Jason Moffat

30.8k citations

168 papers · 16.3k indexed · 8 hit papers · h-index 56

Impact in

Biophysics top 0.05%
- Cell Image Analysis Techniques
Aging top 0.5%

Papers in

Aging 4
Molecular Biology 139
- CRISPR and Genetic Engineering 35
- RNA and protein synthesis mechanisms 16
- Ubiquitin and proteasome pathways 15
- Single-cell and spatial transcriptomics 14
- Fungal and yeast genetics research 13
- RNA Research and Splicing 12

Co-authors: David M. Sabatini David A. Guertin Anne E. Carpenter Thouis R. Jones Michael R. Lamprecht Polina Golland Joseph Chang Robert A. Lindquist
Journals: Cancer Research (13 papers)Cell (10 papers)Proceedings of the National Academy of Sciences (8 papers)Cell Reports (5 papers)Oncogene (4 papers)
Partner nations: Canada United States United Kingdom

In The Last Decade

Jason Moffat

163 papers receiving 16.1k citations

Hit Papers

8 papers align trajectories log scale

High-content CRISPR screening 2022 · 276 citations

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if any of the following hold:

it has ≥500 total citations;
it reaches ≥1.5× the top-1% citation threshold for papers in the same subfield and year (the threshold is the minimum needed to enter the top 1%, not the average within it);
it reaches the top citation threshold in at least one of its specific research topics.

2022 Nature Reviews Methods Primers
2022 Nature Reviews Methods Primers
2015 Cell
2015 Cell
2006 Genome biology
2006 Developmental Cell
2006 Cell
1997 Journal of Biological Chemistry

Peers

Countries citing papers authored by Jason Moffat

Since Specialization

Citations

This map shows the geographic impact of Jason Moffat's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Jason Moffat with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Jason Moffat more than expected).

Fields of papers citing papers by Jason Moffat

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Jason Moffat. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Jason Moffat. The network helps show where Jason Moffat may publish in the future.

Co-authors

The 25 scholars most cited alongside Jason Moffat, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Jason Moffat Line = papers co-authored together Jason Moffat links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

