Lawrence A. Donehower

70.9k total citations · 5 hit papers
148 papers, 17.7k citations indexed

About

Lawrence A. Donehower is a scholar working on Molecular Biology, Oncology and Cancer Research. According to data from OpenAlex, Lawrence A. Donehower has authored 148 papers receiving a total of 17.7k indexed citations (citations by other indexed papers that have themselves been cited), including 103 papers in Molecular Biology, 100 papers in Oncology and 32 papers in Cancer Research. Recurrent topics in Lawrence A. Donehower's work include Cancer-related Molecular Pathways (89 papers), Epigenetics and DNA Methylation (28 papers) and Cancer Research and Treatments (23 papers). Lawrence A. Donehower is often cited by papers focused on Cancer-related Molecular Pathways (89 papers), Epigenetics and DNA Methylation (28 papers) and Cancer Research and Treatments (23 papers). Lawrence A. Donehower collaborates with scholars based in United States, Japan and United Kingdom. Lawrence A. Donehower's co-authors include Allan Bradley, Michele Harvey, Charles A. Montgomery, Mark J. McArthur, Janet S. Butel, Betty L. Slagle, Stephen N. Jones, Xiongbin Lu, Hannes Vogel and Thuy‐Ai Nguyen and has published in prestigious journals such as Nature, Science and Cell.

In The Last Decade

Lawrence A. Donehower

148 papers receiving 17.3k citations

Hit Papers

5 papers align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

1992 3.8k citations Lawrence A. Donehower, Janet S. Butel et al. profile →
p53 mutant mice that display early ageing-associated phenotypes

2002 1.1k citations Sundaresan Venkatachalam, Stephen N. Jones et al. profile →
Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53

1995 1.0k citations Stephen N. Jones, Lawrence A. Donehower et al. profile →
Aging Hematopoietic Stem Cells Decline in Function and Exhibit Epigenetic Dysregulation

2007 580 citations Stuart M. Chambers, Chad A. Shaw et al. PLoS Biology profile →
Integrated Analysis of TP53 Gene and Pathway Alterations in The Cancer Genome Atlas

2019 421 citations Lawrence A. Donehower, Teng‐Kuei Hsu et al. profile →

Peers

Countries citing papers authored by Lawrence A. Donehower

Since Specialization

Citations

This map shows the geographic impact of Lawrence A. Donehower's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Lawrence A. Donehower with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Lawrence A. Donehower more than expected).

Fields of papers citing papers by Lawrence A. Donehower

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Lawrence A. Donehower. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Lawrence A. Donehower. The network helps show where Lawrence A. Donehower may publish in the future.

Co-authorship network of co-authors of Lawrence A. Donehower

This figure shows the co-authorship network connecting the top 25 collaborators of Lawrence A. Donehower. A scholar is included among the top collaborators of Lawrence A. Donehower based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Lawrence A. Donehower. Lawrence A. Donehower is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

