John M. Domagala

4.1k total citations · 1 hit paper
62 papers, 3.2k citations indexed

About

John M. Domagala is a scholar working on Organic Chemistry, Molecular Biology and Infectious Diseases. According to data from OpenAlex, John M. Domagala has authored 62 papers receiving a total of 3.2k indexed citations (citations by other indexed papers that have themselves been cited), including 35 papers in Organic Chemistry, 31 papers in Molecular Biology and 21 papers in Infectious Diseases. Recurrent topics in John M. Domagala's work include Cancer therapeutics and mechanisms (26 papers), HIV/AIDS drug development and treatment (12 papers) and Synthesis and Biological Evaluation (11 papers). John M. Domagala is often cited by papers focused on Cancer therapeutics and mechanisms (26 papers), HIV/AIDS drug development and treatment (12 papers) and Synthesis and Biological Evaluation (11 papers). John M. Domagala collaborates with scholars based in United States, Canada and United Kingdom. John M. Domagala's co-authors include Karl Drlica, Xilin Zhao, Yuzhi Dong, Joseph P. Sanchez, Carl L. Heifetz, Chen Xu, Marland P. Hutt, Robert D. Bach, Susan E. Hagen and T. F. MICH and has published in prestigious journals such as Science, Proceedings of the National Academy of Sciences and Journal of the American Chemical Society.

In The Last Decade

John M. Domagala

62 papers receiving 2.9k citations

Hit Papers

Structure-activity and st... 1994 2026 2004 2015 1994 100 200 300 400 500
What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

  1. Structure-activity and structure-side-effect relationships for the quinolone antibacterials
    1994 556 citations John M. Domagala profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name h Career Trend Papers Cites
John M. Domagala United States 27 1.4k 1.1k 1.0k 941 657 62 3.2k
Violetta Cecchetti Italy 35 1.5k 1.0× 379 0.3× 1.4k 1.4× 361 0.4× 832 1.3× 134 3.4k
Scott J. Hecker United States 22 1.1k 0.8× 577 0.5× 779 0.7× 967 1.0× 405 0.6× 47 2.5k
Oriana Tabarrini Italy 35 1.4k 1.0× 312 0.3× 1.5k 1.4× 325 0.3× 800 1.2× 131 3.4k
Mark Brönstrup Germany 37 1.8k 1.3× 808 0.7× 1.2k 1.2× 425 0.5× 313 0.5× 163 4.4k
Anders Karlén Sweden 35 2.2k 1.6× 359 0.3× 1.1k 1.1× 280 0.3× 481 0.7× 124 4.3k
D P Bonner United States 30 764 0.5× 1.1k 0.9× 497 0.5× 929 1.0× 824 1.3× 72 2.9k
H. Vanderhaeghe Belgium 25 1.0k 0.7× 516 0.5× 870 0.8× 148 0.2× 557 0.8× 142 2.7k
Thavendran Govender South Africa 36 2.0k 1.4× 406 0.4× 2.3k 2.2× 232 0.2× 743 1.1× 270 5.2k
Gary I. Dmitrienko Canada 22 498 0.4× 333 0.3× 677 0.7× 309 0.3× 300 0.5× 74 1.5k
Michael H. Cynamon United States 41 1.5k 1.1× 434 0.4× 946 0.9× 573 0.6× 2.9k 4.4× 132 4.8k

Countries citing papers authored by John M. Domagala

Since Specialization
Citations

This map shows the geographic impact of John M. Domagala's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by John M. Domagala with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites John M. Domagala more than expected).

Fields of papers citing papers by John M. Domagala

Since Specialization
Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by John M. Domagala. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by John M. Domagala. The network helps show where John M. Domagala may publish in the future.

Co-authorship network of co-authors of John M. Domagala

This figure shows the co-authorship network connecting the top 25 collaborators of John M. Domagala. A scholar is included among the top collaborators of John M. Domagala based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with John M. Domagala. John M. Domagala is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

