k 0.7× 2.5k 0.8× 1.1k 0.6× 286 23.3k
Caroline S. Hill 12.2k 0.8× 3.4k 0.7× 1.9k 0.5× 1.7k 0.6× 933 0.5× 106 15.6k
Raphael Kopan 17.5k 1.1× 2.7k 0.5× 3.7k 1.0× 1.9k 0.6× 548 0.3× 163 25.2k
Martine F. Roussel 19.4k 1.3× 12.4k 2.4× 2.9k 0.8× 3.3k 1.1× 1.4k 0.8× 242 27.9k

Countries citing papers authored by Frans van Roy

Since Specialization
Citations

This map shows the geographic impact of Frans van Roy's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Frans van Roy with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Frans van Roy more than expected).

Fields of papers citing papers by Frans van Roy

Since Specialization
Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Frans van Roy. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Frans van Roy. The network helps show where Frans van Roy may publish in the future.

Co-authorship network of co-authors of Frans van Roy

This figure shows the co-authorship network connecting the top 25 collaborators of Frans van Roy. A scholar is included among the top collaborators of Frans van Roy based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Frans van Roy. Frans van Roy is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

20 of 20 papers shown
1.
Zhou, Rong, Ana Cabrera, Frans van Roy, et al.. (2025). Diagnosing progressive multifocal leukoencephalopathy: Positive predictive value of CSF JC virus quantitative PCR and importance of recognizing suggestive neuroimaging findings. Journal of the Neurological Sciences. 469. 123379–123379.
2.
Francis, Annick, Elise Pepermans, Geert Baggerman, et al.. (2024). Altered socio-affective communication and amygdala development in mice with protocadherin10-deficient interneurons. Open Biology. 14(6). 240113–240113. 2 indexed citations
3.
Thorat, Rahul, et al.. (2021). Plakophilin3 loss leads to increased adenoma formation and rectal prolapse in APCmin mice. Biochemical and Biophysical Research Communications. 586. 14–19. 9 indexed citations
4.
Blin, Guillaume, K G Macleod, Neil O. Carragher, et al.. (2019). N-cadherin stabilises neural identity by dampening anti-neural signals. Development. 146(21). 18 indexed citations
5.
Hulpiau, Paco, et al.. (2013). New Insights into the Evolution of Metazoan Cadherins and Catenins. Progress in molecular biology and translational science. 116. 71–94. 41 indexed citations
6.
Rysman, Evelien, Koen Brusselmans, Griet Van Imschoot, et al.. (2010). Aberrant Activation of Fatty Acid Synthesis Suppresses Primary Cilium Formation and Distorts Tissue Development. Cancer Research. 70(22). 9453–9462. 32 indexed citations
7.
Hooghe, Bart, Paco Hulpiau, Frans van Roy, & Pieter De Bleser. (2008). ConTra: a promoter alignment analysis tool for identification of transcription factor binding sites across species. Nucleic Acids Research. 36(suppl_2). W128–W132. 55 indexed citations
8.
Chuah, Marinee, Bing Yan, Pieter De Bleser, et al.. (2008). Combinations of hepatocyte-specific transcription factor binding sites identified de novo using a novel bioinformatics algorithm yield robust liver-specific expression. Human Gene Therapy. 19(10). 1077–1078. 1 indexed citations
9.
Strumane, Kristin, Arnaud Bonnomet, Christophe P. Stove, et al.. (2006). E-Cadherin Regulates Human Nanos1, which Interacts with p120ctn and Induces Tumor Cell Migration and Invasion. Cancer Research. 66(20). 10007–10015. 27 indexed citations
10.
Craene, Bram De, Barbara Gilbert, Christophe P. Stove, et al.. (2005). The Transcription Factor Snail Induces Tumor Cell Invasion through Modulation of the Epithelial Cell Differentiation Program. Cancer Research. 65(14). 6237–6244. 204 indexed citations
11.
Ciesiolka, Malgorzata, Mieke Delvaeye, Griet Van Imschoot, et al.. (2004). p120 catenin is required for morphogenetic movements involved in the formation of the eyes and the craniofacial skeleton in Xenopus. Journal of Cell Science. 117(18). 4325–4339. 42 indexed citations
12.
Bellacosa, Alfonso, John J. Upson, Andres J. Klein–Szanto, et al.. (2003). The protein kinase Akt induces epithelial mesenchymal transition and promotes enhanced motility and invasiveness of squamous cell carcinoma lines.. Ghent University Academic Bibliography (Ghent University). 63(9). 2172–8. 537 indexed citations breakdown →
13.
Soares, Paula, Geert Berx, Frans van Roy, & Manuel Sobrinho‐Simões. (1997). E-cadherin gene alterations are rare events in thyroid tumors. International Journal of Cancer. 70(1). 32–38. 73 indexed citations
14.
Soares, Paula, Geert Berx, Frans van Roy, & Manuel Sobrinho‐Simões. (1997). Ecadherin gene alterations are rare events in thyroid tumors. International Journal of Cancer. 70(1). 32–38. 4 indexed citations
15.
Mareel, Marcus, et al.. (1997). Molecular mechanisms of cancer invasion. Ghent University Academic Bibliography (Ghent University). 7 indexed citations
16.
Mareel, Marcus, et al.. (1994). Downregulation in vivo of the invasion-suppressor molecule E-cadherin in experimental and clinical cancer. Ghent University Academic Bibliography (Ghent University). 5 indexed citations
17.
Mareel, M., et al.. (1993). Expression of E-cadherin in embryogenetic ingression and cancer invasion. The International Journal of Developmental Biology. 37(1). 227–235. 15 indexed citations
18.
Mareel, Marcus, et al.. (1991). Normal and chimeric avian embryo ecosystems of invasion. Ghent University Academic Bibliography (Ghent University). 1 indexed citations
19.
Fiers, Walter, Rudi Beyaert, Peter Brouckaert, et al.. (1987). Tumor Necrosis Factor: A Potential Antitumor Agent?. Journal of Interferon Research. 7(5). 627–634. 6 indexed citations
20.
Mareel, Marcus, Robert Hooghe, Erik Bruyneel, et al.. (1986). Expression of cell surface glycoproteins in tumour invasion in vitro. Ghent University Academic Bibliography (Ghent University). 5 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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