John R. Hepler

10.2k total citations · 2 hit papers
104 papers, 8.1k citations indexed

About

John R. Hepler is a scholar working on Molecular Biology, Cellular and Molecular Neuroscience and Cell Biology. According to data from OpenAlex, John R. Hepler has authored 104 papers receiving a total of 8.1k indexed citations (citations by other indexed papers that have themselves been cited), including 89 papers in Molecular Biology, 30 papers in Cellular and Molecular Neuroscience and 17 papers in Cell Biology. Recurrent topics in John R. Hepler's work include Protein Kinase Regulation and GTPase Signaling (58 papers), Receptor Mechanisms and Signaling (41 papers) and Neuroscience and Neuropharmacology Research (22 papers). John R. Hepler is often cited by papers focused on Protein Kinase Regulation and GTPase Signaling (58 papers), Receptor Mechanisms and Signaling (41 papers) and Neuroscience and Neuropharmacology Research (22 papers). John R. Hepler collaborates with scholars based in United States, Canada and Japan. John R. Hepler's co-authors include Alfred G. Gilman, Alan V. Smrcka, Paul C. Sternweis, T K Harden, Maurine E. Linder, Tohru Kozasa, Suneela Ramineni, Ronald Taussig, Susanne M. Mumby and H. Shelton Earp and has published in prestigious journals such as Science, Proceedings of the National Academy of Sciences and Journal of Biological Chemistry.

In The Last Decade

John R. Hepler

101 papers receiving 8.0k citations

Hit Papers

align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Regulation of Polyphosphoinositide-specific Phospholipase C Activity by Purified G _q

1991 757 citations John R. Hepler et al. profile →
G proteins

1992 745 citations John R. Hepler, Alfred G. Gilman profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name	h						Papers	Cites
John R. Hepler United States	44	6.4k	2.4k	1.2k	691	478	104	8.1k
Tohru Kozasa United States	50	7.9k 1.2×	1.9k 0.8×	1.7k 1.4×	611 0.9×	671 1.4×	107	9.7k
David R. Manning United States	45	4.1k 0.6×	1.2k 0.5×	914 0.8×	456 0.7×	449 0.9×	76	5.5k
Alan V. Smrcka United States	50	7.1k 1.1×	2.0k 0.8×	1.6k 1.3×	799 1.2×	471 1.0×	145	9.1k
Yehia Daaka United States	45	7.6k 1.2×	3.1k 1.3×	1.2k 1.0×	1.1k 1.6×	521 1.1×	97	10.0k
Randy A. Hall United States	55	6.1k 1.0×	4.0k 1.6×	1.2k 1.0×	744 1.1×	354 0.7×	133	8.5k
Brian E. Hawes United States	35	4.1k 0.6×	1.6k 0.7×	567 0.5×	583 0.8×	247 0.5×	71	5.7k
John K. Northup United States	42	5.4k 0.8×	2.0k 0.8×	1.3k 1.1×	618 0.9×	464 1.0×	84	7.1k
Christophé Erneux Belgium	49	5.6k 0.9×	818 0.3×	2.1k 1.7×	669 1.0×	333 0.7×	234	7.4k
Henryk Dudek United States	19	7.4k 1.2×	2.0k 0.8×	1.0k 0.8×	707 1.0×	828 1.7×	41	10.3k
L.M. Fredrik Leeb-Lundberg United States	43	3.3k 0.5×	1.6k 0.7×	482 0.4×	548 0.8×	976 2.0×	90	6.1k

Countries citing papers authored by John R. Hepler

Since Specialization

Citations

This map shows the geographic impact of John R. Hepler's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by John R. Hepler with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites John R. Hepler more than expected).

Fields of papers citing papers by John R. Hepler

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by John R. Hepler. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by John R. Hepler. The network helps show where John R. Hepler may publish in the future.

Co-authorship network of co-authors of John R. Hepler

This figure shows the co-authorship network connecting the top 25 collaborators of John R. Hepler. A scholar is included among the top collaborators of John R. Hepler based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with John R. Hepler. John R. Hepler is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

Sneddon, W. Bruce, et al.. (2025). Noncanonical RGS14 structural determinants control hormone-sensitive NPT2A-mediated phosphate transport. Biochemical Journal. 482(3). 135–146.

Sneddon, W. Bruce, et al.. (2024). Distinct and overlapping RGS14 and RGS12 actions regulate NPT2A-mediated phosphate transport. Biochemical and Biophysical Research Communications. 733. 150700–150700. 2 indexed citations

Smith, Yoland, et al.. (2024). Regulator of G protein signalling 14 (RGS14) protein expression profile in the adult mouse brain. European Journal of Neuroscience. 60(12). 7058–7085.

