Karl Drlica

18.8k citations

170 papers · 14.6k indexed · 5 hit papers · h-index 60

Impact in

Molecular Medicine top 0.02%
- Antibiotic Resistance in Bacteria
Pharmacology top 0.05%
- Antibiotics Pharmacokinetics and Efficacy

Papers in

Molecular Medicine 79
- Antibiotic Resistance in Bacteria 79
Pharmacology 50
- Antibiotics Pharmacokinetics and Efficacy 50

Co-authors: Xilin Zhao Josette Rouvière‐Yaniv Muhammad Malik Gail J. Pruss M Snyder Robert J. Kerns John M. Domagala Robert J. Franco
Journals: Antimicrobial Agents and Chemotherapy (40 papers)Journal of Bacteriology (12 papers)Journal of Antimicrobial Chemotherapy (11 papers)Journal of Molecular Biology (9 papers)Proceedings of the National Academy of Sciences (8 papers)
Partner nations: United States China Canada

In The Last Decade

Karl Drlica

168 papers receiving 13.8k citations

Hit Papers

5 papers align trajectories log scale

Post-stress bacterial cell death mediated by reactive oxygen species 2019 · 360 citations

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if any of the following hold:

it has ≥500 total citations;
it reaches ≥1.5× the top-1% citation threshold for papers in the same subfield and year (the threshold is the minimum needed to enter the top 1%, not the average within it);
it reaches the top citation threshold in at least one of its specific research topics.

2019 Proceedings of the National Academy of Sciences
2014 Current Opinion in Microbiology
1997 Microbiology and Molecular Biology Reviews
1997 Microbiology and Molecular Biology Reviews
1987 Microbiological Reviews

Peers

Countries citing papers authored by Karl Drlica

Since Specialization

Citations

This map shows the geographic impact of Karl Drlica's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Karl Drlica with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Karl Drlica more than expected).

Fields of papers citing papers by Karl Drlica

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Karl Drlica. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Karl Drlica. The network helps show where Karl Drlica may publish in the future.

Co-authors

The 25 scholars most cited alongside Karl Drlica, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Karl Drlica Line = papers co-authored together Karl Drlica links everyone, so they are left out of the graph.

All Works

Sort: Min cites: Since: Top N: Style:

20 of 20 papers shown

#	Work
1	Prophage-encoded methyltransferase drives adaptation of community-acquired methicillin-resistant Staphylococcus aureus Journal of Clinical Investigation ·Robert J. Ulrich, Magdalena Podkowik, Chiara Visintini, Irnov Irnov, Gregory Putzel, Fiona Dresel, Keenan A. Lacey, Daiane Boff, Wen-Yi Wu, R Verma, Theodora K. Karagounis, Erin E. Zwack, Suar Oh, Randie H. Kim, Karl Drlica, Alejandro Pironti, Harm van Bakel, Victor J. Torres, Bo Shopsin	2025	0
2	Broad-spectrum tolerance to disinfectant-mediated bacterial killing due to mutation of the PheS aminoacyl tRNA synthetase Proceedings of the National Academy of Sciences ·Miaomiao Chen, Ana Ivón Durán, 張志相, Natal'ja D. Kocetkova, Qiong Yang, Danny Shipka, Zan Nie, 武艳兵, Saori Iwatani, Yunxin Xue, Dai Wang, Yuzhi Hong, Karl Drlica, Jianjun Niu, Xilin Zhao	2025	3
3	Moxifloxacin-Mediated Killing of Mycobacterium tuberculosis Involves Respiratory Downshift, Reductive Stress, and Accumulation of Reactive Oxygen Species Antimicrobial Agents and Chemotherapy ·Xindan Wu, Samsher Singh, Azamat Zhalmuratov, Chandrani Thakur, Ai Imamura, Kusumawardhany Airlangga Rijanti, M Regna, Sakshi Kohli, Raju S Rajmani, Nagasuma Chandra, Harinath Chakrapani, Karl Drlica, Amit Singh	2022	29
4	A broadly applicable, stress-mediated bacterial death pathway regulated by the phosphotransferase system (PTS) and the cAMP-Crp cascade Proceedings of the National Academy of Sciences ·Jie Zeng, Yuzhi Hong, Lei-chi Wang, Qianyu Liu, Natal'ja D. Kocetkova, Paula Almodóvar, Khalid Norlin, Miaomiao Chen, 張志相, Liwen Wu, Yunxin Xue, Dai Wang, Jianjun Niu, Karl Drlica, Xilin Zhao	2022	55
5	Fluoroquinolone heteroresistance, antimicrobial tolerance, and lethality enhancement Frontiers in Cellular and Infection Microbiology ·Amit Singh, Xilin Zhao, Karl Drlica	2022	13
6	Susceptibility of Cutibacterium acnes to topical minocycline foam Anaerobe ·Joyce A. Sutcliffe, Robert E. McLaughlin, Guy Webster, Andrew F. Read, Karl Drlica, Sai S Madakasira, Iain Stuart	2020	14
7	Reactive oxygen species play a dominant role in all pathways of rapid quinolone-mediated killing Journal of Antimicrobial Chemotherapy ·Yuzhi Hong, Qiming Li, Qiong Gao, Jianping Xie, Haihui Huang, Karl Drlica, Xilin Zhao	2019	45
8	Fluoroquinolone-Gyrase-DNA Complexes Journal of Biological Chemistry ·Arkady Mustaev, Muhammad Malik, Xilin Zhao, Natalia Kurepina, A. S. Sawal, Lisa M. Oppegard, Hiroshi Hiasa, Izabel Brito Teixeira, Robert J. Kerns, James M. Berger, Karl Drlica	2014	131
9	Daptomycin inoculum effects and mutant prevention concentration with Staphylococcus aureus Journal of Antimicrobial Chemotherapy ·Brian Quinn, Syed Makhdoom Hussain, Muhammad Malik, Karl Drlica, Xilin Zhao	2007	33
10	Effect of Anaerobic Growth on Quinolone Lethality with Escherichia coli Antimicrobial Agents and Chemotherapy ·Muhammad Malik, Jiting Zhou, Karl Drlica	2006	50
11	Bactericidal activity and target preference of a piperazinyl-cross-linked ciprofloxacin dimer with Staphylococcus aureus and Escherichia coli Journal of Antimicrobial Chemotherapy ·Xilin Zhao, Brian Quinn, Robert J. Kerns, Karl Drlica	2006	12
12	Are the new quinolones appropriate treatment for community-acquired methicillin-resistant Staphylococcus aureus? International Journal of Antimicrobial Agents ·Bo Shopsin, Xilin Zhao, Barry N. Kreiswirth, Glenn Tillotson, Karl Drlica	2004	21
13	Fluoroquinolone‐ResistantStreptococcus pneumoniaeAssociated with Levofloxacin Therapy The Journal of Infectious Diseases ·Carl Urban, Erika Balogh, Xilin Zhao, Noriel Mariano, Sorana Segal‐Maurer, Karl Drlica, James J. Rahal	2001	88
14	Selection of Antibiotic‐Resistant Bacterial Mutants: Allelic Diversity among Fluoroquinolone‐Resistant Mutations The Journal of Infectious Diseases ·Chun Long Yao, Yuzhi Dong, Xilin Zhao, Sung-Woo Lee, Amol Amin, Srinivas V. Ramaswamy, John M. Domagala, James M. Musser, Karl Drlica	2000	112
15	Topoisomerase I of Helicobacter pylori: juxtaposition with a flagellin gene (flaB) and functional requirement of a fourth zinc finger motif Gene ·Sebastian Suerbaum, Otero Pujol, Agnès Labigne, Béatrice Cameron, Karl Drlica	1998	32
16	Monovalent cations differ in their effects on transcription initiation from a σ-70 promoter of Escherichia coli Gene ·Jian-Ying Wang, Karl Drlica, Michael Syvanen	1997	6
17	Fluoroquinolone Resistance Associated with Specific Gyrase Mutations in Clinical Isolates of Multidrug-Resistant Mycobacterium tuberculosis The Journal of Infectious Diseases ·Chen Xu, Barry N. Kreiswirth, Srinand Sreevatsan, James M. Musser, Karl Drlica	1996	86
18	Topoisomerase mutations affect the relative abundance of many Escherichia coli proteins Molecular Microbiology ·Todd R. Steck, Robert J. Franco, Jian‐Ying Wang, Karl Drlica	1993	52
19	DNA gyrase on the bacterial chromosome Journal of Molecular Biology ·Robert J. Franco, Karl Drlica	1988	31
20	Inhibitors of DNA topoisomerases Biochemistry ·Karl Drlica, Robert J. Franco	1988	291

About Karl Drlica

Karl Drlica is a scholar working on Molecular Medicine, Pharmacology, Infectious Diseases, Molecular Biology and Applied Microbiology and Biotechnology, having authored 170 papers that have together received 14.6k indexed citations. Recurring topics across this work include Antibiotic Resistance in Bacteria (79 papers), Cancer therapeutics and mechanisms (73 papers), Antibiotics Pharmacokinetics and Efficacy (50 papers), Bacterial Genetics and Biotechnology (34 papers), DNA Repair Mechanisms (20 papers), Tuberculosis Research and Epidemiology (20 papers), Mycobacterium research and diagnosis (18 papers) and DNA and Nucleic Acid Chemistry (18 papers). The work is most often cited by research in Molecular Medicine (5.2k citations), Pharmacology (3.7k citations), Applied Microbiology and Biotechnology (339 citations), Toxicology (532 citations) and Endocrinology (705 citations). Karl Drlica has collaborated with scholars based in United States, China and Canada. Frequent co-authors include Xilin Zhao, Josette Rouvière‐Yaniv, Muhammad Malik, Gail J. Pruss, M Snyder, Robert J. Kerns, John M. Domagala, Robert J. Franco, Yuzhi Hong and Yuzhi Dong. Their work appears in journals such as Antimicrobial Agents and Chemotherapy, Journal of Bacteriology, Journal of Antimicrobial Chemotherapy, Journal of Molecular Biology and Proceedings of the National Academy of Sciences.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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