Scott J. Hecker

3.7k citations

47 papers · 2.5k indexed · 1 hit paper · h-index 22

Co-authors: Mark D. Erion Ving J. Lee Olga Lomovskaya Suzanne Chamberland Roger Léger Johanne Blais Kazuki Hoshino Angela Lee
Topics: Antibiotic Resistance in Bacteria (16 papers)Antibiotics Pharmacokinetics and Efficacy (11 papers)Microbial Natural Products and Biosynthesis (5 papers)
Cited by: Molecular Medicine Pharmacology Applied Microbiology and Biotechnology
Journals: Journal of the American Chemical Society ACS Catalysis Journal of Medicinal Chemistry
Partner nations: United States Japan Australia

In The Last Decade

Scott J. Hecker

47 papers receiving 2.3k citations

Hit Papers

align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Identification and Characterization of Inhibitors of Multidrug Resistance Efflux Pumps in Pseudomonas aeruginosa : Novel Agents for Combination Therapy

2001 731 citations Olga Lomovskaya, Mark S. Warren et al. Antimicrobial Agents and Chemotherapy profile →

Peers

Countries citing papers authored by Scott J. Hecker

Since Specialization

Citations

This map shows the geographic impact of Scott J. Hecker's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Scott J. Hecker with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Scott J. Hecker more than expected).

Fields of papers citing papers by Scott J. Hecker

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Scott J. Hecker. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Scott J. Hecker. The network helps show where Scott J. Hecker may publish in the future.

Co-authorship network of co-authors of Scott J. Hecker

This figure shows the co-authorship network connecting the top 25 collaborators of Scott J. Hecker. A scholar is included among the top collaborators of Scott J. Hecker based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Scott J. Hecker. Scott J. Hecker is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