#	Work
1	Salmonella exploits membrane reservoirs for invasion of host cells Nature Communications ·Hongxian Zhu, Andrew M. Sydor, Kirsten C. Boddy, Étienne Coyaud, Estelle Laurent, Aaron Au, Joel M. J. Tan, Bing-Ru Yan, Jason Moffat, Aleixo M. Muise, Christopher M. Yip, Sergio Grinstein, Brian Raught, John H. Brumell	2024	13
2	Synergistic hyperactivation of both mTORC1 and mTORC2 underlies the neural abnormalities of PTEN-deficient human neurons and cortical organoids Cell Reports ·Navroop K. Dhaliwal, Octavia Yifang Weng, Xiaoxue Dong, Afrin Bhattacharya, Mai Ahmed, Haruka Nishimura, Wendy W. Y. Choi, Aditi Aggarwal, Bryan W. Luikart, Qiang Shu, Xuekun Li, Michael D. Wilson, Jason Moffat, Lu‐Yang Wang, Julien Muffat, Yun Li	2024	11
3	Cytidine deaminases APOBEC3C and APOBEC3D promote DNA replication stress resistance in pancreatic cancer cells Nature Cancer ·Tajinder Ubhi, Olga Zaslaver, Andrew T. Quaile, Dennis Plenker, Pinjiang Cao, Nhu‐An Pham, (unknown), Gun-Ho Jang, Grainne M. O’Kane, Faiyaz Notta, Jason Moffat, Julie M. Wilson, Steven Gallinger, Beáta G. Vértessy, David A. Tuveson, Hannes Röst, Grant W. Brown	2024	12
4	Identification of acquired Notch3 dependency in metastatic Head and Neck Cancer Communications Biology ·Maria Kondratyev, Aleksandra Pesic, Troy Ketela, Natalie Stickle, Christine Beswick, Zvi Shalev, Stefano Marastoni, Soroush Samadian, Anna Dvorkin‐Gheva, Azin Sayad, Mikhail Bashkurov, Pedro Boasquevisque, Alessandro Datti, Trevor J. Pugh, Carl Virtanen, Jason Moffat, Reidar Grénman, Marianne Koritzinsky, Bradly G. Wouters	2023	7
5	Novel Methionine Aminopeptidase 2 Inhibitor M8891 Synergizes with VEGF Receptor Inhibitors to Inhibit Tumor Growth of Renal Cell Carcinoma Models Molecular Cancer Therapeutics ·Manja Friese‐Hamim, Maria J. Ortiz Ruiz, Olga Bogatyrova, Marina Keil, Felix Rohdich, Beatrix Blume, Birgitta Leuthner, Frank Czauderna, Diane Hahn, Julia Jabs, Frank Jaehrling, Timo Heinrich, Roland Kellner, Katherine Chan, Amy H.Y. Tong, Dirk Wienke, Jason Moffat, Andree Blaukat, Frank T. Zenke	2023	1
6	Topoisomerase 1 Inhibition in MYC-Driven Cancer Promotes Aberrant R-Loop Accumulation to Induce Synthetic Lethality Cancer Research ·Peter Lin, Corey Lourenco, Jennifer Cruickshank, Luís Palomero, Jenna E. van Leeuwen, Amy H.Y. Tong, Katherine Chan, Samah El Ghamrasni, Miguel Ángel Pujana, David W. Cescon, Jason Moffat, Linda Z. Penn	2023	18
7	Leveraging the CSF proteome toward minimally-invasive diagnostics surveillance of brain malignancies Neuro-Oncology Advances ·Nicholas Mikolajewicz, Shahbaz Khan, Mara Trifoi, Anna Skakdoub, Vladmir Ignatchenko, Sheila Mansouri, Jeffrey Zuccato, Brad E. Zacharia, Michael Glantz, Gelareh Zadeh, Jason Moffat, Thomas Kislinger, Alireza Mansouri	2022	10
8	Identification of five important genes to predict glioblastoma subtypes Neuro-Oncology Advances ·Yang Tang, Maleeha Qazi, Kevin R. Brown, Nicholas Mikolajewicz, Jason Moffat, Sheila K. Singh, Paul D. McNicholas	2021	9
9	Paralogous synthetic lethality underlies genetic dependencies of the cancer-mutated gene STAG2 Life Science Alliance ·Melanie L. Bailey, David Tieu, Andrea Habsid, Amy H.Y. Tong, Katherine Chan, Jason Moffat, Philip Hieter	2021	12
10	Functional genomics identifies new synergistic therapies for retinoblastoma Oncogene ·Arthur Aubry, Joel D. Pearson, Katherine Huang, Izhar Livne‐Bar, Mohammad Ahmad, Jagadeesan Madhavan, Vikas Khetan, Troy Ketela, Kevin R. Brown, Tao Yu, Suying Lü, Jeffrey L. Wrana, Jason Moffat, Rod Bremner	2020	28
11	Tailored tetravalent antibodies potently and specifically activate Wnt/Frizzled pathways in cells, organoids and mice eLife ·Yuyong Tao, Monika Mis, Levi L. Blazer, Mart Ustav, Zachary Steinhart, Rony Chidiac, Elli Kubarakos, Siobhan O’Brien, Xiaomei Wang, Nick Jarvik, Nish Patel, Jarrett Adams, Jason Moffat, Stéphane Angers, Sachdev S. Sidhu	2019	67