20 of 20 papers shown
1.
Tran, Tuan P., Edmund L. Ellsworth, Joseph P. Sanchez, et al.. (2006). Structure–activity relationships of 3-aminoquinazolinediones, a new class of bacterial type-2 topoisomerase (DNA gyrase and topo IV) inhibitors. Bioorganic & Medicinal Chemistry Letters. 17(5). 1312–1320. 42 indexed citations
2.
Dong, Yuzhi, Xilin Zhao, Sung-Woo Lee, et al.. (2000). Selection of Antibiotic‐Resistant Bacterial Mutants: Allelic Diversity among Fluoroquinolone‐Resistant Mutations. The Journal of Infectious Diseases. 182(2). 517–525. 112 indexed citations
3.
Ellsworth, Edmund L., John M. Domagala, J. V. N. Vara Prasad, et al.. (1999). 4-Hydroxy-5,6-Dihydro-2H-pyran-2-ones. 3. Bicyclic and hetero-aromatic ring systems as 3-position scaffolds to bind to S1′ and S2′ of the HIV-1 protease enzyme. Bioorganic & Medicinal Chemistry Letters. 9(14). 2019–2024. 8 indexed citations
4.
Prasad, J. V. N. Vara, Larry J. Markoski, John M. Domagala, et al.. (1999). Nonpeptidic HIV protease inhibitors: 6-alkyl-5,6-dihydropyran-2-ones possessing a novel and achiral 3-(2-t-butyl-5-methyl-4-sulfamate)phenylthio moiety. Bioorganic & Medicinal Chemistry Letters. 9(15). 2217–2222. 2 indexed citations
5.
Zhao, Xilin, Jian-Ying Wang, Chen Xu, et al.. (1998). Killing of Staphylococcus aureus by C-8-Methoxy Fluoroquinolones. Antimicrobial Agents and Chemotherapy. 42(4). 956–958. 71 indexed citations
6.
Domagala, John M., Maxwell D. Cummings, Stephen J. Gracheck, et al.. (1998). Bacterial Two-Component Signalling as a Therapeutic Target in Drug Design. Advances in experimental medicine and biology. 456. 269–286. 9 indexed citations
7.
Hagen, Susan E., J. V. N. Vara Prasad, F Boyer, et al.. (1997). Synthesis of 5,6-Dihydro-4-hydroxy-2- pyrones as HIV-1 Protease Inhibitors:  The Profound Effect of Polarity on Antiviral Activity. Journal of Medicinal Chemistry. 40(23). 3707–3711. 47 indexed citations
8.
Zhao, Xilin, Chen Xu, John M. Domagala, & Karl Drlica. (1997). DNA topoisomerase targets of the fluoroquinolones: A strategy for avoiding bacterial resistance. Proceedings of the National Academy of Sciences. 94(25). 13991–13996. 161 indexed citations
9.
Sanchez, Joseph P., Rocco D. Gogliotti, John M. Domagala, et al.. (1995). The Synthesis, Structure-Activity, and Structure-Side Effect Relationships of a Series of 8-Alkoxy- and 5-Amino-8-alkoxyquinolone Antibacterial Agents. Journal of Medicinal Chemistry. 38(22). 4478–4487. 55 indexed citations
10.
Lunney, Elizabeth A., Susan E. Hagen, John M. Domagala, et al.. (1994). A Novel Nonpeptide HIV-1 Protease Inhibitor: Elucidation of the Binding Mode and Its Application in the Design of Related Analogs. Journal of Medicinal Chemistry. 37(17). 2664–2677. 70 indexed citations
11.
Schroeder, Mel C., John S. Kiely, Edgardo Laborde, et al.. (1992). Synthesis of the four stereoisomers of several 3‐(1‐aminoethyl)pyrrolidines. Important intermediates in the preparation of quinolone antibacterials. Journal of Heterocyclic Chemistry. 29(6). 1481–1498. 7 indexed citations
12.
Domagala, John M., Alex Bridges, Townley P. Culbertson, et al.. (1991). Synthesis and biological activity of 5-amino- and 5-hydroxyquinolones, and the overwhelming influence of the remote N1-substituent in determining the structure-activity relationship. Journal of Medicinal Chemistry. 34(3). 1142–1154. 42 indexed citations
13.
Hagen, Susan E., John M. Domagala, Carl L. Heifetz, Joseph P. Sanchez, & Marjorie S. Solomon. (1990). New quinolone antibacterial agents. Synthesis and biological activity of 7-(3,3- or 3,4-disubstituted-1-pyrrolidinyl)quinoline-3-carboxylic acids. Journal of Medicinal Chemistry. 33(2). 849–854. 26 indexed citations
14.
Hagen, Susan E. & John M. Domagala. (1990). Synthesis of 5‐methyl‐4‐oxo‐quinolinecarboxylic acids. Journal of Heterocyclic Chemistry. 27(6). 1609–1616. 11 indexed citations
15.
16.
Sanchez, Joseph P., John M. Domagala, Susan E. Hagen, et al.. (1988). Quinolone antibacterial agents. Synthesis and structure-activity relationships of 8-substituted quinoline-3-carboxylic acids and 1,8-naphthyridine-3-carboxylic acids. Journal of Medicinal Chemistry. 31(5). 983–991. 108 indexed citations
17.
Domagala, John M., Carl L. Heifetz, Marland P. Hutt, et al.. (1988). 1-Substituted 7-[3-[(ethylamino)methyl]-1-pyrrolidinyl]-6,8-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acids. New quantitative structure activity relationships at N1 for the quinolone antibacterials. Journal of Medicinal Chemistry. 31(5). 991–1001. 77 indexed citations
18.
Culbertson, Townley P., et al.. (1987). Enantiomers of 1-ethyl-7-[3-[(ethylamino)methyl]-1-pyrrolidinyl]-6,8-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid: preparation and biological activity. Journal of Medicinal Chemistry. 30(10). 1711–1715. 24 indexed citations
19.
Domagala, John M. & Theodore H. Haskell. (1981). Synthesis of (Z)-4-(acylamino)- and 4-(alkylamino)-.alpha.-oximinophenylacetic acids: properties and stereochemical determination. The Journal of Organic Chemistry. 46(1). 134–140. 7 indexed citations
20.
Domagala, John M., Robert D. Bach, & James Wemple. (1976). Rearrangement of optically active ethyl (E)-3-methyl-3-phenylglycidate. Evidence for concerted carbethoxy migration. Journal of the American Chemical Society. 98(7). 1975–1977. 20 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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