Keith Biggadike

1.9k total citations
45 papers, 1.4k citations indexed

About

Keith Biggadike is a scholar working on Organic Chemistry, Molecular Biology and Infectious Diseases. According to data from OpenAlex, Keith Biggadike has authored 45 papers receiving a total of 1.4k indexed citations (citations by other indexed papers that have themselves been cited), including 20 papers in Organic Chemistry, 19 papers in Molecular Biology and 8 papers in Infectious Diseases. Recurrent topics in Keith Biggadike's work include Carbohydrate Chemistry and Synthesis (12 papers), Estrogen and related hormone effects (8 papers) and HIV/AIDS drug development and treatment (8 papers). Keith Biggadike is often cited by papers focused on Carbohydrate Chemistry and Synthesis (12 papers), Estrogen and related hormone effects (8 papers) and HIV/AIDS drug development and treatment (8 papers). Keith Biggadike collaborates with scholars based in United Kingdom, Germany and Belgium. Keith Biggadike's co-authors include Alan D. Borthwick, Barrie E. Kirk, Anne M. Exall, Iain Uings, Stanley M. Roberts, Stuart Farrow, Iain M. McLay, Panayiotis A. Procopiou, Randy K. Bledsoe and David W. Gray and has published in prestigious journals such as Proceedings of the National Academy of Sciences, Analytical Chemistry and Journal of Medicinal Chemistry.

In The Last Decade

Keith Biggadike

45 papers receiving 1.3k citations

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name h Career Trend Papers Cites
Keith Biggadike United Kingdom 19 621 605 305 226 154 45 1.4k
Yvan Guindon Canada 28 744 1.2× 1.3k 2.2× 107 0.4× 178 0.8× 54 0.4× 88 2.0k
Soo S. Ko United States 20 561 0.9× 841 1.4× 169 0.6× 97 0.4× 26 0.2× 32 1.5k
Michael J. Stocks United Kingdom 23 800 1.3× 698 1.2× 66 0.2× 62 0.3× 97 0.6× 81 1.6k
Yutaka Aoyagi Japan 25 808 1.3× 984 1.6× 209 0.7× 45 0.2× 62 0.4× 96 2.1k
I Hayakawa Japan 25 650 1.0× 547 0.9× 142 0.5× 65 0.3× 56 0.4× 77 1.7k
Marco L. Lolli Italy 22 563 0.9× 386 0.6× 152 0.5× 59 0.3× 75 0.5× 67 1.2k
Christiane Yoakim Canada 28 624 1.0× 1.1k 1.8× 306 1.0× 46 0.2× 15 0.1× 51 1.8k
William J. Hoekstra United States 27 609 1.0× 728 1.2× 701 2.3× 50 0.2× 82 0.5× 70 2.2k
Jacques Lacroix Canada 21 451 0.7× 552 0.9× 60 0.2× 54 0.2× 25 0.2× 50 1.1k
Robert E. Schaub Netherlands 21 669 1.1× 800 1.3× 72 0.2× 42 0.2× 32 0.2× 63 1.3k

Countries citing papers authored by Keith Biggadike

Since Specialization
Citations

This map shows the geographic impact of Keith Biggadike's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Keith Biggadike with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Keith Biggadike more than expected).

Fields of papers citing papers by Keith Biggadike

Since Specialization
Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Keith Biggadike. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Keith Biggadike. The network helps show where Keith Biggadike may publish in the future.

Co-authorship network of co-authors of Keith Biggadike

This figure shows the co-authorship network connecting the top 25 collaborators of Keith Biggadike. A scholar is included among the top collaborators of Keith Biggadike based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Keith Biggadike. Keith Biggadike is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