#	Work	Indexed citations
1	Broad-spectrum cyclic boronate β-lactamase inhibitors featuring an intramolecular prodrug for oral bioavailability 2022 ·Bioorganic & Medicinal Chemistry ·K. Raja Reddy,Maxim Totrov,Olga Lomovskaya,David C. Griffith,Ziad Tarazi,Matthew C. Clifton,Scott J. Hecker	6
2	QPX7728, An Ultra-Broad-Spectrum B-Lactamase Inhibitor for Intravenous and Oral Therapy: Overview of Biochemical and Microbiological Characteristics 2021 ·Frontiers in Microbiology ·Olga Lomovskaya,Ruslan Tsivkovski,Dongxu Sun,(unknown),Maxim Totrov,Scott J. Hecker,David C. Griffith,Jeffery S. Loutit,Michael Dudley	34
3	Discovery of Cyclic Boronic Acid QPX7728, an Ultrabroad-Spectrum Inhibitor of Serine and Metallo-β-lactamases 2020 ·Journal of Medicinal Chemistry ·Scott J. Hecker,K. Raja Reddy,Olga Lomovskaya,David C. Griffith,Debora Rubio-Aparicio,Kirk Nelson,Ruslan Tsivkovski,Dongxu Sun,Mojgan Sabet,Ziad Tarazi,Jonathan Parkinson,Maxim Totrov,Serge H. Boyer,Tomasz Glinka,O.A. Pemberton,Yu Chen,Michael N. Dudley	158
4	Methodology for Monobactam Diversification: Syntheses and Studies of 4-Thiomethyl Substituted β-Lactams with Activity against Gram-Negative Bacteria, Including Carbapenemase Producing Acinetobacter baumannii 2017 ·Journal of Medicinal Chemistry ·(unknown),(unknown),Patricia A. Miller,Scott J. Hecker,Tomasz Glinka,Marvin J. Miller	23
5	A Potent and Selective AMPK Activator That Inhibits de Novo Lipogenesis 2010 ·ACS Medicinal Chemistry Letters ·Jorge Gomez‐Galeno,Qun Dang,(unknown),Serge H. Boyer,(unknown),Zhili Sun,Mingwei Chen,(unknown),Paul D. van Poelje,Deidre A. MacKenna,Edward E. Cable,(unknown),Patricia D. Finn,(unknown),David L. Linemeyer,Scott J. Hecker,Mark D. Erion	75
6	Relationships between structure, antibacterial activity, serum stability, pharmacokinetics and efficacy in 3-(heteroarylthio)cephems. Discovery of RWJ-333441 (MC-04,546) 2003 ·Bioorganic & Medicinal Chemistry ·Tomasz Glinka,Keith Huie,Aesop Cho,M. LUDWIKOW,Johanne Blais,David C. Griffith,Scott J. Hecker,Michael Dudley	7
7	Synthetic dihydropacidamycin antibiotics 2003 ·Bioorganic & Medicinal Chemistry Letters ·Constantine G. Boojamra,Rémy C. Lemoine,Johanne Blais,(unknown),(unknown),(unknown),Suzanne Chamberland,Scott J. Hecker,Ving J. Lee	28
8	Synthesis of base-modified dihydropacidamycins 2002 ·Bioorganic & Medicinal Chemistry Letters ·Rémy C. Lemoine,(unknown),Scott J. Hecker	14
9	A tour of recent patent applications addressing antibacterial resistance 2002 ·Expert Opinion on Therapeutic Patents ·Scott J. Hecker,(unknown)	5
10	New anti-MRSA cephalosporins with a basic aminopyridine at the C-7 position 2001 ·Bioorganic & Medicinal Chemistry Letters ·Aesop Cho,Tomasz Glinka,M. LUDWIKOW,(unknown),Michael Wang,Scott J. Hecker	9
11	Identification and Characterization of Inhibitors of Multidrug Resistance Efflux Pumps in Pseudomonas aeruginosa : Novel Agents for Combination Therapybreakdown → 2001 ·Antimicrobial Agents and Chemotherapy ·Olga Lomovskaya,Mark S. Warren,Angela Lee,Jorge L. Galazzo,(unknown),May Lee,Johanne Blais,(unknown),Suzanne Chamberland,(unknown),Roger Léger,Scott J. Hecker,W. J. Watkins,Kazuki Hoshino,Hiroko Ishida,Ving J. Lee	731
12	Stereochemical Elucidation and Total Synthesis of Dihydropacidamycin D, a Semisynthetic Pacidamycin 2001 ·Journal of the American Chemical Society ·Constantine G. Boojamra,Rémy C. Lemoine,Julie C. Lee,Roger Léger,(unknown),(unknown),(unknown),Olga Lomovskaya,Patrick K. Martin,Suzanne Chamberland,May D. Lee,Scott J. Hecker,Ving J. Lee	43
13	Discovery of RWJ-54428 (MC-02,479), a New Cephalosporin Active Against Resistant Gram-positive Bacteria. 2000 ·The Journal of Antibiotics ·Scott J. Hecker,Tomasz Glinka,Aesop Cho,(unknown),(unknown),Suzanne Chamberland,David C. Griffith,Ving J. Lee	16
14	SAR Studies of Anti-MRSA Non-zwitterionic 3-Heteroarylthiocephems. 2000 ·The Journal of Antibiotics ·Tomasz Glinka,(unknown),(unknown),M. LUDWIKOW,(unknown),(unknown),Scott J. Hecker,Michael N. Dudley,(unknown),Suzanne Chamberland	6
15	Antibiotic resistance versus small molecules, the chemical evolution 1999 ·Medicinal Research Reviews ·Ving J. Lee,Scott J. Hecker	37
16	Inhibitors of Efflux Pumps in Pseudomonas aeruginosa Potentiate the Activity of the Fluoroquinolone Antibacterial Levofloxacin 1999 ·Journal of Medicinal Chemistry ·Thomas E. Renau,Roger Léger,Eric M. Flamme,Joan Sangalang,(unknown),Rose Yen,(unknown),David Griffith,Suzanne Chamberland,Olga Lomovskaya,Scott J. Hecker,Ving J. Lee,Toshiharu Ohta,Kiyoshi Nakayama	219
17	In Vitro Microbiological Characterization of Novel Macrolide CP-163,505 for Animal Health Specific Use. 1998 ·The Journal of Antibiotics ·(unknown),Scott B. Seibel,Barbara J. Kamicker,(unknown),(unknown),Scott J. Hecker,Jay Bergeron,James A. Retsema,Shigeru Hayashi	7
18	Semisynthetic modification of hygromycin A. 1. Synthesis and antibacterial activity of vinyl methyl and amide analogs. 1992 ·Bioorganic & Medicinal Chemistry Letters ·Scott J. Hecker,Martha L. Minich,Kim M. Werner	15
19	Hygromycin A: preparation of aminocyclitol analogs defining the minimum functionality required for biological activity 1992 ·Bioorganic & Medicinal Chemistry Letters ·Scott J. Hecker,(unknown),Kim M. Werner	14
20	Total synthesis and biological evaluation of structural analogs of compactin and dihydromevinolin 1987 ·Journal of Medicinal Chemistry ·Clayton H. Heathcock,(unknown),Terry Rosen,(unknown),Scott J. Hecker	31

About Scott J. Hecker

Scott J. Hecker is a scholar working on Molecular Medicine, Pharmacology and Infectious Diseases, having authored 47 papers that have together received 2.5k indexed citations. Recurring topics across this work include Antibiotic Resistance in Bacteria (16 papers), Antibiotics Pharmacokinetics and Efficacy (11 papers) and Microbial Natural Products and Biosynthesis (5 papers). The work is most often cited by research in Molecular Medicine (967 citations), Pharmacology (577 citations) and Applied Microbiology and Biotechnology (67 citations). Scott J. Hecker has collaborated with scholars based in United States, Japan and Australia. Frequent co-authors include Mark D. Erion, Ving J. Lee, Olga Lomovskaya, Suzanne Chamberland, Roger Léger, Johanne Blais, Kazuki Hoshino, Angela Lee, W. J. Watkins and May Lee. Their work appears in journals such as Journal of the American Chemical Society, ACS Catalysis and Journal of Medicinal Chemistry.

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