James E. Brownell

9.7k total citations · 3 hit papers
34 papers, 5.7k citations indexed

About

James E. Brownell is a scholar working on Molecular Biology, Oncology and Cell Biology. According to data from OpenAlex, James E. Brownell has authored 34 papers receiving a total of 5.7k indexed citations (citations by other indexed papers that have themselves been cited), including 31 papers in Molecular Biology, 7 papers in Oncology and 5 papers in Cell Biology. Recurrent topics in James E. Brownell's work include Ubiquitin and proteasome pathways (16 papers), Genomics and Chromatin Dynamics (9 papers) and Protein Degradation and Inhibitors (8 papers). James E. Brownell is often cited by papers focused on Ubiquitin and proteasome pathways (16 papers), Genomics and Chromatin Dynamics (9 papers) and Protein Degradation and Inhibitors (8 papers). James E. Brownell collaborates with scholars based in United States, United Kingdom and Canada. James E. Brownell's co-authors include C. David Allis, Diane G. Edmondson, Zhou Jian-xin, C. David Allis, Tamara A. Ranalli, Sharon Y. Roth, Ryûji Kobayashi, Lawrence R. Dick, Jerry L. Workman and Shelley L. Berger and has published in prestigious journals such as Nature, Cell and Proceedings of the National Academy of Sciences.

In The Last Decade

James E. Brownell

34 papers receiving 5.6k citations

Hit Papers

align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Tetrahymena Histone Acetyltransferase A: A Homolog to Yeast Gcn5p Linking Histone Acetylation to Gene Activation

1996 1.3k citations James E. Brownell, Zhou Jian-xin et al. Cell profile →
Yeast Gcn5 functions in two multisubunit complexes to acetylate nucleosomal histones: characterization of an Ada complex and the SAGA (Spt/Ada) complex.

1997 906 citations Patrick A. Grant, Laura J. Duggan et al. Genes & Development profile →
The TAFII250 Subunit of TFIID Has Histone Acetyltransferase Activity

1996 599 citations Craig A. Mizzen, Xiang‐Jiao Yang et al. Cell profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name	h						Papers	Cites
James E. Brownell United States	21	5.1k	875	547	436	391	34	5.7k
Giuseppe Biamonti Italy	47	5.5k 1.1×	525 0.6×	457 0.8×	445 1.0×	189 0.5×	114	6.3k
Haijuan Yang United States	13	4.5k 0.9×	692 0.8×	221 0.4×	674 1.5×	251 0.6×	20	5.1k
Sharon Y. Roth United States	28	5.6k 1.1×	481 0.5×	742 1.4×	567 1.3×	192 0.5×	39	6.1k
Jamal Tazi France	43	5.3k 1.0×	497 0.6×	259 0.5×	457 1.0×	186 0.5×	87	6.0k
Hisato Saitoh Japan	38	4.6k 0.9×	1.3k 1.4×	601 1.1×	772 1.8×	621 1.6×	92	5.3k
Scott Briggs United States	32	6.1k 1.2×	456 0.5×	875 1.6×	489 1.1×	201 0.5×	50	6.9k
Eric A. Hendrickson United States	44	4.6k 0.9×	1.5k 1.7×	453 0.8×	538 1.2×	332 0.8×	105	5.4k
Andrew C.G. Porter United Kingdom	32	2.8k 0.5×	999 1.1×	265 0.5×	366 0.8×	180 0.5×	83	3.6k
Michael J. Pazin United States	25	4.0k 0.8×	441 0.5×	402 0.7×	530 1.2×	130 0.3×	35	4.7k
Deanna M. Koepp United States	18	4.2k 0.8×	1.2k 1.4×	354 0.6×	437 1.0×	469 1.2×	33	4.8k

Countries citing papers authored by James E. Brownell

Since Specialization

Citations

This map shows the geographic impact of James E. Brownell's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by James E. Brownell with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites James E. Brownell more than expected).

Fields of papers citing papers by James E. Brownell

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by James E. Brownell. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by James E. Brownell. The network helps show where James E. Brownell may publish in the future.

Co-authorship network of co-authors of James E. Brownell

This figure shows the co-authorship network connecting the top 25 collaborators of James E. Brownell. A scholar is included among the top collaborators of James E. Brownell based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with James E. Brownell. James E. Brownell is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

Brownell, James E. & C. David Allis. (2020). HAT discovery: Heading toward an elusive goal with a key biological assist. Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms. 1864(2). 194605–194605. 8 indexed citations

Huang, Shih‐Chung, Sharmila Adhikari, James E. Brownell, et al.. (2020). Discovery and optimization of pyrazolopyrimidine sulfamates as ATG7 inhibitors. Bioorganic & Medicinal Chemistry. 28(19). 115681–115681. 20 indexed citations

He, Xingyue, Jessica Riceberg, Sai Murali Krishna Pulukuri, et al.. (2015). Characterization of the Loss of SUMO Pathway Function on Cancer Cells and Tumor Proliferation. PLoS ONE. 10(4). e0123882–e0123882. 49 indexed citations