20 of 20 papers shown
1.
Procopiou, Panayiotis A., Victoria J. Barrett, Keith Biggadike, et al.. (2013). Discovery of a Rapidly Metabolized, Long-Acting β2Adrenergic Receptor Agonist with a Short Onset Time Incorporating a Sulfone Group Suitable for Once-Daily Dosing. Journal of Medicinal Chemistry. 57(1). 159–170. 20 indexed citations
2.
Changani, K. Kumar, et al.. (2011). Efficacy of the TRPV1 antagonist SB-705498 in an MRI guinea pig model of rhinitis. European Respiratory Journal. 38(Suppl 55). 4690–4690. 1 indexed citations
3.
Diallo, Hawa, Heather Barnett, Keith Biggadike, et al.. (2011). Discovery of a potent series of non-steroidal non α-trifluoromethyl carbinol glucocorticoid receptor agonists with reduced lipophilicity. Bioorganic & Medicinal Chemistry Letters. 21(4). 1126–1133. 5 indexed citations
4.
5.
Biggadike, Keith, Matilde Caivano, Diane M. Coe, et al.. (2009). Highly tractable, sub-nanomolar non-steroidal glucocorticoid receptor agonists. Bioorganic & Medicinal Chemistry Letters. 19(16). 4846–4850. 8 indexed citations
6.
Biggadike, Keith, Randy K. Bledsoe, Dan Coe, et al.. (2009). Design and x-ray crystal structures of high-potency nonsteroidal glucocorticoid agonists exploiting a novel binding site on the receptor. Proceedings of the National Academy of Sciences. 106(43). 18114–18119. 58 indexed citations
7.
Biggadike, Keith, Randy K. Bledsoe, Anne M. Hassell, et al.. (2008). X-ray Crystal Structure of the Novel Enhanced-Affinity Glucocorticoid Agonist Fluticasone Furoate in the Glucocorticoid Receptor−Ligand Binding Domain. Journal of Medicinal Chemistry. 51(12). 3349–3352. 88 indexed citations
8.
Biggadike, Keith, et al.. (2007). Pharmacological properties of the enhanced-affinity glucocorticoid fluticasone furoate in vitro and in an in vivo model of respiratory inflammatory disease. American Journal of Physiology-Lung Cellular and Molecular Physiology. 293(3). L660–L667. 119 indexed citations
9.
Biggadike, Keith, Iain Uings, & Stuart Farrow. (2004). Designing Corticosteroid Drugs for Pulmonary Selectivity. Proceedings of the American Thoracic Society. 1(4). 352–355. 16 indexed citations
10.
Biggadike, Keith, et al.. (2003). Structure–activity relationship on human serum paraoxonase (PON1) using substrate analogues and inhibitors. Bioorganic & Medicinal Chemistry Letters. 13(10). 1623–1626. 18 indexed citations
11.
12.
Grabowska, Urszula, et al.. (1997). Diastereoselective resolution of 6-substituted glycosides via enzymatic hydrolysis. Carbohydrate Research. 305(3-4). 351–361. 12 indexed citations
13.
Jackson, Helen C., Keith Biggadike, Elaine McKilligin, et al.. (1996). 6,7-disubstituted 2,4-diaminopteridines: novel inhibitors of Pneumocystis carinii and Toxoplasma gondii dihydrofolate reductase. Antimicrobial Agents and Chemotherapy. 40(6). 1371–1375. 14 indexed citations
14.
Blériot, Yves, Joan A. Cadefau, Willy Stalmans, et al.. (1996). The first example of a 6-C-: Inhibition of glucokinase. Tetrahedron Asymmetry. 7(9). 2761–2772. 10 indexed citations
15.
Blériot, Yves, Joan A. Cadefau, Mathieu Bollen, et al.. (1996). 7-Carbon mimics of D-glucose and L-fucose: Activation by 6R-, and inactivation by 6S, -6C-methylglucose of glycogen synthase: Inhibition of glucokinase and/or glucose-6-phosphatase. Tetrahedron Letters. 37(39). 7155–7158. 14 indexed citations
16.
Biggadike, Keith, et al.. (1994). Short synthesis of a bicyclic mimic of α-L-fucose. Journal of the Chemical Society Chemical Communications. 2001–2002. 5 indexed citations
17.
Borthwick, Alan D., Barrie E. Kirk, Keith Biggadike, et al.. (1991). Fluorocarbocyclic nucleosides: synthesis and antiviral activity of 2'- and 6'-fluorocarbocyclic 2'-deoxyguanosines. Journal of Medicinal Chemistry. 34(3). 907–914. 44 indexed citations
18.
19.
Biggadike, Keith, Alan D. Borthwick, Anne M. Exall, et al.. (1987). Synthesis of fluorinated carbocyclic nucleosides: preparation of carbocyclic 1-(2′-deoxy-6′-fluororibofuranosyl)-5-iodouracils. Journal of the Chemical Society Chemical Communications. 255–256. 24 indexed citations
20.
Biggadike, Keith, et al.. (1977). The Synthesis of Some Halogenopyrimidines and Some Routes to Cyanopyrimidines. Heterocycles. 6(12). 2005–2005. 4 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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