Karsten Melcher

16.4k total citations · 6 hit papers
100 papers, 8.7k citations indexed

About

Karsten Melcher is a scholar working on Molecular Biology, Cellular and Molecular Neuroscience and Plant Science. According to data from OpenAlex, Karsten Melcher has authored 100 papers receiving a total of 8.7k indexed citations (citations by other indexed papers that have themselves been cited), including 77 papers in Molecular Biology, 23 papers in Cellular and Molecular Neuroscience and 20 papers in Plant Science. Recurrent topics in Karsten Melcher's work include Receptor Mechanisms and Signaling (23 papers), Metabolism, Diabetes, and Cancer (11 papers) and Neuropeptides and Animal Physiology (10 papers). Karsten Melcher is often cited by papers focused on Receptor Mechanisms and Signaling (23 papers), Metabolism, Diabetes, and Cancer (11 papers) and Neuropeptides and Animal Physiology (10 papers). Karsten Melcher collaborates with scholars based in United States, China and Singapore. Karsten Melcher's co-authors include H. Eric Xu, Yi Jiang, X. Edward Zhou, Yan Yan, Ting-Hai Xu, Eu‐Leong Yong, Jiyuan Ke, Stephen Albert Johnston, Jun Li and M-H. Tan and has published in prestigious journals such as Nature, Science and Cell.

In The Last Decade

Karsten Melcher

100 papers receiving 8.6k citations

Hit Papers

5 papers align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Amyloid beta: structure, biology and structure-based therapeutic development

2017 1.4k citations Ting-Hai Xu, Yan Yan et al. Acta Pharmacologica Sinica profile →
Androgen receptor: structure, role in prostate cancer and drug discovery

2014 650 citations H. Eric Xu, Karsten Melcher et al. Acta Pharmacologica Sinica profile →
DWARF 53 acts as a repressor of strigolactone signalling in rice

2013 649 citations Liang Jiang, Xue Liu et al. Nature profile →
Structural basis for molecular recognition of folic acid by folate receptors

2013 582 citations Jiyuan Ke, X. Edward Zhou et al. Nature profile →
Structural insights into the lipid and ligand regulation of serotonin receptors

2021 185 citations Peiyu Xu, Sijie Huang et al. Nature profile →
Structures of the entire human opioid receptor family

2023 106 citations X. Edward Zhou, Karsten Melcher et al. profile →

Peers

Countries citing papers authored by Karsten Melcher

Since Specialization

Citations

This map shows the geographic impact of Karsten Melcher's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Karsten Melcher with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Karsten Melcher more than expected).

Fields of papers citing papers by Karsten Melcher

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Karsten Melcher. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Karsten Melcher. The network helps show where Karsten Melcher may publish in the future.

Co-authorship network of co-authors of Karsten Melcher

This figure shows the co-authorship network connecting the top 25 collaborators of Karsten Melcher. A scholar is included among the top collaborators of Karsten Melcher based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Karsten Melcher. Karsten Melcher is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