Lustberg, Daniel J., Shannon Farris, Meilan Zhao, et al.. (2023). Mechanisms of mGluR‐dependent plasticity in hippocampal area CA2. Hippocampus. 33(6). 730–744. 5 indexed citations

Lustberg, Daniel J., Cheyenne Hurst, Jean‐François Paré, et al.. (2023). RGS14 limits seizure-induced mitochondrial oxidative stress and pathology in hippocampus. Neurobiology of Disease. 181. 106128–106128. 2 indexed citations

Squires, Katherine E., Kyle J. Gerber, Daniel J. Lustberg, et al.. (2020). Human genetic variants disrupt RGS14 nuclear shuttling and regulation of LTP in hippocampal neurons. Journal of Biological Chemistry. 296. 100024–100024. 9 indexed citations

Gerber, Kyle J., Eric B. Dammer, Duc M. Duong, et al.. (2019). Specific Proteomes of Hippocampal Regions CA2 and CA1 Reveal Proteins Linked to the Unique Physiology of Area CA2. Journal of Proteome Research. 18(6). 2571–2584. 14 indexed citations

Gerber, Kyle J., Eric B. Dammer, Duc M. Duong, et al.. (2018). Interactome Analysis Reveals Regulator of G Protein Signaling 14 (RGS14) is a Novel Calcium/Calmodulin (Ca²⁺/CaM) and CaM Kinase II (CaMKII) Binding Partner. Journal of Proteome Research. 17(4). 1700–1711. 18 indexed citations

Parra-Bueno, Paula, et al.. (2018). RGS14 Restricts Plasticity in Hippocampal CA2 by Limiting Postsynaptic Calcium Signaling. eNeuro. 5(3). ENEURO.0353–17.2018. 38 indexed citations

10.

Brown, Nicole, J Blumer, & John R. Hepler. (2015). Bioluminescence Resonance Energy Transfer to Detect Protein-Protein Interactions in Live Cells. Methods in molecular biology. 1278. 457–465. 25 indexed citations

11.

Ghil, Sungho, Kelly L. McCoy, & John R. Hepler. (2014). Regulator of G Protein Signaling 2 (RGS2) and RGS4 Form Distinct G Protein-Dependent Complexes with Protease Activated-Receptor 1 (PAR1) in Live Cells. PLoS ONE. 9(4). e95355–e95355. 21 indexed citations

12.

Jernigan, Kristin K., Curtis A. Thorne, Alison Hanson, et al.. (2010). Gβγ Activates GSK3 to Promote LRP6-Mediated β-Catenin Transcriptional Activity. Science Signaling. 3(121). ra37–ra37. 47 indexed citations

13.

McCoy, Kelly L. & John R. Hepler. (2009). Chapter 3 Regulators of G Protein Signaling Proteins as Central Components of G Protein‐Coupled Receptor Signaling Complexes. Progress in molecular biology and translational science. 86. 49–74. 22 indexed citations

14.

Nicole, Olivier, Cecily E. Hamill, Scott D. Sorensen, et al.. (2005). Activation of Protease-Activated Receptor-1 Triggers Astrogliosis after Brain Injury. Journal of Neuroscience. 25(17). 4319–4329. 117 indexed citations

15.

Hague, Chris, Leah S. Bernstein, Suneela Ramineni, et al.. (2005). Selective Inhibition of α1A-Adrenergic Receptor Signaling by RGS2 Association with the Receptor Third Intracellular Loop. Journal of Biological Chemistry. 280(29). 27289–27295. 88 indexed citations

16.

Hepler, John R.. (2003). RGS Protein and G Protein Interactions: A Little Help from Their Friends. Molecular Pharmacology. 64(3). 547–549. 43 indexed citations

17.

Hollinger, Susanne & John R. Hepler. (2003). Methods for Measuring RGS Protein Phosphorylation by G Protein-Regulated Kinases. Humana Press eBooks. 237. 205–220. 8 indexed citations

18.

Hepler, John R., David M. Berman, Alfred G. Gilman, & Tohru Kozasa. (1997). RGS4 and GAIP are GTPase-activating proteins for G _qα and block activation of phospholipase Cβ by γ-thio-GTP-G _qα. Proceedings of the National Academy of Sciences. 94(2). 428–432. 330 indexed citations

19.

Hepler, John R., N Nakahata, Timothy W. Lovenberg, et al.. (1987). Epidermal growth factor stimulates the rapid accumulation of inositol (1,4,5)-trisphosphate and a rise in cytosolic calcium mobilized from intracellular stores in A431 cells.. Journal of Biological Chemistry. 262(7). 2951–2956. 174 indexed citations

20.

Myers, R.D. & John R. Hepler. (1983). Glass-plastic push-pull cannula system for regional perfusion of sites in the brain. Journal of Neuroscience Methods. 9(2). 163–171. 9 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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