Keith Brown

12.9k citations

55 papers · 10.2k indexed · 6 hit papers · h-index 40

Molecular Biology top 1%
Cancer Research top 0.1%
Immunology top 0.2%
Oncology top 1%
Genetics top 2%

Co-authors: Ulrich Siebenlist Guido Franzoso Louise Carlson Estefanı́a Claudio Susan M. Gerstberger R. Eric Davis Louis M. Staudt Charles Yanofsky
Topics: NF-κB Signaling Pathways (24 papers)Immune Response and Inflammation (13 papers)interferon and immune responses (9 papers)
Cited by: Cancer Research Immunology Oncology
Journals: Science Proceedings of the National Academy of Sciences Journal of Biological Chemistry
Partner nations: United States Australia Belgium

In The Last Decade

Keith Brown

55 papers receiving 9.8k citations

Hit Papers

5 papers align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Structure, Regulation and Function of NF-kappaB

1994 1.9k citations Ulrich Siebenlist, Guido Franzoso et al. PubMed profile →
Control of IκB-α Proteolysis by Site-Specific, Signal-Induced Phosphorylation

1995 1.3k citations Keith Brown, Susan M. Gerstberger et al. Science profile →
Requirement for NF-κB in osteoclast and B-cell development

1997 840 citations Guido Franzoso, Louise Carlson et al. Genes & Development profile →
Constitutive Nuclear Factor κB Activity Is Required for Survival of Activated B Cell–like Diffuse Large B Cell Lymphoma Cells

2001 821 citations R. Eric Davis, Keith Brown et al. The Journal of Experimental Medicine profile →
BAFF-induced NEMO-independent processing of NF-κB2 in maturing B cells

2002 569 citations Estefanı́a Claudio, Keith Brown et al. Nature Immunology profile →
Mutual regulation of the transcriptional activator NF-kappa B and its inhibitor, I kappa B-alpha.

1993 569 citations Keith Brown, Guido Franzoso et al. profile →

Peers

Countries citing papers authored by Keith Brown

Since Specialization

Citations

This map shows the geographic impact of Keith Brown's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Keith Brown with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Keith Brown more than expected).

Fields of papers citing papers by Keith Brown

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Keith Brown. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Keith Brown. The network helps show where Keith Brown may publish in the future.

Co-authorship network of co-authors of Keith Brown

This figure shows the co-authorship network connecting the top 25 collaborators of Keith Brown. A scholar is included among the top collaborators of Keith Brown based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Keith Brown. Keith Brown is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

