John M. Domagala

4.1k citations

62 papers · 3.2k indexed · 1 hit paper · h-index 27

Co-authors: Karl Drlica Xilin Zhao Yuzhi Dong Joseph P. Sanchez Carl L. Heifetz Chen Xu Marland P. Hutt Robert D. Bach
Topics: Cancer therapeutics and mechanisms (26 papers)HIV/AIDS drug development and treatment (12 papers)Synthesis and Biological Evaluation (11 papers)
Cited by: Molecular Medicine Pharmacology Virology
Journals: Science Proceedings of the National Academy of Sciences Journal of the American Chemical Society
Partner nations: United States Canada United Kingdom

In The Last Decade

John M. Domagala

62 papers receiving 2.9k citations

Hit Papers

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What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Structure-activity and structure-side-effect relationships for the quinolone antibacterials

1994 556 citations John M. Domagala profile →

Peers

Countries citing papers authored by John M. Domagala

Since Specialization

Citations

This map shows the geographic impact of John M. Domagala's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by John M. Domagala with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites John M. Domagala more than expected).

Fields of papers citing papers by John M. Domagala

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by John M. Domagala. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by John M. Domagala. The network helps show where John M. Domagala may publish in the future.

Co-authorship network of co-authors of John M. Domagala

This figure shows the co-authorship network connecting the top 25 collaborators of John M. Domagala. A scholar is included among the top collaborators of John M. Domagala based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with John M. Domagala. John M. Domagala is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