#	Work	Indexed citations
1	A general calculus of fitness landscapes finds genes under selection in cancers 2022 ·Genome Research ·Teng‐Kuei Hsu, (unknown), Amanda Koire, Byung‐Kwon Choi, (unknown), (unknown), (unknown), (unknown), Young Won Kim, Curtis R. Pickering, Marek Kimmel, Lawrence A. Donehower, Mitchell J. Frederick, Jeffrey N. Myers, Panagiotis Katsonis, Olivier Lichtarge	7
2	A pediatric brain tumor atlas of genes deregulated by somatic genomic rearrangement 2021 ·Nature Communications ·Yiqun Zhang, Fengju Chen, Lawrence A. Donehower, Michael E. Scheurer, Chad J. Creighton	31
3	Secreted Frizzled-Related Protein 2 (sFRP2) promotes osteosarcoma invasion and metastatic potential 2016 ·BMC Cancer ·(unknown), Yang Gao, Lyazat Kurenbekova, Ryan L. Shuck, Lawrence A. Donehower, Jason T. Yustein	41
4	A Practical Example of Bringing Computation to Data 2014 ·Journal of Biomolecular Techniques JBT ·(unknown), (unknown), William Hale, Lili Xi, Lawrence A. Donehower, D. Kalra	1
5	Mouse Tissues that Undergo Neoplastic Progression after K-Ras Activation Are Distinguished by Nuclear Translocation of phospho-Erk1/2 and Robust Tumor Suppressor Responses 2012 ·Molecular Cancer Research ·Neha Parikh, Ryan L. Shuck, Thuy‐Ai Nguyen, Alan J. Herron, Lawrence A. Donehower	15
6	MMP13, Birc2 (cIAP1), and Birc3 (cIAP2), Amplified on Chromosome 9, Collaborate with p53 Deficiency in Mouse Osteosarcoma Progression 2009 ·Cancer Research ·Ou Ma, Wei‐Wen Cai, Lars Zender, Tajhal Dayaram, (unknown), Alan J. Herron, Scott W. Lowe, Tsz‐Kwong Man, Ching C. Lau, Lawrence A. Donehower	81
7	How does suppression of IGF-1 signaling by DNA damage affect aging and longevity? 2008 ·Mechanisms of Ageing and Development ·George Hinkal, Lawrence A. Donehower	25
8	Aging Hematopoietic Stem Cells Decline in Function and Exhibit Epigenetic Dysregulation breakdown → 2007 ·PLoS Biology ·Stuart M. Chambers, Chad A. Shaw, Catherine E. Gatza, (unknown), Lawrence A. Donehower, Margaret A. Goodell	580
9	Organ‐dependent susceptibility of p53 knockout mice to 2‐amino‐3‐methylimidazo[4,5‐f]quinoline (IQ) 2007 ·Cancer Science ·Akihiro Hirata, Tetsuya Tsukamoto, Masami Yamamoto, Shinji Takasu, Hiroki Sakai, Hisayo Ban, Tokuma Yanai, Toshiaki Masegi, Lawrence A. Donehower, Masae Tatematsu	1
10	Medulloblastomas overexpress the p53-inactivating oncogene WIP1/PPM1D 2007 ·Journal of Neuro-Oncology ·Robert C. Castellino, Massimiliano De Bortoli, Xiongbin Lu, Sung‐Hwan Moon, Thuy‐Ai Nguyen, (unknown), Pulivarthi H. Rao, Lawrence A. Donehower, John Y.H. Kim	108
11	Diet-Gene Interactions in p53-Deficient Mice: Insulin-like Growth Factor-1 as a Mechanistic Target 2004 ·Journal of Nutrition ·Stephen D. Hursting, Jackie A. Lavigne, David Berrigan, Lawrence A. Donehower, Barbara J. Davis, James M. Phang, J. Carl Barrett, Susan N. Perkins	23
12	Lack of elevated liver carcinogenicity of aminophenylnorharman in p53-deficient mice 2004 ·Cancer Letters ·(unknown), Tetsuya Tsukamoto, Yukari Totsuka, Akihiro Hirata, Hiroki Sakai, Norimitsu Shirai, Masami Yamamoto, Keiji Wakabayashi, Tokuma Yanai, Toshiaki Masegi, Lawrence A. Donehower, Masae Tatematsu	6
13	The p53-Induced Oncogenic Phosphatase PPM1D Interacts with Uracil DNA Glycosylase and Suppresses Base Excision Repair 2004 ·Molecular Cell ·Xiongbin Lu, Dora Bocangel, (unknown), Hiroshi Yamaguchi, Ettore Appella, Lawrence A. Donehower	105
14	Transgenic tumor models for carcinogen identification: the heterozygous Trp53-deficient and RasH2 mouse lines 2003 ·Mutation Research/Genetic Toxicology and Environmental Mutagenesis ·Richard D. Storer, John E. French, Lawrence A. Donehower, (unknown), Kunitoshi Mitsumori, Leslie Recio, Robert H. Schiestl, Frank D. Sistare, Norikazu Tamaoki, Tomohiko Usui, Harry van Steeg	5
15	High susceptibility of nullizygous p53 knockout mice to colorectal tumor induction by 1,2-dimethylhydrazine 2003 ·Journal of Cancer Research and Clinical Oncology ·Hiroki Sakai, Tetsuya Tsukamoto, Masami Yamamoto, Norimitsu Shirai, (unknown), Akihiro Hirata, Tokuma Yanai, Toshiaki Masegi, Lawrence A. Donehower, Masae Tatematsu	11
16	Effect of Intragastric Application ofN-Methylnitrosourea inp53 Knockout Mice 2000 ·Molecular Carcinogenesis ·Hiroko Ohgaki, Masakatsu Fukuda, Yasuo Tohma, Huatao Huang, George Stoica, (unknown), Lawrence A. Donehower	19
17	Cooperation between Ha-ras andfos or transforming growth factor ? overcomes a paradoxic tumor-inhibitory effect ofp53 loss in transgenic mouse epidermis 2000 ·Molecular Carcinogenesis ·Xiao‐Jing Wang, David A. Greenhalgh, Lawrence A. Donehower, Dennis R. Roop	6
18	Overexpression of Mdm2 in mice reveals a p53-independent role for Mdm2 in tumorigenesis 1998 ·Proceedings of the National Academy of Sciences ·Stephen N. Jones, (unknown), Hannes Vogel, Lawrence A. Donehower, Allan Bradley	322
19	Murine tumor suppressor models 1998 ·Mutation research. Fundamental and molecular mechanisms of mutagenesis ·Sundaresan Venkatachalam, Lawrence A. Donehower	9
20	Infrequent p53 mutations in 7,12‐dimethylbenz[a]anthracene–induced mammary tumors in BALB/c and p53 hemizygous mice 1994 ·Molecular Carcinogenesis ·D. Joseph Jerry, Janet S. Butel, Lawrence A. Donehower, (unknown), Charles Cochran, Roger W. Wiseman, Daniel Medina	49

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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