#	Work	Indexed citations
1	Precision medicine in kidney disease: the patient’s view 2020 ·Nature Reviews Nephrology ·Keith Brown,Catherine E. Campbell,Glenda V. Roberts	8
2	The roles of the classical and alternative nuclear factor-kappaB pathways: potential implications for autoimmunity and rheumatoid arthritis 2008 ·Arthritis Research & Therapy ·Keith Brown,Estefanı́a Claudio,Ulrich Siebenlist	208
3	Lipopolysaccharide-mediated Interferon Regulatory Factor Activation Involves TBK1-IKKϵ-dependent Lys63-linked Polyubiquitination and Phosphorylation of TANK/I-TRAF 2007 ·Journal of Biological Chemistry ·Jean‐Stéphane Gatot,Romain Gioia,Tieu‐Lan Chau,(unknown),(unknown),Pierre Close,(unknown),Éric Muraille,Keith Brown,Ulrich Siebenlist,Jacques Piette,Emmanuel Dejardin,Alain Chariot	75
4	A Role for the IκB Family Member Bcl-3 in the Control of Central Immunologic Tolerance 2007 ·Immunity ·Xiaoren Zhang,Hongshan Wang,Estefanı́a Claudio,Keith Brown,Ulrich Siebenlist	65
5	Control of lymphocyte development by nuclear factor-κB 2005 ·Nature reviews. Immunology ·Ulrich Siebenlist,Keith Brown,Estefanı́a Claudio	237
6	BCL-3 and NF-κB p50 Attenuate Lipopolysaccharide-induced Inflammatory Responses in Macrophages 2004 ·Journal of Biological Chemistry ·(unknown),Mark Baer,Howard A. Young,Estefanı́a Claudio,Keith Brown,Ulrich Siebenlist,Peter F. Johnson	171
7	BAFF-induced NEMO-independent processing of NF-κB2 in maturing B cellsbreakdown → 2002 ·Nature Immunology ·Estefanı́a Claudio,Keith Brown,Sun Park,Hongshan Wang,Ulrich Siebenlist	569
8	Association of the Adaptor TANK with the IκB Kinase (IKK) Regulator NEMO Connects IKK Complexes with IKKε and TBK1 Kinases 2002 ·Journal of Biological Chemistry ·Alain Chariot,Antonio Leonardi,Jürgen R. Müller,(unknown),Keith Brown,Ulrich Siebenlist	135
9	Constitutive Nuclear Factor κB Activity Is Required for Survival of Activated B Cell–like Diffuse Large B Cell Lymphoma Cellsbreakdown → 2001 ·The Journal of Experimental Medicine ·R. Eric Davis,Keith Brown,Ulrich Siebenlist,Louis M. Staudt	821
10	Heterogeneity of in vitro radiosensitivity in human bladder cancer cells 1999 ·Radiation Oncology Investigations ·(unknown),(unknown),Richard Fisher,Hedy Mameghan,(unknown),Keith Brown,(unknown),Shane M. O’Mara,Pamela J. Russell	12
11	IκB-α Enhances Transactivation by the HOXB7 Homeodomain-containing Protein 1999 ·Journal of Biological Chemistry ·Alain Chariot,Frédéric Princen,Jacques Gielen,Marie‐Paule Merville,Guido Franzoso,Keith Brown,Ulrich Siebenlist,Vincent Bours	27
12	The Signal Response of IκBα Is Regulated by Transferable N- and C-Terminal Domains 1997 ·Molecular and Cellular Biology ·Keith Brown,Guido Franzoso,Lucia Baldi,Louise Carlson,Laura Mills,(unknown),Susan M. Gerstberger,Ulrich Siebenlist	42
13	Requirement for NF-κB in osteoclast and B-cell developmentbreakdown → 1997 ·Genes & Development ·Guido Franzoso,Louise Carlson,Lianping Xing,Ljiljana Poljak,Elizabeth W. Shores,Keith Brown,Antonio Leonardi,(unknown),Brendan F. Boyce,Ulrich Siebenlist	840
14	Critical Role for Lysines 21 and 22 in Signal-induced, Ubiquitin-mediated Proteolysis of IkB-α 1996 ·Journal of Biological Chemistry ·Lucia Baldi,Keith Brown,Guido Franzoso,Ulrich Siebenlist	161
15	Control of IκB-α Proteolysis by Site-Specific, Signal-Induced Phosphorylationbreakdown → 1995 ·Science ·Keith Brown,Susan M. Gerstberger,Louise Carlson,Guido Franzoso,Ulrich Siebenlist	1311
16	Binding of the protease-sensitive form of PrP (prion protein) to sulfated glycosaminoglycan and congo red [corrected] 1994 ·Journal of Virology ·Byron Caughey,Keith Brown,Gregory J. Raymond,(unknown),Wayne C. Thresher	201
17	A family of serine proteases expressed exclusively in myelo-monocytic cells specifically processes the nuclear factor-kappa B subunit p65 in vitro and may impair human immunodeficiency virus replication in these cells. 1994 ·The Journal of Experimental Medicine ·Guido Franzoso,Priscilla Biswas,Guido Poli,Louise Carlson,Keith Brown,(unknown),A S Fauci,Ulrich Siebenlist	85
18	Structure, Regulation and Function of NF-kappaBbreakdown → 1994 ·PubMed ·Ulrich Siebenlist,Guido Franzoso,Keith Brown	1898
19	Lymphocyte Activation and the Family of NF-κB Transcription Factor Complexes 1992 ·Current topics in microbiology and immunology ·Vincent Bours,Guido Franzoso,Keith Brown,S. Park,(unknown),(unknown),Kathleen Kelly,Ulrich Siebenlist	28
20	Control of three isoenzymic 7-phospho-2-oxo-3-deoxy-d-arabino-heptonate-d-erythrose-4-phosphate lyases of Escherichia coli W and derived mutants by repressive and “inductive” effects of the aromatic amino acids 1966 ·Biochimica et Biophysica Acta (BBA) - Enzymology and Biological Oxidation ·Keith Brown,Colin H. Doy	45

About Keith Brown

Keith Brown is a scholar working on Cancer Research, Immunology and Biochemistry, having authored 55 papers that have together received 10.2k indexed citations. Recurring topics across this work include NF-κB Signaling Pathways (24 papers), Immune Response and Inflammation (13 papers) and interferon and immune responses (9 papers). The work is most often cited by research in Cancer Research (4.8k citations), Immunology (4.5k citations) and Oncology (2.2k citations). Keith Brown has collaborated with scholars based in United States, Australia and Belgium. Frequent co-authors include Ulrich Siebenlist, Guido Franzoso, Louise Carlson, Estefanı́a Claudio, Susan M. Gerstberger, R. Eric Davis, Louis M. Staudt, Charles Yanofsky, Antonio Leonardi and T. Kanno. Their work appears in journals such as Science, Proceedings of the National Academy of Sciences and Journal of Biological Chemistry.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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