#	Work	Indexed citations
1	Design, Synthesis, and Biological Activity of Novel Ornithine Decarboxylase (ODC) Inhibitors 2025 ·Journal of Medicinal Chemistry ·Chad R. Schultz, (unknown), Xiaofeng Zhou, Kelly Suino-Powell, Karsten Melcher, Nuno M. S. Almeida, Angela K. Wilson, Edmund L. Ellsworth, André S. Bachmann	1
2	Assembly of JAZ–JAZ and JAZ–NINJA complexes in jasmonate signaling 2023 ·Plant Communications ·X. Edward Zhou, (unknown), Jian Yao, Jie Zheng, Yuxin Zhou, Qing He, Javier E. Moreno, Quang Vinh Lam, Xiaoman Cao, Koichi Sugimoto, (unknown), (unknown), Kelly Suino-Powell, Yuanye Zhu, Scott J. Novick, Patrick R. Griffin, Feng Zhang, Gregg A. Howe, Karsten Melcher	10
3	Structural insights into the lipid and ligand regulation of serotonin receptors breakdown → 2021 ·Nature ·Peiyu Xu, Sijie Huang, Huibing Zhang, Chunyou Mao, X. Edward Zhou, Xi Cheng, Ícaro A. Simon, Dandan Shen, Hsin‐Yung Yen, Carol V. Robinson, Kasper Harpsøe, Bo Svensson, Jia Guo, Hualiang Jiang, David E. Gloriam, Karsten Melcher, Yi Jiang, Yan Zhang, H. Eric Xu	185
4	Structures of the human dopamine D3 receptor-Gi complexes 2021 ·Molecular Cell ·Peiyu Xu, Sijie Huang, Chunyou Mao, B. Krumm, X. Edward Zhou, Yangxia Tan, Xi‐Ping Huang, Yongfeng Liu, Dandan Shen, Yi Jiang, Xuekui Yu, Hualiang Jiang, Karsten Melcher, Bryan L. Roth, Xi Cheng, Yan Zhang, H. Eric Xu	57
5	Structure of an AMPK complex in an inactive, ATP-bound state 2021 ·Science ·Yan Yan, Somnath Mukherjee, Kaleeckal G. Harikumar, Timothy S. Strutzenberg, X. Edward Zhou, Kelly Suino-Powell, Ting-Hai Xu, Ryan D. Sheldon, Jared Lamp, J.S. Brunzelle, (unknown), Abigail E. Ellis, Scott J. Novick, Irving E. Vega, Russell G. Jones, Laurence J. Miller, H. Eric Xu, Patrick R. Griffin, Anthony A. Kossiakoff, Karsten Melcher	74
6	Long-chain fatty acyl-CoA esters regulate metabolism via allosteric control of AMPK β1 isoforms 2020 ·Nature Metabolism ·Stephen L. Pinkosky, John W. Scott, Eric M. Desjardins, Brennan K. Smith, Emily A. Day, Rebecca J. Ford, Christopher G. Langendorf, Naomi X.Y. Ling, Tracy L. Nero, Kim Loh, Sandra Galić, Ashfaqul Hoque, William J. Smiles, Kevin R. W. Ngoei, Michael W. Parker, Yan Yan, Karsten Melcher, Bruce E. Kemp, Jonathan S. Oakhill, Gregory R. Steinberg	101
7	Structure of nucleosome-bound DNA methyltransferases DNMT3A and DNMT3B 2020 ·Nature ·Ting-Hai Xu, Minmin Liu, X. Edward Zhou, Gangning Liang, Gongpu Zhao, H. Eric Xu, Karsten Melcher, Peter A. Jones	80
8	A complex structure of arrestin-2 bound to a G protein-coupled receptor 2019 ·Cell Research ·Wanchao Yin, Zhihai Li, Mingliang Jin, Yu-Ling Yin, Parker W. de Waal, Kuntal Pal, Yanting Yin, Xiang Gao, Yuanzheng He, Jing Gao, Xiaoxi Wang, Yan Zhang, Hu Zhou, Karsten Melcher, Yi Jiang, Yao Cong, X. Edward Zhou, Xuekui Yu, H. Eric Xu	148
9	Deconvoluting AMP-activated protein kinase (AMPK) adenine nucleotide binding and sensing 2017 ·Journal of Biological Chemistry ·Xin Gu, Yan Yan, Scott J. Novick, Amanda Kovach, Devrishi Goswami, Jiyuan Ke, Michelle H. Tan, Lili Wang, Xiaodan Li, Parker W. de Waal, Martin R. Webb, Patrick R. Griffin, H. Eric Xu, Karsten Melcher	41
10	An intrinsic agonist mechanism for activation of glucagon-like peptide-1 receptor by its extracellular domain 2016 ·Cell Discovery ·Yanting Yin, X. Edward Zhou, Li Hou, Lihua Zhao, Bo Liu, Gaihong Wang, Yi Jiang, Karsten Melcher, H. Eric Xu	24
11	Destabilization of strigolactone receptor DWARF14 by binding of ligand and E3-ligase signaling effector DWARF3 2015 ·Cell Research ·Lihua Zhao, X. Edward Zhou, Wei Yi, Zhongshan Wu, Yue Liu, Yanyong Kang, Li Hou, Parker W. de Waal, Suling Li, Yi Jiang, Adrian Scaffidi, Gavin R. Flematti, Steven M. Smith, Quang Vinh Lam, Patrick R. Griffin, Yonghong Wang, Jiayang Li, Karsten Melcher, H. Eric Xu	134
12	High yield and efficient expression and purification of the human 5-HT3A receptor 2015 ·Acta Pharmacologica Sinica ·Zhongshan Wu, Zhicheng Cui, Hao Cheng, Fan Chen, Karsten Melcher, Yi Jiang, Chenghai Zhang, Hualiang Jiang, Yao Cong, Qian Liu, H. Eric Xu	5
13	H2O2 Inhibits ABA-Signaling Protein Phosphatase HAB1 2014 ·PLoS ONE ·(unknown), Amanda Kovach, Yang Zhao, Jian‐Kang Zhu, H. Eric Xu, Kunchithapadam Swaminathan, Karsten Melcher	23
14	Structure of a PLS-class Pentatricopeptide Repeat Protein Provides Insights into Mechanism of RNA Recognition 2013 ·Journal of Biological Chemistry ·(unknown), Jiyuan Ke, Runze Chen, Xin Gu, Mingyue Tan, X. Edward Zhou, Yanyong Kang, Karsten Melcher, Jian‐Kang Zhu, H. Eric Xu	50
15	DWARF 53 acts as a repressor of strigolactone signalling in rice breakdown → 2013 ·Nature ·Liang Jiang, Xue Liu, Guosheng Xiong, Huihui Liu, (unknown), Lei Wang, Xiangbing Meng, Guifu Liu, Hong Yu, Yundong Yuan, Wei Yi, Lihua Zhao, Honglei Ma, Yuanzheng He, Zhongshan Wu, Karsten Melcher, Qian Qian, H. Eric Xu, Yonghong Wang, Jiayang Li	649
16	Protein Conformation Ensembles Monitored by HDX Reveal a Structural Rationale for Abscisic Acid Signaling Protein Affinities and Activities 2013 ·Structure ·Graham M. West, Bruce D. Pascal, (unknown), F.-F. Soon, Karsten Melcher, H. Eric Xu, Michael J. Chalmers, Patrick R. Griffin	30
17	The Crystal Structure of the Orphan Nuclear Receptor NR2E3/PNR Ligand Binding Domain Reveals a Dimeric Auto-Repressed Conformation 2013 ·PLoS ONE ·Mingyue Tan, X. Edward Zhou, F.-F. Soon, Xiaodan Li, Jun Li, Eu‐Leong Yong, Karsten Melcher, H. Eric Xu	34
18	Structure and mechanism for recognition of peptide hormones by Class B G-protein-coupled receptors 2012 ·Acta Pharmacologica Sinica ·Kuntal Pal, Karsten Melcher, H. Eric Xu	94
19	Identification and characterization of the activation domain of Ifh1, an activator of model TATA-less genes 2010 ·Biochemical and Biophysical Research Communications ·(unknown), Karsten Melcher	7
20	Zero Background Yeast Reporter Plasmids 2000 ·Gene ·Karsten Melcher, (unknown), Wei Ding, (unknown)	33

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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