Yang, Xiaofeng, James E. Brownell, Qing Xu, et al.. (2013). Absolute Quantification of E1, Ubiquitin-Like Proteins and Nedd8–MLN4924 Adduct by Mass Spectrometry. Cell Biochemistry and Biophysics. 67(1). 139–147. 11 indexed citations

Bruzzese, Frank J., Michael A. Milhollen, James M. Gavin, Helen R. Josephine, & James E. Brownell. (2012). Identification and Application of NEDD8 E1 Inhibitors. Methods in molecular biology. 832. 577–588. 5 indexed citations

Gavin, James M., Hua Liao, Xiaofeng Yang, et al.. (2012). Mechanistic Studies on Activation of Ubiquitin and Di-ubiquitin-like Protein, FAT10, by Ubiquitin-like Modifier Activating Enzyme 6, Uba6. Journal of Biological Chemistry. 287(19). 15512–15522. 31 indexed citations

Tsu, Christopher, James M. Gavin, Michael A. Milhollen, et al.. (2011). Mechanistic Studies of Substrate-assisted Inhibition of Ubiquitin-activating Enzyme by Adenosine Sulfamate Analogues. Journal of Biological Chemistry. 286(47). 40867–40877. 66 indexed citations

Dick, Lawrence R., et al.. (2010). The NEDD8 Conjugation Pathway and Its Relevance in Cancer Biology and Therapy. Genes & Cancer. 1(7). 708–716. 185 indexed citations

Bedford, Lynn, James Lowe, Lawrence R. Dick, R. John Mayer, & James E. Brownell. (2010). Ubiquitin-like protein conjugation and the ubiquitin–proteasome system as drug targets. Nature Reviews Drug Discovery. 10(1). 29–46. 441 indexed citations

10.

Brownell, James E., Craig A. Mizzen, & C. David Allis. (2003). An SDS-PAGE-Based Enzyme Activity Assay for the Detection and Identification of Histone Acetyltransferases. Humana Press eBooks. 119. 343–354. 6 indexed citations

11.

Podust, Vladimir N., James E. Brownell, Tatiana Gladysheva, et al.. (2000). A Nedd8 conjugation pathway is essential for proteolytic targeting of p27 ^Kip1 by ubiquitination. Proceedings of the National Academy of Sciences. 97(9). 4579–4584. 215 indexed citations

12.

Mizzen, Craig A., James E. Brownell, Richard G. Cook, & C. David Allis. (1999). Histone acetyltransferases: Preparation of substrates and assay procedures. Methods in enzymology on CD-ROM/Methods in enzymology. 304. 675–696. 59 indexed citations

13.

Grant, Patrick A., Laura J. Duggan, Jacques Côté, et al.. (1997). Yeast Gcn5 functions in two multisubunit complexes to acetylate nucleosomal histones: characterization of an Ada complex and the SAGA (Spt/Ada) complex.. Genes & Development. 11(13). 1640–1650. 906 indexed citations breakdown →

14.

Brownell, James E. & C. David Allis. (1996). Special HATs for special occasions: linking histone acetylation to chromatin assembly and gene activation. Current Opinion in Genetics & Development. 6(2). 176–184. 441 indexed citations

15.

Mizzen, Craig A., Xiang‐Jiao Yang, Tetsuro Kokubo, et al.. (1996). The TAFII250 Subunit of TFIID Has Histone Acetyltransferase Activity. Cell. 87(7). 1261–1270. 599 indexed citations breakdown →

16.

Brownell, James E., Zhou Jian-xin, Tamara A. Ranalli, et al.. (1996). Tetrahymena Histone Acetyltransferase A: A Homolog to Yeast Gcn5p Linking Histone Acetylation to Gene Activation. Cell. 84(6). 843–851. 1251 indexed citations breakdown →

17.

Kuo, Min‐Hao, James E. Brownell, Richard Sobel, et al.. (1996). Transcription-linked acetylation by Gcn5p of histones H3 and H4 at specific lysines. Nature. 383(6597). 269–272. 478 indexed citations

18.

Brownell, James E., et al.. (1994). Comparison of Native Matrix Metalloproteinases and Their Recombinant Catalytic Domains Using a Novel Radiometric Assay. Archives of Biochemistry and Biophysics. 314(1). 120–125. 6 indexed citations

19.

Alvarez, Maria E., David R. Houck, James E. Brownell, et al.. (1994). Isolation and structure elucidation of two new calpain inhibitors from Streptomyces griseus.. The Journal of Antibiotics. 47(11). 1195–1201. 25 indexed citations

20.

Sedlock, David M., et al.. (1994). WIN 64821, a novel neurokinin antagonist produced by an Aspergillus sp. I. Fermentation and isolation.. The Journal of Antibiotics. 47(4). 391–398. 30 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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