12	The Inhibitory NKR-P1B:Clr-b Recognition Axis Facilitates Detection of Oncogenic Transformation and Cancer Immunosurveillance Cancer Research ·Miho Tanaka, Jason H. Fine, Christina L. Kirkham, Oscar A. Aguilar, A. Belcheva, Alberto Martín, Troy Ketela, Jason Moffat, David Allan, James R. Carlyle	2018	8
13	A synthetic anti-Frizzled antibody engineered for broadened specificity exhibits enhanced anti-tumor properties mAbs ·Zvezdan Pavlovic, Jarrett Adams, Levi L. Blazer, Amandeep K. Gakhal, Nick Jarvik, Zachary Steinhart, Mélanie Robitaille, Keith Mascall, James Pan, Stéphane Angers, Jason Moffat, Sachdev S. Sidhu	2018	55
14	Identification of P450 Oxidoreductase as a Major Determinant of Sensitivity to Hypoxia-Activated Prodrugs Cancer Research ·Francis W. Hunter, Richard J. Young, Zvi Shalev, Ravi N. Vellanki, Jingli Wang, Yongchuan Gu, Naveen Joshi, Sreevalsan Sreebhavan, Ilan Weinreb, David P. Goldstein, Jason Moffat, Troy Ketela, Kevin R. Brown, Marianne Koritzinsky, Benjamin Solomon, Danny Rischin, William R. Wilson, Bradly G. Wouters	2015	59
15	Yeast Proteome Dynamics from Single Cell Imaging and Automated Analysis Cell ·Yolanda Chong, Judice L.Y. Koh, Helena Friesen, Supipi Duffy, Michael J. Cox, Alan M Moses, Jason Moffat, Charles Boone, Brenda Andrews	2015	7
16	Measuring error rates in genomic perturbation screens: gold standards for human functional genomics Molecular Systems Biology ·Traver Hart, Kevin R. Brown, Fabrice Sircoulomb, Robert Rottapel, Jason Moffat	2014	215
17	shRNA Kinome Screen Identifies TBK1 as a Therapeutic Target for HER2+ Breast Cancer Cancer Research ·Tao Deng, Jeff C. Liu, Philip E.D. Chung, David Uehling, Asma M. Aman, Babu Joseph, Troy Ketela, Zhe Jiang, Nathan F. Schachter, Robert Rottapel, Sean E. Egan, Rima Al‐awar, Jason Moffat, Eldad Zacksenhaus	2014	29
18	Targeting HER2 + breast cancer cells: Lysosomal accumulation of anti-HER2 antibodies is influenced by antibody binding site and conjugation to polymeric nanoparticles Journal of Controlled Release ·Shawn C. Owen, Nish Patel, Jennifer Logie, Guohua Pan, Helena Persson, Jason Moffat, Sachdev S. Sidhu, Molly S. Shoichet	2013	46
19	The Mixed Lineage Leukemia (MLL) Fusion–Associated Gene AF4 Promotes CD133 Transcription Cancer Research ·Anthony B. Mak, Allison M.L. Nixon, Jason Moffat	2012	35
20	Selective Inhibition of Histone Deacetylases Sensitizes Malignant Cells to Death Receptor Ligands Molecular Cancer Therapeutics ·Tabitha E. Wood, Shadi Dalili, Craig D. Simpson, Mahadeo A. Sukhai, Rose Hurren, Kika Anyiwe, Xinliang Mao, Fernando Suárez, Marcela Gronda, Yanina Eberhard, Neil MacLean, Troy Ketela, John C. Reed, Jason Moffat, Mark D. Minden, Robert A. Batey, Aaron D. Schimmer	2010	56

About Jason Moffat

Jason Moffat is a scholar working on Aging, Molecular Biology, Biophysics, Genetics and Oncology, having authored 168 papers that have together received 16.3k indexed citations. Recurring topics across this work include CRISPR and Genetic Engineering (35 papers), RNA and protein synthesis mechanisms (16 papers), Ubiquitin and proteasome pathways (15 papers), Single-cell and spatial transcriptomics (14 papers), Monoclonal and Polyclonal Antibodies Research (14 papers), Fungal and yeast genetics research (13 papers), RNA Research and Splicing (12 papers) and Glioma Diagnosis and Treatment (12 papers). The work is most often cited by research in Biophysics (1.9k citations), Aging (326 citations), Molecular Biology (11.9k citations), Cell Biology (2.0k citations) and Cancer Research (1.4k citations). Jason Moffat has collaborated with scholars based in Canada, United States and United Kingdom. Frequent co-authors include David M. Sabatini, David A. Guertin, Anne E. Carpenter, Thouis R. Jones, Michael R. Lamprecht, Polina Golland, Joseph Chang, Robert A. Lindquist, Ola Friman and Colin Clarke. Their work appears in journals such as Cancer Research, Cell, Proceedings of the National Academy of Sciences, Cell Reports and Oncogene.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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