#	Work	Indexed citations
1	Structure–activity relationships of 3-aminoquinazolinediones, a new class of bacterial type-2 topoisomerase (DNA gyrase and topo IV) inhibitors 2006 ·Bioorganic & Medicinal Chemistry Letters ·Tuan P. Tran,Edmund L. Ellsworth,Joseph P. Sanchez,Brian M. Watson,Michael A. Stier,Hollis D. Showalter,John M. Domagala,Martin A. Shapiro,(unknown),Stephen J. Gracheck,(unknown),Paul Bird,(unknown),(unknown),(unknown),(unknown),Xiujuan Wu,Rajeshwar Singh	42
2	Synthesis and structural–activity relationships of 3-hydroxyquinazoline-2,4-dione antibacterial agents 2004 ·Bioorganic & Medicinal Chemistry Letters ·Tuan P. Tran,Edmund L. Ellsworth,Michael A. Stier,John M. Domagala,Hollis D. Showalter,Stephen J. Gracheck,Martin A. Shapiro,(unknown),Rajeshwar Singh	63
3	Inhibition of the early phase of HIV replication by an isothiazolone, PD 161374 2001 ·Antiviral Research ·L Sharmeen,Thomas J. McQuade,Andrea Heldsinger,Rocco D. Gogliotti,John M. Domagala,Stephen J. Gracheck	23
4	Selection of Antibiotic‐Resistant Bacterial Mutants: Allelic Diversity among Fluoroquinolone‐Resistant Mutations 2000 ·The Journal of Infectious Diseases ·(unknown),Yuzhi Dong,Xilin Zhao,Sung-Woo Lee,Amol Amin,Srinivas V. Ramaswamy,John M. Domagala,James M. Musser,Karl Drlica	112
5	Nonpeptidic HIV protease inhibitors: 6-alkyl-5,6-dihydropyran-2-ones possessing a novel and achiral 3-(2-t-butyl-5-methyl-4-sulfamate)phenylthio moiety 1999 ·Bioorganic & Medicinal Chemistry Letters ·J. V. N. Vara Prasad,Larry J. Markoski,(unknown),John M. Domagala,Edmund L. Ellsworth,Christopher Gajda,Susan E. Hagen,Bradley D. Tait,Elizabeth A. Lunney,Peter J. Tummino,Donna Ferguson,Tod P. Holler,Donald Hupe,(unknown),Stephen J. Gracheck,(unknown),(unknown),K. R. Krishna Iyer,Michael Sinz	2
6	4-Hydroxy-5,6-Dihydro-2H-pyran-2-ones. 3. Bicyclic and hetero-aromatic ring systems as 3-position scaffolds to bind to S1′ and S2′ of the HIV-1 protease enzyme 1999 ·Bioorganic & Medicinal Chemistry Letters ·Edmund L. Ellsworth,John M. Domagala,J. V. N. Vara Prasad,Susan E. Hagen,Donna Ferguson,Tod P. Holler,Donald Hupe,Neil M.H. Graham,(unknown),Peter J. Tummino,(unknown),Elizabeth A. Lunney	8
7	2,2′-dithiobisbenzamides derived from α-, β- and γ-amino acids possessing anti-HIV activities: synthesis and structure–activity relationship 1998 ·Bioorganic & Medicinal Chemistry ·J. V. N. Vara Prasad,Joseph A. Loo,F Boyer,Michael A. Stier,Rocco D. Gogliotti,William J. Turner,Patricia J. Harvey,(unknown),David P. Mack,(unknown),Stephen J. Gracheck,John M. Domagala	21
8	Bacterial Two-Component Signalling as a Therapeutic Target in Drug Design 1998 ·Advances in experimental medicine and biology ·John M. Domagala,(unknown),Maxwell D. Cummings,Stephen J. Gracheck,Liren Huang,Michael D. Huband,(unknown),Eric R. Olson,Martin A. Shapiro,Rajeshwar Singh,Yuntao Song,(unknown),(unknown),(unknown)	9
9	A new class of anti-HIV-1 agents targeted toward the nucleocapsid protein NCp7: The 2,2′-dithiobisbenzamides 1997 ·Bioorganic & Medicinal Chemistry ·John M. Domagala,John P. Bader,Rocco D. Gogliotti,Joseph P. Sanchez,Michael A. Stier,Yuntao Song,J. V. N. Vara Prasad,Peter J. Tummino,Jeffrey D. Scholten,Patricia J. Harvey,Tod P. Holler,(unknown),Donald Hupe,William G. Rice,Robert Schultz	33
10	Discovery and optimization of nonpeptide HIV-1 protease inhibitors 1996 ·Bioorganic & Medicinal Chemistry ·Peter J. Tummino,J. V. N. Vara Prasad,Donna Ferguson,(unknown),Neil M.H. Graham,John M. Domagala,Edmund L. Ellsworth,Christopher Gajda,Susan E. Hagen,Elizabeth A. Lunney,Kimberly S. Para,Bradley D. Tait,A.G. Pavlovsky,John W. Erickson,Stephen J. Gracheck,Thomas J. McQuade,Donald Hupe	22
11	The Synthesis, Structure-Activity, and Structure-Side Effect Relationships of a Series of 8-Alkoxy- and 5-Amino-8-alkoxyquinolone Antibacterial Agents 1995 ·Journal of Medicinal Chemistry ·Joseph P. Sanchez,Rocco D. Gogliotti,John M. Domagala,Stephen J. Gracheck,Michael D. Huband,(unknown),Michael A. Cohen,Martin A. Shapiro	55
12	A Novel Nonpeptide HIV-1 Protease Inhibitor: Elucidation of the Binding Mode and Its Application in the Design of Related Analogs 1994 ·Journal of Medicinal Chemistry ·Elizabeth A. Lunney,Susan E. Hagen,John M. Domagala,Christine Humblet,(unknown),Bradley D. Tait,Joseph S. Warmus,Michael T. Wilson,Donna Ferguson	70
13	Synthesis and biological activity of 5-amino- and 5-hydroxyquinolones, and the overwhelming influence of the remote N1-substituent in determining the structure-activity relationship 1991 ·Journal of Medicinal Chemistry ·John M. Domagala,Alex Bridges,Townley P. Culbertson,Laura Gambino,Susan E. Hagen,Gregory L. Karrick,(unknown),Joseph P. Sanchez,(unknown)	42
14	New quinolone antibacterial agents. Synthesis and biological activity of 7-(3,3- or 3,4-disubstituted-1-pyrrolidinyl)quinoline-3-carboxylic acids 1990 ·Journal of Medicinal Chemistry ·Susan E. Hagen,John M. Domagala,Carl L. Heifetz,Joseph P. Sanchez,Marjorie S. Solomon	26
15	1-Substituted 7-[3-[(ethylamino)methyl]-1-pyrrolidinyl]-6,8-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acids. New quantitative structure activity relationships at N1 for the quinolone antibacterials 1988 ·Journal of Medicinal Chemistry ·John M. Domagala,Carl L. Heifetz,Marland P. Hutt,T. F. MICH,(unknown),Marjorie Solomon,Donald F. Worth	77
16	Quinolone antibacterial agents. Synthesis and structure-activity relationships of 8-substituted quinoline-3-carboxylic acids and 1,8-naphthyridine-3-carboxylic acids 1988 ·Journal of Medicinal Chemistry ·Joseph P. Sanchez,John M. Domagala,Susan E. Hagen,Carl L. Heifetz,Marland P. Hutt,(unknown),Ashok K. Trehan	108
17	7-Substituted 5-amino-1-cyclopropyl-6,8-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acids: synthesis and biological activity of a new class of quinolone antibacterials 1988 ·Journal of Medicinal Chemistry ·John M. Domagala,Susan E. Hagen,Carl L. Heifetz,Marland P. Hutt,T. F. MICH,Joseph P. Sanchez,Ashok K. Trehan	24
18	Enantiomers of 1-ethyl-7-[3-[(ethylamino)methyl]-1-pyrrolidinyl]-6,8-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid: preparation and biological activity 1987 ·Journal of Medicinal Chemistry ·Townley P. Culbertson,John M. Domagala,(unknown),(unknown),Richard W. Skeean	24
19	The effect of Lewis acid and solvent on concerted 1,2-acyl migration 1984 ·The Journal of Organic Chemistry ·Robert D. Bach,John M. Domagala	35
20	Synthesis of (Z)-4-(acylamino)- and 4-(alkylamino)-.alpha.-oximinophenylacetic acids: properties and stereochemical determination 1981 ·The Journal of Organic Chemistry ·John M. Domagala,Theodore H. Haskell	7

About John M. Domagala

John M. Domagala is a scholar working on Molecular Medicine, Virology and Organic Chemistry, having authored 62 papers that have together received 3.2k indexed citations. Recurring topics across this work include Cancer therapeutics and mechanisms (26 papers), HIV/AIDS drug development and treatment (12 papers) and Synthesis and Biological Evaluation (11 papers). The work is most often cited by research in Molecular Medicine (941 citations), Pharmacology (1.1k citations) and Virology (198 citations). John M. Domagala has collaborated with scholars based in United States, Canada and United Kingdom. Frequent co-authors include Karl Drlica, Xilin Zhao, Yuzhi Dong, Joseph P. Sanchez, Carl L. Heifetz, Chen Xu, Marland P. Hutt, Robert D. Bach, Susan E. Hagen and T. F. MICH. Their work appears in journals such as Science, Proceedings of the National Academy of Sciences and Journal of the American Chemical Society.

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